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10 results on '"Khan, Md. Siddiqur Rahman"'

1. Diversity and Genetic Reassortment of Keystone Virus in Mosquito Populations in Florida

Author

Elbadry, Maha A., primary, Efstathion, Caroline A., additional, Qualls, Whitney A., additional, Tagliamonte, Massimiliano S., additional, Alam, Md. Mahbubul, additional, Khan, Md. Siddiqur Rahman, additional, Ryan, Sadie J., additional, Xue, Rui-de, additional, Charrel, Remi N., additional, Bangonan, Lea, additional, Salemi, Marco, additional, Ayhan, Nazli, additional, Lednicky, John A., additional, and Morris, J. Glenn, additional

Published
2023
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3. Characterization of the significant decline in humoral immune response six months post‐SARS‐CoV‐2 mRNA vaccination: A systematic review

Author

Notarte, Kin Israel, primary, Guerrero‐Arguero, Israel, additional, Velasco, Jacqueline Veronica, additional, Ver, Abbygail Therese, additional, Santos de Oliveira, Maria Helena, additional, Catahay, Jesus Alfonso, additional, Khan, Md. Siddiqur Rahman, additional, Pastrana, Adriel, additional, Juszczyk, Grzegorz, additional, Torrelles, Jordi B., additional, Lippi, Giuseppe, additional, Martinez‐Sobrido, Luis, additional, and Henry, Brandon Michael, additional

Published
2022
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4. Characterization of the significant decline in humoral immune response six months post-SARS-CoV-2 mRNA vaccination: A systematic review

Author

Notarte, Kin Israel, primary, Guerrero-Arguero, Israel, additional, Velasco, Jacqueline Veronica, additional, Ver, Abbygail Therese, additional, de Oliveira, Maria Helena Santos, additional, Catahay, Jesus Alfonso, additional, Khan, Md. Siddiqur Rahman, additional, Pastrana, Adriel, additional, Juszczyk, Grzegorz, additional, Torrelles, Jordi B., additional, Lippi, Giuseppe, additional, Martinez-Sobrido, Luis, additional, and Henry, Brandon Michael, additional

Published
2021
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8. Quantitative Drug-Susceptibility in Patients Treated for Multidrug-Resistant Tuberculosis in Bangladesh: Implications for Regimen Choice

Author

Heysell, Scott K., primary, Ahmed, Shahriar, additional, Ferdous, Sara Sabrina, additional, Khan, Md. Siddiqur Rahman, additional, Rahman, S. M. Mazidur, additional, Gratz, Jean, additional, Rahman, Md. Toufiq, additional, Mahmud, Asif Mujtaba, additional, Houpt, Eric R., additional, and Banu, Sayera, additional

Published
2015
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9. An avirulent Burkholderia pseudomallei ΔpurM strain with atypical type B LPS: expansion of the toolkit for biosafe studies of melioidosis.

Author

Norris, Michael H., Khan, Md Siddiqur Rahman, Schweizer, Herbert P., and Tuanyok, Apichai

Subjects
*MELIOIDOSIS, *BURKHOLDERIA pseudomallei, *VIRULENCE of bacteria, *LIPOPOLYSACCHARIDES, *AUXOTROPHY, *BIOSAFETY, *PUBLIC health
Abstract

Background: The work was undertaken to expand the tools available for researching Burkholderia pseudomallei (Bp), the etiological agent of the tropical disease melioidosis. Melioidosis has the potential to pose a severe threat to public health and safety. In the United States, Bp is listed as a Tier-1 select agent by the Centers for Disease Control and Prevention (CDC), thus requiring high levels of regulation and biosafety level 3 (BSL3) facilities for experimental manipulation of live organisms. An avirulent ΔpurM derivative of strain 1026b (Bp82) has proven to be a valuable tool for biosafe research as a select-agent excluded strain, but the high level of genetic diversity between Bp strains necessitates an expansion of the biosafe toolset. Results: The ΔpurM mutation was recapitulated in the Bp 576a strain, a serotype B background. An important difference between strains 1026b and 576a is the lipopolysaccharide (LPS), a major virulence factor and protective antigen. Polyclonal sera from 1026b-challenged non-human primates showed no cross reactivity with strain 576a LPS and low reactivity with whole cell lysate. Strain 576a replicates to higher levels in mouse organs and induces more TNF-a in the lungs of BALB/c mice compared to 1026b. The newly created Bp 576a ΔpurM strain, designated 576mn, was auxotrophic for adenine in minimal media, capable of wild-type growth in rich media with addition of adenine, and auxotrophy was abrogated with single-copy complementation. Bp 576mn was unable to replicate in human cells and was avirulent in BALB/c mice following high-dose intranasal inoculation, similar to Bp82. Organ loads indicated a significant reduction in bacterial replication. Conclusions: In this work, the new biosafe strain 576mn with atypical type B LPS was generated. This strain should prove a valuable addition to the toolkit for biosafe studies of Bp and development of therapeutic and preventative strategies aimed at combatting melioidosis. Strain 576mn is an ideal candidate for select-agent exclusion. [ABSTRACT FROM AUTHOR]

Published
2017
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