2,764 results on '"Kessler, David"'
Search Results
2. A tale of three approaches: dynamical phase transitions for weakly bound Brownian particles
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Defaveri, Lucianno, Barkai, Eli, and Kessler, David A.
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Condensed Matter - Statistical Mechanics - Abstract
We investigate a system of Brownian particles weakly bound by attractive parity-symmetric potentials that grow at large distances as $V(x) \sim |x|^\alpha$, with $0 < \alpha < 1$. The probability density function $P(x,t)$ at long times reaches the Boltzmann-Gibbs equilibrium state, with all moments finite. However, the system's relaxation is not exponential, as is usual for a confining system with a well-defined equilibrium, but instead follows a stretched exponential $e^{- \mathrm{const} \, t^\nu}$ with exponent $\nu=\alpha/(2+\alpha)$. This problem is studied from three perspectives. First, we propose a straightforward and general scaling rate-function solution for $P(x,t)$. This rate-function, which is an important tool from large deviation theory, also displays anomalous time scaling and a dynamical phase transition. Second, through the eigenfunctions of the Fokker-Planck operator, we obtain, using the WKB method, more complete solutions that reproduce the rate function approach. Finally, we show how the alternative path-integral formalism allows us to recover the same results, with the above rate-function being the solution of the classical Hamilton-Jacobi equation describing the most probable path. Properties such as parity, the role of initial conditions, and the dynamical phase transition are thoroughly studied in all three approaches., Comment: 42 pages, 11 figures, 1 table
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- 2024
3. Dominance to egalitarian transition in diverse communities
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Kessler, David A. and Shnerb, Nadav M.
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Quantitative Biology - Populations and Evolution ,Nonlinear Sciences - Adaptation and Self-Organizing Systems - Abstract
Diverse communities of competing species are generally characterized by substantial niche overlap and strongly stochastic dynamics. Abundance fluctuations are proportional to population size, so the dynamics of rare populations is slower. Hence, once a population becomes rare, its abundance gets stuck at low values. Here, we analyze the effect of this phenomenon on community structure. We identify two different phases: a dominance phase, in which a tiny number of species constitute most of the community, and an egalitarian phase, where it takes a finite fraction of all species to constitute most of the community. We demonstrate the validity of the theory using empirical findings for a variety of hyperdiverse communities, and clarify the role of demographic stochasticity in shaping patterns of commonness and rarity.
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- 2024
4. Weaving Objects: Spatial Design and Functionality of 3D-Woven Textiles
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Harvey, Claire, Holtzman, Emily, Ko, Joy, Hagan, Brooks, Wu, Rundong, Marschner, Steve, and Kessler, David
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- 2019
5. Design Considerations for the Integrated Delivery of Cognitive Behavioral Therapy for Depression: User-Centered Design Study
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Stawarz, Katarzyna, Preist, Chris, Tallon, Debbie, Wiles, Nicola, Kessler, David, Turner, Katrina, Shafran, Roz, and Coyle, David
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Psychology ,BF1-990 - Abstract
BackgroundAdherence to computerized cognitive behavioral therapy (cCBT) programs in real-world settings can be poor, and in the absence of therapist support, effects are modest and short term. Moreover, because cCBT systems tend toward limited support and thus low-intensity treatment, they are typically most appropriate for people experiencing mild to moderate mental health difficulties. Blended therapy, that is, combining direct therapist contact with cCBT or psychoeducational materials, has been identified as one possible approach to address these limitations and widen access to individual CBT for depression. Building on the initial success of blended therapy, we explore an integrated approach that seeks to seamlessly combine face-to-face contact, electronic contact, and between-session activities. Integration also considers how the technology can support therapists’ workflow and integrate with broader health care systems. The ultimate aim is to provide a structure within which therapists can deliver high-intensity treatments, while also greatly reducing face-to-face contact. ObjectiveThe research aimed to explore patients’ and therapists’ views on using a system for the delivery of individual treatment for depression that integrates face-to-face therapist contact with access to online resources and with synchronous online therapy sessions that allow collaborative exercises, and to establish design requirements and thus key design considerations for integrated systems that more seamlessly combine different modes of communication. MethodsWe conducted a series of four user-centered design studies. This included four design workshops and seven prototype testing sessions with 18 people who had received CBT for depression in the past, and 11 qualitative interviews and three role-play sessions with 12 CBT therapists experienced in the treatment of depression. Studies took place between July and December 2017 in Bristol, United Kingdom. ResultsWorkshops and prototyping sessions with people who had received CBT identified three important requirements for integrated platforms delivering CBT therapy for depression as follows: (1) features that help to overcome depression-related barriers, (2) features that support engagement, and (3) features that reinforce learning and support the development of new skills. Research with therapists highlighted the importance of the therapist and client working together, the impact of technology on therapists’ workflow and workload, challenges and opportunities related to the use of online resources, and the potential of technology to support patient engagement. We use these findings to inform 12 design considerations for developing integrated therapy systems. ConclusionsTo meet clients’ and therapists’ needs, integrated systems need to help retain the personal connection, support both therapist- and patient-led activities, and provide access to materials and the ability to monitor progress. However, developers of such systems should be mindful of their capacity to disrupt current work practices and increase therapists’ workload. Future research should evaluate the impact of integrated systems on patients and therapists in a real-world context.
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- 2020
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6. Recruiting Adolescents With Chronic Fatigue Syndrome/Myalgic Encephalomyelitis to Internet-Delivered Therapy: Internal Pilot Within a Randomized Controlled Trial
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Anderson, Emma, Parslow, Roxanne, Hollingworth, William, Mills, Nicola, Beasant, Lucy, Gaunt, Daisy, Metcalfe, Chris, Kessler, David, Macleod, John, Pywell, Susan, Pitts, Kieren, Price, Simon, Stallard, Paul, Knoop, Hans, Van de Putte, Elise, Nijhof, Sanne, Bleijenberg, Gijs, and Crawley, Esther
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Computer applications to medicine. Medical informatics ,R858-859.7 ,Public aspects of medicine ,RA1-1270 - Abstract
BackgroundChronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) in adolescents is common and disabling. Teenagers in the United Kingdom are more likely to recover if they access specialist care, but most do not have access to a local specialist CFS/ME service. Delivering treatment remotely via the internet could improve access to treatment. ObjectiveThis study aims to assess (1) the feasibility of recruitment and retention into a trial of internet-delivered specialist treatment for adolescents with CFS/ME and (2) the acceptability of trial processes and 2 web-based treatments (to inform continuation to full trial). MethodsThis study is an internal pilot for the initial 12 months of a full randomized controlled trial (RCT), with integrated qualitative methods (analysis of recruitment consultations and participant and clinician interviews). Recruitment and treatment were delivered remotely from a specialist pediatric CFS/ME treatment service within a hospital in South West United Kingdom. Adolescents (aged 11-17 years) from across the United Kingdom with a diagnosis of CFS/ME and no access to local specialist treatment were referred by their general practitioner to the treatment center. Eligibility assessment and recruitment were conducted via remote methods (telephone and on the web), and participants were randomized (via a computer-automated system) to 1 of 2 web-based treatments. The trial intervention was Fatigue in Teenagers on the InterNET in the National Health Service, a web-based modular CFS/ME-specific cognitive behavioral therapy program (designed to be used by young people and their parents or caregivers) supported by individualized clinical psychologist electronic consultations (regular, scheduled therapeutic message exchanges between participants and therapist within the platform). The comparator was Skype-delivered activity management with a CFS/ME clinician (mainly a physiotherapist or occupational therapist). Both treatments were intended to last for up to 6 months. The primary outcomes were (1) the number of participants recruited (per out-of-area referrals received between November 1, 2016, to October 31, 2017) and the proportion providing 6-month outcome data (web-based self-report questionnaire assessing functioning) and (2) the qualitative outcomes indicating the acceptability of trial processes and treatments. ResultsA total of 89 out of 150 (59.3% of potentially eligible referrals) young people and their parents or caregivers were recruited, with 75 out of 89 (84.2%) providing 6-month outcome data. Overall, web-based treatment was acceptable; however, participants and clinicians described both the advantages and disadvantages of remote methods. No serious adverse events were reported. ConclusionsRecruiting young people (and their parents or caregivers) into an RCT of web-based treatment via remote methods is feasible and acceptable. Delivering specialist treatment at home via the internet is feasible and acceptable, although some families prefer to travel across the United Kingdom for face-to-face treatment. Trial RegistrationISRCTN 18020851; http://www.isrctn.com/ISRCTN18020851 International Registered Report Identifier (IRRID)RR2-10.1186/s13063-018-2500-3
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- 2020
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7. Critical Event Checklists for Simulated In-Hospital Dysrhythmias in Children with Heart Disease
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Spencer, Robert, Sen, Anita I., Kessler, David O., Salabay, Kristina, Compagnone, Tammy, Zhang, Yun, and Choudhury, Tarif A.
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- 2024
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8. Multiple possible patterns can emerge from virus-immune coevolution
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Kessler, David A. and Levine, Herbert
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Quantitative Biology - Populations and Evolution ,Condensed Matter - Statistical Mechanics ,Nonlinear Sciences - Pattern Formation and Solitons - Abstract
The adaptive immune system engages in an arms race with evolving viruses, trying to generate new responses to viral strains that continually move away from the set of variants that have already elicited a functional immune response. In previous work, it has been argued that this dynamical process can lead to a propagating pulse of ever-changing viral population and concomitant immune response. Here, we introduce a new stochastic model of viral-host coevolution and a deterministic approximation thereof with which to study these dynamics. We show that there is indeed a possible pulse solution, but for a large host population size, the pulse becomes unstable to the generation of new infections in its wake, leading to an extended endemic infection pattern. This time-dependent endemic pattern eventually reaches a fluctuating steady-state when the infected population size reaches a large enough fraction of the total number of hosts., Comment: Revised version
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- 2023
9. Contrastive Self-Supervised Learning for Spatio-Temporal Analysis of Lung Ultrasound Videos
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Chen, Li, Rubin, Jonathan, Ouyang, Jiahong, Balaraju, Naveen, Patil, Shubham, Mehanian, Courosh, Kulhare, Sourabh, Millin, Rachel, Gregory, Kenton W, Gregory, Cynthia R, Zhu, Meihua, Kessler, David O, Malia, Laurie, Dessie, Almaz, Rabiner, Joni, Coneybeare, Di, Shopsin, Bo, Hersh, Andrew, Madar, Cristian, Shupp, Jeffrey, Johnson, Laura S, Avila, Jacob, Dwyer, Kristin, Weimersheimer, Peter, Raju, Balasundar, Kruecker, Jochen, and Chen, Alvin
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Electrical Engineering and Systems Science - Image and Video Processing - Abstract
Self-supervised learning (SSL) methods have shown promise for medical imaging applications by learning meaningful visual representations, even when the amount of labeled data is limited. Here, we extend state-of-the-art contrastive learning SSL methods to 2D+time medical ultrasound video data by introducing a modified encoder and augmentation method capable of learning meaningful spatio-temporal representations, without requiring constraints on the input data. We evaluate our method on the challenging clinical task of identifying lung consolidations (an important pathological feature) in ultrasound videos. Using a multi-center dataset of over 27k lung ultrasound videos acquired from over 500 patients, we show that our method can significantly improve performance on downstream localization and classification of lung consolidation. Comparisons against baseline models trained without SSL show that the proposed methods are particularly advantageous when the size of labeled training data is limited (e.g., as little as 5% of the training set)., Comment: ISBI 2023, 2023 IEEE 20th International Symposium on Biomedical Imaging (ISBI)
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- 2023
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10. Sertraline for anxiety in adults with a diagnosis of autism (STRATA): study protocol for a pragmatic, multicentre, double-blind, placebo-controlled randomised controlled trial
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Rai, Dheeraj, Webb, Doug, Lewis, Amanda, Cotton, Leonora, Norris, Jade Eloise, Alexander, Regi, Baldwin, David S., Brugha, Traolach, Cochrane, Madeleine, Del Piccolo, Maria Chiara, Glasson, Emma J., Hatch, Katherine K., Kessler, David, Langdon, Peter E., Leonard, Helen, MacNeill, Stephanie J., Mills, Nicola, Morales, Maximiliano Vazquez, Morgan, Zoe, Mukherjee, Raja, Realpe, Alba X., Russell, Ailsa, Starkstein, Sergio, Taylor, Jodi, Turner, Nicholas, Thorn, Joanna, Welch, Jack, and Wiles, Nicola
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- 2024
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11. Stretched-exponential relaxation in weakly-confined Brownian systems through large deviation theory
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Defaveri, Lucianno, Barkai, Eli, and Kessler, David A.
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Condensed Matter - Statistical Mechanics - Abstract
Stretched-exponential relaxation is a widely observed phenomenon found in ordered ferromagnets as well as glassy systems. One modeling approach connects this behavior to a droplet dynamics described by an effective Langevin equation for the droplet radius with a $r^{2/3}$ potential. Here, we study a Brownian particle under the influence of a general confining, albeit weak, potential field that grows with distance as a sub-linear power law. We find that for this memoryless model, observables display stretched-exponential relaxation. The probability density function of the system is studied using a rate function ansatz. We obtain analytically the stretched-exponential exponent along with an anomalous power-law scaling of length with time. The rate function exhibits a point of nonanalyticity, indicating a dynamical phase transition. In particular, the rate function is double-valued both to the left and right of this point, leading to four different rate functions, depending on the choice of initial conditions and symmetry., Comment: 6 pages (12 with SM), 3 figures
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- 2023
12. Weakly Semi-Supervised Detection in Lung Ultrasound Videos
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Ouyang, Jiahong, Chen, Li, Li, Gary Y., Balaraju, Naveen, Patil, Shubham, Mehanian, Courosh, Kulhare, Sourabh, Millin, Rachel, Gregory, Kenton W., Gregory, Cynthia R., Zhu, Meihua, Kessler, David O., Malia, Laurie, Dessie, Almaz, Rabiner, Joni, Coneybeare, Di, Shopsin, Bo, Hersh, Andrew, Madar, Cristian, Shupp, Jeffrey, Johnson, Laura S., Avila, Jacob, Dwyer, Kristin, Weimersheimer, Peter, Raju, Balasundar, Kruecker, Jochen, and Chen, Alvin
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Electrical Engineering and Systems Science - Image and Video Processing - Abstract
Frame-by-frame annotation of bounding boxes by clinical experts is often required to train fully supervised object detection models on medical video data. We propose a method for improving object detection in medical videos through weak supervision from video-level labels. More concretely, we aggregate individual detection predictions into video-level predictions and extend a teacher-student training strategy to provide additional supervision via a video-level loss. We also introduce improvements to the underlying teacher-student framework, including methods to improve the quality of pseudo-labels based on weak supervision and adaptive schemes to optimize knowledge transfer between the student and teacher networks. We apply this approach to the clinically important task of detecting lung consolidations (seen in respiratory infections such as COVID-19 pneumonia) in medical ultrasound videos. Experiments reveal that our framework improves detection accuracy and robustness compared to baseline semi-supervised models, and improves efficiency in data and annotation usage., Comment: IPMI 2023
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- 2023
13. Extinction time distributions of populations and genotypes
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Kessler, David and Shnerb, Nadav M.
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Quantitative Biology - Populations and Evolution - Abstract
In the long run, the eventual extinction of any biological population is an inevitable outcome. While extensive research has focused on the average time it takes for a population to go extinct under various circumstances, there has been limited exploration of the distributions of extinction times and the likelihood of significant fluctuations. Recently, Hathcock and Strogatz [PRL 128, 218301 (2022)] identified Gumbel statistics as a universal asymptotic distribution for extinction-prone dynamics in a stable environment. In this study, we aim to provide a comprehensive survey of this problem by examining a range of plausible scenarios, including extinction-prone, marginal (neutral), and stable dynamics. We consider the influence of demographic stochasticity, which arises from the inherent randomness of the birth-death process, as well as cases where stochasticity originates from the more pronounced effect of random environmental variations. Our work proposes several generic criteria that can be used for the classification of experimental and empirical systems, thereby enhancing our ability to discern the mechanisms governing extinction dynamics. By employing these criteria, we can improve our understanding of the underlying mechanisms driving extinction processes.
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- 2023
14. Stability and Fluctuations in Complex Ecological Systems
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Forgoston, Eric, Day, Sarah, de Ruiter, Peter C., Doelman, Arjen, Hartemink, Nienke, Hastings, Alan, Hemerik, Lia, Hening, Alexandru, Hofbauer, Josef, Kefi, Sonia, Kessler, David A., Klauschies, Toni, Kuehn, Christian, Li, Xiaoxiao, Moore, John C., Morrien, Elly, Neutel, Anje-Margriet, Pantel, Jelena, Schreiber, Sebastian J., Shaw, Leah B., Shnerb, Nadav, Siero, Eric, Storch, Laura S., Thorne, Michael A. S., van de Leemput, Ingrid, van Velzen, Ellen, and Weinans, Els
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Quantitative Biology - Populations and Evolution - Abstract
From 08-12 August, 2022, 32 individuals participated in a workshop, Stability and Fluctuations in Complex Ecological Systems, at the Lorentz Center, located in Leiden, The Netherlands. An interdisciplinary dialogue between ecologists, mathematicians, and physicists provided a foundation of important problems to consider over the next 5-10 years. This paper outlines eight areas including (1) improving our understanding of the effect of scale, both temporal and spatial, for both deterministic and stochastic problems; (2) clarifying the different terminologies and definitions used in different scientific fields; (3) developing a comprehensive set of data analysis techniques arising from different fields but which can be used together to improve our understanding of existing data sets; (4) having theoreticians/computational scientists collaborate closely with empirical ecologists to determine what new data should be collected; (5) improving our knowledge of how to protect and/or restore ecosystems; (6) incorporating socio-economic effects into models of ecosystems; (7) improving our understanding of the role of deterministic and stochastic fluctuations; (8) studying the current state of biodiversity at the functional level, taxa level and genome level., Comment: 22 pages
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- 2023
15. Non-normalizable quasi-equilibrium states under fractional dynamics
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Defaveri, Lucianno, Santos, Maike A. F. dos, Kessler, David A., Barkai, Eli, and Anteneodo, Celia
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Condensed Matter - Statistical Mechanics - Abstract
We study non-normalizable quasi-equilibrium states (NNQE) arising from anomalous diffusion. Initially, particles in contact with a thermal bath are released from an asymptotically flat potential well, with dynamics that is described by fractional calculus. For temperatures that are sufficiently low compared to the potential depth, the properties of the system remain almost constant in time. We use the fractional-time Fokker-Planck equation (FTFPE) and continuous-time random walk approaches to calculate the ensemble averages of observables. We obtain analytical estimates of the duration of NNQE, depending on the fractional order, from approximate theoretical solutions of the FTFPE. We study and compare two types of observables, the mean square displacement typically used to characterize diffusion, and the thermodynamic energy. We show that the typical time scales for stagnation depend exponentially on the activation energy in units of temperature multiplied by a function of the fractional exponent., Comment: 9 pages, 6 figures
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- 2023
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16. The National Emergency Department Overcrowding Scale and Perceived Staff Workload: Evidence for Construct Validity in a Pediatric Setting
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McKinley, Kenneth W., Bregstein, Joan S., Perotte, Rimma, Fenster, Daniel, Kwok, Maria, Rose, Jake, Nye, Megan, Sonnett, Meridith, and Kessler, David O.
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- 2024
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17. Brownian particles in periodic potentials: coarse-graining versus fine structure
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Defaveri, Lucianno, Barkai, Eli, and Kessler, David A.
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Condensed Matter - Statistical Mechanics - Abstract
We study the motion of an overdamped particle connected to a thermal heat bath in the presence of an external periodic potential in one dimension. When we coarse-grain, i.e., bin the particle positions using bin sizes that are larger than the periodicity of the potential, the packet of spreading particles, all starting from a common origin, converges to a normal distribution centered at the origin with a mean-squared displacement that grows as $2 D^* t$, with an effective diffusion constant that is smaller than that of a freely diffusing particle. We examine the interplay between this coarse-grained description and the fine structure of the density, which is given by the Boltzmann-Gibbs (BG) factor $e^{-V(x)/k_B T}$, the latter being non-normalizable. We explain this result and construct a theory of observables using the Fokker-Planck equation. These observables are classified as those that are related to the BG fine structure, like the energy or occupation times, while others, like the positional moments, for long times, converge to those of the large-scale description. Entropy falls into a special category as it has a coarse-grained and a fine structure description. The basic thermodynamic formula $F=TS - E$ is extended to this far-from-equilibrium system. The ergodic properties are also studied using tools from infinite ergodic theory., Comment: 17 pages, 8 figures
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- 2022
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18. Structural Competency in Simulation-Based Health Professions Education: A Call to Action and Pragmatic Guide
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Sagalowsky, Selin T., Woodward, Hilary, Agnant, Joanne, Bailey, Bart, Duncan, Ellen, Grad, Jennifer, and Kessler, David O.
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- 2024
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19. Numerical sensitivity analysis of HTPB counterflow combustion using neural networks
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Bojko, Brian T., Geipel, Clayton M., Fisher, Brian T., and Kessler, David A.
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- 2025
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20. Beta-blockers for the treatment of anxiety disorders: A systematic review and meta-analysis
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Archer, Charlotte, Wiles, Nicola, Kessler, David, Turner, Katrina, and Caldwell, Deborah M.
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- 2025
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21. Designing exceptional-point-based graphs yielding topologically guaranteed quantum search
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Liu, Quancheng, Kessler, David A., and Barkai, Eli
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Quantum Physics ,Condensed Matter - Statistical Mechanics - Abstract
Quantum walks underlie an important class of quantum computing algorithms, and represent promising approaches in various simulations and practical applications. Here we design stroboscopically monitored quantum walks and their subsequent graphs that can naturally boost target searches. We show how to construct walks with the property that all the eigenvalues of the non-Hermitian survival operator, describing the mixed effects of unitary dynamics and the back-action of measurement, coalesce to zero, corresponding to an exceptional point whose degree is the size of the system. Generally, the resulting search is guaranteed to succeed in a bounded time for any initial condition, which is faster than classical random walks or quantum walks on typical graphs. We then show how this efficient quantum search is related to a quantized topological winding number and further discuss the connection of the problem to an effective massless Dirac particle.
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- 2022
22. Diaphragmatic Ultrasound in Children With Asthma Exacerbations
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Chiang, Elaine, Kessler, David O., Liebman, Melissa, and Rabiner, Joni E.
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- 2024
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23. Discrete Sampling of Extreme Events Modifies Their Statistics
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Zarfaty, Lior, Barkai, Eli, and Kessler, David A.
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Condensed Matter - Statistical Mechanics ,Physics - Data Analysis, Statistics and Probability - Abstract
Extreme value (EV) statistics of correlated systems are widely investigated in many fields, spanning the spectrum from weather forecasting to earthquake prediction. Does the unavoidable discrete sampling of a continuous correlated stochastic process change its EV distribution? We explore this question for correlated random variables modeled via Langevin dynamics for a particle in a potential field. For potentials growing at infinity faster than linearly and for long measurement times, we find that the EV distribution of the discretely sampled process diverges from that of the full continuous dataset and converges to that of independent and identically distributed random variables drawn from the process's equilibrium measure. However, for processes with sublinear potentials, the long-time limit is the EV statistics of the continuously sampled data. We treat processes whose equilibrium measures belong to the three EV attractors: Gumbel, Fr\'echet, and Weibull. Our work shows that the EV statistics can be extremely sensitive to the sampling rate of the data., Comment: Main text: 7 pages, 7 figures. Supplemental Material: 11 pages. This work is a short version of a still-in-preparation study (arXiv:2108.06778)
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- 2021
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24. Discrete sampling of correlated random variables modifies the long-time behavior of their extreme value statistics
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Zarfaty, Lior, Barkai, Eli, and Kessler, David A.
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Condensed Matter - Statistical Mechanics ,Mathematical Physics ,Physics - Data Analysis, Statistics and Probability - Abstract
We consider the extreme value statistics of correlated random variables that arise from a Langevin equation. Recently, it was shown that the extreme values of the Ornstein-Uhlenbeck process follow a different distribution than those originating from its equilibrium measure, composed of independent and identically distributed Gaussian random variables. Here, we first focus on the discretely sampled Ornstein-Uhlenbeck process, which interpolates between these two limits. We show that in the limit of large times, its extreme values converge to those of the equilibrium distribution, instead of those of the continuously sampled process. This finding folds for any positive sampling interval, with an abrupt transition at zero. We then analyze the Langevin equation for any force that gives rise to a stable equilibrium distribution. For forces which asymptotically grow with the distance from the equilibrium point, the above conclusion continues to hold, and the extreme values for large times correspond to those of independent variables drawn from the equilibrium distribution. However, for forces which asymptotically decay to zero with the distance, the discretely sampled extreme value statistics at large times approach those of the continuously sampled process., Comment: 21 pages, 10 figures
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- 2021
25. Anomalous statistics of laser-cooled atoms in dissipative optical lattices
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Afek, Gadi, Davidson, Nir, Kessler, David A., and Barkai, Eli
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Condensed Matter - Statistical Mechanics ,Physics - Atomic Physics ,Quantum Physics - Abstract
Diffusion occurs in numerous physical systems throughout nature, drawing its generality from the universality of the central limit theorem. Around a century ago it was realized that an extension to this type of dynamics can be obtained in the form of ``anomalous" diffusion where distributions are allowed to have heavy, power-law tails. Due to a unique feature of its momentum-dependant dissipative friction force, laser-cooled atomic ensembles can be used as a test bed for such dynamics. The interplay between laser cooling and anomalous dynamics bears deep, predictive implications for fundamental concepts in both equilibrium and non-equilibrium statistical physics. The high degree of control available in cold-atom experiments allows for tuning of the parameters of the friction force, revealing transitions in the dynamical properties of the system. Rare events, in both the momentum and spatial distributions, are described by non-normalized states using tools adapted from infinite ergodic theory. This leads to new experimental and theoretical results, illuminating the various features of the system.
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- 2021
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26. A smartwatch-based CPR feedback device improves chest compression quality among health care professionals and lay rescuers
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LaPrad, Adam S., Joseph, Bridgid, Chokshi, Sara, Aldrich, Kelly, Kessler, David, and Oppenheimer, Beno W.
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- 2024
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27. Driving quantum systems with repeated conditional measurements
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Liu, Quancheng, Ziegler, Klaus, Kessler, David A., and Barkai, Eli
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Quantum Physics ,Condensed Matter - Statistical Mechanics - Abstract
We investigate the effect of conditional null measurements on a quantum system and find a rich variety of behaviors. Specifically, quantum dynamics with a time independent $H$ in a finite dimensional Hilbert space are considered with repeated strong null measurements of a specified state. We discuss four generic behaviors that emerge in these monitored systems. The first arises in systems without symmetry, along with their associated degeneracies in the energy spectrum, and hence in the absence of dark states as well. In this case, a unique final state can be found which is determined by the largest eigenvalue of the survival operator, the non-unitary operator encoding both the unitary evolution between measurements and the measurement itself. For a three-level system, this is similar to the well known shelving effect. Secondly, for systems with built-in symmetry and correspondingly a degenerate energy spectrum, the null measurements dynamically select the degenerate energy levels, while the non-degenerate levels are effectively wiped out. Thirdly, in the absence of dark states, and for specific choices of parameters, two or more eigenvalues of the survival operator match in magnitude, and this leads to an oscillatory behavior controlled by the measurement rate and not solely by the energy levels. Finally, when the control parameters are tuned, such that the eigenvalues of the survival operator all coalesce to zero, one has exceptional points that corresponds to situations that violate the null measurement condition, making the conditional measurement process impossible.
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- 2021
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28. Uncertainty relation between detection probability and energy fluctuations
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Thiel, Felix, Mualem, Itay, Kessler, David, and Barkai, Eli
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Quantum Physics ,Condensed Matter - Statistical Mechanics - Abstract
A classical random walker starting on a node of a finite graph will always reach any other node since the search is ergodic, namely it is fully exploring space, hence the arrival probability is unity. For quantum walks, destructive interference may induce effectively non-ergodic features in such search processes. Under repeated projective local measurements, made on a target state, the final detection of the system is not guaranteed since the Hilbert space is split into a bright subspace and an orthogonal dark one. Using this we find an uncertainty relation for the deviations of the detection probability from its classical counterpart, in terms of the energy fluctuations., Comment: 12 pages, special issue Axiomatic Approaches to Quantum Mechanics, 4 figures
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- 2021
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29. I Ran Operation Warp Speed. I’m Concerned About Bird Flu
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Kessler, David A.
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Avian influenza -- Personal narratives - Abstract
As Donald Trump gets ready to return to the White House on Jan. 20, he must be prepared to tackle one issue immediately: the possibility that the spreading avian flu [...]
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- 2024
30. Non-normalizable quasi-equilibrium solution of the Fokker-Planck equation for nonconfining fields
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Anteneodo, Celia, Defaveri, Lucianno, Barkai, Eli, and Kessler, David A.
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Condensed Matter - Statistical Mechanics - Abstract
We investigate the overdamped Langevin motion for particles in a potential well that is asymptotically flat. When the potential well is deep compared to temperature, physical observables like the mean square displacement are essentially time-independent over a long time interval, the stagnation epoch. However the standard Boltzmann-Gibbs (BG) distribution is non-normalizable, given that the usual partition function is divergent. For this regime, we have previously shown that a regularization of BG statistics allows the prediction of the values of dynamical and thermodynamical observables in the non-normalizable quasi-equilibrium state. In this work, based on the eigenfunction expansion of the time-dependent solution of the associated Fokker-Planck equation with free boundary conditions, we obtain an approximate time-independent solution of the BG form, valid for times which are long, but still short compared to the exponentially large escape time. The escaped particles follow a general free-particle statistics, where the solution is a an error function, shifted due to the initial struggle to overcome the potential well. With the eigenfunction solution of the Fokker-Planck equation in hand, we show the validity of the regularized BG statistics and how it perfectly describes the time-independent regime though the quasi-stationary state is non-normalizable., Comment: 22 pages, 8 figures
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- 2021
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31. Soil water storage capacity and soil nutrients drive tree ring growth of six European tree species across a steep environmental gradient
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Gadermaier, Josef, Vospernik, Sonja, Grabner, Michael, Wächter, Elisabeth, Keßler, David, Kessler, Michael, Lehner, Fabian, Klebinder, Klaus, and Katzensteiner, Klaus
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- 2024
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32. The first detection time of a quantum state under random probing
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Kessler, David A., Barkai, Eli, and Ziegler, Klaus
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Quantum Physics ,Condensed Matter - Statistical Mechanics - Abstract
We solve for the statistics of the first detection of a quantum system in a particular desired state, when the system is subject to a projective measurement at independent identically distributed random time intervals. We present formulas for the probability of detection in the $n$th attempt. We calculate as well the mean and mean square both of the number of the first successful detection attempt and the time till first detection. We present explicit results for a particle initially localized at a site on a ring of size $L$, probed at some arbitrary given site, in the case when the detection intervals are distributed exponentially. We prove that, for all interval distributions and finite-dimensional Hamiltonians, the mean detection time is equal to the mean attempt number times the mean time interval between attempts. We further prove that for the return problem when the initial and target state are identical, the total detection probability is unity and the mean attempts till detection is an integer, which is the size of the Hilbert space (symmetrized about the target state). We study an interpolation between the fixed time interval case to an exponential distribution of time intervals via the Gamma distribution with constant mean and varying width. The mean arrival time as a function of the mean interval changes qualitatively as we tune the inter-arrival time distribution from very narrow (delta peaked) to exponential, as resonances are wiped out by the randomness of the sampling.
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- 2020
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33. Saffman-Taylor Fingers at Intermediate Noise
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Shafir, Dan and Kessler, David A.
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Condensed Matter - Soft Condensed Matter ,Nonlinear Sciences - Pattern Formation and Solitons - Abstract
We study Saffman-Taylor flow in the presence of intermediate noise numerically by using both a boundary-integral approach as well as the Kadanoff-Liang modified Diffusion-Limited Aggregation model that incorporates surface tension and reduced noise. For little to no noise, both models result reproduce the well-known Saffman-Taylor finger. We compare both models in the region of intermediate noise where we get occasional tip-splitting events, focusing on the ensemble-average. We show that as the noise in the system is increased, the mean behavior in both models approaches the $\cos^2(\pi y/W)$ transverse density profile far behind the leading front. We also investigate how the noise scales and affects both models.
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- 2020
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34. Accurately approximating extreme value statistics
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Zarfaty, Lior, Barkai, Eli, and Kessler, David A.
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Condensed Matter - Statistical Mechanics ,Mathematical Physics ,Physics - Data Analysis, Statistics and Probability - Abstract
We consider the extreme value statistics of $N$ independent and identically distributed random variables, which is a classic problem in probability theory. When $N\to\infty$, fluctuations around the maximum of the variables are described by the Fisher-Tippett-Gnedenko theorem, which states that the distribution of maxima converges to one out of three limiting forms. Among these is the Gumbel distribution, for which the convergence rate with $N$ is of a logarithmic nature. Here, we present a theory that allows one to use the Gumbel limit to accurately approximate the exact extreme value distribution. We do so by representing the scale and width parameters as power series, and by a transformation of the underlying distribution. We consider functional corrections to the Gumbel limit as well, showing they are obtainable via Taylor expansion. Our method also improves the description of large deviations from the mean extreme value. Additionally, it helps to characterize the extreme value statistics when the underlying distribution is unknown, for example when fitting experimental data., Comment: 17 pages, 10 figures
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- 2020
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35. Non-Hermitian and Zeno limit of quantum systems under rapid measurements
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Thiel, Felix and Kessler, David A.
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Quantum Physics ,Condensed Matter - Statistical Mechanics - Abstract
We investigate in depth the relation between the first detection time of an isolated quantum system that is repeatedly perturbed by strong local measurements with a large fixed frequency $1/\tau$, determining whether it is in some given state $| \psi_\text{d} \rangle$, and the time of absorption to the same state of the same system with the added imaginary potential $2i\hbar | \psi_\text{d} \rangle \langle \psi_\text{d} | / \tau$. As opposed to previous works, we compare directly the solutions of both problems in the small $\tau$, i.e., Zeno, limit. We find a scaling collapse in $F(t)$ with respect to $\tau$ and compute the total detection probability as well as the moments of the first detection time probability density $F(t)$ in the Zeno limit. We show that both solutions approach the same result in this small $\tau$ limit, as long as the initial state $| \psi_\text{in} \rangle$ is not parallel to the detection state, i.e. as long as $| \langle \psi_\text{d} | \psi_\text{in} \rangle | < 1$. However, when this condition is violated, the small probability density to detect the state on time scales much larger than $\tau$ is precisely a factor of four different for all such times. We express the solution of the Zeno limit of both problems formally in terms of an electrostatic analogy. Our results are corroborated with numerical simulations., Comment: 22 pages, 8 Figures
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- 2020
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36. Regularized Boltzmann-Gibbs statistics for a Brownian particle in a non-confining field
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Defaveri, Lucianno, Anteneodo, Celia, Kessler, David A., and Barkai, Eli
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Condensed Matter - Statistical Mechanics - Abstract
We consider an overdamped Brownian particle subject to an asymptotically flat potential with a trap of depth $U_0$ around the origin. When the temperature is small compared to the trap depth ($\xi=k_B T/U_0 \ll 1$), there exists a range of timescales over which physical observables remain practically constant. This range can be very long, of the order of the Arrhenius factor ${\rm e}^{1/\xi}$. For these quasi-equilibrium states, the usual Boltzmann-Gibbs recipe does not work, since the partition function is divergent due to the flatness of the potential at long distances. However, we show that the standard Boltzmann-Gibbs (BG) statistical framework and thermodynamic relations can still be applied through proper regularization. This can be a valuable tool for the analysis of metastability in the non-confining potential fields that characterize a vast number of systems., Comment: 9 pages, 6 figures
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- 2020
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37. The Moving Discontinuous Galerkin Finite Element Method with Interface Condition Enforcement for Compressible Viscous Flows
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Kercher, Andrew D., Corrigan, Andrew, and Kessler, David A.
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Mathematics - Numerical Analysis ,Physics - Computational Physics - Abstract
The moving discontinuous Galerkin finite element method with interface condition enforcement (MDG-ICE) is applied to the case of viscous flows. This method uses a weak formulation that separately enforces the conservation law, constitutive law, and the corresponding interface conditions in order to provide the means to detect interfaces or under-resolved flow features. To satisfy the resulting overdetermined weak formulation, the discrete domain geometry is introduced as a variable, so that the method implicitly fits a priori unknown interfaces and moves the grid to resolve sharp, but smooth, gradients, achieving a form of anisotropic curvilinear $r$-adaptivity. This approach avoids introducing low-order errors that arise using shock capturing, artificial dissipation, or limiting. The utility of this approach is demonstrated with its application to a series of test problems culminating with the compressible Navier-Stokes solution to a Mach 5 viscous bow shock for a Reynolds number of $10^{5}$ in two-dimensional space. Time accurate solutions of unsteady problems are obtained via a space-time formulation, in which the unsteady problem is formulated as a higher dimensional steady space-time problem. The method is shown to accurately resolve and transport viscous structures without relying on numerical dissipation for stabilization., Comment: 29 pages, 11 figures
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- 2020
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38. Effect of Inflow Turbulence on Premixed Combustion in a Cavity Flameholder
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Goodwin, Gabriel B., Johnson, Ryan F., Kessler, David A., Kercher, Andrew D., and Chelliah, Harsha K.
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Physics - Fluid Dynamics - Abstract
A discontinuous Galerkin finite element method code, JENRE, was used to perform highly resolved simulations of ramjet-mode combustion in the University of Virginia Supersonic Combustion Facility cavity flameholder at a flight enthalpy of Mach 5. Prior experiments measured a freestream turbulence intensity at the inflow to the cavity ranging from 10 - 15%. A synthetic turbulence inflow generator was implemented for the simulations in this work to reproduce the turbulence at the inflow to the cavity. Velocity perturbations and turbulence intensity generated by the turbulent inflow boundary condition are shown to match those values measured in the facility using particle induced velocimetry. Simulations were performed both with and without inflow turbulence to study the effect of turbulence on flame stability and structure. In both cases, a cavity-stabilized flame was achieved. The inflow turbulence promoted more robust combustion, causing the flame to propagate further from the cavity into the core flow, broadening the flame angle with respect to the axial flow direction. The flame angle captured in the simulation agrees with experimental results and theoretical prediction. The cavity's vortex shedding frequency was identified. Flame strain rate and pressure fluctuations in the cavity shear layer were also measured and found to vary periodically at a frequency equal to that of the vortex shedding. High flow strain rate in the cavity shear layer, driven by the vortex shedding process, is identified as a cause of flame stretching and low OH concentrations as the flame traverses the cavity ramp. The effect of spatial resolution on the simulations is discussed through a comparison of cases using second-order and third-order accurate discontinuous Galerkin finite elements.
- Published
- 2020
39. Non-randomised feasibility study of training workshops for Talking Therapies service high-intensity therapists to optimise depression and anxiety outcomes for individuals with co-morbid personality difficulties: a study protocol
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Warbrick, Laura A., Dunn, Barnaby D., Moran, Paul A., Campbell, John, Kessler, David, Marchant, Katie, Farr, Michelle, Ryan, Mary, Parkin, Megan, Sharpe, Richard, Turner, Katrina, Sylianou, Mona, Sumner, Gemma, and Wood, Emma
- Published
- 2023
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40. Trauma-specific mindfulness-based cognitive therapy for women with post-traumatic stress disorder and a history of domestic abuse: intervention refinement and a randomised feasibility trial (coMforT study)
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Lewis, Natalia V., Gregory, Alison, Feder, Gene S., Angill-Williams, Aishlyn, Bates, Sophie, Glynn, Joel, Halliwell, Gemma, Hawcroft, Claire, Kessler, David, Lawton, Michael, Leach, Rwth, Millband, Sarah, Pitt, Katherine, Zammit, Stan, and Malpass, Alice
- Published
- 2023
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41. Integrated therapist and online CBT for depression in primary care (INTERACT): study protocol for a multi-centre randomised controlled trial
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Tallon, Debbie, Thomas, Laura, Brabyn, Sally, Ching, Brian Chi Fung, Hahn, Jane Sungmin, Jude, Berry, X Logan, Mekeda, Burrage, Alex, Fox, Fiona, Gilbody, Simon, Lanham, Paul, Lewis, Glyn, Li, Jinshuo, MacNeill, Stephanie J., Nazareth, Irwin, Parrott, Steve, Peters, Tim J., Shafran, Roz, Turner, Katrina, Williams, Chris, Kessler, David, and Wiles, Nicola
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- 2023
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42. 714: PAUSES IN CHEST COMPRESSIONS DURING ECPR: USING SIMULATION TO DETERMINE THE CAUSE
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Sugarman, Ariel, Fischman, Elizabeth, Kessler, David, Sen, Anita, and Choudhury, Tarif
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- 2024
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43. Development and interobserver reliability of a rating scale for lung ultrasound pathology in lower respiratory tract infection
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Baloescu, Cristiana, Chen, Alvin, Schnittke, Nikolai, Hicks, Bryson, Zhu, Meihua, Kaili, Matt, Shupp, Jeffrey, Chan, Daniela K.I., Malia, Laurie, Coneybeare, Di, Gregory, Kenton, Kessler, David, Raju, Balasundar, and Moore, Christopher L.
- Published
- 2023
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44. Mean pressure gradient effects on the performance of ramjet cavity stabilized flames
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Morales, Anthony J., Smerina, David M., Thornton, Mason.R., Rising, Cal J., Sosa, Jonathan, Johnson, Ryan F., Kessler, David A., Goodwin, Gabriel, and Ahmed, Kareem A.
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- 2023
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45. Machine Learning Algorithm Detection of Confluent B-Lines
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Baloescu, Cristiana, Rucki, Agnieszka A., Chen, Alvin, Zahiri, Mohsen, Ghoshal, Goutam, Wang, Jing, Chew, Rita, Kessler, David, Chan, Daniela K.I., Hicks, Bryson, Schnittke, Nikolai, Shupp, Jeffrey, Gregory, Kenton, Raju, Balasundar, and Moore, Christopher
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- 2023
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46. Infinite ergodic theory meets Boltzmann statistics
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Aghion, Erez, Kessler, David A., and Barkai, Eli
- Subjects
Condensed Matter - Statistical Mechanics ,Condensed Matter - Soft Condensed Matter - Abstract
We investigate the overdamped stochastic dynamics of a particle in an asymptotically flat external potential field, in contact with a thermal bath. For an infinite system size, the particles may escape the force field and diffuse freely at large length scales. The partition function diverges and hence the standard canonical ensemble fails. This is replaced with tools stemming from infinite ergodic theory. Boltzmann-Gibbs statistics, even though not normalized, still describes integrable observables, like energy and occupation times. The Boltzmann infinite density is derived heuristically using an entropy maximization principle, as well as via a first-principles calculation using an eigenfunction expansion in the continuum of low-energy states. A generalized virial theorem is derived, showing how the virial coefficient describes the delay in the diffusive spreading of the particles, found at large distances. When the process is non-recurrent, e.g. diffusion in three dimensions with a Coulomb-like potential, we use weighted time averages to restore basic canonical relations between time and ensemble averages., Comment: 21 pages (including Refs), 18 figures
- Published
- 2019
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47. Quantization of the mean decay time for non-Hermitian quantum systems
- Author
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Thiel, Felix, Kessler, David A., and Barkai, Eli
- Subjects
Quantum Physics - Abstract
We show that the mean time, which a quantum particle needs to escape from a system to the environment, is quantized and independent from most dynamical details of the system. In particular, we consider a quantum system with a general Hermitian Hamiltonian $\hat{H}$ and one decay channel, through which probability dissipates to the environment with rate $\Gamma$. When the system is initially prepared exactly in the decay state, the mean decay time $\langle T \rangle$ is quantized and equal to $w/(2\Gamma)$. $w$ is the number of distinct energy levels, i.e. eigenvalues of $\hat{H}$, that have overlap with the decay state, and is also the winding number of a transform of the resolvent in the complex plane. Apart from the integer $w$, $\langle T \rangle$ is completely independent of the system's dynamics. The complete decay time distribution can be obtained from an electrostatic analogy and features rare events of very large dissipation times for parameter choices close to critical points, where $w$ changes, e.g. when a degeneracy is lifted. Experiments of insufficient observation time may thus measure a too small value of $w$. We discuss our findings in a disordered tight-binding model and in the two-level atom in a continuous-wave field., Comment: Revised and extended version, 12 pages, 7 figures
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- 2019
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48. Biological Regulatory Networks are Minimally Frustrated
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Tripathi, Shubham, Kessler, David A., and Levine, Herbert
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Quantitative Biology - Molecular Networks - Abstract
Characterization of the differences between biological and random networks can reveal the design principles that enable the robust realization of crucial biological functions including the establishment of different cell types. Previous studies, focusing on identifying topological features that are present in biological networks but not in random networks, have, however, provided few functional insights. We use a Boolean modeling framework and ideas from spin glass literature to identify functional differences between five real biological networks and random networks with similar topological features. We show that minimal frustration is a fundamental property that allows biological networks to robustly establish cell types and regulate cell fate choice, and this property can emerge in complex networks via Darwinian evolution. The study also provides clues regarding how the regulation of cell fate choice can go awry in a disease like cancer and lead to the emergence of aberrant cell types., Comment: 5 pages, 4 figures
- Published
- 2019
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49. Quantum total detection probability from repeated measurements II. Exploiting symmetry
- Author
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Thiel, Felix, Mualem, Itay, Kessler, David A., and Barkai, Eli
- Subjects
Quantum Physics ,Condensed Matter - Statistical Mechanics - Abstract
A quantum walker on a graph, prepared in the state $| \psi_{\rm in} \rangle$, e.g. initially localized at node $r_{\rm in}$, is repeatedly probed, with fixed frequency $1/\tau$, to test its presence at some target node $r_{\rm d}$ until the first successful detection. This is a quantum version of the first-passage problem. We investigate the total detection probability $P_{\rm det}$, i.e. the probability to eventually detect the particle after an arbitrary number of detection attempts. It is demonstrated that this total detection probability is less than unity in symmetric systems, where it is possible to find initial states which are shielded from the detector by destructive interference, so-called dark states. The identification of physically equivalent initial states yields an upper bound for $P_{\rm det}$ in terms of the reciprocal of the number $\nu$ of physically equivalent states. The relevant subgroup of the system's symmetry operations is found to be the stabilizer of the detection state. Using this, we prove that all bright, i.e. surely detectable, states are symmetric with respect to the stabilizer. This implies that $P_{\rm det}$ can be obtained from a diagonalization of the "symmetrized" Hamiltonian, instead of having to find all eigenstates of the Hamiltonian.
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- 2019
50. Uncertainty and symmetry bounds for the quantum total detection probability
- Author
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Thiel, Felix, Mualem, Itay, Kessler, David A., and Barkai, Eli
- Subjects
Quantum Physics ,Condensed Matter - Statistical Mechanics - Abstract
We investigate a generic discrete quantum system prepared in state $|\psi_\text{in}\rangle$, under repeated detection attempts aimed to find the particle in state $|d\rangle$, for example a quantum walker on a finite graph searching for a node. For the corresponding classical random walk, the total detection probability $P_\text{det}$ is unity. Due to destructive interference, one may find initial states $|\psi_\text{in}\rangle$ with $P_\text{det}<1$. We first obtain an uncertainty relation which yields insight on this deviation from classical behavior, showing the relation between $P_\text{det}$ and energy fluctuations: $ \Delta P \,\mathrm{Var}[\hat{H}]_d \ge | \langle d| [\hat{H}, \hat{D}] | \psi_\text{in} \rangle |^2$ where $\Delta P = P_\text{det} - |\langle\psi_\text{in}|d\rangle |^2$, and $\hat{D} = |d\rangle\langle d|$ is the measurement projector. Secondly, exploiting symmetry we show that $P_\text{det}\le 1/\nu$ where the integer $\nu$ is the number of states equivalent to the initial state. These bounds are compared with the exact solution for small systems, obtained from an analysis of the dark and bright subspaces, showing the usefulness of the approach. The upper bounds works well even in large systems, and we show how to tighten the lower bound in this case., Comment: 8 pages, 3 figures, 1 table, revised and extended version
- Published
- 2019
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