39 results on '"Ketchem, Randal R"'
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2. Framework Mutations of the 10-1074 bnAb Increase Conformational Stability, Manufacturability, and Stability While Preserving Full Neutralization Activity
3. A candidate antibody drug for prevention of malaria
4. AI-based antibody discovery platform identifies novel, diverse and pharmacologically active therapeutic antibodies against multiple SARS-CoV-2 strains
5. Native-State Solubility and Transfer Free Energy as Predictive Tools for Selecting Excipients to Include in Protein Formulation Development Studies
6. Computational Refinement Through Solid State NMR and Energy Constraints of a Membrane Bound Polypeptide
7. Chemical Modifications in Therapeutic Protein Aggregates Generated under Different Stress Conditions
8. In Vivo Crystallization of Human IgG in the Endoplasmic Reticulum of Engineered Chinese Hamster Ovary (CHO) Cells
9. Diverse functions of reactive cysteines facilitate unique biosynthetic processes of aggregate-prone interleukin-31
10. Histidine Residue Mediates Radical-induced Hinge Cleavage of Human IgG1
11. Glutamine-linked and Non-consensus Asparagine-linked Oligosaccharides Present in Human Recombinant Antibodies Define Novel Protein Glycosylation Motifs
12. A Central Nervous System-Restricted Isoform of the Interleukin-1 Receptor Accessory Protein Modulates Neuronal Responses to Interleukin-1
13. Biophysical Characterization of Structural Properties and Folding of Interleukin-1 Receptor Antagonist
14. Designing Feature-Controlled Humanoid Antibody Discovery Libraries Using Generative Adversarial Networks
15. Binding-induced activation of DNA alkylation by duocarmycin SA: insights from the structure of an indole derivative-DNA adduct
16. A role for the MHC class I-like Mill molecules in nutrient metabolism and wound healing
17. A Single Amino Acid Difference between Human and Monkey Interleukin (IL)-1β Dictates Effective Binding to Soluble Type II IL-1 Receptor
18. Biophysical Characterization of a Soluble CD40 Ligand (CD154) Coiled-Coil Trimer: Evidence of a Reversible Acid-Denatured Molten Globule
19. Four New Members Expand the Interleukin-1 Superfamily
20. A diversity of antibody epitopes can induce signaling through the erythropoietin receptor
21. Disulfide connectivity of human immunoglobulin G2 structural isoforms
22. Intermolecular interactions involving an acidic patch on immunoglobulin variable domain and the γ2 constant region mediate crystalline inclusion body formation in the endoplasmic reticulum
23. A rare IL33 loss-of-function mutation reduces blood eosinophil counts and protects from asthma
24. A rare IL33 loss-of-function mutation reduces blood eosinophil counts and protects from asthma
25. Anti-PCSK9 Antibody Pharmacokinetics and Low-Density Lipoprotein-Cholesterol Pharmacodynamics in Nonhuman Primates Are Antigen Affinity–Dependent and Exhibit Limited Sensitivity to Neonatal Fc Receptor–Binding Enhancement
26. ADAM8 as a drug target in pancreatic cancer
27. Remediating agitation-induced antibody aggregation by eradicating exposed hydrophobic motifs
28. Entanglement Model of Antibody Viscosity
29. Small-Angle Neutron Scattering Study of a Monoclonal Antibody Using Free-Energy Constraints
30. Corrections to “Banks DD, Latypov RF, Ketchem RR, Woodard J, Scavezze JL, Siska CC, Razinkov VI. 2012. Native-State Solubility and Transfer Free Energy as Predictive Tools for Selecting Excipients to Include in Protein Formulation Development Studies. J Pharm Sci 101:2720-2732.”
31. A Diversity of Antibody Epitopes Can Induce Signaling through the Erythropoietin Receptor
32. Electrophoretic evidence for the presence of structural isoforms specific for the IgG2 isotype
33. EntanglementModel of Antibody Viscosity.
34. Binding-Induced Activation of DNA Alkylation by Duocarmycin SA: Insights from the Structure of an Indole Derivative−DNA Adduct
35. The three-dimensional structure of Ca2+-bound calcyclin: implications for Ca2+-signal transduction by S100 proteins
36. The three-dimensional structure of Ca 2+-bound calcyclin: implications for Ca 2+-signal transduction by S100 proteins
37. Banks DD, Latypov RF, Ketchem RR, Woodard J, Scavezze JL, Siska CC, Razinkov VI. 2012. Native-State Solubility and Transfer Free Energy as Predictive Tools for Selecting Excipients to Include in Protein Formulation Development Studies. J Pharm Sci 101:2720-2732.
38. Chemical Modifications in Therapeutic Protein Aggregates Generated under Different Stress Conditions.
39. A comprehensive engineering strategy improves potency and manufacturability of a near pan-neutralizing antibody against HIV.
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