1. [Purinergic regulation of rat heart function in ontogeny].
- Author
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Sitdikov FG, Anikina TA, Zverev AA, Bilalova GA, and Khamzina EIu
- Subjects
- Animals, Dose-Response Relationship, Drug, Isometric Contraction drug effects, Rats, Receptors, Purinergic P2 metabolism, Adenosine Triphosphate pharmacology, Aging physiology, Heart growth & development, Heart Rate drug effects, Myocardial Contraction drug effects, Purinergic P2 Receptor Agonists
- Abstract
The effect of exogenous ATP and its analogs on heart function was studied in 14-100-day-old rats. Extracellular purines had a positive chronotropic effect on the heart. Intravenous administration of exogenous ATP and its stable analogs induced a dose-dependent increase in heart rate depending on animal age. The analysis of isometric contraction of myocardial strips demonstrated a dose-dependent positive inotropic effect of ATP. The family and subtype of the P2 receptors realizing the positive chronotropic and inotropic effects were identified using selective agonists and blockers. P2X receptors demonstrated the highest sensitivity during early postnatal ontogeny. The age-related pattern of the receptor response to exogenous purines indicated the heterochronic maturation of P2X and P2Y receptors in the myocardium.
- Published
- 2008