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295 results on '"Khanna, Roopali"'

21. Comparison of non-invasive assessment for pulmonary vascular indices by two-dimensional echocardiography and cardiac computed tomography angiography with conventional catheter angiocardiography in unrepaired Tetralogy of Fallot physiology patients weighing more than 10 kg: a retrospective analysis

Author

Kumar, Amarendu, Sahu, Ankit Kumar, Goel, Pravin K, Jain, Neeraj, Garg, Naveen, Khanna, Roopali, Kumar, Sudeep, Tewari, Satyendra, and Kapoor, Aditya

Subjects
PULMONARY artery physiology, ECHOCARDIOGRAPHY, BLOOD vessels, BODY weight, RESEARCH evaluation, TETRALOGY of Fallot, LUNG diseases, RETROSPECTIVE studies, THORACIC aorta, ARRHYTHMOGENIC right ventricular dysplasia, VASCULAR resistance, COMPARATIVE studies, DESCRIPTIVE statistics, COMPUTED tomography, VASCULAR diseases, CATHETERS
Abstract

Aims Assessment of pulmonary vascular dimensions (PVDs) in Tetralogy of Fallot (TOF) is an integral part of planning transcatheter and surgical interventions. We sought to examine the reliability and correlation of echocardiography (ECHO) and computed tomography angiography (CTA) measurements with those obtained by cardiac catheterization and angiography (CCA). Methods and results Tetralogy of Fallot physiology patients undergoing ECHO, CTA, and CCA within a month prior to surgical correction during 2018–2020 were retrospectively enrolled. Indexed diameter of pulmonary annulus (iPAnn), indexed right pulmonary artery (iRPA), indexed left pulmonary artery (iLPA) and indexed descending aorta (iDA) were measured using ECHO and CTA followed by derivation of Nakata index (NI), McGoon's ratio (MGR), ratio of predicted peak right ventricular (RV) and left ventricular (LV) pressures (pRV/pLV) and Z -scores. Comparison with CCA-derived measurements was made and correlational equations were subsequently deduced. Pulmonary vascular dimensions for 54 patients with mean age of 15.5 ± 9.3 years (range: 3–34 years) were analysed. Computed tomography angiography and CCA measurements for iPAnn, iRPA, NI, MGR, pRV/pLV, and Z -score were comparable with each other while ECHO parameters were significantly lower than CCA. However, iLPA diameter was significantly underestimated by ECHO and overestimated by CTA. Correlational analysis showed stronger correlation between CTA- and CCA-derived PVD as against ECHO measurements except for iDA, pRV/pLV, and Z -score. Conclusions For unrepaired TOF physiology patients weighing more than 10 kg, CTA-acquired PVD are reliable and comparable with CCA except for DA for which ECHO is non-inferior. Non-invasive modalities though are inferior to CCA for LPA sizing. Utilizing derived equations, precise estimation of PVD can be carried out using non-invasive tools. [ABSTRACT FROM AUTHOR]

Published
2023
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22. Comparison of non-invasive assessment for pulmonary vascular indices by two-dimensional echocardiography and cardiac computed tomography angiography with conventional catheter angiocardiography in unrepaired Tetralogy of Fallot physiology patients weighing more than 10 kg: a retrospective analysis

Author

Kumar, Amarendu, primary, Sahu, Ankit Kumar, additional, Goel, Pravin K, additional, Jain, Neeraj, additional, Garg, Naveen, additional, Khanna, Roopali, additional, Kumar, Sudeep, additional, Tewari, Satyendra, additional, and Kapoor, Aditya, additional

Published
2022
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26. Exploring the association of fibrinogen and CRP with the clinical spectrum of CAD and periprocedural outcomes in patients undergoing percutaneous coronary interventions

Author

Kapoor, Aditya, primary, Khandelwal, Vijay, additional, Kazmi, Danish, additional, Sinha, Archana, additional, Kashyap, Shiridhar, additional, Khanna, Roopali, additional, Kumar, Sudeep, additional, Garg, Naveen, additional, Tewari, Satyendra, additional, Sahu, Ankit, additional, and Goel, Pravin, additional

Published
2022
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35. Serum Gamma Glutamyltransferase (GGT) in coronary artery disease: Exploring the Asian Indian Connection.

Author

Singh, Kunal, Kapoor, Aditya, Khanna, Roopali, Sahu, Ankit, Kapoor, Vishwas, Kumar, Sudeep, Garg, Naveen, Tewari, Satyendra, Goel, Pravin, and Singh, Kunal K

Subjects
GAMMA-glutamyltransferase, INDIANS (Asians), SEVERITY of illness index, CORONARY angiography, CORONARY artery disease
Abstract

Background: There is a need to identify novel markers for CAD, independent of traditional CV risk factors. One of these is gamma-glutamyl transferase (GGT), a marker of increased oxidative stress. Given the high prevalence of CAD in Asian Indians, the link of GGT and CAD in them needs to be studied.Aim: To assess GGT in patients with angiographically documented CAD.Methods and Results: Two hundred patients aged 58.1 ± 9.95 years, 73% males, hypertension 56%, diabetes 40% were included. Mean GGT was 63.6 ± 44.33 (10-269 U/L). The levels of GGT progressively increased in those with single/double or triple-vessel CAD (36.5, 61.5, and 87 U/L, respectively, P < 0.001). Using objective criteria of CAD burden (SYNTAX and Gensini scores), we reaffirmed these findings. GGT in patients with SYNTAX tertiles 0-22, 23-32, and ≥ 33 was 33, 62, and 97 U/L, respectively and in Gensini tertiles 0-17.65, 17.66-56.65, ≥56.66 was 32, 52, and 88 U/L, respectively, all P < 0.001. SYNTAX score ≥ 23 was present in only 23% patients in GGT tertile 1 (<41 U/L), whereas60% and 94% in GGT tertiles 2 and 3 had SYNTAX ≥ 23. Significant positive correlation was seen between GGT and SYNTAX (r = 0.634) and Gensini score (r = 0.772).Conclusions: In this study, GGT had an independent correlation with angiographic severity of CAD and SYNTAX and Gensini scores. Although the existing evidence seems biologically plausible, more studies are needed to explore the potential role of this inexpensive marker for predicting disease burden in patients with CAD. [ABSTRACT FROM AUTHOR]

Published
2022
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