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22 results on '"Khanyile, Richard"'

13. AI and precision oncology in clinical cancer genomics: From prevention to targeted cancer therapies-an outcomes based patient care

Author

Dlamini, Zodwa, Skepu, Amanda, Kim, Namkug, Mkhabele, Mahlori, Khanyile, Richard, Molefi, Thulo, Mbatha, Sikhumbuzo, Setlai, Botle, Mulaudzi, Thanyani, Mabongo, Mzubanzi, Bida, Meshack, Kgoebane-Maseko, Minah, Mathabe, Kgomotso, Lockhat, Zarina, Kgokolo, Mahlatse, Chauke-Malinga, Nkhensani, Ramagaga, Serwalo, and Hull, Rodney

Published
2022
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19. The SARS-COV-2 Seroprevalence among Oncology Patients

Author

Kgatle, Mankgopo, primary, Das, Rajesh, additional, Lawal, Ismaheel, additional, Boshomane, Tebatso, additional, Mokoala, Kgomotso, additional, Gaspar, Cattleya, additional, Mbokazi, Lydia, additional, Nkambule, Nonhlanhla, additional, Gow, Veronique, additional, Ndlovu, Honest, additional, Mzizi, Yonwaba, additional, Chalwe, Joseph, additional, Diphofa, Jeaneth, additional, Mokobodi, Dinah, additional, Gxekwa, Nobuhle, additional, Zongo, Lusanda, additional, Maphosa, Tinashe, additional, Vorster, Mariza, additional, Bassa, Sheynaz, additional, Venkatesan, Amouda, additional, Khanyile, Richard, additional, Munga, Yunus, additional, Ebenhan, Thomas, additional, Zeevaart, Jan Rijn, additional, and Sathekge, Mike, additional

Published
2023
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20. List of contributors

Author

Basera, Afra, Bates, David O., Belancio, Victoria, Bida, Meshack, Chatziioannou, Aristotelis, Chipiti, Talent, Damane, Botle Precious, Demetriou, Demetra, Dlamini, Zodwa, Ecker, Rupert C., Fadebi, Olalekan, Fourie, Leony, Grech, Godfrey, Hull, Rodney, Kader, Shakeel, Kappo, Abidemi Paul, Kaufmann, Andreas M., Kgomo, Koena A., Khanyile, Richard, Ledet, Elisa, Leenders, William, Lin, Zhen, Lolas, Georgios, Luvhengo, Thifhelimbilu Emmanuel, Lyantagaye, Sylvester, Mabeta, Peace, Mabonga, Lloyd, Makgoo, Lilian, Manabile, Mosebo A., Marima, Rahaba, Mbatha, Sikhumbuzo Z., Mbita, Zukile, Mbodi, Langanani, Mehrotra, Ravi, Mirza, Sheefa, Miya, Thabiso Victor, Mkhize-Kwitshana, Zilungile, Moela, Pontsho, Molefi, Thulo, Montwedi, Odisang Daniel, Mosoane, Benny, Mulaudzi, Thanyani, Naidoo, Pragalathan, Penny, Clem, Pillay, Roxanne, Reis, Rui Manuel, Savkovic, Suzana, Skepu, Amanda, Syrigos, Konstantinos N., and Ubanako, Philemon

Published
2025
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22. Breast cancer in low-middle income countries: abnormality in splicing and lack of targeted treatment options.

Author

Francies FZ, Hull R, Khanyile R, and Dlamini Z

Abstract

Breast cancer is a common malignancy among women worldwide. Regardless of the economic status of a country, breast cancer poses a burden in prevention, diagnosis and treatment. Developed countries such as the U.S. have high incidence and mortality rates of breast cancer. Although low incidence rates are observed in developing countries, the mortality rate is on the rise implying that low- to middle-income countries lack the resources for preventative screening for early detection and adequate treatment resources. The differences in incidence between countries can be attributed to changes in exposure to environmental risk factors, behaviour and lifestyle factors of the different population groups. Genomic modifications are an important factor that significantly alters the risk profile of breast tumourigenesis. The incidence of early-onset breast cancer is increasing and evidence shows that early onset of breast cancer is far more aggressive than late onset of the disease; possibly due to the difference in genetic alterations or tumour biology. Alternative splicing is a pivotal factor in the progressions of breast cancer. It plays a significant role in tumour prognosis, survival and drug resistance; hence, it offers a valuable option as a therapeutic target. In this review, the differences in breast cancer incidence and mortality rates in developed countries will be compared to low- to middle-income countries. The review will also discuss environmental and lifestyle risk factors, and the underlying molecular mechanisms, genetic variations or mutations and alternative splicing that may contribute to the development and novel drug targets for breast cancer., Competing Interests: None., (AJCR Copyright © 2020.)

Published
2020

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