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27 results on '"Khan, Gayasuddin"'

6. Review Paper on Properties of Concrete Partial Replacement of Fine Aggregate and Cement

Author

Khan Gayasuddin Abdul Rauf and Pratiksha Malviya

Subjects
Cement, Aggregate (composite), Materials science, fly ash, Properties of concrete, Geotechnical engineering, Stone Dust, Mix Design, Civil Engineering
Abstract

The main objective of this research is to investigate the use of fly ash and other is Stone dust as partial replacement of cement and concrete production. In this research we analyze the strength of concrete made with using these waste materials one is Fly ash and other is Stone dust. The Fly as his used as 20 replace by weight of cement and Stone Dust as the partial replacement of Fine Aggregate from 0 , 10 , 20 , 30 and 40 . The grade of the concrete here is M 30 grade. Khan Gayasuddin Abdul Rauf | Pratiksha Malviya "Review Paper on Properties of Concrete Partial Replacement of Fine Aggregate & Cement" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-2 | Issue-6 , October 2018, URL: https://www.ijtsrd.com/papers/ijtsrd18919.pdf

Published
2018

10. Periodontal thermoresponsive, mucoadhesive dual antimicrobial loaded in-situgel for the treatment of periodontal disease: Preparation, in-vitrocharacterization and antimicrobial study

Author

Bansal, Monika, Mittal, Neelam, Yadav, Sarita Kumari, Khan, Gayasuddin, Gupta, Pooja, Mishra, Brahmeshwar, and Nath, Gopal

Abstract

This study aimed to formulate and characterize in-situgel containing levofloxacin and metronidazole to release drugs in controlled manner for treatment of periodontitis.

Published
2024
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16. Design, optimization and characterizations of chitosan fortified calcium alginate microspheres for the controlled delivery of dual drugs.

Author

Yadav, Sarita Kumari, Khan, Gayasuddin, Bonde, Gunjan Vasant, Bansal, Monika, and Mishra, Brahmeshwar

Subjects
*MICROSPHERES, *ANTI-infective agents, *CHITOSAN, *DRUG delivery systems, *CALCIUM alginate
Abstract

Periodontal disease is chronic, highly prevalent infectious disease that requires prolonged and controlled delivery of antimicrobial agents into pockets. To achieve this objective, dual antimicrobials encapsulated chitosan fortified calcium alginate (CS-Ca-SA) microspheres were formulated by application of Plackett-Burman factorial design. The microspheres were optimized for particle size (PS), entrapment efficiency (EE) and drug release. The optimized microspheres presented average PS of 74-461 µm and EE of 62.45-86.20% with controlled drug delivery for 120 hours. FTIR disclosed successful complexation between SA and CS. DSC and XRD studies showed changes in the crystallinity of drugs in microspheres. Shape factor and SEM demonstrated spherical to pear-shaped microspheres. Release exponent >0.43 and high diffusion coefficients revealed non-Fickian-based diffusion-limited drug release. CS-Ca-SA microspheres exhibited surface pH of 6.5 ± 0.5, moderate swelling, less erosion and improved mucoadhesion over Ca-SA microspheres. Also, significant antimicrobial activity against Escherichia coli and Staphylococcus aureus and cytocompatibility with L929 cell lines were observed. Further, microspheres exhibited long-term stability on refrigeration. The outcomes of study supported the potential of dual polymer and dual drug-based biodegradable, stable, non-toxic, mucoadhesive, controlled and prolonged drug release microspheres as more patient compliant by administration into periodontal pockets for the management of periodontal disease. [ABSTRACT FROM AUTHOR]

Published
2018
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25. Atorvastatin calcium encapsulated eudragit nanoparticles with enhanced oral bioavailability, safety and efficacy profile.

Author

Kumar, Nagendra, Chaurasia, Sundeep, Patel, Ravi R., Khan, Gayasuddin, Kumar, Vikas, and Mishra, Brahmeshwar

Subjects
ATORVASTATIN, HYPERLIPIDEMIA treatment, IN vitro studies, PHYSIOLOGICAL effects of nanoparticles, BIOAVAILABILITY
Abstract

Atorvastatin calcium (ATR), a second generation statin drug, was encapsulated in eudragit RSPO-based polymeric nanoparticles. The effect of independent variables (polymer content, stabilizer concentration, volume of chloroform and homogenization speed) on response variables (mean diameter particle size and entrapment efficiency) were investigated by employing central composite experimental design. All the independent variables were found to be significant for determining the response variables. Solid-state characterization study indicated the absence of physicochemical interaction between drug and polymer in formulation. Morphological study exhibited homogenous spherical shape of formulated nanoparticles.In vitrorelease study in phosphate buffer (pH 7.4) demonstrated sustained release profile over 24 h. Pharmacokinetic study in Charles Foster rats showed significant enhancement in oral bioavailability as compared to pure drug suspension. Efficacy study (lipid profile and blood glucose level) significantly justified the effectiveness of formulation having 50% less dose of ATR as compared to pure drug suspension. The effectiveness of formulation was further justified with an improved plasma safety profile of treated rats. Hence, ATR encapsulated eudragit RSPO nanoparticles can serve as potential drug delivery approach to enhance drug bioavailability, efficacy and safety profiles to alter existing marketed drug products. [ABSTRACT FROM PUBLISHER]

Published
2017
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27. Advances in Patents Related to Intrapocket Technology for the Management of Periodontitis

Author

K. Yadav, Sarita, Khan, Gayasuddin, and Mishra, Brahmeshwar

Abstract

Increased prevalence of oral diseases such as gingivitis, periodontitis and dental caries has become major health issue worldwide. Such growing incidence of periodontitis has directly affected the development of drug delivery systems and growth of the market. Since the infections are limited to periodontal pockets or oral cavity, localized intrapocket drug delivery will be more beneficial than conventional systemic administration. Advances in intrapocket technology and innovations in the field of periodontal drug delivery led to increased patent applications. Newer trends like use of mucoadhesive polymers, in situ forming gels, viscosity modifiers, plasticizers etc which can enhance intrapocket retention of drugs have gained considerable attention among researchers and industrialists. Current market is flooded with products such as Periostat, Periochip®, Atridox®, Arestin®, Actisite®, Dentomycin®, and Elyzol® and generics such as metronidazole, levofloxacin, tetracycline, doxycyline and minocycline for intrapocket delivery. There is a need of novel drugs and delivery systems with better efficacy profiles than the existing compounds. Inclusion of novel technologies like films, fibers, in situ forming implants, microparticles, nanoparticles, and liposomes as intrapocket drug delivery has great potential. Development of antibiotic free drug delivery such as antiseptics, host modulators, biofilms inhibitors and antibodies has promising role in the improvement of pathogenesis of periodontitis. Further, this review deals with various innovations in drug delivery and patents related to localized intrapocket administration of medicaments in the implications of periodontitis.

Published
2015

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