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Simple Summary: Pancreatic cancer (PanCa) is one of the deadliest forms of cancer with limited therapeutic options. The available conventional therapies are highly toxic and often show resistance. Accumulating evidence suggests that dysregulated ribosome biogenesis has been linked to the survival and aggressive phenotypes of many tumor types, including PanCa. Thus, targeting ribosome biogenesis could be a novel approach for suppressing the growth of PanCa. The current study aimed to investigate the anti-cancer efficacy and underlying molecular mechanisms of honey against PanCa. Our results demonstrated that honey induces apoptosis and inhibits the growth and invasive potential of PanCa cells by targeting ribosome biogenesis components and c-Myc expression. This study suggests that honey can be used as an adjuvant along with conventional chemo/radiation therapy or immunotherapy for the management of PanCa. Pancreatic cancer (PanCa) is one of the deadliest cancers, with limited therapeutic response. Various molecular oncogenic events, including dysregulation of ribosome biogenesis, are linked to the induction, progression, and metastasis of PanCa. Thus, the discovery of new therapies suppressing these oncogenic events and ribosome biogenesis could be a novel therapeutic approach for the prevention and treatment of PanCa. The current study was designed to investigate the anti-cancer effect of honey against PanCa. Our results indicated that honey markedly inhibited the growth and invasive characteristics of pancreatic cancer cells by suppressing the mRNA expression and protein levels of key components of ribosome biogenesis, including RNA Pol-I subunits (RPA194 and RPA135) along with its transcriptional regulators, i.e., UBTF and c-Myc. Honey also induced nucleolar stress in PanCa cells by reducing the expression of various nucleolar proteins (NCL, FBL, and NPM). Honey-mediated regulation on ribosome biogenesis components and nucleolar organization-associated proteins significantly arrested the cell cycle in the G2M phase and induced apoptosis in PanCa cells. These results, for the first time, demonstrated that honey, being a natural remedy, has the potential to induce apoptosis and inhibit the growth and metastatic phenotypes of PanCa by targeting ribosome biogenesis. [ABSTRACT FROM AUTHOR]

Background: Vascularized (VBG) and non-vascularized (NVBG) bone grafting are two crucial biological reconstructive techniques in the management of bone tumours. The objective of this study is to compare the outcomes of reconstruction with vascularized and non-vascularized bone grafts after resection of bone tumours. Methods: A systematic evaluation of the literature from 2012-2021 was undertaken using the online databases PubMed/Medline, Google Scholar, and Cochrane Library considering only comparative articles with specific outcomes for the restoration of the defect with vascularized and non-vascularized bone graft following the resection of bone tumours. The quality of the research methodology was evaluated using Oxford Quality Scoring System and Newcastle Ottawa Scale for randomized trials and non-randomized comparison research respectively. The SPSS version 23 was used to examine the data that was collected. Musculoskeletal tumour society score (MSTS), bone union time, and complications were the outcomes of this review. Results: Four clinical publications were considered, totalling 178 participants (92 men and 86 women) with 90 patients with VBG and 88 with NVBG. MSTS score and bone union time were the key outcomes that were measured. The overall MSTS (p>0.05) and rate of complications (p>0.05) results were comparable between the two groups, however, VBG had a better rate of bone union (p<0.001). Conclusion: As a result of the quicker bone union, our systematic evaluation demonstrated that VBG causes earlier recovery. Complication rates and functional results were the same in both groups. The link between the bone union time and functional score following VBG and NVBG must also be demonstrated. [ABSTRACT FROM AUTHOR]

Objective: To assess the bone mineral density of type 1 and type 2 diabetic and non-diabetic post-menopausal women. Methods: A cross-sectional study was conducted in 98 post-menopausal women aged 60.5±6.4 years. The participants comprised of 20 type 1 diabetics, 28 type 2 diabetic women and 50 non diabetic women. Anthropometry and dietary intake was assessed for all participants. T score for bone mineral density was measured by DEXA at lumbar spine, femoral neck and total body. This was used to classify women as suffering from osteoporosis and osteopenia. Results: The mean weight was significantly higher in type 1 and type 2 diabetics as compared to non-diabetics (p<0.05). Protein and calcium intake was 52-60% of the RDA in diabetics. There was no significant difference in T score at lumbar spine, femoral neck or total body between the 3 groups (p>0.05). After adjusting for weight and nutrient intake, lumbar spine and femoral neck T score was significantly lower in type 1 diabetics (p<0.05). Type 2 diabetics also had significantly lower adjusted femoral neck T score as compared to non-diabetics (p<0.05). Higher percentage of type 2 diabetics (77.8%) and non-diabetics (77.5%) had low bone density (osteopenia + osteoporosis) at lumbar spine as compared to type 1 diabetics (60%). Higher percentage of type 1 diabetics (75%) and type 2 diabetics (82.1%) had low bone density at femoral neck. Conclusion: A high percentage of postmenopausal women in Mumbai were observed to be osteopenic and osteoporotic. Dietary and lifestyle Intervention programs need to be developed to prevent onset of osteopenia and osteoporosis especially in diabetic post-menopausal women. [ABSTRACT FROM AUTHOR]

Homeopathy is considered as the most widely practiced and safe alternative form of medical treatment such as allopathic medicine. It was introduced by a German doctor who believed that minimum dose of a drug can alleviate the symptoms similar to other conventional forms of treatment. The objective of the present study was to determine the factors that influence individual's attitude towards homeopathic treatment. A cross-sectional descriptive study was conducted in different homeopathic clinics of Bhawalpur from January 1 to February 1, 2017. A total of 72 patients (both genders) were included in the study by using convenient sampling technique. A pretested questionnaire containing personal information and subject related questions was used to collect the data. The questions were interviewed from the patients in the local language and were transferred to the questionnaire in English. The study concluded that 87% of the respondents preferred homeopathic treatment while around 13% favored the use of allopathic medicines. The reasons for high utilization of homeopathic medicines can be attributed to the high efficacy, low cost, better taste, minimum side effects and forefathers trend. [ABSTRACT FROM AUTHOR]

Background: Evidence supports high prevalence of periodontitis in patients with chronic kidney disease. Several renal factors have been proposed as possible modifiers of periodontitis pathogenesis in this population. In this cross sectional study, we investigated whether distinct microbial profiles in renal patients could explain high periodontitis prevalence. Methods: We characterized the subgingival microbiome in 14 End Stage Renal Disease (ESRD) and 13 control individuals with chronic periodontitis with similar demographic and clinical parameters. Medical, demographic and periodontal parameters were recorded. Subgingival biofilm samples were collected from the deepest pocket in two different quadrants and characterized via 454-pyrosequencing of the 16S rRNA gene. Results: We found 874 species-level operational taxonomic units (OTU) across samples. Renal and control groups did not differ in the individual proportions of periodontitis-associated taxa. However, in principal coordinate plots of distance among samples based on OTU prevalence, some renal patients clustered apart from controls, with the microbial communities of these outlier subjects showing less diversity. Univariate correlation analysis showed a significant negative correlation between dialysis vintage and community diversity. Conclusions: Within the study limitations, dialysis vintage was associated with a less diverse periodontal microbial community in ESRD suggesting the need for further research. [ABSTRACT FROM AUTHOR]

The article discusses research being done on the bidirectional association between chronic kidney and periodontal disease, which references a study by M. A. Fisher and colleagues in the October 6, 2010 issue of the journal "Kidney International."