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1. Canadian Society of Allergy and Clinical Immunology annual scientific meeting 2016

Author

Mohammad A. Alsayegh, Hanan Alshamali, Mousa Khadada, Amanda Ciccolini, Anne K. Ellis, Diana Quint, William Powley, Laurie Lee, Yahya Fiteih, Shairaz Baksh, Harissios Vliagoftis, Sebastien K. Gerega, Brad Millson, Katia Charland, Stephane Barakat, Xichun Sun, Ricardo Jimenez, Susan Waserman, Mark J. FitzGerald, Jacques Hébert, Josiane Cognet-Sicé, Kevin E. Renahan, Saiful Huq, Rishma Chooniedass, Scott Sawyer, Hans Pasterkamp, Allan Becker, Steven G. Smith, Shiyuan Zhang, Kavisha Jayasundara, Claire Tacon, Alex Simidchiev, Gilbert Nadeau, Necdet Gunsoy, Hana Mullerova, Frank Albers, Young Woong Kim, Casey P. Shannon, Amrit Singh, Helen Neighbour, Mark Larché, Scott J. Tebbutt, Annika Klopp, Lorena Vehling, Allan B. Becker, Padmaja Subbarao, Piushkumar J. Mandhane, Stuart E. Turvey, Malcolm R. Sears, Meghan B. Azad, and the Canadian Healthy Infant Longitudinal Development Study Investigators, Keely Loewen, Barret Monchka, Salaheddin M. Mahmud, Geert ‘t Jong, Cristina Longo, Gillian Bartlett, Francine M. Ducharme, Tibor Schuster, Brenda MacGibbon, Tracie Barnett, Michelle L. North, Jeff Brook, Elizabeth Lee, Vanessa Omana, Jenny Thiele, Lisa M. Steacy, Greg Evans, Miriam Diamond, Gordon L. Sussman, Yann Amistani, Kathy Abiteboul, Mark W. Tenn, ChenXi Yang, Christopher Carlsten, Edward M. Conway, Douglas Mack, Yasmin Othman, Colin M. Barber, Chrystyna Kalicinsky, Andrea E. Burke, Mary Messieh, Parameswaran Nair, Chun T. Che, Lindsay Douglas, Joel Liem, Lucy Duan, Charlotte Miller, Pascale Dupuis, Lori A. Connors, Michael N. Fein, Joseph Shuster, Hani Hadi, Brooke Polk, Nikita Raje, Roxane Labrosse, Philippe Bégin, Louis Paradis, Anne Des Roches, Jonathan Lacombe-Barrios, Sanju Mishra, Gina Lacuesta, Meredith Chiasson, Babar Haroon, Kara Robertson, Thomas Issekutz, Desmond Leddin, Stephen Couban, Lori Connors, Adrienne Roos, Amin Kanani, Edmond S. Chan, Robert Schellenberg, Lana Rosenfield, Anna Cvetkovic, Kevin Woodward, Jaclyn Quirt, Wade T. A. Watson, Edson Castilho, Jennifer A. Sullivan, Beverley Temple, Donna Martin, Victoria E. Cook, Christopher Mills, Elodie Portales-Casamar, Lisa W. Fu, Alexander Ho, Jeffrey Zaltzman, Lucy Chen, Peter Vadas, Sofianne Gabrielli, Ann Clarke, Harley Eisman, Judy Morris, Lawrence Joseph, Sebastien LaVieille, Moshe Ben-Shoshan, François Graham, Charles Barnes, Jay Portnoy, Vincent Stagg, Elinor Simons, Diana Lefebvre, David Dai, Piushkumar Mandhane, Malcolm Sears, Herman Tam, F. Estelle R. Simons, Dhaifallah Alotaibi, Bassel Dawod, Matthew C. Tunis, Jean Marshall, Marylin Desjardins, Marianne Béland, Duncan Lejtenyi, Jean-Phillipe Drolet, Martine Lemire, Christos Tsoukas, Francisco J.D. Noya, Reza Alizadehfar, Christine T. McCusker, Bruce D. Mazer, Danay Maestre-Batlle, Evelyn Gunawan, Christopher F. Rider, Anette K. Bølling, Olga M. Pena, Daniel Suez, Isaac Melamed, Iftikhar Hussain, Mark Stein, Sudhir Gupta, Kenneth Paris, Sandor Fritsch, Christelle Bourgeois, Heinz Leibl, Barbara McCoy, Martin Noel, Leman Yel, Ori Scott, Brenda Reid, Adelle Atkinson, Vy Hong-Diep Kim, Chaim M. Roifman, Eyal Grunebaum, Eiman AlSelahi, Fernando Aleman, Amber Oberle, Mike Trus, Gordon Sussman, Amin S. Kanani, Olivier Chambenoi, Sima Chiva-Razavi, Savannah Grodecki, Nikhil Joshi, Peter Menikefs, David Holt, Teresa Pun, Damian Tworek, Raphael Hanna, Delia Heroux, Elli Rosenberg, Leah Stiemsma, Stuart Turvey, Judah Denburg, Christopher Mill, Timothy Teoh, Preeti Zimmer, Vishal Avinashi, Mihaela Paina, Ahmed A. Darwish Hassan, John Paul Oliveria, Chris Olesovsky, Gail Gauvreau, Linda Pedder, Paul K. Keith, Greg Plunkett, Michelle Bolner, Persia Pourshahnazari, Donald Stark, Kateryna Vostretsova, Andrew Moses, Andrew Wakeman, Alexander Singer, Thomas Gerstner, Elissa Abrams, Sara F. Johnson, and Roberta L. Woodgate

Subjects
Asthma, Food Allergy, Allergic Rhinitis, Chronic Granulomatous Disease, Immunologic diseases. Allergy, RC581-607
Published
2017
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2. Math-free guides for glycerin and allergens at variable subcutaneous injection volumes

Author

Thomas J. Grier, Donna J. Rekkerth, Kevin E. Renahan, and Lorie M. Converse

Subjects
Pulmonary and Respiratory Medicine, medicine.medical_specialty, business.industry, Maintenance dose, Immunology, Effective dose (pharmacology), Surgery, 030207 dermatology & venereal diseases, 03 medical and health sciences, Subcutaneous injection, 0302 clinical medicine, 030228 respiratory system, Background current, medicine, Subcutaneous immunotherapy, Immunology and Allergy, Medical physics, In patient, Dosing, business, Injections subcutaneous
Abstract

Background Current summaries of effective maintenance dose ranges for subcutaneous immunotherapy (SCIT) are based on administration of 0.5-mL volumes. Extract formulations delivering equivalent dose ranges for practices using different injection volumes have not been reported, and calculation of the final glycerin concentrations in these solutions remains an inconvenient and repetitive process. Objective To create math-free guides for allergen doses and glycerin concentrations that identify the extract concentrate volumes required to deliver doses within the ranges cited in the 2011 immunotherapy practice parameters for clinicians using 5.0-mL maintenance vials and injection volumes ranging from 0.2 to 1.0 mL. Methods Algebraic calculations were performed to determine the specific combinations of extract concentrate strengths, volumes of these products in patient vaccines, and injection volumes needed for administration of target allergen doses spanning the current SCIT practice parameter recommendations. Results For each product or group (nonstandardized extracts), tables were constructed to define the allergen doses provided by various combinations of extract concentrate volumes and injection volumes. The values within the effective dose ranges for each product were highlighted to facilitate comparisons of specific conditions relevant to allergy specialists. Glycerin tables were also created to permit convenient assessments of the final concentrations of this stabilizer in patient prescriptions. Conclusion SCIT dosing and glycerin tables are useful tools to assist allergists with practice decisions that involve variable patient formulas and injection volumes and can help identify suitable conditions for treatment of patients presenting with diverse allergen sensitivities and specificity profiles.

Published
2016
Full Text
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3. Canadian Society of Allergy and Clinical Immunology annual scientific meeting 2016

Author

Duncan Lejtenyi, Vincent Stagg, Michael N. Fein, Young Woong Kim, Mark W. Tenn, Peter Vadas, Marylin Desjardins, David Dai, Allan B. Becker, Charlotte Miller, David Holt, Elissa M. Abrams, Jaclyn Quirt, Brenda Reid, Leman Yel, Roxane Labrosse, Daniel Suez, Dhaifallah Alotaibi, Helen Neighbour, Alex Simidchiev, Eiman Al-Selahi, Thomas V. Gerstner, Mary Messieh, Sanju Mishra, Edward M. Conway, Lucy Duan, Xichun Sun, Amin S. Kanani, Chaim M. Roifman, Mark Stein, Delia Heroux, ChenXi Yang, Chrystyna Kalicinsky, Chun T. Che, Barbara McCoy, Louis Paradis, Herman Tam, Martine Lemire, Donna Martin, Philippe Bégin, Linda Pedder, Jeffrey S. Zaltzman, Timothy Teoh, Greg J. Evans, Preeti Zimmer, Lucy Chen, Christopher Mill, Kateryna Vostretsova, Scott J. Tebbutt, Casey P. Shannon, Gillian Bartlett, Nikita Raje, Evelyn Gunawan, Bruce Mazer, Kevin E. Renahan, Stephane Barakat, Charles S. Barnes, Sudhir Gupta, Salaheddin M. Mahmud, Elli Rosenberg, Alexander Ho, Michael Trus, Meghan B. Azad, Harley Eisman, Ricardo Jimenez, Savannah Grodecki, Jean-Phillipe Drolet, Christelle Bourgeois, Lisa W. Fu, Gail M. Gauvreau, Cristina Longo, Shiyuan Zhang, Andrea E. Burke, Frank Albers, Heinz Leibl, Victoria E. Cook, Christopher Carlsten, Elinor Simons, Jenny Thiele, Amber Oberle, Padmaja Subbarao, Matthew C. Tunis, Ahmed A. Darwish Hassan, R. Robert Schellenberg, Alexander Singer, Jennifer A. Sullivan, Paul K. Keith, Isaac Melamed, Meredith D. Chiasson, Andrew Moses, Amin Kanani, Bassel Dawod, Danay Maestre-Batlle, Diana L. Lefebvre, Rishma Chooniedass, Jeffrey R. Brook, Gina Lacuesta, Adelle Atkinson, Lorena Vehling, Sofianne Gabrielli, Tracie A. Barnett, Judy Morris, Iftikhar Hussain, Tibor Schuster, Edson Castilho, Edmond S. Chan, Colin Barber, Mihaela Paina, Brooke I. Polk, Amrit Singh, Keely Loewen, Brenda MacGibbon, Lisa M. Steacy, Michelle L. North, Yasmin Othman, Gordon L. Sussman, Elodie Portales-Casamar, Yahya Fiteih, Joel Liem, Diana Quint, Sandor Fritsch, Yann Amistani, Hanan Alshamali, Kenneth Paris, Francisco J.D. Noya, Vanessa Omana, Jacques Hébert, Harissios Vliagoftis, Vishal Avinashi, Moshe Ben-Shoshan, Olga M. Pena, Lori A. Connors, Annika Klopp, Andrew Wakeman, Desmond Leddin, François Graham, Ori Scott, Lori Connors, Amanda Ciccolini, Hans Pasterkamp, Eyal Grunebaum, Stephen Couban, Sebastien LaVieille, Geert W. ‘t Jong, Claire Tacon, Kavisha Jayasundara, Anne K. Ellis, S.E. Turvey, Beverley Temple, Fernando Aleman, Jean S. Marshall, Malcolm R. Sears, Peter Menikefs, Kevin Woodward, Roberta L. Woodgate, Piushkumar J. Mandhane, Martin Noel, Marianne Beland, Necdet B Gunsoy, John-Paul Oliveria, Saiful Huq, Adrienne Roos, Josiane Cognet-Sicé, Lawrence Joseph, Mark Larché, Anne Des Roches, Katia Charland, Michelle Bolner, Anette Kocbach Bølling, Gordon Sussman, Teresa Pun, Olivier Chambenoi, Nikhil Joshi, Mark FitzGerald, Francine M. Ducharme, M.R. Sears, Vy Hong-Diep Kim, Raphael Hanna, Leah T. Stiemsma, Piushkumar Mandhane, Brad Millson, Donald Stark, Persia Pourshahnazari, Laurie Lee, Mohammad A. Alsayegh, Joseph Shuster, Hani Hadi, Thomas B. Issekutz, Anna Cvetkovic, Barret A. Monchka, Christos M. Tsoukas, Jonathan Lacombe-Barrios, Douglas P. Mack, Elizabeth A. Lee, Susan Waserman, Sebastien K. Gerega, Scott Sawyer, Parameswaran Nair, Shairaz Baksh, Miriam Diamond, Judah A. Denburg, Wade Watson, Ann E. Clarke, Christopher F. Rider, Christopher Mills, Kara Robertson, Jay M. Portnoy, Sima Chiva-Razavi, Lindsay Douglas, Kathy Abiteboul, Damian Tworek, Babar Haroon, F. Estelle R. Simons, Hana Müllerová, Pascale Dupuis, Sara F. Johnson, Gilbert Nadeau, William Powley, Lana Rosenfield, Stuart E. Turvey, Reza Alizadehfar, Greg Plunkett, Steven G. Smith, Chris Olesovsky, Christine McCusker, and Mousa Khadada

Subjects
Allergic Rhinitis, lcsh:Immunologic diseases. Allergy, Allergy, medicine.medical_specialty, Clinical immunology, business.industry, Alternative medicine, General Medicine, 030204 cardiovascular system & hematology, medicine.disease, Meeting Abstracts, Food Allergy, Chronic Granulomatous Disease, Asthma, 03 medical and health sciences, 0302 clinical medicine, 030220 oncology & carcinogenesis, Family medicine, Immunology, Medicine, lcsh:RC581-607, business
Published
2017
Full Text
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4. Math-free guides for glycerin and allergens at variable subcutaneous injection volumes: How's my dosing? Update

Author

Thomas J, Grier, Lorie M, Converse, Donna J, Rekkerth, and Kevin E, Renahan

Subjects
Glycerol, Desensitization, Immunologic, Injections, Subcutaneous, Statistics as Topic, Mathematical Concepts, Allergens
Abstract

Current summaries of effective maintenance dose ranges for subcutaneous immunotherapy (SCIT) are based on administration of 0.5-mL volumes. Extract formulations delivering equivalent dose ranges for practices using different injection volumes have not been reported, and calculation of the final glycerin concentrations in these solutions remains an inconvenient and repetitive process.To create math-free guides for allergen doses and glycerin concentrations that identify the extract concentrate volumes required to deliver doses within the ranges cited in the 2011 immunotherapy practice parameters for clinicians using 5.0-mL maintenance vials and injection volumes ranging from 0.2 to 1.0 mL.Algebraic calculations were performed to determine the specific combinations of extract concentrate strengths, volumes of these products in patient vaccines, and injection volumes needed for administration of target allergen doses spanning the current SCIT practice parameter recommendations.For each product or group (nonstandardized extracts), tables were constructed to define the allergen doses provided by various combinations of extract concentrate volumes and injection volumes. The values within the effective dose ranges for each product were highlighted to facilitate comparisons of specific conditions relevant to allergy specialists. Glycerin tables were also created to permit convenient assessments of the final concentrations of this stabilizer in patient prescriptions.SCIT dosing and glycerin tables are useful tools to assist allergists with practice decisions that involve variable patient formulas and injection volumes and can help identify suitable conditions for treatment of patients presenting with diverse allergen sensitivities and specificity profiles.

Published
2016

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