Search

In this work, soap was converted into a hydrocarbon-rich product through catalytic pyrolysis using cement as a catalyst. The intention was to develop a new economical and effective method for preparing diesel and gasoline from soap waste in food processing. The optimum conditions for pyrolysis were investigated in a batch process under static conditions at different reactor temperatures, catalyst amounts, and reaction durations. The resulting oil product was analyzed using GC-FID, GC-MS, and FTIR. The best yield occurred at a reaction temperature of 400 °C for 60 min with 0.3 g/g (30 mass%) catalyst in soap waste, which resulted in 0.71 g/g (71 mass%) hydrocarbons with small fractions of pyran, ketone, and oxygenated compounds of mixed functional groups. The resulting liquid pyrolysate mainly consisted of diesel-like oil with a small fraction of gasoline and some oils that had boiling-point temperature ranges similar to kerosene. [ABSTRACT FROM AUTHOR]

A variety of esters of thiazolidine-4-caboxylic acid were synthesized and investigated for their urease inhibitory properties. A significant increase in urease inhibitory activities of these ester derivatives has been observed. The order of activity increases from methyl ester to heptyl ester but further prolongation of the alkyl chain was proved to be detrimental for receptor binding. These findings provide evidence that the nature of the alkyl chain has a significant impact on the coordination of thiazolidine esters with bi-metallic nickel center of urease. It was also observed that inhibition potentiated by lower pH and with increase in time. [ABSTRACT FROM AUTHOR]

In the present work, a series of 2-O-substituted derivatives of 1-[(3,5-dichloro-2-hydroxy phenyl) sulfonyl]piperidine (5a-j) were synthesized. These derivatives were geared up by the coupling of 3,5-dichloro-2-hydroxy benzenesullbnyl chloride (1) with piperidine (2) under dynamic pH control in aqueous media to form parent compound 1-[(3,5-dichloro-2-hydroxyphenyl)sulfonyl]piperidine (3), followed by the substitution at oxygen atom with different electrophiles (4a-j) in the presence of sodium hydride (Nail) and dimethyl formamide (DMF) to give a series of O- substituted derivatives of sulfonamides bearing piperidine nucleus 5a-j. The synthesized O-substituted sultbnamides were spectrally characterized. The bioactivity of all the synthesized compounds were evaluated against lipoxygenase (LOX), acetylcholinesterae (ACHE) and butyrylcholinesterase (BChE) enzymes and found to be having talented activity against butyrylcholinesterase enzyme. [ABSTRACT FROM AUTHOR]

Background: Non-Hodgkin lymphoma of B cell origin is the common type of lymphoma- related malignancy with poor response rate with conventional front-line therapies., Aim: The aim of the present study was to investigate the potential of new anti-inflammatory oxadiazole derivatives of Diclofenac as an anti-lymphoma agent through in vitro and in silico approaches., Methods: Anti-lymphoma potential was evaluated by alamar blue technique. MTT assay employed for cytotoxicity. Gene and protein expression studies was performed by qRT-PCR and ELISA respectively. Docking studies was performed by using MOE program., Results: Among five diclofenac derivatives, (II) showed promising anti-lymphoma effects, where it inhibited the expression of BCL-2, p-38 MAPK and TGF-β in both follicular and Burkitt's lymphoma cells and was non-toxic against normal human fibroblast cells. The in silico studies against BCL-2 revealed that the unsubstituted Sulphur group in (II) is involved in the crucial interactions with the binding site residue., Conclusion: The compound (II) can be a potential therapeutic candidate for B-cell non-Hodgkin lymphoma and deserves further development as a novel anti-lymphoma agent., (Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.)