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Abstract An accurate and efficient approach is required to identify the unknown parameters of solid oxide fuel cell (SOFC) mathematical model for a robust design of any energy system considering SOFC. This research study proposes a modified fire hawk algorithm (MFHA) to determine the values of SOFC model parameters. The performance evaluation of MFHA is tested on two case studies. Firstly, the performance of MFHA is tested on commercially available cylindrical cell developed by Siemens at four temperatures. Results reveal that the least value of sum of squared error (SSE) is 1.04E−05, 2.30E−05, 1.03E−05, and 1.60E−05 at 1073 K, 1173 K, 1213 K, and 1273 K respectively. Results obtained using MFHA have been compared with original fire hawk algorithm (FHA) and other well established and recent algorithms. Secondly, MFHA is implemented for estimating unknown parameters of a 5 kW dynamic tabular stack of 96 cells at various pressures and temperatures. The obtained value of SSE at different temperatures of 873 K, 923 K, 973 K, 1023 K and 1073 K is 1.18E−03, 6.12E−03, 2.21E−02, 5.18E−02, and 6.00E−02, respectively whereas, SSE at different pressures of 1 atm, 2 atm, 3 atm, 4 atm, and 5 atm is 6.05E−02, 6.11E−02, 5.53E−02, 5.11E−02, and 6.64E−02 respectively.

Abstract Breast cancer is one of the leading causes of death among women globally, making its diagnosis and treatment challenging. The use of nanotechnology for cancer diagnosis and treatment is an emerging area of research. To address this issue, multiwalled carbon nanotubes (MWCNTs) were ligand exchanged with butyric acid (BA) to gain hydrophilic character. The successful functionalization was confirmed by FTIR spectroscopy. Surface morphology changes were observed using SEM, while TEM confirmed the structural integrity of the MWCNTs after functionalization. Particle size, zeta potential, and UV spectroscopy were also performed to further characterize the nanoparticles. The breast cancer aptamer specific to Mucin-1 (MUC-1) was then conjugated with the functionalized MWCNTs. These MWCNTs successfully targeted breast cancer cells (MDA-MB-231) as examined by cellular uptake studies and exhibited a reduction in cancer-induced inflammation, as evidenced by gene transcription (qPCR) and protein expression (immunoblotting) levels. Immunoblot and confocal-based immunofluorescence assay (IFA) indicated the ability of CNTs to induce photothermal cell death of MDA-MB-231 cells. Upon imaging, cancer cells were effectively visualized due to the MWCNTs’ ability to act as magnetic resonance imaging (MRI) contrast agents. Additionally, MWCNTs demonstrated photothermal capabilities to eliminate bound cancer cells. Collectively, our findings pave the way for developing aptamer-labeled MWCNTs as viable “theranostic alternatives” for breast cancer treatment. Graphical abstract

When repairing facial wounds, it is crucial to possess a thorough understanding of suitable suture materials and their evidence base. The absence of high-quality and comprehensive systematic reviews poses challenges in making informed decisions. In this study, we conducted a review of the existing literature and assessed the quality of the current evidence pertaining to the clinical, aesthetic, and patient-reported outcomes associated with absorbable and nonabsorbable sutures for facial skin closure.

Background:. Perioperative bleeding is a challenge in rhinoplasty and septoplasty. Tranexamic acid (TXA) may help reduce this, but its effectiveness is unclear. This systematic review and meta-analysis aimed to evaluate TXA’s impact on bleeding in these procedures. Methods:. The protocol was registered a priori to PROSPERO (CRD42023393458). PubMed, Embase, Google Scholar, and Web of Science were searched from inception to October 2023. Eligible studies were randomized controlled trials of adult patients undergoing rhinoplasty or septoplasty. Primary outcomes were intraoperative blood loss, surgery duration, and surgeon satisfaction. A random-effects model was used. Methodological quality was assessed using GRADE. The risk of bias was assessed using Cochrane’s RoB 2 tool for randomized studies. Results:. The search yielded 154 results; 11 randomized controlled trials, with 968 patients, were included. The meta-analysis showed a significant reduction in intraoperative blood loss with TXA (MD −39.67; 95% CI: −15.10 to −64.24; P = 0.002) and superior surgeon satisfaction in favor of TXA use (SMD −2.73; 95% CI: −5.33 to −0.12; P = 0.04). Subgroup analyses for intraoperative blood loss, according to administration routes, were also in favor of intravenous TXA (MD −13.02; 95% CI: −1.65 to −24.38; P = 0.02) and oral TXA (MD −44.98; 95% CI: −83.66 to −6.31; P = 0.02); no statistical difference was noted in surgery duration (MD −0.99; 95% CI: 0.63 to −2.81; P = 0.23). All studies were found to be of high quality, with low bias. Conclusions:. The findings support TXA’s efficacy in reducing blood loss during rhinoplasty and septoplasty, with high surgeon satisfaction.

Introduction: This study aimed to investigate the pattern of developmental milestones of children born during the COVID-19 pandemic and the impact of caregivers' physical, psychosocial and economic wellbeing on achievement of developmental milestones in children. Methodology: A cross-sectional study was conducted on children (6 to 10 and