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Photocatalytic generation of H2 via water splitting emerges as a promising avenue for the next generation of green hydrogen due to its low carbon footprint. Herein, a versatile platform is designed to the preparation of functional π‐conjugated organic nanoparticles dispersed in aqueous phase via mini‐emulsification. Such particles are composed of donor–acceptor–donor (DAD) trimers prepared via Stille coupling, stabilized by amphiphilic block copolymers synthesized by reversible addition‐fragmentation chain transfer polymerization. The hydrophilic segment of the block copolymers will not only provide colloidal stability, but also allow for precise control over the surface functionalization. Photocatalytic tests of the resulting particles for H2 production resulted in promising photocatalytic activity (≈0.6 mmol g−1 h−1). This activity is much enhanced compared to that of DAD trimers dispersed in the water phase without stabilization by the block copolymers. [ABSTRACT FROM AUTHOR]

Photocatalytic generation of H2 via water splitting emerges as a promising avenue for the next generation of green hydrogen due to its low carbon footprint. Herein, a versatile platform is designed to the preparation of functional π‐conjugated organic nanoparticles dispersed in aqueous phase via mini‐emulsification. Such particles are composed of donor–acceptor–donor (DAD) trimers prepared via Stille coupling, stabilized by amphiphilic block copolymers synthesized by reversible addition‐fragmentation chain transfer polymerization. The hydrophilic segment of the block copolymers will not only provide colloidal stability, but also allow for precise control over the surface functionalization. Photocatalytic tests of the resulting particles for H2 production resulted in promising photocatalytic activity (≈0.6 mmol g−1 h−1). This activity is much enhanced compared to that of DAD trimers dispersed in the water phase without stabilization by the block copolymers. [ABSTRACT FROM AUTHOR]

Esophageal adenocarcinoma (EAC) is a leading cause of cancer-related mortality. Sitravatinib is a novel multi-gene tyrosine kinase inhibitor (TKI) that targets tumor-associated macrophage (TAM) receptors, VEGF, PDGF and c-Kit. Currently, sitravatinib is actively being studied in clinical trials across solid tumors and other TKIs have shown efficacy in combination with immune checkpoint inhibitors (ICI) in cancer models. In this study, we investigated the anti-tumor activity of sitravatinib alone and in combination with PD-1 blockade in an EAC rat model. Treatment response was evaluated by mortality, pre- and post-treatment MRI, gene expression, immunofluorescence and immunohistochemistry. Our results demonstrated adequate safety and significant tumor shrinkage in animals treated with sitravatinib, and more profoundly, sitravatinib and PD-1 inhibitor, AUNP-12 (P  < 0.01). Suppression of TAM receptors resulted in increased gene expression of pro-inflammatory cytokines and decreased expression of anti-inflammatory cytokines, enhanced infiltration of CD8+ T cells, and M2 to M1 macrophage phenotype repolarization in the tumor microenvironment of treated animals (P  < 0.01). Moreover, endpoint immunohistochemistry staining corroborated the anti-tumor activity by downregulation of Ki67 and upregulation of Caspase-3 in the treated animals. Additionally, pretreatment gene expression of TAM receptors and PD-L1 were significantly higher in major responders compared with the non-responders, in animals that received sitravatinib and AUNP-12 (P  < 0.02), confirming that TAM suppression enhances the efficacy of PD-1 blockade. In conclusion, this study proposes a promising immunomodulatory strategy using a multi-gene TKI to overcome developed resistance to an ICI in EAC, establishing rationale for future clinical development. [ABSTRACT FROM AUTHOR]

Front Cover: A versatile platform is developed for creating functional π‐conjugated organic nanoparticles stabilized by amphiphilic block copolymers for green H2 photocatalytic generation. The donor–acceptor–donor trimers nanoparticles show enhanced photocatalytic activity (≈0.6 mmol g−1 h−1) for H2 production via water splitting. More details can be found in article 2400395 by Thiago R. Guimarães, Jean‐Louis Bobet, Eric Cloutet, and co‐workers..By Thiago R. Guimarães; Alisha Khan; Hynd Remita; Jean‐Louis Bobet and Eric CloutetReported by Author; Author; Author; Author; Author [Extracted from the article]

Front Cover: A versatile platform is developed for creating functional π‐conjugated organic nanoparticles stabilized by amphiphilic block copolymers for green H2 photocatalytic generation. The donor–acceptor–donor trimers nanoparticles show enhanced photocatalytic activity (≈0.6 mmol g−1 h−1) for H2 production via water splitting. More details can be found in article 2400395 by Thiago R. Guimarães, Jean‐Louis Bobet, Eric Cloutet, and co‐workers..By Thiago R. Guimarães; Alisha Khan; Hynd Remita; Jean‐Louis Bobet and Eric CloutetReported by Author; Author; Author; Author; Author [Extracted from the article]

Background and Aims: Evaluation of a player's dietary intake is important both for training and research. Along with body composition it provides an insight into their positive adaptation to training. This study aimed at assessing the effect of the nutritional profile of Indian long-distance runners on their body composition and performance. Material and Method: Dietary intake of 53 Indian long-distance runners was assessed using 24 hours dietary recall method. Body composition was analyzed using bioelectrical impedance analysis. Performance was assessed through indirect measurement of VO2 max using Astrand protocol. Results: BMI was correlated positively with energy and fat intake (p < 0.05). Sum of skinfolds was correlated positively with fat intake and energy intake (only among males) (p < 0.05). Fat % was correlated positively with energy intake, carbohydrate intake, fat intake (only among females) (p < 0.05) and negatively with VO2 max though not significant. Fat free mass % was negatively associated with energy and carbohydrate intake (p < 0.05). Association of VO2 max was significantly positive with protein, calcium and iron intake and negative with carbohydrate intake (p > 0.05). Energy intake was significantly positively correlated with carbohydrate intake for the group as a whole and with fat intake specifically in females (p < 0.05). Fat free mass had significant negative correlation with energy, carbohydrate intake, and fat intake in females. Inverse association of fat free mass % and VO2 max was also observed though non-significant in both males and females. Conclusions: Dietary intake has an impact on both body composition and VO2 max. Body weight, fat, and fat free mass distribution in long distance runners can be managed through diet and can form an important part of athletic development. [ABSTRACT FROM AUTHOR]

Strongyloidiasis is an intestinal infection caused by the parasitic nematodes of the Strongyloides species, most commonly Strongyloides stercoralis. We report a case of a 66-year-old immigrant male from Haiti who presented with complaints of diarrhea and an unintentional 80-lb weight loss over the past 5 years. Stool examination was positive for strongyloidiasis. Following albendazole therapy, esophagogastroduodenoscopy (EGD) showed a unique ampullary lesion. Histopathology of the ampullary lesion showed reactive epithelium with Strongyloides larva. In addition, endoscopic ultrasound (EUS) detected a large pancreatic cyst. Both these findings were absent on EGD 5 years previously, prior to the onset of his symptoms. This paper documents a rare case of an ampullary lesion and pancreatic cyst secondary to hepatobiliary strongyloidiasis in a non-Human Immunodeficiency Virus (HIV) patient. We review the epidemiology, life cycle, clinical presentation and treatment of strongyloidiasis. [ABSTRACT FROM AUTHOR]

Replacement of a missing tooth involves different therapeutic options in dentistry. The usual treatment options of implants, removable partial dentures and fixed partial dentures are often inapplicable for children. In such situation, a resin bonded bridge fulfills all the requirements of an interim solution till the growth period is complete and a permanent tooth replacement option can be explored. This paper presents a conservative, functional, cost effective and time saving procedure of an interim replacement of a tooth in the anterior as well as posterior region. [ABSTRACT FROM AUTHOR]

Photocatalytic generation of H 2 via water splitting emerges as a promising avenue for the next generation of green hydrogen due to its low carbon footprint. Herein, a versatile platform is designed to the preparation of functional π-conjugated organic nanoparticles dispersed in aqueous phase via mini-emulsification. Such particles are composed of donor-acceptor-donor (DAD) trimers prepared via Stille coupling, stabilized by amphiphilic block copolymers synthesized by reversible addition-fragmentation chain transfer polymerization. The hydrophilic segment of the block copolymers will not only provide colloidal stability, but also allow for precise control over the surface functionalization. Photocatalytic tests of the resulting particles for H 2 production resulted in promising photocatalytic activity (≈0.6 mmol g -1 h -1 ). This activity is much enhanced compared to that of DAD trimers dispersed in the water phase without stabilization by the block copolymers., (© 2024 The Author(s). Macromolecular Rapid Communications published by Wiley‐VCH GmbH.)