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2. Vegetarian diet as a risk factor for symptomatic gallstone disease

Author

McConnell, T J, Appleby, P N, and Key, T J

Subjects
Vegetarianism -- Health aspects, Gallstones -- Risk factors, Food/cooking/nutrition, Health
Abstract

Background/Objectives: Previous small studies have shown either no difference or a lower risk of symptomatic gallstone disease in vegetarians than in non-vegetarians. This study examined the incidence of symptomatic gallstone disease in a cohort of British vegetarians and non-vegetarians, and investigated the associations between nutrient intake and risk of symptomatic gallstone disease. Subjects/Methods: The data were analysed from 49 652 adults enroled in the European Prospective Investigation into Cancer and Nutrition (EPIC)-Oxford study, one-third of whom were vegetarian. The linked databases of hospital records were used to identify incident cases. Risk by diet group was estimated using Cox proportional hazards models. Further analysis quantified risk by intakes of selected macronutrients. Results: There were 1182 cases of symptomatic gallstone disease during 687 822 person-years of follow-up (mean=13.85 years). There was a large significant association between increasing body mass index (BMI) and risk of developing symptomatic gallstone disease (overall trend P Conclusions: There is a highly significant association of increased BMI with risk of symptomatic gallstone disease. After adjusting for BMI, there is a small but statistically significant positive association between vegetarian diet and symptomatic gallstone disease., Author(s): T J McConnell [sup.1] , P N Appleby [sup.1] , T J Key [sup.1] Author Affiliations: (1) Nuffield Department of Population Health, Cancer Epidemiology Unit, University of Oxford, Oxford, [...]

Published
2017
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3. Physical activity, sex steroid, and growth factor concentrations in pre- and post-menopausal women: a cross-sectional study within the EPIC cohort

Author

Rinaldi, S., Kaaks, R., Friedenreich, C. M., Key, T. J., Travis, R., Biessy, C., Slimani, N., Overvad, K., Østergaard, J. N., Tjønneland, A., Olsen, A., Mesrine, S., Fournier, A., Dossus, L., Lukanova, A., Johnson, T., Boeing, H., Vigl, M., Trichopoulou, A., Benetou, V., Trichopoulos, D., Masala, G., Krogh, V., Tumino, R., Ricceri, F., Panico, S., Bueno-de-Mesquita, H. B., Monninkhof, E. M., May, A. M., Weiderpass, E., Quirós, J. R., Travier, N., Molina-Montes, E., Amiano, P., Huerta, J. M., Ardanaz, E., Sund, M., Johansson, M., Khaw, K. T., Wareham, N., Scalbert, A., Gunter, M. J., Riboli, E., and Romieu, I.

Published
2014

5. Consumption of fatty foods and incident type 2 diabetes in populations from eight European countries

Author

Buijsse, B, Boeing, H, Drogan, D, Schulze, M B, Feskens, E J, Amiano, P, Barricarte, A, Clavel-Chapelon, F, de Lauzon-Guillain, B, Fagherazzi, G, Fonseca-Nunes, A, Franks, P W, Huerta, J M, Jakobsen, M U, Kaaks, R, Key, T J, Khaw, K T, Masala, G, Moskal, A, Nilsson, P M, Overvad, K, Pala, V, Panico, S, Redondo, M L, Ricceri, F, Rolandsson, O, Sánchez, M-J, Sluijs, I, Spijkerman, A M, Tjonneland, A, Tumino, R, van der A, D L, van der Schouw, Y T, Langenberg, C, Sharp, S J, Forouhi, N G, Riboli, E, and Wareham, N J

Published
2015
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7. Fruits and vegetables consumption and the risk of histological subtypes of lung cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC)

Author

Büchner, F. L., Bueno-de-Mesquita, H. B., Linseisen, J., Boshuizen, H. C., Kiemeney, L. A. L. M., Ros, M. M., Overvad, K., Hansen, L., Tjonneland, A., Raaschou-Nielsen, O., Clavel-Chapelon, F., Boutron-Ruault, M.-C., Touillaud, M., Kaaks, R., Rohrmann, S., Boeing, H., Nöthlings, U., Trichopoulou, A., Zylis, D., Dilis, V., Palli, D., Sieri, S., Vineis, P., Tumino, R., Panico, S., Peeters, P. H. M., van Gils, C. H., Lund, E., Gram, I. T., Braaten, T., Martinez, C., Agudo, A., Arriola, L., Ardanaz, E., Navarro, C., Rodríguez, L., Manjer, J., Wirfält, E., Hallmans, G., Rasmuson, T., Key, T. J., Roddam, A. W., Bingham, S., Khaw, K.-T., Slimani, N., Bofetta, P., Byrnes, G., Norat, T., Michaud, D., and Riboli, E.

Published
2010

8. Dietary Folate Intake and Breast Cancer Risk: European Prospective Investigation Into Cancer and Nutrition

Author

de Batlle, J., Ferrari, P., Chajes, V., Park, J. Y., Slimani, N., McKenzie, F., Overvad, K., Roswall, N., Tjønneland, A., Boutron-Ruault, M. C., Clavel-Chapelon, F., Fagherazzi, G., Katzke, V., Kaaks, R., Bergmann, M. M., Trichopoulou, A., Lagiou, P., Trichopoulos, D., Palli, D., Sieri, S., Panico, S., Tumino, R., Vineis, P., Bueno-de-Mesquita, H. B., Peeters, P. H., Hjartåker, A., Engeset, D., Weiderpass, E., Sánchez, S., Travier, N., Sánchez, M. J., Amiano, P., Chirlaque, M. D., Barricarte Gurrea, A., Khaw, K. T., Key, T. J., Bradbury, K. E., Ericson, U., Sonestedt, E., Van Guelpen, B., Schneede, J., Riboli, E., and Romieu, I.

Published
2015
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9. Meat Intake and Bladder Cancer in a Prospective Study: A Role for Heterocyclic Aromatic Amines?

Author

Lumbreras, B., Garte, S., Overvad, K., Tjonneland, A., Clavel-Chapelon, F., Linseisen, J. P., Boeing, H., Trichopoulou, A., Palli, D., Peluso, M., Krogh, V., Tumino, R., Panico, S., Bueno-De-Mesquita, H. B., Peeters, P. H., Lund, E., Martinez, C., Dorronsoro, M., Barricarte, A., Chirlaque, M.-D., Quiros, J. R., Berglund, G., Hallmans, G., Day, N. E., Key, T. J., Saracci, R., Kaaks, R., Malaveille, C., Ferrari, P., Boffetta, P., Norat, T., Riboli, E., Gonzalez, C. A., and Vineis, P.

Published
2008
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11. Dietary vitamin D intake and risk of type 2 diabetes in the European Prospective Investigation into Cancer and Nutrition: the EPIC-InterAct study

Author

Abbas, S, Linseisen, J, Rohrmann, S, Beulens, J W J, Buijsse, B, Amiano, P, Ardanaz, E, Balkau, B, Boeing, H, Clavel-Chapelon, F, Fagherazzi, G, Franks, P W, Gavrila, D, Grioni, S, Kaaks, R, Key, T J, Khaw, K T, Kühn, T, Mattiello, A, Molina-Montes, E, Nilsson, P M, Overvad, K, Quirós, J R, Rolandsson, O, Sacerdote, C, Saieva, C, Slimani, N, Sluijs, I, Spijkerman, A M W, Tjonneland, A, Tumino, R, van der A, D L, Zamora-Ros, R, Sharp, S J, Langenberg, C, Forouhi, N G, Riboli, E, and Wareham, N J

Published
2014
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14. Healthy lifestyle index and risk of gastric adenocarcinoma in the EPIC cohort study

Author

Buckland, G., Travier, N., Huerta, J. M., Bueno-de-Mesquita, H. B(as), Siersema, P. D., Skeie, G., Weiderpass, E., Engeset, D., Ericson, U., Ohlsson, B., Agudo, A., Romieu, I., Ferrari, P., Freisling, H., Colorado-Yohar, S., Li, K., Kaaks, R., Pala, V., Cross, A. J., Riboli, E., Trichopoulou, A., Lagiou, P., Bamia, C., Boutron-Ruault, M. C., Fagherazzi, G., Dartois, L., May, A. M., Peeters, P. H., Panico, S., Johansson, M., Wallner, B., Palli, D., Key, T. J., Khaw, K. T., Ardanaz, E., Overvad, K., Tjnneland, A., Dorronsoro, M., Sánchez, M. J., Quirós, J. R., Naccarati, A., Tumino, R., Boeing, H., and Gonzalez, C. A.

Published
2015
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15. Corrigendum to 'Measures of body fatness and height in early and mid-to-late adulthood and prostate cancer : risk and mortality in The Pooling Project of Prospective Studies of Diet and Cancer'

Author

Genkinger, J M, Wu, K, Wang, M, Albanes, D, Black, A, van den Brandt, P A, Burke, K A, Cook, M B, Gapstur, S M, Giles, G G, Giovannucci, E, Goodman, G G, Goodman, P J, Håkansson, N, Key, T J, Männistö, S, Le Marchand, L, Liao, L M, MacInnis, R J, Neuhouser, M L, Platz, E A, Sawada, N, Schenk, J M, Stevens, V L, Travis, R C, Tsugane, S, Visvanathan, K, Wilkens, L R, Wolk, Alicja, Smith-Warner, S A, Genkinger, J M, Wu, K, Wang, M, Albanes, D, Black, A, van den Brandt, P A, Burke, K A, Cook, M B, Gapstur, S M, Giles, G G, Giovannucci, E, Goodman, G G, Goodman, P J, Håkansson, N, Key, T J, Männistö, S, Le Marchand, L, Liao, L M, MacInnis, R J, Neuhouser, M L, Platz, E A, Sawada, N, Schenk, J M, Stevens, V L, Travis, R C, Tsugane, S, Visvanathan, K, Wilkens, L R, Wolk, Alicja, and Smith-Warner, S A

Abstract

Background: Advanced prostate cancer etiology is poorly understood. Few studies have examined associations ofanthropometric factors (e.g. early adulthood obesity) with advanced prostate cancer risk. Patients and methods: We carried out pooled analyses to examine associations between body fatness, height, andprostate cancer risk. Among 830 772 men, 51 734 incident prostate cancer cases were identified, including 4762advanced (T4/N1/M1 or prostate cancer deaths) cases, 2915 advanced restricted (same as advanced, but excludinglocalized cancers that resulted in death) cases, 9489 high-grade cases, and 3027 prostate cancer deaths. Coxproportional hazards models were used to calculate study-specific hazard ratios (HR) and 95% confidence intervals(CI); results were pooled using random effects models. Results: No statistically significant associations were observed for body mass index (BMI) in early adulthood for advanced,advanced restricted, and high-grade prostate cancer, and prostate cancer mortality. Positive associations were shown forBMI at baseline with advanced prostate cancer (HR ¼ 1.30, 95% CI ¼ 0.95e1.78) and prostate cancer mortality (HR ¼1.52, 95% CI ¼ 1.12e2.07) comparing BMI 35.0 kg/m2 with 21e22.9 kg/m2. When considering early adulthood andbaseline BMI together, a 27% higher prostate cancer mortality risk (95% CI ¼ 9% to 49%) was observed for men withBMI <25.0 kg/m2 in early adulthood and BMI 30.0 kg/m2 at baseline compared with BMI <25.0 kg/m2 in earlyadulthood and BMI <30.0 kg/m2 at baseline. Baseline waist circumference, comparing 110 cm with <90 cm, andwaist-to-hip ratio, comparing 1.00 with <0.90, were associated with significant 14%e16% increases in high-gradeprostate cancer risk and suggestive or significant 20%e39% increases in prostate cancer mortality risk. Height wasassociated with suggestive or significant 33%e56% risks of advanced or advanced restricted prostate cancer andprostate cancer mortality, comparing 1.90 m with <1.65 m, [Annals of Oncology Volume 31, Issue 1, January 2020, Pages 103-114]

Published
2021
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16. Fruit and vegetable intake and type 2 diabetes: EPIC-InterAct prospective study and meta-analysis

Author

Cooper, A J, Forouhi, N G, Ye, Z, Buijsse, B, Arriola, L, Balkau, B, Barricarte, A, Beulens, J W J, Boeing, H, Büchner, F L, Dahm, C C, de Lauzon-Guillain, B, Fagherazzi, G, Franks, P W, Gonzalez, C, Grioni, S, Kaaks, R, Key, T J, Masala, G, Navarro, C, Nilsson, P, Overvad, K, Panico, S, Ramón Quirós, J, Rolandsson, O, Roswall, N, Sacerdote, C, Sánchez, M-J, Slimani, N, Sluijs, I, Spijkerman, A M W, Teucher, B, Tjonneland, A, Tumino, R, Sharp, S J, Langenberg, C, Feskens, E J M, Riboli, E, and Wareham, N J

Published
2012
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17. Dietary fibre intake and ischaemic heart disease mortality: the European Prospective Investigation into Cancer and Nutrition-Heart study

Author

Crowe, F L, Key, T J, Appleby, P N, Overvad, K, Schmidt, E B, Egeberg, R, Tjønneland, A, Kaaks, R, Teucher, B, Boeing, H, Weikert, C, Trichopoulou, A, Ouranos, V, Valanou, E, Masala, G, Sieri, S, Panico, S, Tumino, R, Matullo, G, Bueno-de-Mesquita, H B, Boer, J M A, Beulens, J W J, van der Schouw, Y T, Quirós, J R, Buckland, G, Sánchez, M-J, Dorronsoro, M, Huerta, J M, Moreno-Iribas, C, Hedblad, B, Jansson, J H, Wennberg, P, Khaw, K-T, Wareham, N, Ferrari, P, Illner, A-K, Chuang, S-C, Norat, T, Danesh, J, and Riboli, E

Published
2012
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20. Dietary β-carotene, vitamin C and E intake and breast cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC)

Author

Nagel, G., Linseisen, J., van Gils, C. H., Peeters, P. H., Boutron-Ruault, M. C., Clavel-Chapelon, F., Romieu, I., Tjønneland, A., Olsen, A., Roswall, N., Witt, P. M., Overvad, K., Rohrmann, S., Kaaks, R., Drogan, D., Boeing, H., Trichopoulou, A., Stratigakou, V., Zylis, D., Engeset, D., Lund, E., Skeie, G., Berrino, F., Grioni, S., Mattiello, A., Masala, G., Tumino, R., Zanetti, R., Ros, M. M., Bueno-de-Mesquita, H. B., Ardanaz, E., Sánchez, M. J., Huerta, J. M., Amiano, P., Rodríguez, L., Manjer, J., Wirfält, E., Lenner, P., Hallmans, G., Spencer, E. A., Key, T. J., Bingham, S., Khaw, K. T., Rinaldi, S., Slimani, N., Boffetta, P., Gallo, V., Norat, T., and Riboli, E.

Published
2010
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21. Circulating prolactin and breast cancer risk among pre- and postmenopausal women in the EPIC cohort

Author

Tikk, K., Sookthai, D., Johnson, T., Rinaldi, S., Romieu, I., Tjønneland, A., Olsen, A., Overvad, K., Clavel-Chapelon, F., Baglietto, L., Boeing, H., Trichopoulou, A., Lagiou, P., Trichopoulos, D., Palli, D., Pala, V., Tumino, R., Rosso, S., Panico, S., Agudo, A., Menéndez, V., Sánchez, M.-J., Amiano, P., Huerta Castaño, J. M., Ardanaz, E., Bueno-de-Mesquita, H. B., Monninkhof, E., Onland-Moret, C., Andersson, A., Sund, M., Weiderpass, E., Khaw, K.-T., Key, T. J., Travis, R. C., Gunter, M. J., Riboli, E., Dossus, L., and Kaaks, R.

Published
2014
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22. Adherence to the Mediterranean diet and risk of bladder cancer in the EPIC cohort study

Author

Buckland, G., Ros, M. M., Roswall, N., Bueno-de-Mesquita, H. B., Travier, N., Tjonneland, A., Kiemeney, L. A., Sacerdote, C., Tumino, R., Ljungberg, B., Gram, I. T., Weiderpass, E., Skeie, G., Malm, J., Ehrnström, R., Chang-Claude, J., Mattiello, A., Agnoli, C., Peeters, P. H., Boutron-Ruault, M. C., Fagherazzi, G., Clavel-Chapelon, F., Nilsson, L. M., Amiano, P., Trichopoulou, A., Oikonomou, E., Tsiotas, K., Sánchez, M. J., Overvad, K., Quirós, J. R., Chirlaque, M. D, Barricarte, A., Key, T. J., Allen, N. E., Khaw, K. T., Wareham, N., Riboli, E., Kaaks, R., Boeing, H., Palli, D., Romieu, I., Romaguera, D., and Gonzalez, C. A.

Published
2014
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23. Diet, serum insulin-like growth factor-I and IGF-binding protein-3 in European women

Author

Norat, T, Dossus, L, Rinaldi, S, Overvad, K, Grønbæk, H, Tjønneland, A, Olsen, A, Clavel-Chapelon, F, Boutron-Ruault, M C, Boeing, H, Lahmann, P H, Linseisen, J, Nagel, G, Trichopoulou, A, Trichopoulos, D, Kalapothaki, V, Sieri, S, Palli, D, Panico, S, Tumino, R, Sacerdote, C, Bueno-de-Mesquita, H B, Peeters, P H M, van Gils, C H, Agudo, A, Amiano, P, Ardanoz, E, Martinez, C, Quirós, R, Tormo, M J, Bingham, S, Key, T J, Allen, N E, Ferrari, P, Slimani, N, Riboli, E, and Kaaks, R

Published
2007
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24. Measures of body fatness and height in early and mid-to-late adulthood and prostate cancer : risk and mortality in The Pooling Project of Prospective Studies of Diet and Cancer

Author

Genkinger, J. M., Wu, K., Wang, M., Albanes, D., Black, A., van den Brandt, P. A., Burke, K. A., Cook, M. B., Gapstur, S. M., Giles, G. G., Giovannucci, E., Goodman, G. G., Goodman, P. J., Håkansson, N., Key, T. J., Mannistö, S., Le Marchand, L., Liao, L. M., MacInnis, R. J., Neuhouser, M. L., Platz, E. A., Sawada, N., Schenk, J. M., Stevens, V. L., Travis, R. C., Tsugane, S., Visvanathan, K., Wilkens, L. R., Wolk, Alicja, Smith-Warner, S. A., Genkinger, J. M., Wu, K., Wang, M., Albanes, D., Black, A., van den Brandt, P. A., Burke, K. A., Cook, M. B., Gapstur, S. M., Giles, G. G., Giovannucci, E., Goodman, G. G., Goodman, P. J., Håkansson, N., Key, T. J., Mannistö, S., Le Marchand, L., Liao, L. M., MacInnis, R. J., Neuhouser, M. L., Platz, E. A., Sawada, N., Schenk, J. M., Stevens, V. L., Travis, R. C., Tsugane, S., Visvanathan, K., Wilkens, L. R., Wolk, Alicja, and Smith-Warner, S. A.

Abstract

Background: Advanced prostate cancer etiology is poorly understood. Few studies have examined associations of anthropometric factors (e.g. early adulthood obesity) with advanced prostate cancer risk. Patients and methods: We carried out pooled analyses to examine associations between body fatness, height, and prostate cancer risk. Among 830 772 men, 51 734 incident prostate cancer cases were identified, including 4762 advanced (T4/N1/M1 or prostate cancer deaths) cases, 2915 advanced restricted (same as advanced, but excluding localized cancers that resulted in death) cases, 9489 high-grade cases, and 3027 prostate cancer deaths. Cox proportional hazards models were used to calculate study-specific hazard ratios (HR) and 95% confidence intervals (CI); results were pooled using random effects models. Results: No statistically significant associations were observed for body mass index (BMI) in early adulthood for advanced, advanced restricted, and high-grade prostate cancer, and prostate cancer mortality. Positive associations were shown for BMI at baseline with advanced prostate cancer (HR = 1.30, 95% CI = 0.95-1.78) and prostate cancer mortality (HR = 1.52, 95% CI = 1.12-2.07) comparing BMI >= 35.0 kg/m(2) with 21-22.9 kg/m(2). When considering early adulthood and baseline BMI together, a 27% higher prostate cancer mortality risk (95% CI = 9% to 49%) was observed for men with BMI <25.0 kg/m(2) in early adulthood and BMI >= 30.0 kg/m(2) at baseline compared with BMI <25.0 kg/m(2) in early adulthood and BMI <30.0 kg/m(2) at baseline. Baseline waist circumference, comparing >= 110 cm with <90 cm, and waist-to-hip ratio, comparing >= 1.00 with <0.90, were associated with significant 14%-16% increases in high-grade prostate cancer risk and suggestive or significant 20%-39% increases in prostate cancer mortality risk. Height was associated with suggestive or significant 33%-56% risks of advanced or advanced restricted prostate cancer and prostat, Correction in: Annals of Oncology, Vol. 32, Issue 9, page 1201DOI: 10.1016/j.annonc.2021.07.001

Published
2020
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26. Plasma carotenoids as biomarkers of intake of fruits and vegetables: individual-level correlations in the European Prospective Investigation into Cancer and Nutrition (EPIC)

Author

Al-Delaimy, W K, Ferrari, P, Slimani, N, Pala, V, Johansson, I, Nilsson, S, Mattisson, I, Wirfalt, E, Galasso, R, Palli, D, Vineis, P, Tumino, R, Dorronsoro, M, Pera, G, Ocké, M C, Bueno-de-Mesquita, H B, Overvad, K, Chirlaque, MaD, Trichopoulou, A, Naska, A, Tjønneland, A, Olsen, A, Lund, E, Alsaker, E H R, Barricarte, A, Kesse, E, Boutron-Ruault, M-C, Clavel-Chapelon, F, Key, T J, Spencer, E, Bingham, S, Welch, A A, Sanchez-Perez, M-J, Nagel, G, Linseisen, J, Quirós, J R, Peeters, P H M, van Gils, C H, Boeing, H, van Kappel, A L, Steghens, J-P, and Riboli, E

Published
2005
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27. Consumption of fish and meats and risk of hepatocellular carcinoma: the European Prospective Investigation into Cancer and Nutrition (EPIC)

Author

Fedirko, V., Trichopolou, A., Bamia, C., Duarte-Salles, T., Trepo, E., Aleksandrova, K., Nöthlings, U., Lukanova, A., Lagiou, P., Boffetta, P., Trichopoulos, D., Katzke, V. A., Overvad, K., Tjønneland, A., Hansen, L., Boutron-Ruault, M. C., Fagherazzi, G., Bastide, N., Panico, S., Grioni, S., Vineis, P., Palli, D., Tumino, R., Bueno-de-Mesquita, H. B., Peeters, P. H., Skeie, G., Engeset, D., Parr, C. L., Jakszyn, P., Sánchez, M. J., Barricarte, A., Amiano, P., Chirlaque, M., Quirós, J. R., Sund, M., Werner, M., Sonestedt, E., Ericson, U., Key, T. J., Khaw, K. T., Ferrari, P., Romieu, I., Riboli, E., and Jenab, M.

Published
2013
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28. Adherence to the mediterranean diet and risk of breast cancer in the European prospective investigation into cancer and nutrition cohort study

Author

Buckland, G., Travier, N., Cottet, V., González, C. A., Luján-Barroso, L., Agudo, A., Trichopoulou, A., Lagiou, P., Trichopoulos, D., Peeters, P. H., May, A., Bueno-de-Mesquita, H. B., Bvan Duijnhoven, F. J., Key, T. J., Allen, N., Khaw, K. T., Wareham, N., Romieu, I., McCormack, V., Boutron-Ruault, M., Clavel-Chapelon, F., Panico, S., Agnoli, C., Palli, D., Tumino, R., Vineis, P., Amiano, P., Barricarte, A., Rodríguez, L., Sanchez, M. J., Chirlaque, M. D., Kaaks, R., Teucher, B., Boeing, H., Bergmann, M. M., Overvad, K., Dahm, C. C., Tjnneland, A., Olsen, A., Manjer, J., Wirfält, E., Hallmans, G., Johansson, I., Lund, E., Hjartåker, A., Skeie, G., Vergnaud, A. C., Norat, T., Romaguera, D., and Riboli, E.

Published
2013
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29. Alcohol consumption and risk of type 2 diabetes in European men and women: influence of beverage type and body sizeThe EPIC–InterAct study

Author

Beulens, J. W. J., van der Schouw, Y. T., Bergmann, M. M., Rohrmann, S., Schulze, M. B., Buijsse, B., Grobbee, D. E., Arriola, L., Cauchi, S., Tormo, M.-J., Allen, N. E., van der A, D. L., Balkau, B., Boeing, H., Clavel-Chapelon, F., de Lauzon-Guillan, B., Franks, P., Froguel, P., Gonzales, C., Halkjær, J., Huerta, J. M., Kaaks, R., Key, T. J., Khaw, K. T., Krogh, V., Molina-Montes, E., Nilsson, P., Overvad, K., Palli, D., Panico, S., Quirós, Ramón J., Ronaldsson, O., Romieu, I., Romaguera, D., Sacerdote, C., Sánchez, M.-J., Spijkerman, A. M. W., Teucher, B., Tjonneland, A., Tumino, R., Sharp, S., Forouhi, N. G., Langenberg, C., Feskens, E. J. M., Riboli, E., and Wareham, N. J.

Published
2012
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30. Variety in vegetable and fruit consumption and the risk of gastric and esophageal cancer in the European prospective investigation into cancer and nutrition

Author

Jeurnink, S. M., Büchner, F. L., Bueno-de-Mesquita, H. B., Siersema, P. D., Boshuizen, H. C., Numans, M. E., Dahm, C. C., Overvad, K., Tjnneland, A., Roswall, N., Clavel-Chapelon, F., Boutron-Ruault, M. C., Morois, S., Kaaks, R., Teucher, B., Boeing, H., Buijsse, B., Trichopoulou, A., Benetou, V., Zylis, D., Palli, D., Sieri, S., Vineis, P., Tumino, R., Panico, S., Ocké, M. C., Peeters, P. H.M., Skeie, G., Brustad, M., Lund, E., Sánchez-Cantalejo, E., Navarro, C., Amiano, P., Ardanaz, E., Ramón Quirós, J., Hallmans, G., Johansson, I., Lindkvist, B., Regnér, S., Khaw, K. T., Wareham, N., Key, T. J., Slimani, N., Norat, T., Vergnaud, A. C., Romaguera, D., and Gonzalez, C. A.

Published
2012
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31. Primary brain tumours and specific serum immunoglobulin E: a case–control study nested in the European Prospective Investigation into Cancer and Nutrition cohort

Author

Schlehofer, B., Siegmund, B., Linseisen, J., Schüz, J., Rohrmann, S., Becker, S., Michaud, D., Melin, B., Bueno-de-Mesquita, Bas H., Peeters, P. H. M., Vineis, P., Tjonneland, A., Olsen, A., Overvad, K., Romieu, I., Boeing, H., Aleksandrova, K., Trichopoulou, A., Bamia, C., Lagiou, P., Sacerdote, C., Palli, D., Panico, S., Sieri, S., Tumino, R., Sanchez, M.-J., Rodriguez, L., Dorronsoro, M., Duell, E. J., Chirlaque, M.-D., Barricarte, A., Borgquist, S., Manjer, J., Gallo, V., Allen, N. E., Key, T. J., Riboli, E., Kaaks, R., and Wahrendorf, J.

Published
2011
Full Text
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33. Physical activity is differentially associated with change in body weight and waist circumference: results from the European prospective investigation into cancer and nutrition (EPIC) study in 288,498 men and women: T4:OS1.1

Author

Ekelund, U, Besson, H, Luan, J, May, A M, Sharp, S J, Brage, S, Travier, N, Agudo, A, Slimani, N, Rinaldi, S, Jenab, M, Norat, T, Mouw, T, Rohrmann, S, Kaaks, R, Bergmann, M M, Boeing, H, Clavel-Chapelon, F, Boutron-Ruault, M C, Overvad, K, Jakobsen, M U, Føns Johnsen, N, Halkjaer, J, Gonzalez, C A, Rodriguez, L, Sanchez, M J, Arriola, L, Barricarte, A, Navarro, C, Key, T J, Spencer, E A, Orfanos, P, Naska, A, Trichopoulou, A, Manjer, J, Wirfält, E, Lund, E, Palli, D, Pala, V, Vineis, P, Matiello, A, Tumino, R, Bueno-de-Mesquita, H B, van den Berg, S W, Odysseos, A D, Riboli, E, Wareham, N J, and Peeters, P H

Published
2010

34. Total dietary carbohydrate, sugar, starch and fibre intakes in the European Prospective Investigation into Cancer and Nutrition

Author

Cust, A E, Skilton, M R, van Bakel, MME, Halkjær, J, Olsen, A, Agnoli, C, Psaltopoulou, T, Buurma, E, Sonestedt, E, Chirlaque, M D, Rinaldi, S, Tjønneland, A, Jensen, M K, Clavel-Chapelon, F, Boutron-Ruault, M C, Kaaks, R, Nöthlings, U, Chloptsios, Y, Zylis, D, Mattiello, A, Caini, S, Ocké, M C, van der Schouw, Y T, Skeie, G, Parr, C L, Molina-Montes, E, Manjer, J, Johansson, I, McTaggart, A, Key, T J, Bingham, S, Riboli, E, and Slimani, N

Published
2009

35. A cross-sectional analysis of physical activity and obesity indicators in European participants of the EPIC-PANACEA study

Author

Besson, H, Ekelund, U, Luan, J, May, A M, Sharp, S, Travier, N, Agudo, A, Slimani, N, Rinaldi, S, Jenab, M, Norat, T, Mouw, T, Rohrmann, S, Kaaks, R, Bergmann, M, Boeing, H, Clavel-Chapelon, F, Boutron-Ruault, M C, Overvad, K, Andreasen, E L, Føns Johnsen, N, Halkjaer, J, Gonzalez, C, Rodriguez, L, Sanchez, M J, Arriola, L, Barricarte, A, Navarro, C, Key, T J, Spencer, E A, Orfanos, P, Naska, A, Trichopoulou, A, Manjer, J, Wirfält, E, Lund, E, Palli, D, Agnoli, C, Vineis, P, Panico, S, Tumino, R, Bueno-de-Mesquita, H B, van den Berg, S W, Odysseos, A D, Riboli, E, Wareham, N J, and Peeters, P H

Published
2009

36. Cytokine gene polymorphisms and the risk of adenocarcinoma of the stomach in the European prospective investigation into cancer and nutrition (EPIC-EURGAST)

Author

Crusius, J. B. A., Canzian, F., Capellá, G., Peña, A. S., Pera, G., Sala, N., Agudo, A., Rico, F., Del Giudice, G., Palli, D., Plebani, M., Boeing, H., Bueno-de-Mesquita, H. B., Carneiro, F., Pala, V., Save, V. E., Vineis, P., Tumino, R., Panico, S., Berglund, G., Manjer, J., Stenling, R., Hallmans, G., Martínez, C., Dorronsoro, M., Barricarte, A., Navarro, C., Quirós, J. R., Allen, N., Key, T. J., Binghan, S., Caldas, C., Linseisen, J., Kaaks, R., Overvad, K., Tjønneland, A., Büchner, F. C., Peeters, P. H. M., Numans, M. E., Clavel-Chapelon, F., Trichopoulou, A., Lund, E., Jenab, M., Rinaldi, S., Ferrari, P., Riboli, E., and González, C. A.

Published
2008

37. A multifactorial score for pancreatic ductal adenocarcinoma risk prediction

Author

Gentiluomo, M., Galeotti, A. A., Rizzato, C., Obazee, O., Neoptolemos, J. P., Pasquali, C., Nentwick, M., Cavestro, G. M., Pezzilli, R., Greenhalf, W., Holleczek, B., Shroeder, C., Shottker, B., Ivanauskas, A., Ginocchi, L., Key, T. J., Hegyi, P., Archibugi, L., Darvasi, E., Basso, D., Sperti, C., Bijlisma, M. F., Palmieri, G., Hlavac, V., Talar-Wojnarowska, R., Mohelnikova – Duchonova, B., Hackert, T., Vahist, Y., Strouhal, O., van Laarhoven, C., Tavano, F., Lovecek, M., Dervenis, C., Izbeki, F., Padoan, A., Malencka-Panas, E., Maiello, E., Vanella, G., Capurso, G., Izbicki, J. R., Theodoropulos, G. E., Jamroziak, K., Katzke, V., Kaaks, R., Mambrini, A., Papanikolaou, I. S., Szentesi, A., Kupcinskas, J., Bursi, S., Costello, E., Boggi, U., Milanetto, A. C., Landi, S., Gazouli, M., Vodickova, L., Soucek, P., Gioffreda, D., Gemignani, F., Brenner, H., Strobel, O., Bukler, M. W., Vodicka, P., Paiella, S, Canzian, F., and Campa, D. :.

Published
2019

39. Genetic susceptibility according to three metabolic pathways in cancers of the lung and bladder and in myeloid leukemias in nonsmokers

Author

Vineis, P., Veglia, F., Garte, S., Malaveille, C., Matullo, G., Dunning, A., Peluso, M., Airoldi, L., Overvad, K., Raaschou-Nielsen, O., Clavel-Chapelon, F., Linseisen, J. P., Kaaks, R., Boeing, H., Trichopoulou, A., Palli, D., Crosignani, P., Tumino, R., Panico, S., Bueno-De-Mesquita, H. B., Peeters, P. H., Lund, E., Gonzalez, C. A., Martinez, C., Dorronsoro, M., Barricarte, A., Navarro, C., Quiros, J. R., Berglund, G., Jarvholm, B., Day, N. E., Key, T. J., Saracci, R., Riboli, E., and Autrup, H.

Published
2007

46. Circulating plasma phospholipid fatty acids and risk of pancreatic cancer in a large European cohort

Author

Matejcic, M. Lesueur, F. Biessy, C. Renault, A. L. and Mebirouk, N. Yammine, S. Keski-Rahkonen, P. Li, K. and Hemon, B. Weiderpass, E. Rebours, V. Boutron-Ruault, M. C. and Carbonnel, F. Kaaks, R. Katzke, V. Kuhn, T. Boeing, H. Trichopoulou, A. Palli, D. Agnoli, C. Panico, S. and Tumino, R. Sacerdote, C. Quiros, J. R. Duell, E. J. and Porta, M. Sanchez, M. J. Chirlaque, M. D. Barricarte, A. and Amiano, P. Ye, W. Peeters, P. H. Khaw, K. T. and Perez-Cornago, A. Key, T. J. Bueno-de-Mesquita, H. B. and Riboli, E. Vineis, P. Romieu, I. Gunter, M. J. Chajes, V.

Abstract

There are both limited and conflicting data on the role of dietary fat and specific fatty acids in the development of pancreatic cancer. In this study, we investigated the association between plasma phospholipid fatty acids and pancreatic cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. The fatty acid composition was measured by gas chromatography in plasma samples collected at recruitment from375 incident pancreatic cancer cases and375 matched controls. Associations of specific fatty acids with pancreatic cancer risk were evaluated using multivariable conditional logistic regression models with adjustment for established pancreatic cancer risk factors. Statistically significant inverse associations were found between pancreatic cancer incidence and levels of heptadecanoic acid (ORT3-T1[odds ratio for highest versus lowest tertile] =0.63; 95%CI[confidence interval] = 0.41-0.98; p(trend) = 0.036), n-3 polyunsaturated -linolenic acid (ORT3-T1 = 0.60; 95%CI = 0.39-0.92; p(trend) = 0.02) and docosapentaenoic acid (ORT3-T1 = 0.52; 95%CI = 0.32-0.85; p(trend) = 0.008). Industrial trans-fatty acids were positively associated with pancreatic cancer risk among men (ORT3-T1 = 3.00; 95%CI = 1.13-7.99; p(trend) = 0.029), while conjugated linoleic acids were inversely related to pancreatic cancer among women only (ORT3-T1 = 0.37; 95%CI = 0.17-0.81; p(trend) = 0.008). Among current smokers, the long-chain n-6/n-3 polyunsaturated fatty acids ratio was positively associated with pancreatic cancer risk (ORT3-T1 = 3.40; 95%CI = 1.39-8.34; p(trend) = 0.007). Results were robust to a range of sensitivity analyses. Our findings suggest that higher circulating levels of saturated fatty acids with an odd number of carbon atoms and n-3 polyunsaturated fatty acids may be related to lower risk of pancreatic cancer. The influence of some fatty acids on the development of pancreatic cancer may be sex-specific and modulated by smoking.

Published
2018

48. Biomarkers of folate and vitamin B12 and breast cancer risk: report from the EPIC cohort

Author

Matejcic, M., de Batlle, J., Ricci, C., Biessy, C., Perrier, F., Huybrechts, I., Weiderpass, E., Boutron-Ruault, M. C., Cadeau, C., His, M., Cox, D. G., Boeing, H., Fortner, R. T., Kaaks, R., Lagiou, P., Trichopoulou, A., Benetou, V., Tumino, R., Panico, S., Sieri, S., Palli, D., Ricceri, F., Bueno-de-Mesquita, H. Bas, Skeie, G., Amiano, P., Sánchez, M. J., Chirlaque, M. D., Barricarte, A., Quirós, J. R., Buckland, G., van Gils, C. H., Peeters, P. H., Key, T. J., Riboli, E., Gylling, B., Zeleniuch-Jacquotte, A., Gunter, M. J., Romieu, I., Chajès, V., Matejcic, M, de Batlle, J, Ricci, C, Biessy, C, Perrier, F, Huybrechts, I, Weiderpass, E, Boutron Ruault, M. C, Cadeau, C, His, M, Cox, D. G, Boeing, H, Fortner, R. T, Kaaks, R, Lagiou, P, Trichopoulou, A, Benetou, V, Tumino, R, Panico, Salvatore, Sieri, S, Palli, D, Ricceri, F, Bueno de Mesquita, H. B. A, Skeie, G, Amiano, P, Sánchez, M. J, Chirlaque, M. D, Barricarte, A, Quirós, J. R, Buckland, G, van Gils, C. H, Peeters, P. H, Key, T. J, Riboli, E, Gylling, B, Zeleniuch Jacquotte, A, Gunter, M. J, Romieu, I, Chajès, V., University Medical Center Utrecht, and Imperial College Trust

Subjects
hormone receptor status, Cancer Research, MTHFR polymorphism, Risk Factors, Neoplasms, Progesterone, Medicine(all), alcohol, plasma biomarker, Single Nucleotide, vitamin B12, Middle Aged, Multicenter Study, Europe, Vitamin B 12, Oncology, Female, breast cancer, folate, plasma biomarkers, Adult, Aged, Alcohol Drinking, Biomarkers, Breast Neoplasms, Case-Control Studies, Diet, Estrogens, Folic Acid, Folic Acid Deficiency, Follow-Up Studies, Genes, erbB-2, Humans, Life Style, Methylenetetrahydrofolate Reductase (NADPH2), Neoplasms, Hormone-Dependent, Polymorphism, Single Nucleotide, Vitamin B 12 Deficiency, Journal Article, Oncology & Carcinogenesis, Hormone-Dependent, Polymorphism, erbB-2, hormone receptor statu, VDP::Medical disciplines: 700::Clinical medical disciplines: 750::Oncology: 762, VDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Onkologi: 762, Genes, 1112 Oncology And Carcinogenesis
Abstract

This is the peer reviewed version of the following article: Matejcic, M., De Batlle, J., Ricci, C., Biessy, C., Perrier, F., Huybrechts, I., ... Chajès, V. (2017). Biomarkers of folate and vitamin B12 and breast cancer risk: report from the EPIC cohort. International Journal of Cancer, 140(6), 1246-1259. https://doi.org/10.1002/ijc.30536, which has been published in final form at https://doi.org/10.1002/ijc.30536. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. Epidemiological studies have reported inconsistent findings for the association between B vitamins and breast cancer (BC) risk. We investigated the relationship between biomarkers of folate and vitamin B12 and the risk of BC in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Plasma concentrations of folate and vitamin B12 were determined in 2,491 BC cases individually matched to 2,521 controls among women who provided baseline blood samples. Multivariable logistic regression models were used to estimate odds ratios by quartiles of either plasma B vitamin. Subgroup analyses by menopausal status, hormone receptor status of breast tumors (estrogen receptor [ER], progesterone receptor [PR] and human epidermal growth factor receptor 2 [HER2]), alcohol intake and MTHFR polymorphisms (677C > T and 1298A > C) were also performed. Plasma levels of folate and vitamin B12 were not significantly associated with the overall risk of BC or by hormone receptor status. A marginally positive association was found between vitamin B12 status and BC risk in women consuming above the median level of alcohol (ORQ4‐Q1 = 1.26; 95% CI 1.00–1.58; Ptrend = 0.05). Vitamin B12 status was also positively associated with BC risk in women with plasma folate levels below the median value (ORQ4‐Q1 = 1.29; 95% CI 1.02–1.62; Ptrend = 0.03). Overall, folate and vitamin B12 status was not clearly associated with BC risk in this prospective cohort study. However, potential interactions between vitamin B12 and alcohol or folate on the risk of BC deserve further investigation.

Published
2016

49. Circulating plasma phospholipid fatty acids and risk of pancreatic cancer in a large European cohort

Author

Matejcic, M., Lesueur, F., Biessy, C., Renault, A. L., Mebirouk, N., Yammine, S., Keski-Rahkonen, P., Li, K., Hemon, B., Weiderpass, E., Rebours, V., Boutron-Ruault, M. C., Carbonnel, F., Kaaks, R., Katzke, V., Kuhn, T., Boeing, H., Trichopoulou, A., Palli, D., Agnoli, C., Panico, S., Tumino, R., Sacerdote, C., Quiros, J. R., Duell, E. J., Porta, M., Sanchez, M. J., Chirlaque, M. D., Barricarte, A., Amiano, P., Ye, Weimin, Peeters, P. H., Khaw, K. T., Perez-Cornago, A., Key, T. J., Bueno-de-Mesquita, H. B., Riboli, E., Vineis, P., Romieu, I., Gunter, M. J., Chajes, V., Matejcic, M., Lesueur, F., Biessy, C., Renault, A. L., Mebirouk, N., Yammine, S., Keski-Rahkonen, P., Li, K., Hemon, B., Weiderpass, E., Rebours, V., Boutron-Ruault, M. C., Carbonnel, F., Kaaks, R., Katzke, V., Kuhn, T., Boeing, H., Trichopoulou, A., Palli, D., Agnoli, C., Panico, S., Tumino, R., Sacerdote, C., Quiros, J. R., Duell, E. J., Porta, M., Sanchez, M. J., Chirlaque, M. D., Barricarte, A., Amiano, P., Ye, Weimin, Peeters, P. H., Khaw, K. T., Perez-Cornago, A., Key, T. J., Bueno-de-Mesquita, H. B., Riboli, E., Vineis, P., Romieu, I., Gunter, M. J., and Chajes, V.

Abstract

There are both limited and conflicting data on the role of dietary fat and specific fatty acids in the development of pancreatic cancer. In this study, we investigated the association between plasma phospholipid fatty acids and pancreatic cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. The fatty acid composition was measured by gas chromatography in plasma samples collected at recruitment from375 incident pancreatic cancer cases and375 matched controls. Associations of specific fatty acids with pancreatic cancer risk were evaluated using multivariable conditional logistic regression models with adjustment for established pancreatic cancer risk factors. Statistically significant inverse associations were found between pancreatic cancer incidence and levels of heptadecanoic acid (ORT3‐T1[odds ratio for highest versus lowest tertile] =0.63; 95%CI[confidence interval] = 0.41–0.98; ptrend = 0.036), n‐3 polyunsaturated α‐linolenic acid (ORT3‐T1 = 0.60; 95%CI = 0.39–0.92; ptrend = 0.02) and docosapentaenoic acid (ORT3‐T1 = 0.52; 95%CI = 0.32–0.85; ptrend = 0.008). Industrial trans‐fatty acids were positively associated with pancreatic cancer risk among men (ORT3‐T1 = 3.00; 95%CI = 1.13–7.99; ptrend = 0.029), while conjugated linoleic acids were inversely related to pancreatic cancer among women only (ORT3‐T1 = 0.37; 95%CI = 0.17–0.81; ptrend = 0.008). Among current smokers, the long‐chain n‐6/n‐3 polyunsaturated fatty acids ratio was positively associated with pancreatic cancer risk (ORT3‐T1 = 3.40; 95%CI = 1.39–8.34; ptrend = 0.007). Results were robust to a range of sensitivity analyses. Our findings suggest that higher circulating levels of saturated fatty acids with an odd number of carbon atoms and n‐3 polyunsaturated fatty acids may be related to lower risk of pancreatic cancer. The influence of some fatty acids on the development of pancreatic cancer may be sex‐specific and modulated by smoking.

Published
2018
Full Text
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50. Risk thresholds for alcohol consumption:combined analysis of individual-participant data for 599 912 current drinkers in 83 prospective studies

Author

Wood, A. M. (Angela M.), Kaptoge, S. (Stephen), Butterworth, A. S. (Adam S.), Willeit, P. (Peter), Warnakula, S. (Samantha), Bolton, T. (Thomas), Paige, E. (Ellie), Paul, D. S. (Dirk S.), Sweeting, M. (Michael), Burgess, S. (Stephen), Bell, S. (Steven), Astle, W. (William), Stevens, D. (David), Koulman, A. (Albert), Selmer, R. M. (Randi M.), Verschuren, W. M. (W. M. Monique), Sato, S. (Shinichi), Njolstad, I. (Inger), Woodward, M. (Mark), Salomaa, V. (Veikko), Nordestgaard, B. G. (Borge G.), Yeap, B. B. (Bu B.), Fletcher, A. (Astrid), Melander, O. (Olle), Kuller, L. H. (Lewis H.), Balkau, B. (Beverley), Marmot, M. (Michael), Koenig, W. (Wolfgang), Casiglia, E. (Edoardo), Cooper, C. (Cyrus), Arndt, V. (Volker), Franco, O. H. (Oscar H.), Wennberg, P. (Patrik), Gallacher, J. (John), de la Camara, A. G. (Agustin Gomez), Volzke, H. (Henry), Dahm, C. C. (Christina C.), Dale, C. E. (Caroline E.), Bergmann, M. M. (Manuela M.), Crespo, C. J. (Carlos J.), van der Schouw, Y. T. (Yvonne T.), Kaaks, R. (Rudolf), Simons, L. A. (Leon A.), Lagiou, P. (Pagona), Schoufour, J. D. (Josje D.), Boer, J. M. (Jolanda M. A.), Key, T. J. (Timothy J.), Rodriguez, B. (Beatriz), Moreno-Iribas, C. (Conchi), Davidson, K. W. (Karina W.), Taylor, J. O. (James O.), Sacerdote, C. (Carlotta), Wallace, R. B. (Robert B.), Quiros, J. R. (J. Ramon), Tumino, R. (Rosario), Blazer, D. G. (Dan G., II), Linneberg, A. (Allan), Daimon, M. (Makoto), Panico, S. (Salvatore), Howard, B. (Barbara), Skeie, G. (Guri), Strandberg, T. (Timo), Weiderpass, E. (Elisabete), Nietert, P. J. (Paul J.), Psaty, B. M. (Bruce M.), Kromhout, D. (Daan), Salamanca-Fernandez, E. (Elena), Kiechl, S. (Stefan), Krumholz, H. M. (Harlan M.), Grioni, S. (Sara), Palli, D. (Domenico), Huerta, J. M. (Jose M.), Price, J. (Jackie), Sundstrom, J. (Johan), Arriola, L. (Larraitz), Arima, H. (Hisatomi), Travis, R. C. (Ruth C.), Panagiotakos, D. B. (Demosthenes B.), Karakatsani, A. (Anna), Trichopoulou, A. (Antonia), Kuhn, T. (Tilman), Grobbee, D. E. (Diederick E.), Barrett-Connor, E. (Elizabeth), van Schoor, N. (Natasja), Boeing, H. (Heiner), Overvad, K. (Kim), Kauhanen, J. (Jussi), Wareham, N. (Nick), Langenberg, C. (Claudia), Forouhi, N. (Nita), Wennberg, M. (Maria), Despres, J.-P. (Jean-Pierre), Cushman, M. (Mary), Cooper, J. A. (Jackie A.), Rodriguez, C. J. (Carlos J.), Sakurai, M. (Masaru), Shaw, J. E. (Jonathan E.), Knuiman, M. (Matthew), Voortman, T. (Trudy), Meisinger, C. (Christa), Tjonneland, A. (Anne), Brenner, H. (Hermann), Palmieri, L. (Luigi), Dallongeville, J. (Jean), Brunner, E. J. (Eric J.), Assmann, G. (Gerd), Trevisan, M. (Maurizio), Gillum, R. F. (Richard F.), Ford, I. (Ian), Sattar, N. (Naveed), Lazo, M. (Mariana), Thompson, S. G. (Simon G.), Ferrari, P. (Pietro), Leon, D. A. (David A.), Smith, G. D. (George Davey), Peto, R. (Richard), Jackson, R. (Rod), Banks, E. (Emily), Di Angelantonio, E. (Emanuele), Danesh, J. (John), Wood, A. M. (Angela M.), Kaptoge, S. (Stephen), Butterworth, A. S. (Adam S.), Willeit, P. (Peter), Warnakula, S. (Samantha), Bolton, T. (Thomas), Paige, E. (Ellie), Paul, D. S. (Dirk S.), Sweeting, M. (Michael), Burgess, S. (Stephen), Bell, S. (Steven), Astle, W. (William), Stevens, D. (David), Koulman, A. (Albert), Selmer, R. M. (Randi M.), Verschuren, W. M. (W. M. Monique), Sato, S. (Shinichi), Njolstad, I. (Inger), Woodward, M. (Mark), Salomaa, V. (Veikko), Nordestgaard, B. G. (Borge G.), Yeap, B. B. (Bu B.), Fletcher, A. (Astrid), Melander, O. (Olle), Kuller, L. H. (Lewis H.), Balkau, B. (Beverley), Marmot, M. (Michael), Koenig, W. (Wolfgang), Casiglia, E. (Edoardo), Cooper, C. (Cyrus), Arndt, V. (Volker), Franco, O. H. (Oscar H.), Wennberg, P. (Patrik), Gallacher, J. (John), de la Camara, A. G. (Agustin Gomez), Volzke, H. (Henry), Dahm, C. C. (Christina C.), Dale, C. E. (Caroline E.), Bergmann, M. M. (Manuela M.), Crespo, C. J. (Carlos J.), van der Schouw, Y. T. (Yvonne T.), Kaaks, R. (Rudolf), Simons, L. A. (Leon A.), Lagiou, P. (Pagona), Schoufour, J. D. (Josje D.), Boer, J. M. (Jolanda M. A.), Key, T. J. (Timothy J.), Rodriguez, B. (Beatriz), Moreno-Iribas, C. (Conchi), Davidson, K. W. (Karina W.), Taylor, J. O. (James O.), Sacerdote, C. (Carlotta), Wallace, R. B. (Robert B.), Quiros, J. R. (J. Ramon), Tumino, R. (Rosario), Blazer, D. G. (Dan G., II), Linneberg, A. (Allan), Daimon, M. (Makoto), Panico, S. (Salvatore), Howard, B. (Barbara), Skeie, G. (Guri), Strandberg, T. (Timo), Weiderpass, E. (Elisabete), Nietert, P. J. (Paul J.), Psaty, B. M. (Bruce M.), Kromhout, D. (Daan), Salamanca-Fernandez, E. (Elena), Kiechl, S. (Stefan), Krumholz, H. M. (Harlan M.), Grioni, S. (Sara), Palli, D. (Domenico), Huerta, J. M. (Jose M.), Price, J. (Jackie), Sundstrom, J. (Johan), Arriola, L. (Larraitz), Arima, H. (Hisatomi), Travis, R. C. (Ruth C.), Panagiotakos, D. B. (Demosthenes B.), Karakatsani, A. (Anna), Trichopoulou, A. (Antonia), Kuhn, T. (Tilman), Grobbee, D. E. (Diederick E.), Barrett-Connor, E. (Elizabeth), van Schoor, N. (Natasja), Boeing, H. (Heiner), Overvad, K. (Kim), Kauhanen, J. (Jussi), Wareham, N. (Nick), Langenberg, C. (Claudia), Forouhi, N. (Nita), Wennberg, M. (Maria), Despres, J.-P. (Jean-Pierre), Cushman, M. (Mary), Cooper, J. A. (Jackie A.), Rodriguez, C. J. (Carlos J.), Sakurai, M. (Masaru), Shaw, J. E. (Jonathan E.), Knuiman, M. (Matthew), Voortman, T. (Trudy), Meisinger, C. (Christa), Tjonneland, A. (Anne), Brenner, H. (Hermann), Palmieri, L. (Luigi), Dallongeville, J. (Jean), Brunner, E. J. (Eric J.), Assmann, G. (Gerd), Trevisan, M. (Maurizio), Gillum, R. F. (Richard F.), Ford, I. (Ian), Sattar, N. (Naveed), Lazo, M. (Mariana), Thompson, S. G. (Simon G.), Ferrari, P. (Pietro), Leon, D. A. (David A.), Smith, G. D. (George Davey), Peto, R. (Richard), Jackson, R. (Rod), Banks, E. (Emily), Di Angelantonio, E. (Emanuele), and Danesh, J. (John)

Abstract

Background: Low-risk limits recommended for alcohol consumption vary substantially across different national guidelines. To define thresholds associated with lowest risk for all-cause mortality and cardiovascular disease, we studied individual-participant data from 599 912 current drinkers without previous cardiovascular disease. Methods: We did a combined analysis of individual-participant data from three large-scale data sources in 19 high-income countries (the Emerging Risk Factors Collaboration, EPIC-CVD, and the UK Biobank). We characterised dose–response associations and calculated hazard ratios (HRs) per 100 g per week of alcohol (12·5 units per week) across 83 prospective studies, adjusting at least for study or centre, age, sex, smoking, and diabetes. To be eligible for the analysis, participants had to have information recorded about their alcohol consumption amount and status (ie, non-drinker vs current drinker), plus age, sex, history of diabetes and smoking status, at least 1 year of follow-up after baseline, and no baseline history of cardiovascular disease. The main analyses focused on current drinkers, whose baseline alcohol consumption was categorised into eight predefined groups according to the amount in grams consumed per week. We assessed alcohol consumption in relation to all-cause mortality, total cardiovascular disease, and several cardiovascular disease subtypes. We corrected HRs for estimated long-term variability in alcohol consumption using 152 640 serial alcohol assessments obtained some years apart (median interval 5·6 years [5th–95th percentile 1·04–13·5]) from 71 011 participants from 37 studies. Findings: In the 599 912 current drinkers included in the analysis, we recorded 40 310 deaths and 39 018 incident cardiovascular disease events during 5·4 million person-years of follow-up. For all-cause mortality, we recorded a positive and curvilinear association with the level of alcohol consumption, with the minimum mortality ris

Published
2018

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