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2. 011 QT PEAK DISPERSION CORRELATED WITH LV SIZE AND MASS IN PATIENTS WITH CHRONIC HEART FAILURE, BUT NOT TO THE AMOUNT OF SCAR PRESENT
- Author
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Khaleva, O, primary, Sherwi, N, additional, Lukaschuk, E, additional, Borovickova, M, additional, Khan, Z H, additional, Lee, V, additional, Joshi, A, additional, Loh, H, additional, Bourantas, C, additional, Clark, A L, additional, Cleland, J G F, additional, and Wong, K, additional
- Published
- 2013
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3. Poster session I * Thursday 9 December 2010, 08:30-12:30
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Kuznetsov, V. A., primary, Kozhurina, A. O., additional, Plusnin, A. V., additional, Szulik, M., additional, Sredniawa, B., additional, Streb, W., additional, Lenarczyk, R., additional, Stabryla-Deska, J., additional, Sedkowska, A., additional, Kowalski, O., additional, Kalarus, Z., additional, Kukulski, T., additional, Katova, T. M., additional, Nesheva, A., additional, Simova, I., additional, Hristova, K., additional, Kostova, V., additional, Boiadjiev, L., additional, Dimitrov, N., additional, Papamichalis Michalis, M. P., additional, Sitafidis George, S. G., additional, Dimopoulos Basilios, B. D., additional, Kelepesis Glafkos, G. K., additional, Economou Dimitrios, D. E., additional, Skoularigis John, J. S., additional, Triposkiadis Filippos, F. T., additional, Attenhofer Jost, C. H., additional, Pfyffer, M., additional, Naegeli, B., additional, Levis, P., additional, Faeh-Gunz, A., additional, Brunner-Larocca, H. P., additional, Velasco Del Castillo, M. S., additional, Cacicedo, A., additional, Onaindia, J. J., additional, Gonzalez Ruiz, J., additional, Subinas, A., additional, Alarcon, J. A., additional, Quintana, O., additional, Rodriguez, I., additional, Laraudogoitia, E., additional, Lam, Y.-Y., additional, Henein, M. Y., additional, Mazzone, A., additional, Vianello, A., additional, Perlini, S., additional, Corciu, A. I., additional, Cappelli, S., additional, Cerillo, A., additional, Chiappino, D., additional, Berti, S., additional, Glauber, M., additional, Herrmann, S., additional, Niemann, M., additional, Stoerk, S., additional, Strotmann, J., additional, Voelker, W., additional, Ertl, G., additional, Weidemann, F., additional, Yong, Z. Y., additional, Boerlage - Van Dijk, K., additional, Koch, K. T., additional, Vis, M. M., additional, Bouma, B. J., additional, Henriques, J. P. S., additional, Cocchieri, R., additional, De Mol, B. A. J. M., additional, Piek, J. J., additional, Baan, J., additional, Keenan, N. G. J., additional, Cueff, C., additional, Cimadevilla, C., additional, Brochet, E., additional, Lepage, L., additional, Detaint, D., additional, Iung, B., additional, Vahanian, A., additional, Messika-Zeitoun, D., additional, Otsuka, T., additional, Suzuki, M., additional, Yoshikawa, H., additional, Hashimoto, G., additional, Osaki, T., additional, Tsuchida, T., additional, Matsuyama, M., additional, Yamashita, H., additional, Ozaki, S., additional, Sugi, K., additional, Garcia Alonso, C. J., additional, Vallejo Camazon, N., additional, Ferrer Sistach, E., additional, Camara, M. L., additional, Lopez Ayerbe, J., additional, Bosch Carabante, C., additional, Espriu Simon, M., additional, Gual Capllonch, F., additional, Bayes Genis, A., additional, Deswarte, G., additional, Vanesson, C., additional, Polge, A. S., additional, Huchette, D., additional, Modine, T., additional, Marboeuf, P., additional, Lamblin, N., additional, Bauters, C., additional, Deklunder, G., additional, Le Tourneau, T., additional, Agricola, A., additional, Gullace, M., additional, Stella, S., additional, D'amato, R., additional, Slavich, M., additional, Oppizzi, M., additional, Ancona, M., additional, Margonato, A., additional, Le Ven, F., additional, Etienne, Y., additional, Jobic, Y., additional, Frachon, I., additional, Castellant, P., additional, Fatemi, M., additional, Blanc, J. J., additional, Muratori, M., additional, Montorsi, P., additional, Maffessanti, F., additional, Gripari, P., additional, Teruzzi, G., additional, Ghulam Ali, S., additional, Fusini, L., additional, Celeste, F., additional, Pepi, M., additional, Goebel, B., additional, Haugaa, K., additional, Meyer, K., additional, Otto, S., additional, Lauten, A., additional, Jung, C., additional, Edvardsen, T., additional, Figulla, H. R., additional, Poerner, T. C., additional, Aksoy, H., additional, Okutucu, S., additional, Evranos, B., additional, Aytemir, K., additional, Kaya, E. B., additional, Kabakci, G., additional, Tokgozoglu, L., additional, Ozkutlu, H., additional, Oto, A., additional, Valeur, N., additional, Pedersen, H. H., additional, Videbaek, R., additional, Hassager, C., additional, Svendsen, J. H., additional, Kober, L., additional, Tigen, M. K., additional, Karaahmet, T., additional, Gurel, E., additional, Pala, S., additional, Dundar, C., additional, Basaran, Y., additional, Caldararu, C. I., additional, Ene, E., additional, Dorobantu, M., additional, Vatasescu, R. 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T., additional, Nedeljkovic, I., additional, Zamaklar-Trifunovic, D., additional, Calovic, Z., additional, Jelic, V., additional, Boricic, M., additional, Petrovic, I., additional, Kuchynka, P., additional, Palecek, T., additional, Simek, S., additional, Nemecek, E., additional, Horak, J., additional, Hulinska, D., additional, Schramlova, J., additional, Vitkova, I., additional, Aster, V., additional, Linhart, A., additional, Paluszkiewicz, L., additional, Guersoy, D., additional, Ozegowski, S., additional, Spiliopoulos, S., additional, Koerfer, R., additional, Tenderich, G., additional, Gaggl, M., additional, Heinze, G., additional, Sunder-Plassmann, G., additional, Graf, S., additional, Zehetmayer, M., additional, Voigtlaender, T., additional, Mannhalter, C., additional, Paschke, E., additional, Fauler, G., additional, Mundigler, G., additional, Tesic, M., additional, Trifunovic, D., additional, Djordjevic-Dikic, A., additional, Petrovic, O., additional, Petrovic, M., additional, Beleslin, B., additional, Ostojic, M., additional, Draganic, G., additional, Correia, C. E., additional, Rodrigues, B., additional, Santos, L. F., additional, Moreira, D., additional, Gama, P., additional, Nunes, L., additional, Nascimento, C., additional, Dionisio, O., additional, Santos, O., additional, Prinz, C., additional, Oldenburg, O., additional, Bitter, T., additional, Piper, C., additional, Horstkotte, D., additional, Faber, L., additional, Nemes, A., additional, Gavaller, H., additional, Csanady, M., additional, Forster, T., additional, Calcagnino, M., additional, O'mahony, C., additional, Tsovolas, K., additional, Lambiase, P. D., additional, Elliott, P., additional, Olezac, A. S., additional, Bensaid, A., additional, Nahum, J., additional, Teiger, E., additional, Dubois-Rande, J. L., additional, Gueret, P., additional, Lim, P., additional, Langer, C., additional, Kansal, M., additional, Surapaneni, P., additional, Sengupta, P. P., additional, Lester, S. J., additional, Ommen, S. R., additional, Ressler, S. W., additional, Hurst, R. T., additional, Monivas Palomero, V., additional, Mingo Santos, S., additional, Mitroi, C., additional, Garcia Lunar, I., additional, Garcia Pavia, P., additional, Gonzalez Mirelis, J., additional, Ruiz Bautista, L., additional, Castro Urda, V., additional, Toquero Ramos, J., additional, Fernandez Lozano, I., additional, Sommer, A., additional, Poulsen, S. H., additional, Mogensen, J., additional, Thuesen, L., additional, Egeblad, H., additional, Montisci, R., additional, Ruscazio, M., additional, Vacca, A., additional, Garau, P., additional, Tuveri, F., additional, Soro, C., additional, Matthieu, A., additional, Meloni, L., additional, Kosmala, W., additional, Przewlocka-Kosmala, M., additional, Wojnalowicz, A., additional, Mysiak, A., additional, Marwick, T. 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A., additional, Fiane, A., additional, Bergsland, J., additional, Fosse, E., additional, Aakhus, S., additional, Koopman, L. P., additional, Chahal, N., additional, Slorach, C., additional, Hui, W., additional, Sarkola, T., additional, Manlhiot, C., additional, Bradley, T. J., additional, Jaeggi, E. T., additional, Mccrindle, B. W., additional, Mertens, L., additional, D'aiello, F. A., additional, Mormilw, A., additional, Rea, A., additional, O'Connor, K., additional, Romano, G., additional, Magne, J., additional, Pierard, L., additional, Lancellotti, P., additional, Arita, T., additional, Ando, K., additional, Isotani, A., additional, Soga, Y., additional, Iwabuchi, M., additional, Nobuyoshi, M., additional, Wiesen, M., additional, Skowasch, D., additional, Breunig, F., additional, Beer, M., additional, Hu, K., additional, Wanner, C., additional, Morel, M. A., additional, Bernard, Y. 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A., additional, Stoylen, A., additional, Vatten, L., additional, Bochenek, T., additional, Wita, K., additional, Tabor, Z., additional, Doruchowska, A., additional, Lelek, M., additional, Trusz-Gluza, M., additional, Hamodraka, E., additional, Paraskevaidis, I., additional, Karamanou, A., additional, Michalakeas, C., additional, Vrettou, H., additional, Kapsali, E., additional, Tsiapras, D., additional, Lekakis, I., additional, Anastasiou-Nana, M., additional, Kremastinos, D., additional, Sirugo, L., additional, Bottari, V. E., additional, Licciardi, S., additional, Blundo, A., additional, Atanasio, A., additional, Monte, I. P., additional, Park, C. S., additional, Kim, J. H., additional, Cho, J. S., additional, Kim, M. J., additional, Cho, E. J., additional, Ihm, S. H., additional, Jung, H. O., additional, Jeon, H. K., additional, Youn, H. J., additional, Kim, K. S., additional, Fontana, A., additional, Taravella, L., additional, Zambon, A., additional, Trocino, G., additional, Giannattasio, C., additional, Kalinin, A., additional, Alekhin, M., additional, Bahs, G., additional, Lejnieks, A., additional, Kalvelis, A., additional, Kalnins, A., additional, Shipachovs, P., additional, Zakharova, E., additional, Blumentale, G., additional, Trukshina, M., additional, Biering-Sorensen, T., additional, Mogelvang, R., additional, Haahr-Pedersen, S., additional, Schnohr, P., additional, Sogaard, P., additional, Skov Jensen, J., additional, Gargani, L., additional, Agoston, G., additional, Capati, E., additional, Badano, L., additional, Moreo, A., additional, Costantino, M. F., additional, Caputo, M. L., additional, Mondillo, S., additional, Sicari, R., additional, Picano, E., additional, Malev, E. G., additional, Timofeev, E. V., additional, Reeva, S. V., additional, Zemtsovsky, E. V., additional, Piazza, R., additional, Enache, R., additional, Roman-Pognuz, A., additional, Leiballi, E., additional, Pecoraro, R., additional, Sadeghian, H., additional, Lotfi_Tokaldany, M., additional, Rezvanfard, M., additional, Kasemisaeid, A., additional, Majidi, S., additional, Montazeri, M., additional, Saber-Ayad, M., additional, Nassar, Y. S., additional, Farhan, A., additional, Moussa, A., additional, El-Sherif, A., additional, Cooper, R. M., additional, Somauroo, J. D., additional, Shave, R. E., additional, Williams, K. L., additional, Forster, J., additional, George, C., additional, Bett, T., additional, Gaze, D. C., additional, George, K. P., additional, Mansencal, N., additional, Dupland, A., additional, Caille, V., additional, Perrot, S., additional, Bouferrache, K., additional, Vieillard-Baron, A., additional, Jouffroy, R., additional, Cioroiu, S. G., additional, Alexe, O. 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G., additional, Bergenzaun, L., additional, Chew, M., additional, Ersson, A., additional, Gudmundsson, P., additional, Ohlin, H., additional, Borowiec, A., additional, Dabrowski, R., additional, Wozniak, J., additional, Jasek, S., additional, Chwyczko, T., additional, Kowalik, I., additional, Musiej-Nowakowska, E., additional, Szwed, H., additional, Wen, Y. L., additional, Tian, J., additional, Yan, L., additional, Cheng, H., additional, Yang, H., additional, Luo, B., additional, Wang, J., additional, Kozman, H., additional, Villarreal, D., additional, Liu, K., additional, Karavidas, A., additional, Tsiachris, D., additional, Lazaros, G., additional, Matzaraki, V., additional, Xylomenos, G., additional, Levendopoulos, G., additional, Arapi, S., additional, Perpinia, A., additional, Matsakas, E., additional, Pyrgakis, V., additional, Liu, Y. W., additional, Su, C. T., additional, Tsai, W. C., additional, Huang, J. W., additional, Hung, K. Y., additional, Chen, J. H., additional, Larsson, M., additional, Kremer, F., additional, Kouznetsova, T., additional, Bjallmark, A., additional, Lind, B., additional, Brodin, L.-A., additional, D'hooge, J., additional, Caputo, M., additional, Antonelli, G., additional, Lisi, M., additional, Giacomin, E., additional, Moustafa, S., additional, Alharthi, M., additional, Deng, Y., additional, Chandrasekaran, K., additional, Mookadam, F., additional, Hayashi, S. Y., additional, Nascimento, M. M., additional, Lindholm, B., additional, Seeberger, A., additional, Nowak, J., additional, Riella, M. C., additional, Brodin, L. A., additional, Theodosis, A., additional, Fousteris, E., additional, Tsiaousis, G., additional, Krommydas, A., additional, Margetis, P., additional, Katidis, Z., additional, Beldekos, D., additional, Argirakis, S., additional, Melidonis, A., additional, Foussas, S., additional, Khaleva, O., additional, Onyshchenko, O., additional, Lukaschuk, E., additional, Sherwi, N., additional, Nikitin, N., additional, Cleland, J. G. F., additional, Risum, N., additional, Jons, C., additional, Olsen, N. T., additional, Kronborg, M. B., additional, Jensen, M. T., additional, Fritz-Hansen, T., additional, Bruun, N. E., additional, Hojgaard, M. V., additional, Petrini, J., additional, Yousry, M., additional, Rickenlund, A., additional, Liska, J., additional, Franco-Cereceda, A., additional, Hamsten, A., additional, Eriksson, P., additional, Caidahl, K., additional, Eriksson, M. J., additional, Elmstedt, N., additional, Ferm-Widlund, K., additional, Westgren, M., additional, Szymczyk, E., additional, Kasprzak, J. D., additional, Wozniakowski, B., additional, Rotkiewicz, A., additional, Szymczyk, K., additional, Stefanczyk, L., additional, Michalski, B., additional, Lipiec, P., additional, Ring, L., additional, Eller, T., additional, Deegan, P., additional, Rusk, R., additional, Urbano Moral, J. A., additional, Arias, J. A., additional, Kuvin, J. T., additional, Patel, A. R., additional, Pandian, N. G., additional, Bellsham-Revell, H., additional, Bell, A. J., additional, Miller, O., additional, Greil, G. F., additional, Simpson, J., additional, Ancona, R., additional, Comenale Pinto, S., additional, Caso, P., additional, Severino, S., additional, Nunziata, L., additional, Roselli, T., additional, Dussault, C., additional, Lafitte, S., additional, Habib, G., additional, Reant, P., additional, Derumeaux, G., additional, Thibault, H., additional, Kaladaridis, A., additional, Agrios, I. A., additional, Pamboucas, C. P., additional, Mesogitis, S. M., additional, Vasiladiotis, N. V., additional, Bramos, D. B., additional, Toumanidis, S. T. T., additional, Martiniello, A. R., additional, Santangelo, G., additional, Pedrizzetti, G., additional, Tonti, G., additional, Cioppa, C., additional, Cavallaro, M., additional, Calvi, V., additional, and Chianese, R., additional
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- 2010
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4. 767 Prognostic role of ventricular dyssynchrony in patients with chronic heart failure
- Author
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KHALEVA, O, primary, NIKITIN, N, additional, CLARK, A, additional, GOOD, K, additional, RIGBY, A, additional, and CLELAND, J, additional
- Published
- 2007
- Full Text
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5. Prevalence of, Associations With, and Prognostic Value of Tricuspid Annular Plane Systolic Excursion (TAPSE) Among Out-Patients Referred for the Evaluation of Heart Failure.
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Damy T, Kallvikbacka-Bennett A, Goode K, Khaleva O, Lewinter C, Hobkirk J, Nikitin NP, Dubois-Randé JL, Hittinger L, Clark AL, and Cleland JG
- Abstract
BACKGROUND: Prevalence, predictors, and prognostic value of right ventricular (RV) function measured by the tricuspid annular plane systolic excursion (TAPSE) in patients with chronic heart failure (CHF) symptoms with a broad range of left ventricular ejection fraction (LVEF) are unknown. METHODS AND RESULTS: Of 1,547 patients, mean (±SD) age was 71 ± 11 years, 48% were women, median (interquartile range [IQR]) TAPSE was 18.5 (14.0-22.7) mm, mean LVEF was 47 ± 16%, 47% had LVEF <=45% and 67% were diagnosed with CHF, defined as systolic (S-HF) if LVEF was <=45% and as heart failure with preserved ejection fraction (HFPEF) if LVEF was >45% and treated with a loop diuretic. During a median (IQR) follow-up of 63 (41-75) months, mortality was 34%. In multivariable analysis, increasing age, N-terminal pro-B-type natriuretic peptide (NT-proBNP), New York Heart Association functional class, right atrial volume index, and transtricuspid pressure gradient; lower TAPSE, diastolic blood pressure, and hemoglobin; and atrial fibrillation (AF) or COPD were associated with an adverse prognosis. Receiver operating characteristic curve analysis identified a TAPSE of 15.9 mm as the best prognostic threshold (P = .0001); 47% of S-HF and 20% of HFPEF had a TAPSE of <15.9 mm. The main associations with a TAPSE <15.9 mm were higher NT-proBNP, presence of atrial fibrillation and presence of LV systolic dysfunction. CONCLUSIONS: In patients with CHF, low values for TAPSE are common, especially in those with reduced LVEF. TAPSE, unlike LVEF, was an independent predictor of outcome. [ABSTRACT FROM AUTHOR]
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- 2012
6. Cardiac resynchronization therapy: dyssynchrony imaging from a heart failure perspective.
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Cleland JGF, Cullington D, Khaleva O, Tageldien A, Cleland, John G F, Cullington, Damien, Khaleva, Olga, and Tageldien, Ahmed
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- 2008
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7. Multiple cardiac clots in an individual with essential thrombocythemia and heart failure.
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Pellicori P, Joseph AC, Mabote T, Khaleva O, and Clark AL
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- Aged, Echocardiography, Heart Diseases diagnosis, Heart Diseases etiology, Heart Failure diagnosis, Humans, Male, Thrombocythemia, Essential diagnosis, Thrombosis diagnosis, Heart Failure complications, Thrombocythemia, Essential complications, Thrombosis etiology
- Published
- 2014
- Full Text
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8. Revisiting a classical clinical sign: jugular venous ultrasound.
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Pellicori P, Kallvikbacka-Bennett A, Zhang J, Khaleva O, Warden J, Clark AL, and Cleland JG
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- Aged, Aged, 80 and over, Atrial Function, Right physiology, Chronic Disease, Comorbidity, Female, Heart Failure epidemiology, Heart Failure physiopathology, Humans, Male, Middle Aged, Pulmonary Artery physiology, Risk Factors, Stroke Volume physiology, Valsalva Maneuver physiology, Ventricular Dysfunction, Left epidemiology, Ventricular Dysfunction, Left physiopathology, Heart Failure diagnostic imaging, Jugular Veins diagnostic imaging, Ultrasonography methods, Venous Pressure physiology, Ventricular Dysfunction, Left diagnostic imaging
- Abstract
Background: Increased jugular venous pressure, reflecting the increased right atrial pressure, is a classical sign of heart failure (HF) but clinical assessment may be difficult., Methods: In ambulatory patients with HF and control subjects, jugular vein diameter (JVD) was measured using a linear high-frequency ultrasound probe (10 MHz) at rest, during a Valsalva manoeuvre and during deep inspiration. JVD ratio was calculated as diameter during Valsalva to that at rest., Results: 211 patients (mean age 70 years; mean left ventricular ejection fraction 43%) and 20 controls were included. JVD (median and inter-quartile [IQR] range) at rest was 0.17 (0.15-0.20) cm in controls and 0.23 (0.17-0.33) cm in patients with HF (p=0.012), JVD ratio was 6.3 (4.3-6.8) in controls and 4.4 (2.7-5.8) in patients with HF (p=0.001).With increasing quartiles of plasma NT-proBNP, JVD at rest rose (0.20 (0.15-0.23) cm, 0.21 (0.16-0.29) cm, 0.25 (0.18-0.35) cm and 0.34 (0.20-0.53) cm (P=<0.001), whilst JVD ratio decreased (5.4 (4.2-6.4), 4.4 (3.5-6.3), 3.9 (2.4-5.4) and 2.8 (1.7-4.7); p=<0.001). JVD ratio correlated with log (NT-proBNP) (r=-0.39, p=<0.001), LV filling pressures (E/E', r=-0.33, p=<0.001) and left atrial volume (r=-0.21, p=0.002). In a multivariable regression model, only trans-tricuspid gradient and TAPSE were independently associated with JVD ratio (R(2)=0.27)., Conclusions: Distension of the JV at rest relative to the maximum diameter during a Valsalva manoeuvre (JVD ratio) identifies patients with heart failure who have higher plasma NT-proBNP levels, right ventricular dysfunction and raised pulmonary artery pressure., (Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.)
- Published
- 2014
- Full Text
- View/download PDF
9. Global longitudinal strain in patients with suspected heart failure and a normal ejection fraction: does it improve diagnosis and risk stratification?
- Author
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Pellicori P, Kallvikbacka-Bennett A, Khaleva O, Carubelli V, Costanzo P, Castiello T, Wong K, Zhang J, Cleland JG, and Clark AL
- Subjects
- Aged, Aged, 80 and over, Atrial Fibrillation mortality, Atrial Fibrillation physiopathology, Biomarkers blood, Disease Progression, Female, Heart Atria diagnostic imaging, Heart Failure blood, Heart Failure mortality, Heart Failure physiopathology, Hospitalization, Humans, Kaplan-Meier Estimate, Male, Middle Aged, Multivariate Analysis, Natriuretic Peptide, Brain blood, Peptide Fragments blood, Predictive Value of Tests, Prognosis, Proportional Hazards Models, Risk Assessment, Risk Factors, Stress, Mechanical, Time Factors, Vena Cava, Inferior diagnostic imaging, Echocardiography, Doppler, Heart Failure diagnostic imaging, Stroke Volume, Systole, Ventricular Function, Left
- Abstract
Many patients have clinical, structural or bio-marker evidence of heart failure (HF) but a normal left ventricular ejection fraction (LVEF; HeFNEF). Measurement of global longitudinal strain (GLS) may add diagnostic and prognostic information. Patients with symptoms suggesting heart failure and LVEF ≥50% were studied: 76 had no substantial cardiac dysfunction (left atrial diameter (LAD) <40 mm and amino-terminal pro-brain natriuretic peptide (NTproBNP) <400 ng/l); 99 had "possible HeFNEF" (LAD ≥40 mm or NTproBNP ≥400 ng/l); and 138 had "definite HeFNEF" (LAD ≥40 mm and NTproBNP ≥400 ng/L). Mean LVEF was 58% in each subgroup. Patients with definite HeFNEF were older, more likely to have atrial fibrillation, had more symptoms and signs of fluid retention, were more likely to have right ventricular dysfunction and had higher pulmonary pressures than other groups. Mean GLS (SD) was less negative in patients with definite HeFNEF (-13.6 (3.0)% vs. possible HeFNEF: -15.2 (3.1)% vs. no substantial cardiac dysfunction: -15.9 (2.4)%; p < 0.001). GLS was -19.1 (2.1)% in 20 controls. During a median follow up of 647 days, cardiovascular death or an unplanned hospitalisation for heart failure occurred in 62 patients. In univariable analysis, GLS but not LVEF predicted events. However, in a multi-variable analysis, only urea, NTproBNP, left atrial volume, inferior vena cava diameter and atrial fibrillation independently predicted adverse outcome. GLS is abnormal in patients who have other evidence of HeFNEF, is associated with a worse prognosis in this population but is not a powerful independent predictor of outcome.
- Published
- 2014
- Full Text
- View/download PDF
10. An atrial mass: the value of echocardiographic three-dimensional reconstruction.
- Author
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Pellicori P, Sherwi N, Khaleva O, Wong K, and Cleland JG
- Subjects
- Aged, 80 and over, Biomarkers blood, Diagnosis, Differential, Female, Heart Atria diagnostic imaging, Humans, Image Interpretation, Computer-Assisted, Magnetic Resonance Imaging, Natriuretic Peptide, Brain blood, Peptide Fragments blood, Predictive Value of Tests, Ventricular Function, Left, Echocardiography, Three-Dimensional, Heart Neoplasms diagnostic imaging, Hernia, Hiatal diagnostic imaging
- Abstract
An 88-year-old lady was referred to our Heart Failure Clinic with a history of 'occasional' breathlessness. Electrocardiography showed sinus rhythm and no other major abnormalities and N-terminal pro-B-type natriuretic peptide (NT-proBNP) was normal. Transthoracic echocardiography showed a non-dilated left ventricle with good systolic function. A bright and well-circumscribed, echogenic mass appeared inside a mildly dilated left atrium, visible in both parasternal and apical views. A three-dimensional echocardiographic reconstruction showed no mass within the left atrium; however, an extracardiac mass impinging its posterior wall was seen. Suspicion of an intrathoracic tumour was raised and cardiac magnetic resonance showed a hiatus hernia immediately adjacent to the left atrium. Care must be taken when evaluating masses in or close to the heart.
- Published
- 2012
- Full Text
- View/download PDF
11. Clinical trials update from the European Society of Cardiology Congress 2007: 3CPO, ALOFT, PROSPECT and statins for heart failure.
- Author
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Cleland JG, Abdellah AT, Khaleva O, Coletta AP, and Clark AL
- Subjects
- Acute Disease, Amides therapeutic use, Atorvastatin, Cardiac Pacing, Artificial, Fumarates therapeutic use, Heart Failure physiopathology, Heptanoic Acids therapeutic use, Humans, Hydroxymethylglutaryl-CoA Reductase Inhibitors therapeutic use, Pulmonary Edema, Pyrroles therapeutic use, Renin antagonists & inhibitors, Respiration, Artificial, Clinical Trials as Topic, Heart Failure therapy
- Abstract
This article provides information and a commentary on trials relevant to the pathophysiology, prevention and treatment of heart failure, presented at the European Society of Cardiology Congress 2007. Unpublished reports should be considered as preliminary data, as analyses may change in the final publication. In the 3CPO study, non-invasive ventilation produced a more rapid resolution of symptoms in patients hospitalised with acute cardiogenic pulmonary oedema; but had no effect on survival, compared to standard oxygen therapy. The ALOFT study showed that the selective oral renin inhibitor aliskiren reduces plasma BNP levels and is well tolerated in patients with heart failure receiving ACE inhibitors or ARBs, although the study was not powered to show clinical benefit. In the PROSPECT study, no echocardiographic measure of mechanical dyssynchrony was identified that was useful for identifying patients more or less likely to respond to CRT. Low dose atorvastatin reduced the incidence of sudden cardiac death in a small placebo controlled study of patients with advanced chronic heart failure.
- Published
- 2007
- Full Text
- View/download PDF
12. Should patients who have persistent severe symptoms receive a left ventricular assist device or cardiac resynchronization therapy as the next step?
- Author
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Cleland J, Tageldien A, Khaleva O, Hobson N, and Clark AL
- Subjects
- Electrocardiography, Humans, Patient Selection, Randomized Controlled Trials as Topic, Ventricular Remodeling, Cardiac Output, Low surgery, Electric Countershock methods, Heart-Assist Devices, Ventricular Dysfunction, Left surgery
- Abstract
Currently, cardiac resynchronization therapy (CRT) should be considered before a left ventricular assist device for most patients who have moderate or severe left ventricular systolic dysfunction and have not responded symptomatically to conventional pharmacologic measures. There is little evidence that the severity of cardiac dyssynchrony as measured using current techniques is useful in predicting the benefits of CRT. QRS duration on the surface ECG is a surrogate marker of the severity of the left ventricular ejection fraction as well as of several types of dyssynchrony. More clinical trials are required to determine whether excluding patients who have QRS duration less than 120 msec or those who have no evidence of dyssynchrony from implantation of CRT is appropriate. Perhaps all patients who have moderate or severe left ventricular systolic dysfunction should be considered for CRT, either to improve symptoms if they are persistent or relapsing, or to improve outcome. In the longer-term future, it is possible that the development of less expensive, small, and safe left ventricular assist devices will supplant the role of both CRT and CRT-defibrillator devices.
- Published
- 2007
- Full Text
- View/download PDF
13. How many patients need cardiac resynchronization therapy?
- Author
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Cleland JG, Goode K, Khaleva O, and Khan N
- Subjects
- Clinical Trials as Topic, Humans, Cardiac Pacing, Artificial, Heart Failure therapy
- Published
- 2006
- Full Text
- View/download PDF
14. [Prognostic significance of treadmill stress-echocardiography in patients with ischemic heart disease].
- Author
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Alekhin MN, Khaleva OIu, and Sidorenko BA
- Subjects
- Adult, Aged, Aged, 80 and over, Female, Humans, Male, Middle Aged, Prospective Studies, Severity of Illness Index, Echocardiography, Stress methods, Exercise Test, Myocardial Ischemia diagnosis, Myocardial Ischemia physiopathology
- Abstract
Prognostic value of treadmill echocardiography was studied in 146 patients (125 men, 21 women, age 58,6-/+9 years) with overt or suspected ischemic heart disease. During 35-/+6 months of follow-up there were 26 cardiac events (11 cardiovascular deaths, 6 myocardial infarctions and 9 revascularization procedures). Independent predictors of events were presence of angina, maximal heart rate, and result of a stress test. Both exercise tolerance and echocardiographical signs of ischemia were related to development of events however the latter had better predictive power. Among patients with exercise tolerance below 7 METS with and without ischemia rates of events were 33 and 11%, respectively. Among patients with exercise tolerance above 7 METS with and without ischemia event rates were 23 and 6.8%, respectively.
- Published
- 2002
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