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Healthy state is priority in today's world which can be achieved using effective medicines. But due to overuse and misuse of antibiotics, a menace of resistance has increased in pathogenic microbes. World Health Organization (WHO) has announced ESKAPE pathogens (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter spp.) as the top priority pathogens as these have developed resistance against certain antibiotics. To combat such a global issue, it is utmost important to identify novel therapeutic strategies/agents as an alternate to such antibiotics. To name certain antibiotic adjuvants including: inhibitors of beta–lactamase, efflux pumps and permeabilizers for outer membrane can potentially solve the antibiotic resistance problems. In this regard, inhibitors of lytic domain of lytic transglycosylases provide a novel way to not only act as an alternate to antibiotics but also capable of restoring the efficiency of previously resistant antibiotics. Further, use of bacteriophages is another promising strategy to deal with antibiotic resistant pathogens. Taking in consideration the alternatives of antibiotics, a green synthesis nanoparticle-based therapy exemplifies a good option to combat microbial resistance. As horizontal gene transfer (HGT) in bacteria facilitates the evolution of new resistance strains, therefore identifying the mechanism of resistance and development of inhibitors against it can be a novel approach to combat such problems. In our perspective, host-directed therapy (HDT) represents another promising strategy in combating antimicrobial resistance (AMR). This approach involves targeting specific factors within host cells that pathogens rely on for their survival, either through replication or persistence. As many new drugs are under clinical trials it is advisable that more clinical data and antimicrobial stewardship programs should be conducted to fully assess the clinical efficacy and safety of new therapeutic agents. [ABSTRACT FROM AUTHOR]

This research leverages bibliometric methodologies, enhanced by the visual analytics capabilities of CiteSpace, to meticulously examine the evolution and current trends in energy trading within power markets, analyzing 642 scholarly articles from the Web of Science Core Collection spanning from 1996 to 2023. The study aims to illuminate the prevailing research landscape, growth patterns, and future directions in energy trading dynamics. Key findings include: (1) A noticeable escalation in the volume of publications, especially from 2021 to 2023, indicating a burgeoning interest and rapid evolution in this research area; (2) The author and institutional collaboration networks are in a nascent stage, with a predominantly China-centric international collaboration pattern, including significant partnerships with the United States, Australia, and the United Kingdom; (3) The focal points of research are centered around themes such as "energy management", "demand-side innovation", "decentralized energy trading", and "strategic optimization", covering areas such as intelligent grid technologies, energy market dynamics, and sustainable energy solutions. The study recommends enhancing collaborative networks, fusing technological and strategic dimensions in research, increasing focus and funding for emerging technologies, and promoting wider international and cross-disciplinary collaborations to enrich the understanding of energy trading dynamics in the context of electricity markets. [ABSTRACT FROM AUTHOR]

In this paper, we introduce the novel concept of generalized distance denoted as J θ and call it an extended b-generalized pseudo-distance. With the help of this generalized distance, we define a generalized point to set distance J θ (u , H ★) , a generalized Hausdorff type distance and a P J θ -property of a pair (H ★ , K ★) of nonempty subsets of extended b-metric space (U ★ , ρ θ). Additionally, we establish several best proximity point theorems for multi-valued contraction mappings of Nadler type defined on b-metric spaces and extended b-metric spaces. Our findings generalize numerous existing results found in the literature. To substantiate the introduced notion and validate our main results, we provide some concrete examples. [ABSTRACT FROM AUTHOR]