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272 results on '"Khalife, M."'

10. McKittrick–Wheelock syndrome presenting with dermatomyositis and rectal prolapse

Author

Khalife M, Eloubeidi MA, and Aboul Hosn M

Subjects
Diseases of the digestive system. Gastroenterology, RC799-869
Abstract

Mohamad Khalife,1 Mohamad A Eloubeidi,2 Maen Aboul Hosn11Department of Surgery, 2Department of Internal Medicine, American University of Beirut, Beirut, LebanonAbstract: McKittrick–Wheelock syndrome is a rare disease characterized by a large hypersecretory rectosigmoid villous adenoma resulting in persistent large volume diarrhea, electrolyte abnormalities, and renal dysfunction. We report an unusual presentation of this syndrome in a patient who developed persistent diarrhea along with dermatomyositis and rectal prolapse and was later discovered to have a large rectal villous adenoma along with a smaller sigmoid tubulovillous adenoma. In our literature review, we were able to find one case report of a dermatomyositis occurring in conjunction with a tubulovillous adenoma and few case reports of rectal prolapse in the setting of a secretory villous adenoma. However, there were no reports on both occurring in association with McKittrick–Wheelock syndrome. This report highlights the variable manifestations of colorectal adenomas and the importance of searching for an underlying neoplastic entity in patients with new onset dermatomyositis or rectal prolapse or both.Keywords: villous adenoma, McKittrick–Wheelock syndrome, dermatomyositis, rectal prolapse, secretory adenoma, rectal polyps

Published
2013

29. Safety of a thickened extensive casein hydrolysate formula

Author

Vandenplas, Yvan, De Greef, Elisabeth, Xinias, I, Vrani, O, Mavroudi, A, Hammoud, M, Al Refai, F, Khalife, M C, Sayad, A, Noun, P, Farah, A, Makhoul, G, Orel, R, Sokhn, M, L'Homme, A, Mohring, M P, Merhi, B Abou, Boulos, J, El Masri, H, Halut, C, Allar Study Group, Growth and Development, Clinical sciences, and Faculty of Medicine and Pharmacy

Subjects
0301 basic medicine, (Extensive) hydrolysate, Dietary Fiber, Male, Allergy, Pediatrics, thickened formula, Protein Hydrolysates, Endocrinology, Diabetes and Metabolism, Milk allergy, Gastroenterology, Cow's milk allergy, Infant nutrition, 0302 clinical medicine, Child Development, Hydrolyzed protein formula, Casein, Prospective Studies, health care economics and organizations, education.field_of_study, Nutrition and Dietetics, Viscosity, Caseins, humanities, Infant Formula, Milk, Female, Dietary Proteins, medicine.medical_specialty, Population, antiregurgitation formula, Hydrolysate, 03 medical and health sciences, Double-Blind Method, 030225 pediatrics, Internal medicine, medicine, Dietary Carbohydrates, Laryngopharyngeal Reflux, Animals, Humans, education, 030109 nutrition & dietetics, business.industry, Body Weight, Infant, Hypoallergenic, Immunoglobulin E, medicine.disease, Dietary Fats, Body Height, Infant formula, Milk Hypersensitivity, business, Energy Intake
Abstract

Objectives Cow's milk allergy (CMA) is treated in formula-fed infants with an extensive protein hydrolysate. This study aimed to evaluate the nutritional safety of a non-thickened and thickened extensively casein hydrolyzed protein formula (NT- and T-eCHF) in infants with CMA. Methods Infants younger than 6 mo old with a positive cow milk challenge test, positive IgE, or skin prick test for cow milk were selected. Weight and length were followed during the 6 mo intervention with the NT-eCHF and T-eCHF. Results A challenge was performed in 50/71 infants with suspected CMA and was positive in 34/50. All children with confirmed CMA tolerated the eCHF. The T-eCHF leads to a significant improvement of the stool consistency in the whole population and in the subpopulation of infants with proven CMA. Height and weight evolution was satisfactory throughout the 6 mo study. Conclusions The eCHF fulfills the criteria of a hypoallergenic formula and the NT- and T-eCHF reduced CMA symptoms. Growth was within normal range.

Published
2015

30. Drain or No Drain Following Pancreaticoduodenectomy: The Unsolved Dilemma

Author

Zaghal, A., Tamim, H., Habib, S., Jaafar, R., Mukherji, D., Khalife, M., Mailhac, A., and Faraj, W.

Abstract

Background and aims: There is no consensus regarding the routine placement of intra-abdominal drains after pancreaticoduodenectomy. We aim to determine the effects of intraperitoneal drain placement during pancreaticoduodenectomy on 30-day postoperative morbidity and mortality.Methods: Patients who underwent pancreaticoduodenectomy for pancreatic tumors were identified from the 2014–2015 American College of Surgeons—National Surgical Quality Improvement Program Database. Univariate and multivariate analyses adjusting for known prognostic variables were performed. A subgroup analysis was performed based on the risk for development of postoperative pancreatic leak determined by the pancreatic duct caliber, parenchymal texture, and body mass index.Results: A total of 6858 patients with pancreatic tumors who underwent pancreaticoduodenectomy were identified in the 2014–2015 American College of Surgeons—National Surgical Quality Improvement Program Database dataset. In all, 87.4% of patients had intraperitoneal drains placed. A 30-day mortality rate was higher in the no-drain group (2.9% vs. 1.7%, P = 0.003). Patients in the drain group had a higher incidence of overall morbidity (49.5% vs. 41.2%, P = 0.0008), delayed gastric emptying (18.1% vs. 13.7%, P = 0.004), pancreatic fistulae (19.4% vs. 9.9%, P ⩽ 0.0001), and prolonged length of hospital stay over 10 days (43.7% vs. 34.9%, P < 0.0001). Subgroup analysis based on risk categories revealed a higher 30-day mortality rate in the no-drain group among patients with high-risk features (3.1% vs. 1.6%, P = 0.02). Delayed gastric emptying and pancreatic fistula development remained significantly higher in the drain group only in the high-risk category. Prolonged length of hospital stay and composite morbidity remained higher in the drain group regardless of the risk category.Conclusion: To our knowledge, this is the largest study to date that aims at clarifying the pros and cons of the intraperitoneal drain placement during pancreaticoduodenectomy for pancreatic tumors. We showed a higher 30-day mortality rate if drain insertion was omitted during pancreaticoduodenectomy in patients with softer pancreatic textures, smaller pancreatic duct caliber, and body mass index over 25. Postoperative 30-day morbidity rate was higher if a drain was inserted regardless of the risk category. Further randomized controlled trials with prospective evaluation of stratification factors for fistula risk are needed to establish a clear recommendation.

Published
2020
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37. A 71-Year-Old Man with a Large Cystic Pancreatic Mass

Author

Mukherji, D., Faraj, W., Khalife, M., Shamseddine, A., Majzoub, N. E., Zaatari, G., Shah, M., Abou-Alfa, G. K., and Eileen M. O'Reilly

Subjects
Gastrointestinal Cancer Educational Case Series
Published
2012

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