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457 results on '"Kharas, Michael G"'

1. RNA binding protein SYNCRIP maintains proteostasis and self-renewal of hematopoietic stem and progenitor cells

Author

Herrejon Chavez, Florisela, Luo, Hanzhi, Cifani, Paolo, Pine, Alli, Chu, Eren L., Joshi, Suhasini, Barin, Ersilia, Schurer, Alexandra, Chan, Mandy, Chang, Kathryn, Han, Grace Y. Q., Pierson, Aspen J., Xiao, Michael, Yang, Xuejing, Kuehm, Lindsey M., Hong, Yuning, Nguyen, Diu T. T., Chiosis, Gabriela, Kentsis, Alex, Leslie, Christina, Vu, Ly P., and Kharas, Michael G.

Published
2023
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4. TP53 mutations and RNA-binding protein MUSASHI-2 drive resistance to PRMT5-targeted therapy in B-cell lymphoma

Author

Erazo, Tatiana, Evans, Chiara M., Zakheim, Daniel, Chu, Eren L., Refermat, Alice Yunsi, Asgari, Zahra, Yang, Xuejing, Da Silva Ferreira, Mariana, Mehta, Sanjoy, Russo, Marco Vincenzo, Knezevic, Andrea, Zhang, Xi-Ping, Chen, Zhengming, Fennell, Myles, Garippa, Ralph, Seshan, Venkatraman, de Stanchina, Elisa, Barbash, Olena, Batlevi, Connie Lee, Leslie, Christina S., Melnick, Ari M., Younes, Anas, and Kharas, Michael G.

Published
2022
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6. Transcriptional control of CBX5 by the RNA-binding proteins RBMX and RBMXL1 maintains chromatin state in myeloid leukemia

Author

Prieto, Camila, Nguyen, Diu T. T., Liu, Zhaoqi, Wheat, Justin, Perez, Alexendar, Gourkanti, Saroj, Chou, Timothy, Barin, Ersilia, Velleca, Anthony, Rohwetter, Thomas, Chow, Arthur, Taggart, James, Savino, Angela M., Hoskova, Katerina, Dhodapkar, Meera, Schurer, Alexandra, Barlowe, Trevor S., Vu, Ly P., Leslie, Christina, Steidl, Ulrich, Rabadan, Raul, and Kharas, Michael G.

Published
2021
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10. SON is an essential m6A target for hematopoietic stem cell fate

Author

Luo, Hanzhi, primary, Cortés-López, Mariela, additional, Tam, Cyrus L., additional, Xiao, Michael, additional, Wakiro, Isaac, additional, Chu, Karen L., additional, Pierson, Aspen, additional, Chan, Mandy, additional, Chang, Kathryn, additional, Yang, Xuejing, additional, Fecko, Daniel, additional, Han, Grace, additional, Ahn, Eun-Young Erin, additional, Morris, Quaid D., additional, Landau, Dan A., additional, and Kharas, Michael G., additional

Published
2023
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11. Metabolic adaptation of acute lymphoblastic leukemia to the central nervous system microenvironment depends on stearoyl-CoA desaturase

Author

Savino, Angela Maria, Fernandes, Sara Isabel, Olivares, Orianne, Zemlyansky, Anna, Cousins, Antony, Markert, Elke K., Barel, Shani, Geron, Ifat, Frishman, Liron, Birger, Yehudit, Eckert, Cornelia, Tumanov, Sergey, MacKay, Gillian, Kamphorst, Jurre J., Herzyk, Pawel, Fernández-García, Jonatan, Abramovich, Ifat, Mor, Inbal, Bardini, Michela, Barin, Ersilia, Janaki-Raman, Sudha, Cross, Justin R., Kharas, Michael G., Gottlieb, Eyal, Izraeli, Shai, and Halsey, Christina

Published
2020
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13. ChromaFold predicts the 3D contact map from single-cell chromatin accessibility

Author

Gao, Vianne R., primary, Yang, Rui, additional, Das, Arnav, additional, Luo, Renhe, additional, Luo, Hanzhi, additional, McNally, Dylan R., additional, Karagiannidis, Ioannis, additional, Rivas, Martin A., additional, Wang, Zhong-Min, additional, Barisic, Darko, additional, Karbalayghareh, Alireza, additional, Wong, Wilfred, additional, Zhan, Yingqian A., additional, Chin, Christopher R., additional, Noble, William, additional, Bilmes, Jeff A., additional, Apostolou, Effie, additional, Kharas, Michael G., additional, Béguelin, Wendy, additional, Viny, Aaron D., additional, Huangfu, Danwei, additional, Rudensky, Alexander Y., additional, Melnick, Ari M., additional, and Leslie, Christina S., additional

Published
2023
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14. Supplementary Tables 1-6 from Patient-Derived iPSCs Faithfully Represent the Genetic Diversity and Cellular Architecture of Human Acute Myeloid Leukemia

Author

Kotini, Andriana G., primary, Carcamo, Saul, primary, Cruz-Rodriguez, Nataly, primary, Olszewska, Malgorzata, primary, Wang, Tiansu, primary, Demircioglu, Deniz, primary, Chang, Chan-Jung, primary, Bernard, Elsa, primary, Chao, Mark P., primary, Majeti, Ravindra, primary, Luo, Hanzhi, primary, Kharas, Michael G., primary, Hasson, Dan, primary, and Papapetrou, Eirini P., primary

Published
2023
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15. Data from Patient-Derived iPSCs Faithfully Represent the Genetic Diversity and Cellular Architecture of Human Acute Myeloid Leukemia

Author

Kotini, Andriana G., primary, Carcamo, Saul, primary, Cruz-Rodriguez, Nataly, primary, Olszewska, Malgorzata, primary, Wang, Tiansu, primary, Demircioglu, Deniz, primary, Chang, Chan-Jung, primary, Bernard, Elsa, primary, Chao, Mark P., primary, Majeti, Ravindra, primary, Luo, Hanzhi, primary, Kharas, Michael G., primary, Hasson, Dan, primary, and Papapetrou, Eirini P., primary

Published
2023
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16. Supplementary Figures 1-8 from Patient-Derived iPSCs Faithfully Represent the Genetic Diversity and Cellular Architecture of Human Acute Myeloid Leukemia

Author

Kotini, Andriana G., primary, Carcamo, Saul, primary, Cruz-Rodriguez, Nataly, primary, Olszewska, Malgorzata, primary, Wang, Tiansu, primary, Demircioglu, Deniz, primary, Chang, Chan-Jung, primary, Bernard, Elsa, primary, Chao, Mark P., primary, Majeti, Ravindra, primary, Luo, Hanzhi, primary, Kharas, Michael G., primary, Hasson, Dan, primary, and Papapetrou, Eirini P., primary

Published
2023
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19. The N6-methyladenosine (m6A)-forming enzyme METTL3 controls myeloid differentiation of normal hematopoietic and leukemia cells

Author

Vu, Ly P, Pickering, Brian F, Cheng, Yuanming, Zaccara, Sara, Nguyen, Diu, Minuesa, Gerard, Chou, Timothy, Chow, Arthur, Saletore, Yogesh, MacKay, Matthew, Schulman, Jessica, Famulare, Christopher, Patel, Minal, Klimek, Virginia M, Garrett-Bakelman, Francine E, Melnick, Ari, Carroll, Martin, Mason, Christopher E, Jaffrey, Samie R, and Kharas, Michael G

Subjects
Hematopoiesis -- Research, Embryonic stem cells -- Research, Cell differentiation -- Research, Apoptosis -- Research, Myelocytic leukemia -- Diagnosis -- Care and treatment -- Research, Nonlymphoid leukemia -- Diagnosis -- Care and treatment -- Research, Biological sciences, Health
Abstract

N[sup.6]-methyladenosine (m[sup.6]A) is an abundant nucleotide modification in mRNA that is required for the differentiation of mouse embryonic stem cells. However, it remains unknown whether the m[sup.6]A modification controls the differentiation of normal and/or malignant myeloid hematopoietic cells. Here we show that shRNA-mediated depletion of the m[sup.6]A-forming enzyme METTL3 in human hematopoietic stem/progenitor cells (HSPCs) promotes cell differentiation, coupled with reduced cell proliferation. Conversely, overexpression of wild-type METTL3, but not of a catalytically inactive form of METTL3, inhibits cell differentiation and increases cell growth. METTL3 mRNA and protein are expressed more abundantly in acute myeloid leukemia (AML) cells than in healthy HSPCs or other types of tumor cells. Furthermore, METTL3 depletion in human myeloid leukemia cell lines induces cell differentiation and apoptosis and delays leukemia progression in recipient mice in vivo. Single-nucleotide-resolution mapping of m[sup.6]A coupled with ribosome profiling reveals that m[sup.6]A promotes the translation of c-MYC, BCL2 and PTEN mRNAs in the human acute myeloid leukemia MOLM-13 cell line. Moreover, loss of METTL3 leads to increased levels of phosphorylated AKT, which contributes to the differentiation-promoting effects of METTL3 depletion. Overall, these results provide a rationale for the therapeutic targeting of METTL3 in myeloid leukemia., Author(s): Ly P Vu [1, 12]; Brian F Pickering [2, 12]; Yuanming Cheng [1, 12]; Sara Zaccara [2]; Diu Nguyen [1]; Gerard Minuesa [1]; Timothy Chou [1]; Arthur Chow [1]; [...]

Published
2017
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20. Patient-Derived iPSCs Faithfully Represent the Genetic Diversity and Cellular Architecture of Human Acute Myeloid Leukemia

Author

Kotini, Andriana G., primary, Carcamo, Saul, additional, Cruz-Rodriguez, Nataly, additional, Olszewska, Malgorzata, additional, Wang, Tiansu, additional, Demircioglu, Deniz, additional, Chang, Chan-Jung, additional, Bernard, Elsa, additional, Chao, Mark P., additional, Majeti, Ravindra, additional, Luo, Hanzhi, additional, Kharas, Michael G., additional, Hasson, Dan, additional, and Papapetrou, Eirini P., additional

Published
2023
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21. Table S5 from Altered Nuclear Export Signal Recognition as a Driver of Oncogenesis

Author

Taylor, Justin, primary, Sendino, Maria, primary, Gorelick, Alexander N., primary, Pastore, Alessandro, primary, Chang, Matthew T., primary, Penson, Alexander V., primary, Gavrila, Elena I., primary, Stewart, Connor, primary, Melnik, Ella M., primary, Herrejon Chavez, Florisela, primary, Bitner, Lillian, primary, Yoshimi, Akihide, primary, Lee, Stanley Chun-Wei, primary, Inoue, Daichi, primary, Liu, Bo, primary, Zhang, Xiao J., primary, Mato, Anthony R., primary, Dogan, Ahmet, primary, Kharas, Michael G., primary, Chen, Yuhong, primary, Wang, Demin, primary, Soni, Rajesh K., primary, Hendrickson, Ronald C., primary, Prieto, Gorka, primary, Rodriguez, Jose A., primary, Taylor, Barry S., primary, and Abdel-Wahab, Omar, primary

Published
2023
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22. Data from Altered Nuclear Export Signal Recognition as a Driver of Oncogenesis

Author

Taylor, Justin, primary, Sendino, Maria, primary, Gorelick, Alexander N., primary, Pastore, Alessandro, primary, Chang, Matthew T., primary, Penson, Alexander V., primary, Gavrila, Elena I., primary, Stewart, Connor, primary, Melnik, Ella M., primary, Herrejon Chavez, Florisela, primary, Bitner, Lillian, primary, Yoshimi, Akihide, primary, Lee, Stanley Chun-Wei, primary, Inoue, Daichi, primary, Liu, Bo, primary, Zhang, Xiao J., primary, Mato, Anthony R., primary, Dogan, Ahmet, primary, Kharas, Michael G., primary, Chen, Yuhong, primary, Wang, Demin, primary, Soni, Rajesh K., primary, Hendrickson, Ronald C., primary, Prieto, Gorka, primary, Rodriguez, Jose A., primary, Taylor, Barry S., primary, and Abdel-Wahab, Omar, primary

Published
2023
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23. Supplementary Figures from Altered Nuclear Export Signal Recognition as a Driver of Oncogenesis

Author

Taylor, Justin, primary, Sendino, Maria, primary, Gorelick, Alexander N., primary, Pastore, Alessandro, primary, Chang, Matthew T., primary, Penson, Alexander V., primary, Gavrila, Elena I., primary, Stewart, Connor, primary, Melnik, Ella M., primary, Herrejon Chavez, Florisela, primary, Bitner, Lillian, primary, Yoshimi, Akihide, primary, Lee, Stanley Chun-Wei, primary, Inoue, Daichi, primary, Liu, Bo, primary, Zhang, Xiao J., primary, Mato, Anthony R., primary, Dogan, Ahmet, primary, Kharas, Michael G., primary, Chen, Yuhong, primary, Wang, Demin, primary, Soni, Rajesh K., primary, Hendrickson, Ronald C., primary, Prieto, Gorka, primary, Rodriguez, Jose A., primary, Taylor, Barry S., primary, and Abdel-Wahab, Omar, primary

Published
2023
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24. Supplementary Methods from Altered Nuclear Export Signal Recognition as a Driver of Oncogenesis

Author

Taylor, Justin, primary, Sendino, Maria, primary, Gorelick, Alexander N., primary, Pastore, Alessandro, primary, Chang, Matthew T., primary, Penson, Alexander V., primary, Gavrila, Elena I., primary, Stewart, Connor, primary, Melnik, Ella M., primary, Herrejon Chavez, Florisela, primary, Bitner, Lillian, primary, Yoshimi, Akihide, primary, Lee, Stanley Chun-Wei, primary, Inoue, Daichi, primary, Liu, Bo, primary, Zhang, Xiao J., primary, Mato, Anthony R., primary, Dogan, Ahmet, primary, Kharas, Michael G., primary, Chen, Yuhong, primary, Wang, Demin, primary, Soni, Rajesh K., primary, Hendrickson, Ronald C., primary, Prieto, Gorka, primary, Rodriguez, Jose A., primary, Taylor, Barry S., primary, and Abdel-Wahab, Omar, primary

Published
2023
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25. Supplementary Table Captions from Altered Nuclear Export Signal Recognition as a Driver of Oncogenesis

Author

Taylor, Justin, primary, Sendino, Maria, primary, Gorelick, Alexander N., primary, Pastore, Alessandro, primary, Chang, Matthew T., primary, Penson, Alexander V., primary, Gavrila, Elena I., primary, Stewart, Connor, primary, Melnik, Ella M., primary, Herrejon Chavez, Florisela, primary, Bitner, Lillian, primary, Yoshimi, Akihide, primary, Lee, Stanley Chun-Wei, primary, Inoue, Daichi, primary, Liu, Bo, primary, Zhang, Xiao J., primary, Mato, Anthony R., primary, Dogan, Ahmet, primary, Kharas, Michael G., primary, Chen, Yuhong, primary, Wang, Demin, primary, Soni, Rajesh K., primary, Hendrickson, Ronald C., primary, Prieto, Gorka, primary, Rodriguez, Jose A., primary, Taylor, Barry S., primary, and Abdel-Wahab, Omar, primary

Published
2023
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26. Supplementary Materials and Methods from Therapeutic Efficacy of an Fc-Enhanced TCR-like Antibody to the Intracellular WT1 Oncoprotein

Author

Veomett, Nicholas, primary, Dao, Tao, primary, Liu, Hong, primary, Xiang, Jingyi, primary, Pankov, Dmitry, primary, Dubrovsky, Leonid, primary, Whitten, Joseph A., primary, Park, Sun-Mi, primary, Korontsvit, Tatyana, primary, Zakhaleva, Victoria, primary, Casey, Emily, primary, Curcio, Michael, primary, Kharas, Michael G., primary, O'Reilly, Richard J., primary, Liu, Cheng, primary, and Scheinberg, David A., primary

Published
2023
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27. Data from Epigenetically Aberrant Stroma in MDS Propagates Disease via Wnt/β-Catenin Activation

Author

Bhagat, Tushar D., primary, Chen, Si, primary, Bartenstein, Matthias, primary, Barlowe, A. Trevor, primary, Von Ahrens, Dagny, primary, Choudhary, Gaurav S., primary, Tivnan, Patrick, primary, Amin, Elianna, primary, Marcondes, A. Mario, primary, Sanders, Mathijs A., primary, Hoogenboezem, Remco M., primary, Kambhampati, Suman, primary, Ramachandra, Nandini, primary, Mantzaris, Iaonnis, primary, Sukrithan, Vineeth, primary, Laurence, Remi, primary, Lopez, Robert, primary, Bhagat, Prafulla, primary, Giricz, Orsi, primary, Sohal, Davendra, primary, Wickrema, Amittha, primary, Yeung, Cecilia, primary, Gritsman, Kira, primary, Aplan, Peter, primary, Hochedlinger, Konrad, primary, Yu, Yiting, primary, Pradhan, Kith, primary, Zhang, Jinghang, primary, Greally, John M., primary, Mukherjee, Siddhartha, primary, Pellagatti, Andrea, primary, Boultwood, Jacqueline, primary, Will, Britta, primary, Steidl, Ulrich, primary, Raaijmakers, Marc H.G.P., primary, Deeg, H. Joachim, primary, Kharas, Michael G., primary, and Verma, Amit, primary

Published
2023
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28. Supplementary Figure 3 from Therapeutic Efficacy of an Fc-Enhanced TCR-like Antibody to the Intracellular WT1 Oncoprotein

Author

Veomett, Nicholas, primary, Dao, Tao, primary, Liu, Hong, primary, Xiang, Jingyi, primary, Pankov, Dmitry, primary, Dubrovsky, Leonid, primary, Whitten, Joseph A., primary, Park, Sun-Mi, primary, Korontsvit, Tatyana, primary, Zakhaleva, Victoria, primary, Casey, Emily, primary, Curcio, Michael, primary, Kharas, Michael G., primary, O'Reilly, Richard J., primary, Liu, Cheng, primary, and Scheinberg, David A., primary

Published
2023
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29. Supplementary Figure 1 from Therapeutic Efficacy of an Fc-Enhanced TCR-like Antibody to the Intracellular WT1 Oncoprotein

Author

Veomett, Nicholas, primary, Dao, Tao, primary, Liu, Hong, primary, Xiang, Jingyi, primary, Pankov, Dmitry, primary, Dubrovsky, Leonid, primary, Whitten, Joseph A., primary, Park, Sun-Mi, primary, Korontsvit, Tatyana, primary, Zakhaleva, Victoria, primary, Casey, Emily, primary, Curcio, Michael, primary, Kharas, Michael G., primary, O'Reilly, Richard J., primary, Liu, Cheng, primary, and Scheinberg, David A., primary

Published
2023
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30. Supplementary Figure 4 from Therapeutic Efficacy of an Fc-Enhanced TCR-like Antibody to the Intracellular WT1 Oncoprotein

Author

Veomett, Nicholas, primary, Dao, Tao, primary, Liu, Hong, primary, Xiang, Jingyi, primary, Pankov, Dmitry, primary, Dubrovsky, Leonid, primary, Whitten, Joseph A., primary, Park, Sun-Mi, primary, Korontsvit, Tatyana, primary, Zakhaleva, Victoria, primary, Casey, Emily, primary, Curcio, Michael, primary, Kharas, Michael G., primary, O'Reilly, Richard J., primary, Liu, Cheng, primary, and Scheinberg, David A., primary

Published
2023
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31. Supplementary Table 1 from Therapeutic Efficacy of an Fc-Enhanced TCR-like Antibody to the Intracellular WT1 Oncoprotein

Author

Veomett, Nicholas, primary, Dao, Tao, primary, Liu, Hong, primary, Xiang, Jingyi, primary, Pankov, Dmitry, primary, Dubrovsky, Leonid, primary, Whitten, Joseph A., primary, Park, Sun-Mi, primary, Korontsvit, Tatyana, primary, Zakhaleva, Victoria, primary, Casey, Emily, primary, Curcio, Michael, primary, Kharas, Michael G., primary, O'Reilly, Richard J., primary, Liu, Cheng, primary, and Scheinberg, David A., primary

Published
2023
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32. Supplementary Figure 2 from Therapeutic Efficacy of an Fc-Enhanced TCR-like Antibody to the Intracellular WT1 Oncoprotein

Author

Veomett, Nicholas, primary, Dao, Tao, primary, Liu, Hong, primary, Xiang, Jingyi, primary, Pankov, Dmitry, primary, Dubrovsky, Leonid, primary, Whitten, Joseph A., primary, Park, Sun-Mi, primary, Korontsvit, Tatyana, primary, Zakhaleva, Victoria, primary, Casey, Emily, primary, Curcio, Michael, primary, Kharas, Michael G., primary, O'Reilly, Richard J., primary, Liu, Cheng, primary, and Scheinberg, David A., primary

Published
2023
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33. Supp tables 1-5 from Epigenetically Aberrant Stroma in MDS Propagates Disease via Wnt/β-Catenin Activation

Author

Bhagat, Tushar D., primary, Chen, Si, primary, Bartenstein, Matthias, primary, Barlowe, A. Trevor, primary, Von Ahrens, Dagny, primary, Choudhary, Gaurav S., primary, Tivnan, Patrick, primary, Amin, Elianna, primary, Marcondes, A. Mario, primary, Sanders, Mathijs A., primary, Hoogenboezem, Remco M., primary, Kambhampati, Suman, primary, Ramachandra, Nandini, primary, Mantzaris, Iaonnis, primary, Sukrithan, Vineeth, primary, Laurence, Remi, primary, Lopez, Robert, primary, Bhagat, Prafulla, primary, Giricz, Orsi, primary, Sohal, Davendra, primary, Wickrema, Amittha, primary, Yeung, Cecilia, primary, Gritsman, Kira, primary, Aplan, Peter, primary, Hochedlinger, Konrad, primary, Yu, Yiting, primary, Pradhan, Kith, primary, Zhang, Jinghang, primary, Greally, John M., primary, Mukherjee, Siddhartha, primary, Pellagatti, Andrea, primary, Boultwood, Jacqueline, primary, Will, Britta, primary, Steidl, Ulrich, primary, Raaijmakers, Marc H.G.P., primary, Deeg, H. Joachim, primary, Kharas, Michael G., primary, and Verma, Amit, primary

Published
2023
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34. Supp Methods from Epigenetically Aberrant Stroma in MDS Propagates Disease via Wnt/β-Catenin Activation

Author

Bhagat, Tushar D., primary, Chen, Si, primary, Bartenstein, Matthias, primary, Barlowe, A. Trevor, primary, Von Ahrens, Dagny, primary, Choudhary, Gaurav S., primary, Tivnan, Patrick, primary, Amin, Elianna, primary, Marcondes, A. Mario, primary, Sanders, Mathijs A., primary, Hoogenboezem, Remco M., primary, Kambhampati, Suman, primary, Ramachandra, Nandini, primary, Mantzaris, Iaonnis, primary, Sukrithan, Vineeth, primary, Laurence, Remi, primary, Lopez, Robert, primary, Bhagat, Prafulla, primary, Giricz, Orsi, primary, Sohal, Davendra, primary, Wickrema, Amittha, primary, Yeung, Cecilia, primary, Gritsman, Kira, primary, Aplan, Peter, primary, Hochedlinger, Konrad, primary, Yu, Yiting, primary, Pradhan, Kith, primary, Zhang, Jinghang, primary, Greally, John M., primary, Mukherjee, Siddhartha, primary, Pellagatti, Andrea, primary, Boultwood, Jacqueline, primary, Will, Britta, primary, Steidl, Ulrich, primary, Raaijmakers, Marc H.G.P., primary, Deeg, H. Joachim, primary, Kharas, Michael G., primary, and Verma, Amit, primary

Published
2023
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35. Supp Figs 1-5 from Epigenetically Aberrant Stroma in MDS Propagates Disease via Wnt/β-Catenin Activation

Author

Bhagat, Tushar D., primary, Chen, Si, primary, Bartenstein, Matthias, primary, Barlowe, A. Trevor, primary, Von Ahrens, Dagny, primary, Choudhary, Gaurav S., primary, Tivnan, Patrick, primary, Amin, Elianna, primary, Marcondes, A. Mario, primary, Sanders, Mathijs A., primary, Hoogenboezem, Remco M., primary, Kambhampati, Suman, primary, Ramachandra, Nandini, primary, Mantzaris, Iaonnis, primary, Sukrithan, Vineeth, primary, Laurence, Remi, primary, Lopez, Robert, primary, Bhagat, Prafulla, primary, Giricz, Orsi, primary, Sohal, Davendra, primary, Wickrema, Amittha, primary, Yeung, Cecilia, primary, Gritsman, Kira, primary, Aplan, Peter, primary, Hochedlinger, Konrad, primary, Yu, Yiting, primary, Pradhan, Kith, primary, Zhang, Jinghang, primary, Greally, John M., primary, Mukherjee, Siddhartha, primary, Pellagatti, Andrea, primary, Boultwood, Jacqueline, primary, Will, Britta, primary, Steidl, Ulrich, primary, Raaijmakers, Marc H.G.P., primary, Deeg, H. Joachim, primary, Kharas, Michael G., primary, and Verma, Amit, primary

Published
2023
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36. Small-molecule targeting of MUSASHI RNA-binding activity in acute myeloid leukemia

Author

Minuesa, Gerard, Albanese, Steven K., Xie, Wei, Kazansky, Yaniv, Worroll, Daniel, Chow, Arthur, Schurer, Alexandra, Park, Sun-Mi, Rotsides, Christina Z., Taggart, James, Rizzi, Andrea, Naden, Levi N., Chou, Timothy, Gourkanti, Saroj, Cappel, Daniel, Passarelli, Maria C., Fairchild, Lauren, Adura, Carolina, Glickman, J. Fraser, Schulman, Jessica, Famulare, Christopher, Patel, Minal, Eibl, Joseph K., Ross, Gregory M., Bhattacharya, Shibani, Tan, Derek S., Leslie, Christina S., Beuming, Thijs, Patel, Dinshaw J., Goldgur, Yehuda, Chodera, John D., and Kharas, Michael G.

Published
2019
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37. BTG1 mutation yields supercompetitive B cells primed for malignant transformation

Author

Mlynarczyk, Coraline, primary, Teater, Matt, additional, Pae, Juhee, additional, Chin, Christopher R., additional, Wang, Ling, additional, Arulraj, Theinmozhi, additional, Barisic, Darko, additional, Papin, Antonin, additional, Hoehn, Kenneth B., additional, Kots, Ekaterina, additional, Ersching, Jonatan, additional, Bandyopadhyay, Arnab, additional, Barin, Ersilia, additional, Poh, Hui Xian, additional, Evans, Chiara M., additional, Chadburn, Amy, additional, Chen, Zhengming, additional, Shen, Hao, additional, Isles, Hannah M., additional, Pelzer, Benedikt, additional, Tsialta, Ioanna, additional, Doane, Ashley S., additional, Geng, Huimin, additional, Rehman, Muhammad Hassan, additional, Melnick, Jonah, additional, Morgan, Wyatt, additional, Nguyen, Diu T. T., additional, Elemento, Olivier, additional, Kharas, Michael G., additional, Jaffrey, Samie R., additional, Scott, David W., additional, Khelashvili, George, additional, Meyer-Hermann, Michael, additional, Victora, Gabriel D., additional, and Melnick, Ari, additional

Published
2023
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38. Fructose Treatment Targets Myeloid Leukemogenesis in IDH2 Mutants By Exhausting Alpha-Ketoglutarate Pools

Author

Savino, Angela Maria, primary, Turner, Briana, additional, Jeong, Sangmoo, additional, Schild, Tanya, additional, Yang, Xuejing, additional, Luo, Hanzhi, additional, Chirayil, Rachel, additional, Cullen, Quinlan, additional, Chan, Mandy, additional, Han, Grace, additional, Chang, Kathryn, additional, Raman, Sudha Janaki, additional, Cross, Justin R, additional, Keshari, Kayvan, additional, and Kharas, Michael G, additional

Published
2022
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40. Dual IKZF2 and CK1α Degrader Targets Acute Myeloid Leukemia Cells

Author

Park, Sun Mi, primary, Miyamoto, David, additional, Han, Grace, additional, Chan, Mandy, additional, Curnutt, Nicole, additional, Tran, Nathan, additional, Velleca, Anthony, additional, Kim, Jun Hyun, additional, Schurer, Alexandra, additional, Chang, Kathryn, additional, Woo, Christina M, additional, and Kharas, Michael G, additional

Published
2022
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41. Abstract A24: BTG1 mutations confer a fitness advantage and promote aggressive B cell lymphoma development by lowering the threshold for MYC induction

Author

Mlynarczyk, Coraline, primary, Teater, Matt, additional, Pae, Juhee, additional, Wang, Ling, additional, Ersching, Jonatan, additional, Papin, Antonin, additional, Barisic, Darko, additional, Barin, Ersilia, additional, Hoehn, Kenneth B., additional, Chen, Zhengming, additional, Nguyen, Diu T. T., additional, Evans, Chiara, additional, Doane, Ashley S., additional, Kharas, Michael G., additional, Scott, David W., additional, Victora, Gabriel, additional, and Melnick, Ari, additional

Published
2022
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42. In Vivo RNAi Screening Identifies a Leukemia-Specific Dependence on Integrin Beta 3 Signaling

Author

Miller, Peter G., Al-Shahrour, Fatima, Hartwell, Kimberly A., Chu, Lisa P., Järås, Marcus, Puram, Rishi V., Puissant, Alexandre, Callahan, Kevin P., Ashton, John, McConkey, Marie E., Poveromo, Luke P., Cowley, Glenn S., Kharas, Michael G., Labelle, Myriam, Shterental, Sebastian, Fujisaki, Joji, Silberstein, Lev, Alexe, Gabriela, Al-Hajj, Muhammad A., Shelton, Christopher A., Armstrong, Scott A., Root, David E., Scadden, David T., Hynes, Richard O., Mukherjee, Siddhartha, Stegmaier, Kimberly, Jordan, Craig T., and Ebert, Benjamin L.

Published
2013
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43. Musashi2 sustains the mixed-lineage leukemia-driven stem cell regulatory program

Author

Park, Sun-Mi, Gonen, Mithat, Vu, Ly, Minuesa, Gerard, Tivnan, Patrick, Barlowe, Trevor S., Taggart, James, Lu, Yuheng, Deering, Raquel P., Hacohen, Nir, Figueroa, Maria E., Paietta, Elisabeth, Fernandez, Hugo F., Tallman, Martin S., Melnick, Ari, Levine, Ross, Leslie, Christina, Lengner, Christopher J., and Kharas, Michael G.

Subjects
Binding proteins -- Physiological aspects, Leukemia -- Prognosis, Stem cells -- Physiological aspects, RNA -- Physiological aspects, Health care industry
Abstract

Leukemia stem cells (LSCs) are found in most aggressive myeloid diseases and contribute to therapeutic resistance. Leukemia cells exhibit a dysregulated developmental program as the result of genetic and epigenetic [...]

Published
2015
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47. BTG1 Mutation Promotes Aggressive Lymphoma Development By Lowering the Threshold to MYC Activation and Generating "Super-Competitor" B Cells

Author

Mlynarczyk, Coraline, primary, Teater, Matthew, additional, Pae, Juhee, additional, Arulraj, Theinmozhi, additional, Chin, Christopher R, additional, Wang, Ling, additional, Ersching, Jonatan, additional, Kots, Ekaterina, additional, Chadburn, Amy, additional, Barin, Ersilia, additional, Xian Poh, Hui, additional, Isles, Hannah M, additional, Zhengming, Chen, additional, Shen, Hao, additional, Bandyopadhyay, Arnab, additional, Hoehn, Kenneth B, additional, Nguyen, Diu T.T., additional, Doane, Ashley S, additional, Geng, Huimin, additional, Rehman, Muhammad H, additional, Melnick, Jonah, additional, Morgan, Wyatt, additional, Elemento, Olivier, additional, Kharas, Michael G, additional, Scott, David W., additional, Jaffrey, Samie R, additional, Meyer-Hermann, Michael, additional, Khelashvili, George, additional, Victora, Gabriel, additional, and Melnick, Ari, additional

Published
2021
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