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Although there is an urgent need to develop trauma-informed services for autistic youth, little research has evaluated adverse childhood experiences (ACEs) in autistic youth from an intergenerational perspective. 242 caregivers of autistic (n = 117) and non-autistic (n = 125) youth reported on ACEs that they experienced in their own childhoods and ACEs experienced by their children, as well as measures of depression, stress, and child autistic traits and behavioral concerns. Autistic youth and their caregivers both experienced significantly higher rates of ACEs than the non-autistic dyads. Intergenerational continuity, the association between caregiver and child ACEs, was significantly stronger for autistic youth. ACEs showed differential patterns of associations with parent depressive symptoms and child autistic traits across groups.

Ghosal hematodiaphyseal dysplasia (GHDD) is an autosomal recessive disorder characterized by diaphyseal dysplasia of long bones, bone marrow fibrosis, and steroid-responsive anemia. Patients with this disease have a mutation in the thromboxane-AS1 (TBXAS1) gene located on chromosome 7q33.34. They present with short stature, varying grades of myelofibrosis, and, hence cytopenias. Patients with the above presentation were evaluated through clinical presentation, X-ray of long bones, bone marrow examinations, and confirmed by genetic testing. In this article, we present two cases: The first case is a 3-year-old boy who presented with progressive pallor and ecchymotic patches for a year. On investigation, he had bicytopenia and bone marrow fibrosis. His anemia was steroid responsive and was finally diagnosed as GHDD. The second case is a 20-month-old girl who presented with blood in stools, developmental delay, anemia, and increased intensity of long bones on X-ray. Since other investigations were normal, suspicion of GHDD was raised, and a genetic workup was conducted which suggested mutation in TBXAS1 gene, confirming the diagnosis of GHDD. Children with refractory anemia and cortical thickening on skeletogram should always be evaluated for dysplasias. Timely treatment with steroids reduces transfusion requirements and halts bone damage, thus leading to better growth and improved quality of life. [ABSTRACT FROM AUTHOR]

Patients with head and neck cancer are at an increased risk of airway complications, not only because of the tumor itself and the need for a shared airway, but also the treatment of cancer (including surgery, radiotherapy, and chemotherapy) poses major challenges in airway management. The perioperative assessment, therefore, needs to be comprehensive to allow us to predict possible airway difficulty. Moreover, the suitability and feasibility of primary and rescue plans are needed to be assessed for each individual patient. In this case report, we describe a case of a patient, with recurrent tongue cancer with prior history of surgery and radiotherapy to the head and neck region. The difficulty in managing the airway in this case was anticipated correctly and subsequently encountered in almost every step, including bag-mask ventilation, video-laryngoscopy, and laryngeal mask airway (LMA) insertion in a patient. Despite the presence of visual aids and algorithms for the management of a difficult airway, a premeditated airway management plan, and the availability of all necessary equipment and expertise, a break in structure and sequence was encountered, which was quickly corrected and saved the patient from any harm. [ABSTRACT FROM AUTHOR]