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1. Neuroprotective effect of mesenchymal and neural stem and progenitor cells on sensorimotor recovery after brain injury.

Author

Poltavtseva RA, Silachev DN, Pavlovich SV, Kesova MI, Yarygin KN, Lupatov AY, Van'ko LV, Shuvalova MP, and Sukhikh GT

Subjects
Animals, Body Weight, Feedback, Sensory, Humans, Male, Models, Biological, Psychomotor Performance, Rats, Statistics, Nonparametric, Brain Injuries pathology, Brain Injuries therapy, Cell- and Tissue-Based Therapy methods, Mesenchymal Stem Cell Transplantation, Neural Stem Cells transplantation
Abstract

We studied the effect of systemic administration of multipotent stem cells on impaired neurological status in rats with brain injury. It was found that transplantation of multipotent mesenchymal stromal cells of the bone marrow or human neural stem and progenitor cells to rats with local brain injury promoted recovery of the brain control over locomotor function and proprioceptive sensitivity of forelegs. The dynamics of neurological recovery was similar after transplantation of fetal neural stem and progenitor cells and multipotent mesenchymal stromal cells. Transplantation of cell cultures improved survival of experimental animals. It should be noted that administration of neural stem and progenitor cells prevented animal death not only in the acute traumatic period, but also in delayed periods.

Published
2012
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2. [Clinico-morphological and molecular-genetic characteristic of the miometrium with failure of the uterine scar after the Cesarean section at women with undifferentiated forms of connective tissue dysplasia].

Author

Demura TA, Kogan EA, Donnikov AE, Kan NE, Kesova MI, Martynov AI, Bolotova OV, and Sukhikh GT

Subjects
Adult, Amino Acids, Diamino genetics, Amino Acids, Diamino metabolism, Cesarean Section adverse effects, Collagen genetics, Collagen metabolism, Female, Gene Expression, Genetic Association Studies, Genotype, Humans, Immunohistochemistry, Mutation, Myometrium metabolism, Polymorphism, Genetic, Pregnancy, Pregnancy Complications, Receptors, Estrogen genetics, Receptors, Estrogen metabolism, Vascular Endothelial Growth Factor A genetics, Vascular Endothelial Growth Factor A metabolism, Connective Tissue metabolism, Connective Tissue pathology, Myometrium pathology, Uterus metabolism, Uterus pathology, Uterus surgery
Abstract

Connective tissue state, its strength, is actual problem especially in the moment of labor because the weakness of labor activity or accelerated labor can be in depending on its consistency and elasticity. In addition, connective tissue is very important in the involution of the uterus after labor or wounds healing. Clinico-morphological and molecular-genetic investigation of 90 patients with undifferentiated forms of connective tissue dysplasia (uCTD) has been done. Reparation of tissue at patients with uCTD had a number of peculiarities, such as fibromuscular scar formation by substitution mechanisms with the laminin deficiency in the basic capillar membrane and extracellular matrix, accumulation of III and IV types of collagen, low expression of VEGF in the stromal cell and polymorphism of the alpha estrogen receptor gene. This immunohistochemical changes correlated with focuses of connective tissue disorganization as mucoid swelling, fibrinoid changes and hyalinosis, as well pathology of the microvasculature, resulted in chronic ischemia of the tissue. The disorganization is connected with disturbed reparation as a result of the genetically determined polymorphism of alpha and beta estrogen receptors. uCTD in pregnant women is prognostically significant for selection of way of delivery.

Published
2012

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