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2. Proteomic analysis of cardiorespiratory fitness for prediction of mortality and multisystem disease risks

Author

Perry, Andrew S., Farber-Eger, Eric, Gonzales, Tomas, Tanaka, Toshiko, Robbins, Jeremy M., Murthy, Venkatesh L., Stolze, Lindsey K., Zhao, Shilin, Huang, Shi, Colangelo, Laura A., Deng, Shuliang, Hou, Lifang, Lloyd-Jones, Donald M., Walker, Keenan A., Ferrucci, Luigi, Watts, Eleanor L., Barber, Jacob L., Rao, Prashant, Mi, Michael Y., Gabriel, Kelley Pettee, Hornikel, Bjoern, Sidney, Stephen, Houstis, Nicholas, Lewis, Gregory D., Liu, Gabrielle Y., Thyagarajan, Bharat, Khan, Sadiya S., Choi, Bina, Washko, George, Kalhan, Ravi, Wareham, Nick, Bouchard, Claude, Sarzynski, Mark A., Gerszten, Robert E., Brage, Soren, Wells, Quinn S., Nayor, Matthew, and Shah, Ravi V.

Published
2024
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4. Opportunities in the Postpartum Period to Reduce Cardiovascular Disease Risk After Adverse Pregnancy Outcomes: A Scientific Statement From the American Heart Association

Author

Lewey, Jennifer, Beckie, Theresa M, Brown, Haywood L, Brown, Susan D, Garovic, Vesna D, Khan, Sadiya S, Miller, Eliza C, Sharma, Garima, Mehta, Laxmi S, and Care, Perioperative and Resuscitation and Council on Cardiovascular and Stroke Nursing on behalf of the American Heart Association Cardiovascular Disease and Stroke in Women and Underrepresented Populations Committee of the Council on Clinical Cardiology Council on Cardiopulmonary Critical

Subjects
Reproductive Medicine, Biomedical and Clinical Sciences, Health Sciences, Pregnancy, Hypertension, Prevention, Women's Health, Maternal Health, Heart Disease, Cardiovascular, Clinical Trials and Supportive Activities, Clinical Research, Maternal Morbidity and Mortality, 4.1 Discovery and preclinical testing of markers and technologies, 2.1 Biological and endogenous factors, Reproductive health and childbirth, Good Health and Well Being, Female, United States, Humans, Cardiovascular Diseases, American Heart Association, Postpartum Period, Pregnancy Outcome, Blood Pressure, Risk Factors, AHA Scientific Statements, cardiovascular diseases, diabetes, gestational, postpartum period, pregnancy, pregnancy complications, primary prevention, American Heart Association Cardiovascular Disease and Stroke in Women and Underrepresented Populations Committee of the Council on Clinical Cardiology, Council on Cardiopulmonary, Critical Care, Perioperative and Resuscitation, and Council on Cardiovascular and Stroke Nursing, Cardiorespiratory Medicine and Haematology, Clinical Sciences, Public Health and Health Services, Cardiovascular System & Hematology, Cardiovascular medicine and haematology, Clinical sciences, Sports science and exercise
Abstract

Adverse pregnancy outcomes are common among pregnant individuals and are associated with long-term risk of cardiovascular disease. Individuals with adverse pregnancy outcomes also have an increased incidence of cardiovascular disease risk factors after delivery. Despite this, evidence-based approaches to managing these patients after pregnancy to reduce cardiovascular disease risk are lacking. In this scientific statement, we review the current evidence on interpregnancy and postpartum preventive strategies, blood pressure management, and lifestyle interventions for optimizing cardiovascular disease using the American Heart Association Life's Essential 8 framework. Clinical, health system, and community-level interventions can be used to engage postpartum individuals and to reach populations who experience the highest burden of adverse pregnancy outcomes and cardiovascular disease. Future trials are needed to improve screening of subclinical cardiovascular disease in individuals with a history of adverse pregnancy outcomes, before the onset of symptomatic disease. Interventions in the fourth trimester, defined as the 12 weeks after delivery, have great potential to improve cardiovascular health across the life course.

Published
2024

5. Body Mass Index, Adverse Pregnancy Outcomes, and Cardiovascular Disease Risk

Author

Khan, Sadiya S, Petito, Lucia C, Huang, Xiaoning, Harrington, Katharine, McNeil, Rebecca B, Bello, Natalie A, Merz, C Noel Bairey, Miller, Eliza C, Ravi, Rupa, Scifres, Christina, Catov, Janet M, Pemberton, Victoria L, Varagic, Jasmina, Zee, Phyllis C, Yee, Lynn M, Ray, Mitali, Kim, Jin Kyung, Lane-Cordova, Abbi D, Lewey, Jennifer, Theilen, Lauren H, Saade, George R, Greenland, Philip, Grobman, William A, and Networks, for the NICHD nuMoM2b and NHLBI nuMoM2b Heart Health Study

Subjects
Reproductive Medicine, Biomedical and Clinical Sciences, Heart Disease, Maternal Morbidity and Mortality, Contraception/Reproduction, Nutrition, Perinatal Period - Conditions Originating in Perinatal Period, Conditions Affecting the Embryonic and Fetal Periods, Women's Health, Maternal Health, Pediatric, Pregnancy, Cardiovascular, Diabetes, Prevention, Obesity, Preterm, Low Birth Weight and Health of the Newborn, Clinical Research, 4.1 Discovery and preclinical testing of markers and technologies, 2.1 Biological and endogenous factors, Reproductive health and childbirth, Good Health and Well Being, Adult, Female, Infant, Newborn, Humans, United States, Young Adult, Pregnancy Outcome, Diabetes, Gestational, Premature Birth, Cardiovascular Diseases, Hypertension, Pregnancy-Induced, Body Mass Index, Risk Factors, Hyperlipidemias, body mass index, cardiovascular diseases, hypertension, pregnancy, obesity, NICHD nuMoM2b and NHLBI nuMoM2b Heart Health Study Networks, Cardiorespiratory Medicine and Haematology, Clinical Sciences, Cardiovascular System & Hematology, Cardiovascular medicine and haematology, Clinical sciences
Abstract

BackgroundObesity is a well-established risk factor for both adverse pregnancy outcomes (APOs) and cardiovascular disease (CVD). However, it is not known whether APOs are mediators or markers of the obesity-CVD relationship. This study examined the association between body mass index, APOs, and postpartum CVD risk factors.MethodsThe sample included adults from the nuMoM2b (Nulliparous Pregnancy Outcomes Study: Monitoring Mothers-To-Be) Heart Health Study who were enrolled in their first trimester (6 weeks-13 weeks 6 days gestation) from 8 United States sites. Participants had a follow-up visit at 3.7 years postpartum. APOs, which included hypertensive disorders of pregnancy, preterm birth, small-for-gestational-age birth, and gestational diabetes, were centrally adjudicated. Mediation analyses estimated the association between early pregnancy body mass index and postpartum CVD risk factors (hypertension, hyperlipidemia, and diabetes) and the proportion mediated by each APO adjusted for demographics and baseline health behaviors, psychosocial stressors, and CVD risk factor levels.ResultsAmong 4216 participants enrolled, mean±SD maternal age was 27±6 years. Early pregnancy prevalence of overweight was 25%, and obesity was 22%. Hypertensive disorders of pregnancy occurred in 15%, preterm birth in 8%, small-for-gestational-age birth in 11%, and gestational diabetes in 4%. Early pregnancy obesity, compared with normal body mass index, was associated with significantly higher incidence of postpartum hypertension (adjusted odds ratio, 1.14 [95% CI, 1.10-1.18]), hyperlipidemia (1.11 [95% CI, 1.08-1.14]), and diabetes (1.03 [95% CI, 1.01-1.04]) even after adjustment for baseline CVD risk factor levels. APOs were associated with higher incidence of postpartum hypertension (1.97 [95% CI, 1.61-2.40]) and hyperlipidemia (1.31 [95% CI, 1.03-1.67]). Hypertensive disorders of pregnancy mediated a small proportion of the association between obesity and incident hypertension (13% [11%-15%]) and did not mediate associations with incident hyperlipidemia or diabetes. There was no significant mediation by preterm birth or small-for-gestational-age birth.ConclusionsThere was heterogeneity across APO subtypes in their association with postpartum CVD risk factors and mediation of the association between early pregnancy obesity and postpartum CVD risk factors. However, only a small or nonsignificant proportion of the association between obesity and CVD risk factors was mediated by any of the APOs, suggesting APOs are a marker of prepregnancy CVD risk and not a predominant cause of postpartum CVD risk.

Published
2023

6. Heart Failure Epidemiology and Outcomes Statistics: A Report of the Heart Failure Society of America

Author

Bozkurt, Biykem, Ahmad, Tariq, Alexander, Kevin M, Baker, William L, Bosak, Kelly, Breathett, Khadijah, Fonarow, Gregg C, Heidenreich, Paul, Ho, Jennifer E, Hsich, Eileen, Ibrahim, Nasrien E, Jones, Lenette M, Khan, Sadiya S, Khazanie, Prateeti, Koelling, Todd, Krumholz, Harlan M, Khush, Kiran K, Lee, Christopher, Morris, Alanna A, Page, Robert L, Pandey, Ambarish, Piano, Mariann R, Stehlik, Josef, Stevenson, Lynne Warner, Teerlink, John R, Vaduganathan, Muthiah, Ziaeian, Boback, and Members, Writing Committee

Subjects
Biomedical and Clinical Sciences, Cardiovascular Medicine and Haematology, Clinical Sciences, Humans, Heart Failure, Hospitalization, Prevalence, Incidence, Writing Committee Members, Heart failure, epidemiology, incidence, mortality, outcomes, prevalence, Cardiorespiratory Medicine and Haematology, Nursing, Cardiovascular System & Hematology, Cardiovascular medicine and haematology, Clinical sciences
Published
2023

10. Clinical-transcriptional prioritization of the circulating proteome in human heart failure

Author

Perry, Andrew S., Amancherla, Kaushik, Huang, Xiaoning, Lance, Michelle L., Farber-Eger, Eric, Gajjar, Priya, Amrute, Junedh, Stolze, Lindsey, Zhao, Shilin, Sheng, Quanhu, Joynes, Cassandra M., Peng, Zhongsheng, Tanaka, Toshiko, Drakos, Stavros G., Lavine, Kory J., Selzman, Craig, Visker, Joseph R., Shankar, Thirupura S., Ferrucci, Luigi, Das, Saumya, Wilcox, Jane, Patel, Ravi B., Kalhan, Ravi, Shah, Sanjiv J., Walker, Keenan A., Wells, Quinn, Tucker, Nathan, Nayor, Matthew, Shah, Ravi V., and Khan, Sadiya S.

Published
2024
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15. 2024 AHA/ACC/AMSSM/HRS/PACES/SCMR Guideline for the Management of Hypertrophic Cardiomyopathy: A Report of the American Heart Association/American College of Cardiology Joint Committee on Clinical Practice Guidelines

Author

Ommen, Steve R., Ho, Carolyn Y., Asif, Irfan M., Balaji, Seshadri, Burke, Michael A., Day, Sharlene M., Dearani, Joseph A., Epps, Kelly C., Evanovich, Lauren, Ferrari, Victor A., Joglar, José A., Khan, Sadiya S., Kim, Jeffrey J., Kittleson, Michelle M., Krittanawong, Chayakrit, Martinez, Matthew W., Mital, Seema, Naidu, Srihari S., Saberi, Sara, Semsarian, Christopher, Times, Sabrina, and Waldman, Cynthia Burstein

Published
2024
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17. Interconnected Clinical and Social Risk Factors in Breast Cancer and Heart Failure.

Author

Sinha, Arjun, Bavishi, Avni, Hibler, Elizabeth A, Yang, Eric H, Parashar, Susmita, Okwuosa, Tochukwu, DeCara, Jeanne M, Brown, Sherry-Ann, Guha, Avirup, Sadler, Diego, Khan, Sadiya S, Shah, Sanjiv J, Yancy, Clyde W, and Akhter, Nausheen

Abstract

Breast cancer and heart failure share several known clinical cardiovascular risk factors, including age, obesity, glucose dysregulation, cholesterol dysregulation, hypertension, atrial fibrillation and inflammation. However, to fully comprehend the complex interplay between risk of breast cancer and heart failure, factors attributed to both biological and social determinants of health must be explored in risk-assessment. There are several social factors that impede implementation of prevention strategies and treatment for breast cancer and heart failure prevention, including socioeconomic status, neighborhood disadvantage, food insecurity, access to healthcare, and social isolation. A comprehensive approach to prevention of both breast cancer and heart failure must include assessment for both traditional clinical risk factors and social determinants of health in patients to address root causes of lifestyle and modifiable risk factors. In this review, we examine clinical and social determinants of health in breast cancer and heart failure that are necessary to consider in the design and implementation of effective prevention strategies that altogether reduce the risk of both chronic diseases.

Published
2022

18. Relation of Menopause With Cardiovascular Risk Factors in South Asian American Women (from the MASALA Study)

Author

Vijay, Aishwarya, Kandula, Namratha R, Kanaya, Alka M, Khan, Sadiya S, and Shah, Nilay S

Subjects
Reproductive Medicine, Biomedical and Clinical Sciences, Cardiovascular, Aging, Prevention, Heart Disease - Coronary Heart Disease, Contraception/Reproduction, Clinical Research, Heart Disease, Estrogen, Atherosclerosis, Obesity, Aetiology, 2.3 Psychological, social and economic factors, Good Health and Well Being, Asian, Asian People, Cardiovascular Diseases, Carotid Intima-Media Thickness, Female, Heart Disease Risk Factors, Humans, Menopause, Risk Factors, Cardiorespiratory Medicine and Haematology, Cardiovascular System & Hematology, Cardiovascular medicine and haematology
Abstract

The menopausal transition is a time of accelerating risk of cardiovascular disease (CVD), and promoting cardiovascular health during midlife is an important period of time to prevent CVD in women. The association of menopause with cardiovascular risk factors or subclinical atherosclerosis has not previously been evaluated in South Asian American women, a population with a disproportionately higher CVD burden compared with other race/ethnic groups. The objective of this study was to evaluate the association of menopause with CVD risk factors and subclinical cardiometabolic disease markers. We studied women aged 40 to 84 years from the Mediators of Atherosclerosis in South Asians Living in America study. The association of self-reported menopausal status with multiple demographic and clinical variables was assessed with linear and logistic regression adjusted for age and cardiovascular health behaviors. In a secondary ("age-restricted") analysis, postmenopausal participants outside the age range of premenopausal participants were excluded. In the age-restricted sample, menopause was associated with a higher adjusted odds of hypertension (odds ratio = 1.19, 95% confidence interval [CI] 1.02 to 1.41), and higher systolic blood pressure (β = 6.34, 95% CI 0.82 to 11.87), and significantly higher subcutaneous fat area (β = 42.8, 95% CI 5.8 to 91.4). No significant associations between menopause and ectopic fat deposition, coronary artery calcium, or carotid intima-media thickness were observed. In South Asian American women in the Mediators of Atherosclerosis in South Asians Living in America study, menopause was associated with cardiovascular risk factors and higher subcutaneous fat deposition. Menopausal status is an important factor to examine and address CVD risk factors.

Published
2022

22. Association of cardiovascular health and epigenetic age acceleration

Author

Pottinger, Tess D, Khan, Sadiya S, Zheng, Yinan, Zhang, Wei, Tindle, Hilary A, Allison, Matthew, Wells, Gretchen, Shadyab, Aladdin H, Nassir, Rami, Martin, Lisa Warsinger, Manson, JoAnn E, Lloyd-Jones, Donald M, Greenland, Philip, Baccarelli, Andrea A, Whitsel, Eric A, and Hou, Lifang

Subjects
Aging, Genetics, Cardiovascular, Good Health and Well Being, Acceleration, Aged, American Heart Association, Cardiovascular Diseases, Cohort Studies, CpG Islands, Cross-Sectional Studies, DNA Methylation, Epigenesis, Genetic, Female, Health Status, Humans, Longevity, Middle Aged, Postmenopause, United States, Women's Health, Cardiovascular health, Epigenetic age acceleration, Women's health initiative, DNA methylation, Simple seven, Women’s health initiative, Clinical Sciences, Paediatrics and Reproductive Medicine
Abstract

BackgroundCardiovascular health (CVH) has been defined by the American Heart Association (AHA) as the presence of the "Life's Simple 7" ideal lifestyle and clinical factors. CVH is known to predict longevity and freedom from cardiovascular disease, the leading cause of death for women in the United States. DNA methylation markers of aging have been aggregated into a composite epigenetic age score, which is associated with cardiovascular morbidity and mortality. However, it is unknown whether poor CVH is associated with acceleration of aging as measured by DNA methylation markers in epigenetic age.Methods and resultsWe performed a cross-sectional analysis of racially/ethnically diverse post-menopausal women enrolled in the Women's Health Initiative cohort recruited between 1993 and 1998. Epigenetic age acceleration (EAA) was calculated using DNA methylation data on a subset of participants and the published Horvath and Hannum methods for intrinsic and extrinsic EAA. CVH was calculated using the AHA measures of CVH contributing to a 7-point score. We examined the association between CVH score and EAA using linear regression modeling adjusting for self-reported race/ethnicity and education. Among the 2,170 participants analyzed, 50% were white and mean age was 64 (7 SD) years. Higher or more favorable CVH scores were associated with lower extrinsic EAA (~ 6 months younger age per 1 point higher CVH score, p

Published
2021

24. Distribution and Correlates of Incident Heart Failure Risk in South Asian Americans: The MASALA Study

Author

Shah, Nilay S, Agarwal, Anubha, Huffman, Mark D, Gupta, Deepak K, Yancy, Clyde W, Shah, Sanjiv J, Kanaya, Alka M, Ning, Hongyan, Lloyd-Jones, Donald M, Kandula, Namratha R, and Khan, Sadiya S

Subjects
Biomedical and Clinical Sciences, Cardiovascular Medicine and Haematology, Clinical Sciences, Clinical Research, Prevention, Atherosclerosis, Heart Disease, Cardiovascular, Aging, Nutrition, Heart Disease - Coronary Heart Disease, Aged, Asian, Heart Failure, Humans, India, Middle Aged, Heart failure, epidemiology, race and ethnicity, primary prevention, Cardiorespiratory Medicine and Haematology, Nursing, Cardiovascular System & Hematology, Cardiovascular medicine and haematology, Clinical sciences
Abstract

BackgroundSouth Asian Americans experience disproportionately high burden of cardiovascular diseases. Estimating predicted heart failure (HF) risk distribution may facilitate targeted prevention. We estimated the distribution of 10-year predicted risk of incident HF in South Asian Americans and evaluated the associations with social determinants of health and clinical risk factors.Methods and resultsIn the Mediators of Atherosclerosis in South Asians Living in America (MASALA) Study, we calculated 10-year predicted HF risk using the Pooled Cohort Equations to Prevent Heart Failure multivariable model. Distributions of low (

Published
2021

26. HF STATS 2024: Heart Failure Epidemiology and Outcomes Statistics An Updated 2024 Report from the Heart Failure Society of America

Author

Bozkurt, Biykem, Ahmad, Tariq, Alexander, Kevin, Baker, William L., Bosak, Kelly, Breathett, Khadijah, Carter, Spencer, Drazner, Mark H., Dunlay, Shannon M., Fonarow, Gregg C., Greene, Stephen J., Heidenreich, Paul, Ho, Jennifer E., Hsich, Eileen, Ibrahim, Nasrien E., Jones, Lenette M., Khan, Sadiya S., Khazanie, Prateeti, Koelling, Todd, Lee, Christopher S., Morris, Alanna A., Page, Robert L., II, Pandey, Ambarish, Piano, Mariann R., Sandhu, Alexander T., Stehlik, Josef, Stevenson, Lynne W., Teerlink, John, Vest, Amanda R., Yancy, Clyde, and Ziaeian, Boback

Published
2024
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31. Development and Validation of the American Heart Association’s PREVENT Equations

Author

Khan, Sadiya S., Matsushita, Kunihiro, Sang, Yingying, Ballew, Shoshana H., Grams, Morgan E., Surapaneni, Aditya, Blaha, Michael J., Carson, April P., Chang, Alexander R., Ciemins, Elizabeth, Go, Alan S., Gutierrez, Orlando M., Hwang, Shih-Jen, Jassal, Simerjot K., Kovesdy, Csaba P., Lloyd-Jones, Donald M., Shlipak, Michael G., Palaniappan, Latha P., Sperling, Laurence, Virani, Salim S., Tuttle, Katherine, Neeland, Ian J., Chow, Sheryl L., Rangaswami, Janani, Pencina, Michael J., Ndumele, Chiadi E., and Coresh, Josef

Published
2024
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33. 2023 ACC/AHA/SCAI advanced training statement on interventional cardiology (coronary, peripheral vascular, and structural heart interventions): A report of the ACC Competency Management Committee

Author

Bass, Theodore A., Abbott, J. Dawn, Mahmud, Ehtisham, Parikh, Sahil A., Aboulhosn, Jamil, Ashwath, Mahi L., Baranowski, Bryan, Bergersen, Lisa, Chaudry, Hannah I., Coylewright, Megan, Denktas, Ali E., Gupta, Kamal, Gutierrez, J. Antonio, Haft, Jonathan, Hawkins, Beau M., Herrmann, Howard C., Kapur, Navin K., Kilic, Sena, Lesser, John, Lin, C. Huie, Mendirichaga, Rodrigo, Nkomo, Vuyisile T., Park, Linda G., Phoubandith, Dawn R., Quader, Nishath, Rich, Michael W., Rosenfield, Kenneth, Sabri, Saher S., Shames, Murray L., Shernan, Stanton K., Skelding, Kimberly A., Tamis-Holland, Jacqueline, Thourani, Vinod H., Tremmel, Jennifer A., Uretsky, Seth, Wageman, Jessica, Welt, Frederick, Whisenant, Brian K., White, Christopher J., Yong, Celina M., Mendes, Lisa A., Arrighi, James A., Breinholt, John P., III, Day, Jennifer, Dec, G. William, Jr., Drajpuch, David, Faza, Nadeen, Francis, Sanjeev A., Hahn, Rebecca T., Housholder-Hughes, Susan D., Khan, Sadiya S., Kondapaneni, Meera Devi, Lee, Kwan S., Hussain Mahar, Jamal, McConnaughey, Shannon, Niazi, Khusrow, Pearson, Dorothy D., Punnoose, Lynn R., Reejhsinghani, Risheen S., Ryan, Thomas, Silvestry, Frank E., Solomon, Michael A., Spicer, Robert L., Weissman, Gaby, and Werns, Steven W.

Published
2023
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34. Novel Prediction Equations for Absolute Risk Assessment of Total Cardiovascular Disease Incorporating Cardiovascular-Kidney-Metabolic Health: A Scientific Statement From the American Heart Association

Author

Khan, Sadiya S., Coresh, Josef, Pencina, Michael J., Ndumele, Chiadi E., Rangaswami, Janani, Chow, Sheryl L., Palaniappan, Latha P., Sperling, Laurence S., Virani, Salim S., Ho, Jennifer E., Neeland, Ian J., Tuttle, Katherine R., Rajgopal Singh, Radhika, Elkind, Mitchell S.V., and Lloyd-Jones, Donald M.

Published
2023
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35. Outcomes in patients hospitalized for COVID-19 among Asian, Pacific Islander, and Hispanic subgroups in the American Heart Association COVID-19 registry

Author

Shah, Nilay S, Giase, Gina M, Petito, Lucia C, Kandula, Namratha R, Rodriguez, Fatima, Hsu, Jeffrey J, Wang, Daniel R, and Khan, Sadiya S

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Clinical Research, Prevention, Cardiovascular, Good Health and Well Being, Asian, COVID-19, Hispanic, Pacific Islander, disparities
Abstract

BackgroundCoronavirus disease 2019 (COVID-19) data from race/ethnic subgroups remain limited, potentially masking subgroup-level heterogeneity. We evaluated differences in outcomes in Asian American/Pacific Islander (AAPI) and Hispanic/Latino subgroups compared with non-Hispanic White patients hospitalized with COVID-19.MethodsIn the American Heart Association COVID-19 registry including 105 US hospitals, mortality and major adverse cardiovascular events in adults age ≥18 years hospitalized with COVID-19 between March-November 2020 were evaluated. Race/ethnicity groups included AAPI overall and subgroups (Chinese, Asian Indian, Vietnamese, and Pacific Islander), Hispanic/Latino overall and subgroups (Mexican, Puerto Rican), compared with non-Hispanic White (NHW).ResultsAmong 13,511 patients, 7% were identified as AAPI (of whom 17% were identified as Chinese, 9% Asian Indian, 8% Pacific Islander, and 7% Vietnamese); 35% as Hispanic (of whom 15% were identified as Mexican and 1% Puerto Rican); and 59% as NHW. Mean [SD] age at hospitalization was lower in Asian Indian (60.4 [17.4] years), Pacific Islander (49.4 [16.7] years), and Mexican patients (57.4 [16.9] years), compared with NHW patients (66.9 [17.3] years, p

Published
2021

39. Association between plasminogen activator inhibitor‐1 in young adulthood and nonalcoholic fatty liver disease in midlife: CARDIA

Author

Campbell, Patrick T, VanWagner, Lisa B, Colangelo, Laura A, Lewis, Cora E, Henkel, Anne, Ajmera, Veeral H, Lloyd‐Jones, Donald M, Vaughan, Douglas E, and Khan, Sadiya S

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Digestive Diseases, Clinical Research, Prevention, Chronic Liver Disease and Cirrhosis, Liver Disease, Adult, Cross-Sectional Studies, Female, Humans, Male, Non-alcoholic Fatty Liver Disease, Obesity, Plasminogen Activator Inhibitor 1, Risk Factors, Young Adult, computed tomography, hepatic, metabolic syndrome, obesity, steatosis, Gastroenterology & Hepatology, Clinical sciences
Abstract

BackgroundPrior studies have demonstrated a cross-sectional association between elevated plasminogen activator inhibitor-1 (PAI-1) levels and nonalcoholic fatty liver disease (NAFLD). However, there are no prospective longitudinal assessments of the association between PAI-1 and NAFLD. We aimed to describe the association between PAI-1 levels in early adulthood with NAFLD in midlife.MethodsAmong the 5115 participants in the coronary artery risk development in young adults (CARDIA) study, participants were randomly selected from a subset that was free of obesity, diabetes and hypertension at the 1992-1993 exam and attended the 2005-2006 exam (n = 996). A subset of participants (n = 896) also had CT liver fat measured (2010-2011). Participants with secondary causes of steatosis were excluded (n = 87). NAFLD was defined as liver attenuation ≤51 Hounsfield units. Logistic regression models assessed the association between PAI-1 and NAFLD.ResultsOf 809 participants, 53% were female, 37% black with a mean age of 32 years. Median PAI-1 level at 1st assessment (1992-1993) was 23.4 ng/mL among participants with NAFLD vs 11.9 ng/mL among those without NAFLD (P

Published
2020

42. A Synopsis of the Evidence for the Science and Clinical Management of Cardiovascular-Kidney-Metabolic (CKM) Syndrome: A Scientific Statement From the American Heart Association

Author

Ndumele, Chiadi E., Neeland, Ian J., Tuttle, Katherine R., Chow, Sheryl L., Mathew, Roy O., Khan, Sadiya S., Coresh, Josef, Baker-Smith, Carissa M., Carnethon, Mercedes R., Després, Jean-Pierre, Ho, Jennifer E., Joseph, Joshua J., Kernan, Walter N., Khera, Amit, Kosiborod, Mikhail N., Lekavich, Carolyn L., Lewis, Eldrin F., Lo, Kevin B., Ozkan, Bige, Palaniappan, Latha P., Patel, Sonali S., Pencina, Michael J., Powell-Wiley, Tiffany M., Sperling, Laurence S., Virani, Salim S., Wright, Jackson T., Rajgopal Singh, Radhika, Elkind, Mitchell S.V., and Rangaswami, Janani

Published
2023
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43. Cardiovascular-Kidney-Metabolic Health: A Presidential Advisory From the American Heart Association

Author

Ndumele, Chiadi E., Rangaswami, Janani, Chow, Sheryl L., Neeland, Ian J., Tuttle, Katherine R., Khan, Sadiya S., Coresh, Josef, Mathew, Roy O., Baker-Smith, Carissa M., Carnethon, Mercedes R., Despres, Jean-Pierre, Ho, Jennifer E., Joseph, Joshua J., Kernan, Walter N., Khera, Amit, Kosiborod, Mikhail N., Lekavich, Carolyn L., Lewis, Eldrin F., Lo, Kevin B., Ozkan, Bige, Palaniappan, Latha P., Patel, Sonali S., Pencina, Michael J., Powell-Wiley, Tiffany M., Sperling, Laurence S., Virani, Salim S., Wright, Jackson T., Rajgopal Singh, Radhika, and Elkind, Mitchell S.V.

Published
2023
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46. Abstract 17032: Association of Blood Pressure Patterns During Pregnancy With Incident Hypertension and Cardiovascular Disease Risk at 2-7 Years After Delivery: The nuMoM2b Heart Health Study

Author

Cameron, Natalie A, Huang, Xiaoning, Petito, Lucia C, McNeil, Rebecca B, Varagic, Jasmina, Catov, Janet M, Bairey Merz, C Noel, Chung, Judith, Haas, David, Levine, Lisa, Saade, George, Silver, Robert, Reddy, Uma, Mercer, Brian, Yee, Lynn, Greenland, Philip, Grobman, William, and Khan, Sadiya S

Published
2023
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49. Abstract 16315: Associations Between Angiogenic Biomarkers in Early Pregnancy and Predicted 30-year Risk of Cardiovascular Disease 2-7 Years After Delivery

Author

Awoyemi, Toluwalase, Huang, Xiaoning, McNeil, Rebecca, Varagic, Jasmina, Pemberton, Victoria L, Catov, Janet M, Bairey, C Noel N, Chung, Judith, Haas, David, Levine, Lisa, Saade, George, Silver, Robert, Reddy, Uma, Mercer, Brian, Yee, Lynn, Greenland, Philip, Grobman, William, and Khan, Sadiya S

Published
2023
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