Search

Your search keyword '"Ketter, Ralf"' showing total 351 results
Start Over Author "Ketter, Ralf"
351 results on '"Ketter, Ralf"'

5. Clear cell meningiomas are defined by a highly distinct DNA methylation profile and mutations in SMARCE1

Author

Sievers, Philipp, Sill, Martin, Blume, Christina, Tauziede-Espariat, Arnault, Schrimpf, Daniel, Stichel, Damian, Reuss, David E, Dogan, Helin, Hartmann, Christian, Mawrin, Christian, Hasselblatt, Martin, Stummer, Walter, Schick, Uta, Hench, Jürgen, Frank, Stephan, Ketter, Ralf, Schweizer, Leonille, Schittenhelm, Jens, Puget, Stéphanie, Brandner, Sebastian, Jaunmuktane, Zane, Küsters, Benno, Abdullaev, Zied, Pekmezci, Melike, Snuderl, Matija, Ratliff, Miriam, Herold-Mende, Christel, Unterberg, Andreas, Aldape, Kenneth, Ellison, David W, Wesseling, Pieter, Reifenberger, Guido, Wick, Wolfgang, Perry, Arie, Varlet, Pascale, Pfister, Stefan M, Jones, David TW, von Deimling, Andreas, and Sahm, Felix

Subjects
Human Genome, Brain Disorders, Pediatric, Cancer, Genetics, Rare Diseases, Brain Cancer, Aetiology, 2.1 Biological and endogenous factors, Brain Neoplasms, Child, Chromosomal Proteins, Non-Histone, Cohort Studies, DNA Methylation, DNA Mutational Analysis, DNA, Neoplasm, DNA-Binding Proteins, Disease Progression, Epigenesis, Genetic, Female, Genome-Wide Association Study, Humans, Immunohistochemistry, Male, Meningioma, Mutation, Neoplasm Recurrence, Local, Treatment Outcome, Young Adult, Brain tumor, Clear cell, SMARCE1, DNA methylation profile, German Consortium “Aggressive Meningiomas”, Clinical Sciences, Neurosciences, Neurology & Neurosurgery
Abstract

Clear cell meningioma represents an uncommon variant of meningioma that typically affects children and young adults. Although an enrichment of loss-of-function mutations in the SMARCE1 gene has been reported for this subtype, comprehensive molecular investigations are lacking. Here we describe a molecularly distinct subset of tumors (n = 31), initially identified through genome-wide DNA methylation screening among a cohort of 3093 meningiomas, of which most were diagnosed histologically as clear cell meningioma. This cohort was further supplemented by an additional 11 histologically diagnosed clear cell meningiomas for analysis (n = 42). Targeted DNA sequencing revealed SMARCE1 mutations in 33/34 analyzed samples, accompanied by a nuclear loss of expression determined via immunohistochemistry and a decreased SMARCE1 transcript expression in the tumor cells. Analysis of time to progression or recurrence of patients within the clear cell meningioma group (n = 14) in comparison to those with meningioma WHO grade 2 (n = 220) revealed a similar outcome and support the assignment of WHO grade 2 to these tumors. Our findings indicate the existence of a highly distinct epigenetic signature of clear cell meningiomas, separate from all other variants of meningiomas, with recurrent mutations in the SMARCE1 gene. This suggests that these tumors may arise from a different precursor cell population than the broad spectrum of the other meningioma subtypes.

Published
2021

7. N2M2/NOA-20: Phase I/IIa umbrella trial of molecularly matched targeted therapies plus radiotherapy in patients with newly diagnosed glioblastoma without MGMT promoter hypermethylation.

Author

Wick, Wolfgang, primary, Lanz, Lisa-Marie, additional, Wick, Antje, additional, Harting, Inga, additional, Dettmer, Susan, additional, Suwala, Abigail k, additional, Ketter, Ralf, additional, Tabatabai, Ghazaleh, additional, Seliger-Behme, Corinna, additional, Glas, Martin, additional, Burger, Michael C, additional, Timmer, Marco, additional, Ringel, Florian A, additional, Mildenberger, Iris, additional, Schulz-Schaeffer, Walter J, additional, Renovanz, Mirjam, additional, Bendszus, Martin, additional, Sahm, Felix, additional, Platten, Michael, additional, and Kessler, Tobias, additional

Published
2024
Full Text
View/download PDF

9. DNA methylation-based classification of central nervous system tumours.

Author

Capper, David, Jones, David TW, Sill, Martin, Hovestadt, Volker, Schrimpf, Daniel, Sturm, Dominik, Koelsche, Christian, Sahm, Felix, Chavez, Lukas, Reuss, David E, Kratz, Annekathrin, Wefers, Annika K, Huang, Kristin, Pajtler, Kristian W, Schweizer, Leonille, Stichel, Damian, Olar, Adriana, Engel, Nils W, Lindenberg, Kerstin, Harter, Patrick N, Braczynski, Anne K, Plate, Karl H, Dohmen, Hildegard, Garvalov, Boyan K, Coras, Roland, Hölsken, Annett, Hewer, Ekkehard, Bewerunge-Hudler, Melanie, Schick, Matthias, Fischer, Roger, Beschorner, Rudi, Schittenhelm, Jens, Staszewski, Ori, Wani, Khalida, Varlet, Pascale, Pages, Melanie, Temming, Petra, Lohmann, Dietmar, Selt, Florian, Witt, Hendrik, Milde, Till, Witt, Olaf, Aronica, Eleonora, Giangaspero, Felice, Rushing, Elisabeth, Scheurlen, Wolfram, Geisenberger, Christoph, Rodriguez, Fausto J, Becker, Albert, Preusser, Matthias, Haberler, Christine, Bjerkvig, Rolf, Cryan, Jane, Farrell, Michael, Deckert, Martina, Hench, Jürgen, Frank, Stephan, Serrano, Jonathan, Kannan, Kasthuri, Tsirigos, Aristotelis, Brück, Wolfgang, Hofer, Silvia, Brehmer, Stefanie, Seiz-Rosenhagen, Marcel, Hänggi, Daniel, Hans, Volkmar, Rozsnoki, Stephanie, Hansford, Jordan R, Kohlhof, Patricia, Kristensen, Bjarne W, Lechner, Matt, Lopes, Beatriz, Mawrin, Christian, Ketter, Ralf, Kulozik, Andreas, Khatib, Ziad, Heppner, Frank, Koch, Arend, Jouvet, Anne, Keohane, Catherine, Mühleisen, Helmut, Mueller, Wolf, Pohl, Ute, Prinz, Marco, Benner, Axel, Zapatka, Marc, Gottardo, Nicholas G, Driever, Pablo Hernáiz, Kramm, Christof M, Müller, Hermann L, Rutkowski, Stefan, von Hoff, Katja, Frühwald, Michael C, Gnekow, Astrid, Fleischhack, Gudrun, Tippelt, Stephan, Calaminus, Gabriele, Monoranu, Camelia-Maria, Perry, Arie, and Jones, Chris

Subjects
Humans, Central Nervous System Neoplasms, Cohort Studies, Reproducibility of Results, DNA Methylation, Adolescent, Adult, Aged, Aged, 80 and over, Middle Aged, Child, Child, Preschool, Infant, Female, Male, Young Adult, Unsupervised Machine Learning, and over, Preschool, General Science & Technology
Abstract

Accurate pathological diagnosis is crucial for optimal management of patients with cancer. For the approximately 100 known tumour types of the central nervous system, standardization of the diagnostic process has been shown to be particularly challenging-with substantial inter-observer variability in the histopathological diagnosis of many tumour types. Here we present a comprehensive approach for the DNA methylation-based classification of central nervous system tumours across all entities and age groups, and demonstrate its application in a routine diagnostic setting. We show that the availability of this method may have a substantial impact on diagnostic precision compared to standard methods, resulting in a change of diagnosis in up to 12% of prospective cases. For broader accessibility, we have designed a free online classifier tool, the use of which does not require any additional onsite data processing. Our results provide a blueprint for the generation of machine-learning-based tumour classifiers across other cancer entities, with the potential to fundamentally transform tumour pathology.

Published
2018

12. CDKN2A/B homozygous deletion is associated with early recurrence in meningiomas

Author

Sievers, Philipp, Hielscher, Thomas, Schrimpf, Daniel, Stichel, Damian, Reuss, David E., Berghoff, Anna S., Neidert, Marian C., Wirsching, Hans-Georg, Mawrin, Christian, Ketter, Ralf, Paulus, Werner, Reifenberger, Guido, Lamszus, Katrin, Westphal, Manfred, Etminan, Nima, Ratliff, Miriam, Herold-Mende, Christel, Pfister, Stefan M., Jones, David T. W., Weller, Michael, Harter, Patrick N., Wick, Wolfgang, Preusser, Matthias, von Deimling, Andreas, and Sahm, Felix

Published
2020
Full Text
View/download PDF

15. The intra-tumoral heterogeneity in glioblastoma — a limitation for prognostic value of epigenetic markers?

Author

Sippl, Christoph, Saenz, Alicia, Teping, Fritz, Trenkpohl, Vanessa, Ketter, Ralf, Kim, Yoo Jin, Oertel, Joachim, and Urbschat, Steffi

Subjects
microRNA, ddc: 610, Medicine and health, Epigenetic, Surgery, Neurology (clinical), Heterogeneity, Glioblastoma, Methylation
Abstract

Objective: Multilevel heterogeneity is known to be characteristic for glioblastoma. With epigenetic tumor features are getting into focus as prognostic markers, it is likely that such heterogeneity is also to be found correspondingly. Whether intra-tumoral heterogeneity in these epigenetic characteristics [for full text, please go to the a.m. URL]

Published
2023

16. Mutational patterns and regulatory networks in epigenetic subgroups of meningioma

Author

Paramasivam, Nagarajan, Hübschmann, Daniel, Toprak, Umut H, Ishaque, Naveed, Neidert, Marian, Schrimpf, Daniel, Stichel, Damian, Reuss, David, Sievers, Philipp, Reinhardt, Annekathrin, Wefers, Annika K., Jones, David T. W., Gu, Zuguang, Werner, Johannes, Uhrig, Sebastian, Wirsching, Hans-Georg, Schick, Matthias, Bewerunge-Hudler, Melanie, Beck, Katja, Brehmer, Stephanie, Urbschat, Steffi, Seiz-Rosenhagen, Marcel, Hänggi, Daniel, Herold-Mende, Christel, Ketter, Ralf, Eils, Roland, Ram, Zvi, Pfister, Stefan M., Wick, Wolfgang, Weller, Michael, Grossmann, Rachel, von Deimling, Andreas, Schlesner, Matthias, and Sahm, Felix

Published
2019
Full Text
View/download PDF

18. Chordoid meningiomas can be sub-stratified into prognostically distinct DNA methylation classes and are enriched for heterozygous deletions of chromosomal arm 2p

Author

Sievers, Philipp, Stichel, Damian, Hielscher, Thomas, Schrimpf, Daniel, Reinhardt, Annekathrin, Wefers, Annika K., Reuss, David, Jones, David T. W., Bewerunge-Hudler, Melanie, Hartmann, Christian, Baumgarten, Peter, Wirsching, Hans-Georg, Winther-Kristensen, Bjarne, Brokinkel, Benjamin, Ketter, Ralf, Idoate Gastearena, Miguel Angel, Lamszus, Katrin, Seiz-Rosenhagen, Marcel, Mawrin, Christian, Harter, Patrick N., Felsberg, Jörg, Hänggi, Daniel, Herold-Mende, Christel, Berghoff, Anna Sophie, Weller, Michael, Pfister, Stefan M., Wick, Wolfgang, Reifenberger, Guido, Preusser, Matthias, von Deimling, Andreas, and Sahm, Felix

Published
2018
Full Text
View/download PDF

19. DNA methylation-based classification and grading system for meningioma: a multicentre, retrospective analysis

Author

Sahm, Felix, Schrimpf, Daniel, Stichel, Damian, Jones, David T W, Hielscher, Thomas, Schefzyk, Sebastian, Okonechnikov, Konstantin, Koelsche, Christian, Reuss, David E, Capper, David, Sturm, Dominik, Wirsching, Hans-Georg, Berghoff, Anna Sophie, Baumgarten, Peter, Kratz, Annekathrin, Huang, Kristin, Wefers, Annika K, Hovestadt, Volker, Sill, Martin, Ellis, Hayley P, Kurian, Kathreena M, Okuducu, Ali Fuat, Jungk, Christine, Drueschler, Katharina, Schick, Matthias, Bewerunge-Hudler, Melanie, Mawrin, Christian, Seiz-Rosenhagen, Marcel, Ketter, Ralf, Simon, Matthias, Westphal, Manfred, Lamszus, Katrin, Becker, Albert, Koch, Arend, Schittenhelm, Jens, Rushing, Elisabeth J, Collins, V Peter, Brehmer, Stefanie, Chavez, Lukas, Platten, Michael, Hänggi, Daniel, Unterberg, Andreas, Paulus, Werner, Wick, Wolfgang, Pfister, Stefan M, Mittelbronn, Michel, Preusser, Matthias, Herold-Mende, Christel, Weller, Michael, and von Deimling, Andreas

Published
2017
Full Text
View/download PDF

21. Supplementary Figure Legends from Cytotoxic T Cells and their Activation Status are Independent Prognostic Markers in Meningiomas

Author

Rapp, Carmen, primary, Dettling, Steffen, primary, Liu, Fang, primary, Ull, Anna Theresa, primary, Warta, Rolf, primary, Jungk, Christine, primary, Roesch, Saskia, primary, Mock, Andreas, primary, Sahm, Felix, primary, Schmidt, Melissa, primary, Jungwirth, Gerhard, primary, Zweckberger, Klaus, primary, Lamszus, Katrin, primary, Gousias, Konstaninos, primary, Kessler, Almuth F., primary, Grabe, Niels, primary, Loehr, Mario, primary, Ketter, Ralf, primary, Urbschat, Steffi, primary, Senft, Christian, primary, Westphal, Manfred, primary, Abdollahi, Amir, primary, Debus, Juergen, primary, von Deimling, Andreas, primary, Unterberg, Andreas, primary, Simon, Matthias, primary, and Herold-Mende, Christel C., primary

Published
2023
Full Text
View/download PDF

22. Supplementary Tables 1-2 from Cytotoxic T Cells and their Activation Status are Independent Prognostic Markers in Meningiomas

Author

Rapp, Carmen, primary, Dettling, Steffen, primary, Liu, Fang, primary, Ull, Anna Theresa, primary, Warta, Rolf, primary, Jungk, Christine, primary, Roesch, Saskia, primary, Mock, Andreas, primary, Sahm, Felix, primary, Schmidt, Melissa, primary, Jungwirth, Gerhard, primary, Zweckberger, Klaus, primary, Lamszus, Katrin, primary, Gousias, Konstaninos, primary, Kessler, Almuth F., primary, Grabe, Niels, primary, Loehr, Mario, primary, Ketter, Ralf, primary, Urbschat, Steffi, primary, Senft, Christian, primary, Westphal, Manfred, primary, Abdollahi, Amir, primary, Debus, Juergen, primary, von Deimling, Andreas, primary, Unterberg, Andreas, primary, Simon, Matthias, primary, and Herold-Mende, Christel C., primary

Published
2023
Full Text
View/download PDF

23. Supplementary Figure 1 from MGMT Promoter Methylation Is a Strong Prognostic Biomarker for Benefit from Dose-Intensified Temozolomide Rechallenge in Progressive Glioblastoma: The DIRECTOR Trial

Author

Weller, Michael, primary, Tabatabai, Ghazaleh, primary, Kästner, Bärbel, primary, Felsberg, Jörg, primary, Steinbach, Joachim P., primary, Wick, Antje, primary, Schnell, Oliver, primary, Hau, Peter, primary, Herrlinger, Ulrich, primary, Sabel, Michael C., primary, Wirsching, Hans-Georg, primary, Ketter, Ralf, primary, Bähr, Oliver, primary, Platten, Michael, primary, Tonn, Jörg C., primary, Schlegel, Uwe, primary, Marosi, Christine, primary, Goldbrunner, Roland, primary, Stupp, Roger, primary, Homicsko, Krisztian, primary, Pichler, Josef, primary, Nikkhah, Guido, primary, Meixensberger, Jürgen, primary, Vajkoczy, Peter, primary, Kollias, Spyros, primary, Hüsing, Johannes, primary, Reifenberger, Guido, primary, and Wick, Wolfgang, primary

Published
2023
Full Text
View/download PDF

24. Supplementary Tables 1-7 from MGMT Promoter Methylation Is a Strong Prognostic Biomarker for Benefit from Dose-Intensified Temozolomide Rechallenge in Progressive Glioblastoma: The DIRECTOR Trial

Author

Weller, Michael, primary, Tabatabai, Ghazaleh, primary, Kästner, Bärbel, primary, Felsberg, Jörg, primary, Steinbach, Joachim P., primary, Wick, Antje, primary, Schnell, Oliver, primary, Hau, Peter, primary, Herrlinger, Ulrich, primary, Sabel, Michael C., primary, Wirsching, Hans-Georg, primary, Ketter, Ralf, primary, Bähr, Oliver, primary, Platten, Michael, primary, Tonn, Jörg C., primary, Schlegel, Uwe, primary, Marosi, Christine, primary, Goldbrunner, Roland, primary, Stupp, Roger, primary, Homicsko, Krisztian, primary, Pichler, Josef, primary, Nikkhah, Guido, primary, Meixensberger, Jürgen, primary, Vajkoczy, Peter, primary, Kollias, Spyros, primary, Hüsing, Johannes, primary, Reifenberger, Guido, primary, and Wick, Wolfgang, primary

Published
2023
Full Text
View/download PDF

25. Supplementary Figures 1-5 from Cytotoxic T Cells and their Activation Status are Independent Prognostic Markers in Meningiomas

Author

Rapp, Carmen, primary, Dettling, Steffen, primary, Liu, Fang, primary, Ull, Anna Theresa, primary, Warta, Rolf, primary, Jungk, Christine, primary, Roesch, Saskia, primary, Mock, Andreas, primary, Sahm, Felix, primary, Schmidt, Melissa, primary, Jungwirth, Gerhard, primary, Zweckberger, Klaus, primary, Lamszus, Katrin, primary, Gousias, Konstaninos, primary, Kessler, Almuth F., primary, Grabe, Niels, primary, Loehr, Mario, primary, Ketter, Ralf, primary, Urbschat, Steffi, primary, Senft, Christian, primary, Westphal, Manfred, primary, Abdollahi, Amir, primary, Debus, Juergen, primary, von Deimling, Andreas, primary, Unterberg, Andreas, primary, Simon, Matthias, primary, and Herold-Mende, Christel C., primary

Published
2023
Full Text
View/download PDF

26. Data from Cytotoxic T Cells and their Activation Status are Independent Prognostic Markers in Meningiomas

Author

Rapp, Carmen, primary, Dettling, Steffen, primary, Liu, Fang, primary, Ull, Anna Theresa, primary, Warta, Rolf, primary, Jungk, Christine, primary, Roesch, Saskia, primary, Mock, Andreas, primary, Sahm, Felix, primary, Schmidt, Melissa, primary, Jungwirth, Gerhard, primary, Zweckberger, Klaus, primary, Lamszus, Katrin, primary, Gousias, Konstaninos, primary, Kessler, Almuth F., primary, Grabe, Niels, primary, Loehr, Mario, primary, Ketter, Ralf, primary, Urbschat, Steffi, primary, Senft, Christian, primary, Westphal, Manfred, primary, Abdollahi, Amir, primary, Debus, Juergen, primary, von Deimling, Andreas, primary, Unterberg, Andreas, primary, Simon, Matthias, primary, and Herold-Mende, Christel C., primary

Published
2023
Full Text
View/download PDF

35. Surviving a Self-inflicted Transorbital Pen Intrusion to the Cerebellum: Case Report.

Author

Breuskin, David, Ketter, Ralf, and Oertel, Joachim

Subjects
*CEREBELLUM, *VISION, *COMPUTED tomography, *INTENSIVE care units, *BRAIN injuries
Abstract

Background Although intracranial traumas by penetrating foreign objects are not absolute rarities, the nature of trauma, the kind of object, and its trajectory make them a one of a kind case every time they occur. Whereas high-velocity traumas mostly result in fatalities, it is the low-velocity traumas that demand an individualized surgical strategy. Methods We present a case report of a 33-year-old patient who was admitted to our department with a self-inflicted transorbital pen injury to the brain. The authors recall the incident and the technique of the pen removal. Results Large surgical exposure of the pen trajectory was considered too traumatic. Therefore, we opted to remove the pen and have an immediate postoperative computed tomography (CT) scan. Due to its fragility, the pen case could only be removed with a screwdriver, inserted into the case. Post-op CT scan showed a small bleeding in the right peduncular region, which was treated conservatively. The patient was transferred back to intensive care unit and woken up the next day. She lost visual function on her right eye, but suffered from no further neurologic deficit. Conclusion Surgical management of removal of intracranial foreign bodies is no routine procedure. Although some would favor a large surgical exposure, we could not think of an approach to do so without maximum surgical efforts. We opted for a minimal surgical procedure with immediate CT scan and achieved an optimal result. We find this case to be worth considering when deciding on a strategy in the future. [ABSTRACT FROM AUTHOR]

Published
2023
Full Text
View/download PDF

36. TERT Promoter Mutations and Risk of Recurrence in Meningioma

Author

Sahm, Felix, Schrimpf, Daniel, Olar, Adriana, Koelsche, Christian, Reuss, David, Bissel, Juliane, Kratz, Annekathrin, Capper, David, Schefzyk, Sebastian, Hielscher, Thomas, Wang, Qianghu, Sulman, Erik P., Adeberg, Sebastian, Koch, Arend, Okuducu, Ali Fuat, Brehmer, Stefanie, Schittenhelm, Jens, Becker, Albert, Brokinkel, Benjamin, Schmidt, Melissa, Ull, Theresa, Gousias, Konstantinos, Kessler, Almuth Friederike, Lamszus, Katrin, Debus, Jürgen, Mawrin, Christian, Kim, Yoo-Jin, Simon, Matthias, Ketter, Ralf, Paulus, Werner, Aldape, Kenneth D., Herold-Mende, Christel, and von Deimling, Andreas

Published
2016
Full Text
View/download PDF

37. Temozolomide chemotherapy alone versus radiotherapy alone for malignant astrocytoma in the elderly: the NOA-08 randomised, phase 3 trial

Author

Wick, Wolfgang, Platten, Michael, Meisner, Christoph, Felsberg, Jörg, Tabatabai, Ghazaleh, Simon, Matthias, Nikkhah, Guido, Papsdorf, Kirsten, Steinbach, Joachim P, Sabel, Michael, Combs, Stephanie E, Vesper, Jan, Braun, Christian, Meixensberger, Jürgen, Ketter, Ralf, Mayer-Steinacker, Regine, Reifenberger, Guido, and Weller, Michael

Published
2012
Full Text
View/download PDF

40. PATH-39. INTEGRATED MOLECULAR-MORPHOLOGICAL MENINGIOMA CLASSIFICATION: A MULTICENTER RETROSPECTIVE ANALYSIS, RETRO- AND PROSPECTIVELY VALIDATED

Author

Maas, Sybren, primary, Stichel, Damian, additional, Hielscher, Thomas, additional, Sievers, Philipp, additional, Berghoff, Anna, additional, Schrimpf, Daniel, additional, Sill, Martin, additional, Euskirchen, Philipp, additional, Reuss, David, additional, Dohmen, Hildegard, additional, Stein, Marco, additional, Baumgarten, Peter, additional, Ricklefs, Franz, additional, Rushing, Elizabeth, additional, Bewerunge-Hudler, Melanie, additional, Ketter, Ralf, additional, Schittenhelm, Jens, additional, Jaunmuktane, Zane, additional, Leu, Severina, additional, Grady, Conor, additional, Serrano, Jonathan, additional, Golfinos, John, additional, Sen, Chandra, additional, Mawrin, Christian, additional, Jungk, Christine, additional, Hänggi, Daniel, additional, Westphal, Manfred, additional, Lamszus, Katrin, additional, Etminan, Nima, additional, Unterberg, Andreas, additional, Harter, Patrick, additional, Wirsching, Hans-Georg, additional, Neidert, Marian Christoph, additional, Ratliff, Miriam, additional, Platten, Michael, additional, Snuderl, Matija, additional, Aldape, Kenneth, additional, Brandner, Sebastian, additional, Hench, Jürgen, additional, Frank, Stephan, additional, Pfister, Stefan, additional, Jones, David, additional, Reifenberger, Guido, additional, Acker, Till, additional, Wick, Wolfgang, additional, Weller, Michael, additional, Preusser, Matthias, additional, von Deimling, Andreas, additional, and Sahm, Felix, additional

Published
2021
Full Text
View/download PDF

41. AKT1E17K mutations cluster with meningothelial and transitional meningiomas and can be detected by SFRP1 immunohistochemistry

Author

Sahm, Felix, Bissel, Juliane, Koelsche, Christian, Schweizer, Leonille, Capper, David, Reuss, David, Böhmer, Katja, Lass, Ulrike, Göck, Tanja, Kalis, Katrin, Meyer, Jochen, Habel, Antje, Brehmer, Stefanie, Mittelbronn, Michel, Jones, David T. W., Schittenhelm, Jens, Urbschat, Steffi, Ketter, Ralf, Heim, Stephanie, Mawrin, Christian, Hainfellner, Johannes A., Berghoff, Anna-Sophie, Preusser, Matthias, Becker, Albert, Herold-Mende, Christel, Unterberg, Andreas, Hartmann, Christian, Kickingereder, Philipp, Collins, V. Peter, Pfister, Stefan M., and von Deimling, Andreas

Published
2013
Full Text
View/download PDF

43. Secretory meningiomas are defined by combined KLF4 K409Q and TRAF7 mutations

Author

Reuss, David E., Piro, Rosario M., Jones, David T. W., Simon, Matthias, Ketter, Ralf, Kool, Marcel, Becker, Albert, Sahm, Felix, Pusch, Stefan, Meyer, Jochen, Hagenlocher, Christian, Schweizer, Leonille, Capper, David, Kickingereder, Phillipp, Mucha, Jana, Koelsche, Christian, Jäger, Natalie, Santarius, Thomas, Tarpey, Patrick S., Stephens, Philip J., Andrew Futreal, P., Wellenreuther, Ruth, Kraus, Jürgen, Lenartz, Doris, Herold-Mende, Christel, Hartmann, Christian, Mawrin, Christian, Giese, Nathalia, Eils, Roland, Collins, V. Peter, König, Rainer, Wiestler, Otmar D., Pfister, Stefan M., and von Deimling, Andreas

Published
2013
Full Text
View/download PDF

50. Ultrasonic Radio-Frequency Spectrum Analysis Differentiates Normal and Edematous Brain Tissue from Meningioma Intraoperatively

Author

Strowitzki, Martin, Brand, Sebastian, Ketter, Ralf, Steudel, Wolf Ingo, and Jenderka, Klaus-Vitold

Subjects
Brain, Meningioma, Health
Abstract

To purchase or authenticate to the full-text of this article, please visit this link: http://dx.doi.org/10.1111/j.1552-6569.2007.00173.x Byline: Martin Strowitzki (1), Sebastian Brand (1), Ralf Ketter (1), Wolf Ingo Steudel (1), Klaus-Vitold Jenderka (1) Keywords: Tissue characterization; ultrasound spectrum analysis; intraoperative ultrasound; attenuation; backscatter; meningioma Abstract: ABSTRACT Intraoperative ultrasound imaging of the brain is used for tumor localization and resection control. The aim of the present study was to prove whether spectral analysis of radio-frequency (rf) signals is able to improve its diagnostic capabilities by adding quantitative acoustical parameters to pure visual analysis. Meningioma was chosen as a first model because of its distinct borders during surgery as well as in ultrasound imaging. Rf signals were captured intraoperatively. Spectral analysis of rf signals was performed off-line in areas of normal brain, edematous tissue, and meningioma within the bandwidth of the transducer. At 5.0 MHz, attenuation allowed significant differentiation for normal brain versus edema (P= .00002), normal brain versus meningioma (P= .000004), and edema versus meningioma (P= .002). The slope of attenuation reached significant levels among the three groups, too. Backscatter analysis consisted of determination of the power spectral density with a significant difference for edema versus meningioma at 5 MHz (P= .02). The same was true for a relative integrated backscatter coefficient (P= .01). Frequency-dependent backscatter coefficients were estimated using a standard phantom with edema showing the highest values followed by parenchyma and meningioma. Spectral analysis of rf signals has the potential of differentiating intracranial tissues as could be shown exemplarily with meningioma in this study. If this is also true for infiltrating tumors, the method might serve as a tool to better define tumor borders, thus improving the extent of resection. Author Affiliation: (1)Department of Neurosurgery, Saarland University Medical School, Homburg-Saar, Germany (MS, RK, WIS); Orthopedic Department, Martin-Luther-University, Halle-Wittenberg, Germany (SB); and Physikalisch-Technische Bundesanstalt PTB, Braunschweig, Germany (K-VJ). Article History: Acceptance: Received February 21, 2007, and in revised form June 19, 2007. Accepted for publication June 30, 2007. Article note: Correspondence: Address correspondence to Martin Strowitzki, MD, Department of Neurosurgery, Saarland University Medical School, Kirrberger Str., 66421 Homburg-Saar, Germany. E-mail: martin.strowitzki@uniklinik-saarland.de

Published
2008

Catalog

Books, media, physical & digital resources
See catalog results