34 results on '"Kesici U"'
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2. Effects of different intra-abdominal pressure values on different organs: what should be the ideal pressure?
- Author
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Aydin, H. R., Kesici, S., Kesici, U., Saygin, I., Ulusoy, H., Imamoglu, M., and Deger, O.
- Published
- 2014
- Full Text
- View/download PDF
3. Bridge treatment for early cholecystectomy in geriatric patients with acute cholecystitis: Percutaneous cholecystostomy [Akut kolesistitli yaşlı hastalarda erken kolesistektomi için köprü tedavisi: Perkütan kolesistostomi]
- Author
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Zeren S., Bayhan Z., Koçak C., Kesici U., Korkmaz M., Ekici M.F., and Algın M.C.
- Subjects
Bridge treatment ,Cholecystectomy ,Percutaneous cholecystostomy ,Acute cholecystitis ,Postoperative complication - Abstract
BACKGROUND: The main cause of acute cholecystitis (AC) is gallstones, and the incidence of gallstones in elderly patients is high. METHODS: In this study, we aimed to investigate the efficacy of percutaneous cholecystostomy (PC) before early cholecystectomy in geriatric patients with AC. This retrospective study included 85 patients undergoing laparoscopic or conventional cholecystectomy during early stage of calculous AC. RESULTS: All patients were over 65 years old and were divided into two groups: Group I, PC plus early cholecystectomy and Group II, only cholecystectomy without PC. Data on age, sex, status of PC before surgery, postoperative complications, postoperative mortality, surgical method, and postoperative hospitalization duration were recorded in our study. The average age in the groups I and II was 75.7±7.5 and 73.7±7.2 years, respectively, indicating insignificant difference (p=0.223). Although postoperative complication rate was two fold in the non-PC group, the PC plus cholecystectomy group has a few complications (p=0.032). Postoperative mortality was evidently lower in patients who first underwent PC and followed by cholecystectomy (p=0.017). The average hospitalization duration in groups I and II were 5.6±2.4 days and 11.2±7.7 days, respectively (p
- Published
- 2017
4. Subcutaneous and muscular metastasis of the colorectal cancer on F-18 FDG PET/CT
- Author
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Karyagar, S., Kesici, U., Karyagar, S. S., Kece, C., Ali GUNER, Kucuktulu, U., Duman, G., and Giresun Üniversitesi
- Subjects
Adult ,Male ,medicine.medical_specialty ,Skin Neoplasms ,Colorectal cancer ,Multimodal Imaging ,Metastasis ,Text mining ,Fluorodeoxyglucose F18 ,medicine ,Humans ,Neoplasm Metastasis ,Aged ,Retrospective Studies ,Aged, 80 and over ,Multimodal imaging ,Muscle Neoplasms ,medicine.diagnostic_test ,business.industry ,Gastroenterology ,Retrospective cohort study ,Middle Aged ,medicine.disease ,F 18 fdg pet ct ,Tomography x ray computed ,Positron emission tomography ,Positron-Emission Tomography ,Female ,Radiology ,Colorectal Neoplasms ,Tomography, X-Ray Computed ,business - Abstract
Gun, A/0000-0001-7801-8081 WOS: 000351643000022 PubMed: 25835124 …
- Published
- 2015
5. Gluteal hydatid cyst: Report of a case
- Author
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Zeren S., Kesici U., Kesici S., and Giresun Üniversitesi
- Subjects
Hydatid cyst ,Rare localization ,parasitic diseases ,Gluteal muscle - Abstract
PubMed: 26069180 Hydatid cyst locates in the liver (70%), lungs (25%) and rarely in other body tissues. Cases with gluteal muscle localized hydatid cyst are rarely seen in literature. In this case report, a woman with hydatid cyst that was located in gluteal muscle was discussed. After the patient had been diagnosed, complete surgical excision was performed with the patient. Albendazole treatment was applied in preoperative and postoperative period to decrease local recurrence risk. © 2015 Tehran University of Medical Sciences. All rights reserved.
- Published
- 2015
6. Retrorectal/presacral epidermoid cyst: Report of a case [Retrorektal/presakral epidermoid kist: Olgu sunumu]
- Author
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Kesici U., Sakman G., Mataraci E., and Çukurova Üniversitesi
- Subjects
Cyst ,integumentary system ,Presacral ,Rectal ,Epidermoid ,Perianal - Abstract
Although epidermal cysts are frequently observed throughout the body, they are rarely found in the retrorectal/presacral regions. Retrorectal epidermal cysts are congenital lesions of ectodermal origin and generally occur in women during the reproductive period. In this case report, a 47 year old female patient with 25 years of complaint of a mass extending from the perianal region to the retrococcygeal region is discussed. A total mass excision with paracoccygeal incision was performed under spinal anesthesia. The histopathologic examination demonstrated an epidermal cyst. Correct diagnosis and appropriate treatment when first detected significantly decrease the recurrence and complication risks in all retrorectal tumors. Any mass should be completely removed in the treatment.
- Published
- 2013
7. Retrorectal/presacral epidermoid cyst: Report of a case
- Author
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Kesici U., Sakman G., Mataraci E., and Giresun Üniversitesi
- Subjects
Cyst ,integumentary system ,Presacral ,Rectal ,Epidermoid ,Perianal - Abstract
Although epidermal cysts are frequently observed throughout the body, they are rarely found in the retrorectal/presacral regions. Retrorectal epidermal cysts are congenital lesions of ectodermal origin and generally occur in women during the reproductive period. In this case report, a 47 year old female patient with 25 years of complaint of a mass extending from the perianal region to the retrococcygeal region is discussed. A total mass excision with paracoccygeal incision was performed under spinal anesthesia. The histopathologic examination demonstrated an epidermal cyst. Correct diagnosis and appropriate treatment when first detected significantly decrease the recurrence and complication risks in all retrorectal tumors. Any mass should be completely removed in the treatment.
- Published
- 2013
8. Granular Cell Tumor on Perianal Region: A Case Report
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Kesici Ugur, Mataraci Emine, Kesici Sevgi, and Zeren Sezgin
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Granullar cell tumor ,Soft tissue neoplasms ,Perianal region ,Medicine (General) ,R5-920 - Abstract
Granular cell tumor (GCT) was first described by Abrikossoff in 1926. GCT is a rarely seen soft tissue tumor and is generally benign. While the tumor can be seen in all parts of the body it is generally located on the head and neck region, and especially on the tongue. GCT is rarely seen in the anal-perianal region. In accordance with literature this case was reported because it was thought to be the 27th anal-perianal located GCT case. In this case report, approximately 0,5-1 cm pedunculated polypoid lesion was determined in the perianal region during the physical examination of a 23 year old female patient who applied with palpable mass complaint in the perianal region. Lesion in the patient was totally excited with healthy skin-subcutaneous tissue under local anesthesia. A benign granular cell tumor was detected in the histopathological examination. Positive staining was monitored immunohistochemically with S-100 and neuron specific enolase (NSE). GCT is a rarely seen tumor in the anal-perianal region and its malign transformation rate is very low. Even lesions seen in the perianal region have clinically a benign appearance, a histopathological examination should be conducted and also GCT should be kept in mind during diagnosis. Malign-benign separation of these lesions is difficult so histopathological examination should be conducted with great care. Large local excision in the treatment provides curative treatment. But for those presenting malign transformation further examination must be performed for metastasis. After the treatment local recurrence and metastasis should be considered carefully. Prognosis of metastatic disease is very bad.
- Published
- 2013
9. Effect of pre-incisional and peritoneal local anesthetics administration on colon anastomosis and wound healing.
- Author
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Kesici U, Karatepe YK, Mazlum AF, Bozali K, Genç MS, Ercan LD, Duman MG, Sade AG, Guler EM, and Kesici S
- Subjects
- Animals, Male, Rats, Tissue Adhesions prevention & control, Anastomosis, Surgical, Anesthetics, Local administration & dosage, Anesthetics, Local pharmacology, Wound Healing drug effects, Colon surgery, Colon pathology, Rats, Sprague-Dawley, Levobupivacaine administration & dosage, Bupivacaine analogs & derivatives, Bupivacaine administration & dosage, Bupivacaine pharmacology
- Abstract
Background: Previous research has shown that levobupivacaine is as effective as bupivacaine but carries a lower risk of cardiac and central nervous system toxicity. This study explores whether levobupivacaine and bupivacaine are preferable for all patients, includ-ing those with comorbidities, particularly focusing on their effects on colonic anastomosis. The primary objective is to examine the influence of levobupivacaine and bupivacaine on colonic anastomosis. Additionally, the study will assess their impact on wound healing and their anti-adhesive properties., Methods: Conducted between July 28, 2022, to August 4, 2022, at the Hamidiye Animal Experiments Laboratory, this study was approved by the University Science Health, Hamidiye Animal Experiments Local Ethics Committee. This study was conducted using 21 male Sprague rats aged 16-20 weeks. The rats were allocated into three equal groups of seven each: Group C: pre-incisional isotonic; Group B: pre-incisional bupivacaine; and Group L: pre-incisional levobupivacaine. Macroscopic adhesion scores (MAS) were recorded during laparotomy and tissue samples were taken for histopathological examination and hydroxyproline levels measurement. Wound tensile strength along the middle incision line and anastomotic burst pressure were also assessed., Results: MAS was statistically significantly lower in Groups B and L compared to Group C (p<0.001). The wound histopathology score (WHS) was significantly higher in Group L than in Group B (p=0.021). Colon histopathology scores (CHSs) were also signifi-cantly higher in Group L compared to Group C (p=0.011)., Conclusion: TThe study found that bupivacaine and levobupivacaine did not significantly enhance wound healing, although le-vobupivacaine significantly improved WHS relative to bupivacaine. According to the findings of this study, levobupivacaine can enhance clinical practice by being used in patients undergoing colon anastomosis. It contributes significantly to the durability of colon anasto-mosis, has a more positive effect on wound healing compared to bupivacaine, and exhibits anti-adhesive properties. Additional clinical trials are necessary to validate these results further.
- Published
- 2024
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10. Spontaneous Complete Regression of Breast Cancer: Two Case Report.
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Yılmaz O, Kesici U, Duman MG, Yuzer O, Erturk A, and Nayir PO
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- Humans, Female, Middle Aged, Carcinoma, Ductal, Breast surgery, Carcinoma, Ductal, Breast pathology, Aged, Breast Neoplasms surgery, Neoplasm Regression, Spontaneous
- Abstract
Spontaneous regression (SR) is a tumor's partial or complete disappearance without any treatment. In the literature, it has been documented that SR is uncommon in breast cancer (BC) and other types of cancer. Multiple mechanisms are believed to contribute to the development of SR. However, its mechanism still needs to be clearly demonstrated. Although two SR patients were presented in our study, the evidence needed to be more sufficient to determine the mechanism. However, due to Programmed Death-Ligand 1 (PD-L1) negativity in both patients, the hypothesis in the literature that PD-L1 has strong antitumoral activity was not supported. In addition, it was determined that the patient in case 2 was the first Cerb B2 positive case reported in the literature and had the earliest SR period. Due to this, it has been disclosed that the SR mechanism of BC will be concluded within 21 days at the earliest. This situation suggests that breast surgeons, in particular, should conduct a thorough physical examination and, if necessary, re-radiological examination before surgery on patients for whom surgery is decided after diagnosis. Being careful in this regard may increase the number of SR in BC cases and allow molecular investigations on living tissue samples to reveal the underlying mechanism.
- Published
- 2024
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11. Double Recurrent Laryngeal Nerve with Thyroid Carcinoma.
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Kesici U, Duman MG, Mazlum AF, and Ercan LD
- Subjects
- Humans, Female, Middle Aged, Recurrent Laryngeal Nerve Injuries etiology, Recurrent Laryngeal Nerve Injuries prevention & control, Intraoperative Complications prevention & control, Intraoperative Complications etiology, Thyroid Neoplasms surgery, Recurrent Laryngeal Nerve anatomy & histology, Thyroidectomy
- Abstract
The most important and serious complication of thyroid surgery is recurrent laryngeal nerve (RLN) injury, and it has been noted that this risk increases considerably in the presence of anatomical variations. Double recurrent laryngeal nerve (DRLN) is very rare among RLN anatomical variations. There are only a few case reports on DRLN in the literature It is crucial to possess surgical expertise and ensure complete visualization of the nerve to minimize the likelihood of RLN injury. Intraoperative nerve monitoring (IONM) is particularly useful in identifying anatomical variations. In a 54-year-old woman undergoing diagnostic left lobectomy+isthmectomy, a left DRLN was identified during intraoperative exploration and meticulous nerve exploration with the assistance of IONM monitoring verified that the impulse conduction in both branches was identical. The surgical procedure was successfully performed without causing any harm to the nerve. Based on the case reports in the literature and our experience with this patient, we believe that surgical expertise and the utilization of IONM can decrease RLN nerve damage and reveal its anatomical variations during thyroid surgery.
- Published
- 2024
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12. Detection of Thyroid Isthmus Agenesia during Diagnostic Lobectomy: A Case Report.
- Author
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Kesici U, Duman MG, Karatepe YK, Mazlum AF, and Somay M
- Subjects
- Humans, Female, Middle Aged, Incidental Findings, Thyroidectomy methods, Thyroid Gland surgery, Thyroid Gland abnormalities
- Abstract
The thyroid gland is an endocrine organ comprising two lobes connected by an isthmus. Thyroid isthmus agenesia (TIA) is a rare anatomical anomaly, which has only been documented in a limited number of case reports. This report presents the case of a 49-year-old female patient who was diagnosed with intraoperative TIA during diagnostic thyroid lobectomy. The patient was arranged for a diagnostic lobectomy of the right thyroid lobe after identifying an atypical nodule of undetermined significance, in the right lobe, which had been confirmed with two distinct biopsies. The patient was discovered to have isthmus agenesia during a neck exploration performed under general anesthesia. Owing to its rarity, the precise clinical and anatomical characteristics of TIA have not been defined, and its underlying cause is still not completely understood. The detection of TIA warrants the considerations of any other accompanying diseases. Prior identification and assessment of surgical approach are crucial for ensuring a secure surgical procedure and mitigating the risk of surgical complications. Nevertheless, caution must be exercised if TIA is detected during operation because preoperative identification is not always feasible. In summation, additional patient reports and studies are required to uncover the underlying cause of this pathological condition.
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- 2024
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13. Concurrence of Thyrolipomatosis with Hyperthyroidism and Ectopic Thyroid Tissue.
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Kesici U, Karatepe YK, and Isceviren B
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- Humans, Hyperthyroidism complications, Thyroid Dysgenesis complications
- Abstract
Null.
- Published
- 2022
- Full Text
- View/download PDF
14. Malignant Melanoma Metastasis to Sigmoid Colon: New Endoscopic Appearance Detected for the First Time.
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Kesici U
- Subjects
- Colon, Sigmoid, Colonoscopy, Humans, Lymph Nodes, Male, Melanoma diagnosis, Skin Neoplasms
- Abstract
Malignant melanoma (MM) develops as a result of malignant transformation of melanocytes. It accounts for 4% of all skin cancers. MM metastases usually occur in regional lymph nodes, bones and central nervous system. In this case report, a case of a 50-year male, who was found to have MM infiltration on colonoscopy performed for the etiology of anemia, is discussed. The patient underwent gastroscopy and colonoscopy for the determination of the primary tumor. Colonoscopic examination showed multiple submucosal hyperpigmented areas and a sessile polyp with a diameter of 4-5 mm in the sigmoid colon. Biopsies of hyperpigmented lesions were consistent with MM infiltration. Gastrointestinal tract (GIT) metastases are rare in MM. In literature, MM metastases to GIT have endoscopic appearances of 3 types. Typically, on endoscopy, ulceration with nodule or mass is visualised. However, in this case, an appearance of 'only submucosal melanosis without mass or nodule' was identified, distinct from previously described three endoscopic views and it was verified histopathologically. This case will help increase awareness of endoscopists in terms of being careful to look for MM metastasis on endoscopic examinations, which may be defined as 4th type of endoscopic appearance. Key Words: Malignant melanoma, Metastasis, Colon, Endoscopy.
- Published
- 2020
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15. [Antimicrobial effects of fentanyl and bupivacaine].
- Author
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Kesici S, Demırci M, and Kesici U
- Subjects
- Anesthetics, Local administration & dosage, Anti-Infective Agents administration & dosage, Bupivacaine administration & dosage, Drug Synergism, Fentanyl administration & dosage, Hydrochloric Acid pharmacology, Microbial Sensitivity Tests, Prospective Studies, Sodium Hydroxide pharmacology, Anesthetics, Local pharmacology, Anti-Infective Agents pharmacology, Bupivacaine pharmacology, Fentanyl pharmacology
- Abstract
Study Objective: In this study, we aimed to compare the antimicrobial effects of bupivacaine and fentanyl citrate and to reveal the impact on antimicrobial effect potential in the case of combined use., Design: In vitro prospective study., Setting: University Clinical Microbiology Laboratory., Measurements: In our study, in vitro antimicrobial effect of 0.05 mg.mL
-1 fentanyl citrate, 5 mg.mL-1 bupivacaine were tested against Staphylococcus aureus American Type Culture Collection (ATCC) 29213, Pseudomonas aeruginosa ATCC 27853, Klebsiella pneumoniae ATCC 13883, Escherichia coli ATCC 25922 and Candida albicans ATCC 10231 as Group F (Fentanyl Citrate) and Group B (Bupivacaine), respectively. S. aureus ATCC 29213, P. aeruginosa ATCC 27853, Klebsiella pneumoniae ATCC 13883 and Escherichia coli ATCC 25922 were cultured onto Mueller Hinton agar (Oxoid, UK) plates and Candida albicans ATCC 10231 were cultured onto Sabouraud dextrose agar (Oxoid, UK) plates for 18-24 hours at 37°C., Main Results: In terms of inhibition zone diameters, S. Aureus ATCC 29213, P. aeruginosa ATCC 27853, and C. albicans ATCC10231 values obtained after 12 and 24 hours of incubation were significantly higher in Group F than Group B (p < 0.001). In terms of inhibition zone diameters, E. coli ATCC 25922, and K. pneumomiae ATCC 13883 values obtained after 12 and 24hours of incubation were significantly higher in Group B than Group F (p < 0.001, E. coli 12ª hour p = 0.005)., Conclusions: Addition of fentanyl to Local Anesthetics (LAs) is often preferred in regional anesthesia applications in today's practice owing especially to its effect on decreasing the local anesthetic dose and increasing analgesia quality and patient satisfaction. However, when the fact that fentanyl antagonized the antimicrobial effects of LAs in the studies is taken into account, it might be though that it contributes to an increase in infection complications. When the fact that fentanyl citrate, which was used in our study and included hydrochloric acid and sodium hydroxide as protective agents, broadened the antimicrobial effect spectrum of LAs, had no antagonistic effect and showed a synergistic antimicrobial effect against E. Coli is considered, we are of the opinion that the addition of fentanyl to LAs would contribute significantly in preventing the increasing regional anesthesia infection complications., (Copyright © 2020 Sociedade Brasileira de Anestesiologia. Publicado por Elsevier Editora Ltda. All rights reserved.)- Published
- 2020
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16. Bacterial inhibition efficiency of prilocaine and bupivacaine.
- Author
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Kesici S, Demirci M, and Kesici U
- Subjects
- Humans, In Vitro Techniques, Microbial Sensitivity Tests, Sensitivity and Specificity, Statistics, Nonparametric, Bupivacaine pharmacology, Escherichia coli drug effects, Prilocaine pharmacology, Pseudomonas aeruginosa drug effects, Staphylococcus aureus drug effects
- Abstract
This study aimed to demonstrate the antibacterial effects of bupivacaine and prilocaine on Escherichia coli, Staphylococcus aureus, and Pseudomonas aeruginosa. In our study, the in vitro antimicrobial effects of 20 mg/mL prilocaine and 5 mg/mL bupivacaine were tested against a S. aureus American-type culture collection (ATCC) 29213, P. aeruginosa ATCC 27853, and E. coli ATCC 25922, divided into Group P (Prilocaine) and Group B (Bupivacaine), respectively. S. aureus ATCC 29213, P. aeruginosa ATCC 27853, and E. coli ATCC 25922 were cultured on Mueller Hinton agar (Oxoid, Basingstoke, UK) plates for 18 to 24 hours at 37°C. In terms of inhibition zone diameters, inhibition of S. aureus ATCC 29213 was observed in both groups at the 12th and 24th hours. The 12th- and 24th-hour S. aureus ATCC 29213 value was significantly higher in Group P compared with Group B (P = .008). At the 12th and 24th hours, inhibition of E. coli ATCC 25922 was observed in both groups. The 12th- and 24th-hour E. coli ATCC 25922 value was significantly higher in Group P compared with Group B (P = .008). In our study, it was seen that prilocaine and bupivacaine had an antimicrobial effect on S. aureus and E. coli. In the comparison between these two local anesthetics (LAs), this effect was found to be significantly higher in prilocaine than bupivacaine. Therefore, we are of the opinion that antimicrobial effect potentials should also be taken into account in the selection of an LA agent in order to prevent the complications of an infection that might develop during LA infiltration and might lead to serious morbidity., (© 2019 Medicalhelplines.com Inc and John Wiley & Sons Ltd.)
- Published
- 2019
- Full Text
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17. Antibacterial effects of lidocaine and adrenaline.
- Author
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Kesici S, Demirci M, and Kesici U
- Subjects
- Humans, In Vitro Techniques, Microbial Sensitivity Tests methods, Sensitivity and Specificity, Epinephrine pharmacology, Escherichia coli drug effects, Lidocaine pharmacology, Pseudomonas aeruginosa drug effects, Staphylococcus aureus drug effects
- Abstract
The most commonly used local anaesthetics (LAs) for postoperative analgesia and surgical anaesthesia are lidocaine and bupivacaine. Adrenaline is a vasopressor agent, which is widely used in anaesthesia for many purposes. This study aims to determine the antibacterial efficacy of lidocaine, mupirocin, adrenaline, and lidocaine + adrenaline combination. In our study, the in vitro antimicrobial effect of 1 mL of sterile saline, 20 mg/mL mupirocin, 20 mg/mL lidocaine, 1 mg/mL adrenaline, and 20 mg/mL lidocaine and adrenaline were tested against Staphylococcus aureus American-type culture collection (ATCC) 29213, Pseudomonas aeruginosa ATCC 27853, and Escherichia coli ATCC 25922, classified as Group C (control), Group M (mupirocin), Group L (lidocaine), Group A (adrenaline), and Group LA (lidocaine+adrenaline), respectively. S. aureus ATCC 29213, P. aeruginosa ATCC 27853, and E. coli ATCC 25922 were cultured on Mueller-Hinton agar (Oxoid, UK) plates for 18 to 24 hours at 37°C. Colonies from these plates were suspended in sterile saline, and a 0.5 McFarland turbidity standard suspension (corresponding to 1.5 × 10
8 CFU/mL) of each isolate was prepared. In terms of inhibition zone diameters, S. aureus ATCC 29213 values obtained after 12 and 24 hours of incubation were significantly different between groups (P < .001). According to inhibition zone diameters, Group M > Group LA > Group L > Group C = Group A. P. Aeruginosa ATCC 27853 values obtained after 12 and 24 hours of incubation were significantly different between groups (P < .001). According to inhibition zone diameters, Group M > Group LA > Group L = Group C = Group A. E. coli ATCC 25922 values obtained after 12 and 24 hours of incubation were significantly different between groups (P < .001). According to inhibition zone diameters, Group M > Group LA > Group L > Group C = Group A. It is known that LAs have antimicrobial effect potential in addition to their anaesthetic, analgesic, antiarrhythmic, and anti-inflammatory effects. There are also studies showing the antimicrobial effects of vasopressor agents, which are frequently used, particularly in intensive care unit (ICUs). However, it has been observed in the present study that adrenaline alone did not have any antimicrobial effect. Adrenaline, when used in combination with lidocaine, provides a stronger and broad-spectrum antimicrobial activity, suggesting that its combined use in proper indications will be clinically significant. Because the prevention and treatment of wound infections make a positive contribution to wound healing, the potential of antimicrobial effect of LAs can provide successful results in the prevention and treatment of ICU and wound infections. Thus, an important contribution can be made in terms of reducing the costs of antibacterial treatment and reducing morbidity., (© 2019 Medicalhelplines.com Inc and John Wiley & Sons Ltd.)- Published
- 2019
- Full Text
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18. Horseshoe Appendix Is an Extremely Rare Cause of Acute Appendicitis.
- Author
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Serter İ, Eroğlu E, Akbal E, Kesici U, and Altınlı E
- Subjects
- Adult, Appendicitis pathology, Appendicitis surgery, Female, Humans, Appendicitis etiology, Appendix abnormalities
- Published
- 2018
19. [Effects of local anesthetics on wound healing].
- Author
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Kesici S, Kesici U, Ulusoy H, Erturkuner P, Turkmen A, and Arda O
- Abstract
Introduction: Local anesthetic infiltration is used widely for post-operative analgesia in many situations. However the effects of local anesthetics on wound healing are not demonstrated clearly. This study planned to evaluate the effects of lidocaine, prilocaine, bupivacaine and levobupivacaine on wound healing, primarily on wound tensile strength and on collagen ultrastructure., Methods: This study was conducted on male Sprague Dawley rats. On days 0, 8th, 15th, and 21st, all animals were weighed and received a preincisional subcutaneous infiltration of 3mL of a solution according the group. Control saline (C), lidocaine (L) 7mg.kg
-1 , prilocaine (P) 2mg.kg-1 , bupivacaine (B) 2mg.kg-1 and levobupivacaine (LVB) 2.5mg.kg-1 . The infiltrations were done at the back region 1.5cm where incision would be performed at the upper, middle and lower part along the midline, under general anesthesia. Wound tensile strengths were measured after 0.7cm×2cm of cutaneous and subcutaneous tissue samples were obtained vertical to incision from infiltrated regions. Tissue samples were also obtained for electron microscopic examination. Evaluations were on the 8th, 15th and 21st days after infiltration., Results: There was no difference between groups in the weights of the rats at the 0th, 8th, 15th and 21st days. The collagen maturation was no statistically different between groups at the 8th and 15th days. The maturation scores of the B and L groups at the 21st day was significantly lower than the Group C (1.40, 1.64 and 3.56; respectively). The wound tensile strength was no statistically different between groups at the 8th and 15th days but at the 21st day the Groups B and LVB had significantly lower value than Group C (5.42, 5.54 and 6.75; respectively)., Conclusion: Lidocaine and prilocaine do not affect wound healing and, bupivacaine and levobupivacaine affect negatively especially at the late period., (Copyright © 2018 Sociedade Brasileira de Anestesiologia. Publicado por Elsevier Editora Ltda. All rights reserved.)- Published
- 2018
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20. Bridge treatment for early cholecystectomy in geriatric patients with acute cholecystitis: Percutaneous cholecystostomy.
- Author
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Zeren S, Bayhan Z, Koçak C, Kesici U, Korkmaz M, Ekici MF, Algın MC, and Yaylak F
- Subjects
- Aged, Aged, 80 and over, Humans, Length of Stay, Postoperative Complications, Retrospective Studies, Cholecystitis, Acute surgery, Cholecystostomy adverse effects, Cholecystostomy methods, Cholecystostomy statistics & numerical data
- Abstract
Background: The main cause of acute cholecystitis (AC) is gallstones, and the incidence of gallstones in elderly patients is high., Methods: In this study, we aimed to investigate the efficacy of percutaneous cholecystostomy (PC) before early cholecystectomy in geriatric patients with AC. This retrospective study included 85 patients undergoing laparoscopic or conventional cholecystectomy during early stage of calculous AC., Results: All patients were over 65 years old and were divided into two groups: Group I, PC plus early cholecystectomy and Group II, only cholecystectomy without PC. Data on age, sex, status of PC before surgery, postoperative complications, postoperative mortality, surgical method, and postoperative hospitalization duration were recorded in our study. The average age in the groups I and II was 75.7±7.5 and 73.7±7.2 years, respectively, indicating insignificant difference (p=0.223). Although postoperative complication rate was two fold in the non-PC group, the PC plus cholecystectomy group has a few complications (p=0.032). Postoperative mortality was evidently lower in patients who first underwent PC and followed by cholecystectomy (p=0.017). The average hospitalization duration in groups I and II were 5.6±2.4 days and 11.2±7.7 days, respectively (p<0.001)., Conclusion: Urgent laparoscopic cholecystectomy is still the best surgical treatment modality for calculous AC. Further, our study results showed that in geriatric patients, bridge treatment, such as PC, can be useful for reducing postoperative complication rates.
- Published
- 2017
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21. Agenesis of the isthmus of the thyroid gland.
- Author
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Kesici U and Kesici S
- Abstract
The thyroid is an endocrine gland composed of two lobes connected by the isthmus tissue. Thyroid isthmus agenesis is a rare condition, and only a few cases have been reported in the literature. Here, we discuss the case of a 56-year-old female patient in whom agenesis of the thyroid isthmus was discovered incidentally during surgery for a multinodular goitre. When agenesis of the isthmus is found, associated thyroid lobe agenesis and the presence of ectopic thyroid tissue must be considered. In addition, associated autoimmune thyroid nodule, thyroiditis, primary thyroid carcinoma, metastasis, and amyloidosis must be considered in the differential diagnosis. Preoperative awareness of potential agenesis of the isthmus and its associated thyroid anomalies in patients with planned thyroid surgery will significantly contribute to safety during surgical procedures and result in fewer surgery-related complications., Competing Interests: Conflict of Interest: No conflict of interest was declared by the authors.
- Published
- 2015
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22. Missed retrosternal ectopic thyroid tissue in a patient operated for multinodular goiter.
- Author
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Kesici U, Koral Ö, Karyağar S, Kesici S, Yılbaş A, Karyağar S, Mataracı E, and Mataracı İ
- Abstract
Ectopic thyroid tissue has been found from the tongue to the diaphragm. The most common ectopic thyroid tissue has been found in the tongue, submandibular region, cervical lymph nodes, larynx, trachea, oesophagus, mediastinum, diaphragm and heart respectively. "Forgotten goiter" is an extremely rare disease which is defined as a mediastinal thyroid mass found after total thyroidectomy. In this case report, we discussed a 49 year-old female patient whose retrosternal ectopic thyroid tissue was detected by thyroid scintigraphy taken in postoperative period after total thyroidectomy performed with diagnosis of multinodular goiter. Papillary carcinoma was determined by the histopathological examination. Ectopic thyroid tissue was removed by performing sternotomy. We did not observe any postoperative surgical complications. 100 mCi dose of radioactive iodine was administered to the patient. Retrosternal ectopic thyroid tissue detected after total thyroidectomy is a rarely encountered condition. Therefore, retrosternal ectopic thyroid tissue existence should be definitely kept in mind in patients with no increase in thyroid stimulating hormone level after total thyroidectomy.
- Published
- 2015
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23. Effects of glutamine on wound healing.
- Author
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Kesici U, Kesici S, Ulusoy H, Yucesan F, Turkmen AU, Besir A, and Tuna V
- Subjects
- Animals, Disease Models, Animal, Female, Prognosis, Rats, Rats, Sprague-Dawley, Glutamine pharmacology, Wound Healing drug effects, Wounds and Injuries therapy
- Abstract
Studies reporting the need for replacing amino acids such as glutamine (Gln), hydroxymethyl butyrate (HMB) and arginine (Arg) to accelerate wound healing are available in the literature. The primary objective of this study was to present the effects of Gln on tissue hydroxyproline (OHP) levels in wound healing. This study was conducted on 30 female Sprague Dawley rats with a mean weight of 230 ± 20 g. Secondary wounds were formed by excising 2 × 1 cm skin subcutaneous tissue on the back of the rats. The rats were divided into three equal groups. Group C (Control): the group received 1 ml/day isotonic solution by gastric gavage after secondary wound was formed. Group A (Abound): the group received 0·3 g/kg/day/ml Gln, 0·052 g/kg/day/ml HMB and 0·3 g/kg/day/ml Arg by gastric gavage after secondary wound was formed. Group R (Resource): the group received 0·3 g/kg/day/ml Gln by gastric gavage after secondary wound was formed. The OHP levels of the tissues obtained from the upper half region on the 8th day and the lower half region on the 21st day from the same rats in the groups were examined. Statistical analysis was performed using the statistics program SPSS version 17.0. No statistically significant differences were reported with regard to the OHP measurements on the 8th and 21st days (8th day: F = 0·068, P = 0·935 > 0·05; 21st day: F = 0·018, P = 0·983 > 0·05). The increase in mean OHP levels on the 8th and 21st days within each group was found to be statistically significant (F = 1146·34, P = 0·000 < 0·001). We conclude that in adults who eat healthy food, who do not have any factor that can affect wound healing negatively and who do not have large tissue loss at critical level, Gln, Arg and HMB support would not be required to accelerate secondary wound healing., (© 2013 The Authors. International Wound Journal © 2013 Medicalhelplines.com Inc and John Wiley & Sons Ltd.)
- Published
- 2015
- Full Text
- View/download PDF
24. Subcutaneous and muscular metastasis of the colorectal cancer on F-18 FDG PET/CT.
- Author
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Karyağar S, Kesici U, Karyağar S, Kece C, Güner A, Duman G, and Küçütulu U
- Subjects
- Adult, Aged, Aged, 80 and over, Colorectal Neoplasms pathology, Female, Fluorodeoxyglucose F18, Humans, Male, Middle Aged, Multimodal Imaging methods, Muscle Neoplasms diagnostic imaging, Retrospective Studies, Skin Neoplasms diagnostic imaging, Colorectal Neoplasms diagnostic imaging, Muscle Neoplasms secondary, Neoplasm Metastasis diagnostic imaging, Positron-Emission Tomography, Skin Neoplasms secondary, Tomography, X-Ray Computed methods
- Published
- 2015
- Full Text
- View/download PDF
25. Gluteal Hydatid Cyst: Report of a Case.
- Author
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Zeren S, Kesici U, and Kesici S
- Subjects
- Adult, Animals, Echinococcosis drug therapy, Female, Humans, Albendazole therapeutic use, Echinococcosis diagnosis, Echinococcus isolation & purification
- Abstract
Hydatid cyst locates in the liver (70%), lungs (25%) and rarely in other body tissues. Cases with gluteal muscle localized hydatid cyst are rarely seen in literature. In this case report, a woman with hydatid cyst that was located in gluteal muscle was discussed. After the patient had been diagnosed, complete surgical excision was performed with the patient. Albendazole treatment was applied in preoperative and postoperative period to decrease local recurrence risk.
- Published
- 2015
26. Morgagni hernia detected due to pneumothorax development during diagnostic colonoscopy.
- Author
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Polat N, Kesici U, Kesici S, and Yılbaş S
- Subjects
- Female, Humans, Middle Aged, Colonic Diseases etiology, Colonoscopy adverse effects, Hernias, Diaphragmatic, Congenital complications, Hernias, Diaphragmatic, Congenital diagnosis, Intestinal Perforation etiology, Pneumothorax etiology
- Published
- 2014
- Full Text
- View/download PDF
27. Retrorectal/Presacral epidermoid cyst: report of a case.
- Author
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Kesici U, Sakman G, and Mataraci E
- Abstract
Although epidermal cysts are frequently observed throughout the body, they are rarely found in the retrorectal/presacral regions. Retrorectal epidermal cysts are congenital lesions of ectodermal origin and generally occur in women during the reproductive period. In this case report, a 47 year old female patient with 25 years of complaint of a mass extending from the perianal region to the retro-coccygeal region is discussed. A total mass excision with paracoccygeal incision was performed under spinal anesthesia. The histopathologic examination demonstrated an epidermal cyst. Correct diagnosis and appropriate treatment when first detected significantly decrease the recurrence and complication risks in all retrorectal tumors. Any mass should be completely removed in the treatment.
- Published
- 2013
- Full Text
- View/download PDF
28. Effects of levobupivacaine on wound healing.
- Author
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Zeren S, Kesici S, Kesici U, Isbilir S, Turkmen UA, Ulusoy H, Karpuz V, Ozcan O, Polat E, Ipcioglu OM, and Sari MK
- Subjects
- Anesthetics, Local adverse effects, Animals, Biopsy, Bupivacaine adverse effects, Bupivacaine analogs & derivatives, Bupivacaine therapeutic use, Cell Proliferation, Female, Fibrosis, Hydroxyproline analysis, Hydroxyproline metabolism, Levobupivacaine, Postoperative Period, Rats, Rats, Wistar, Skin chemistry, Sutures, Tensile Strength, Wounds and Injuries metabolism, Anesthetics, Local therapeutic use, Wound Healing drug effects, Wounds and Injuries pathology
- Abstract
Background: Local anesthetic infiltration along the incision may be used to provide surgical anesthesia or postoperative analgesia. However, the effect of local anesthetics on wound healing remains controversial. In this investigation, we evaluated the effects of levobupivacaine on wound healing., Methods: Sixty Wistar albino female rats weighing 230±20 g were included, with 10 rats in each group: group early c (early control): 3 mL isotonic saline; group early l1.25 (early levobupivacaine 1.25): 1.25 mg/kg per 3 mL levobupivacaine; group early l2.5 (early levobupivacaine 2.5): 2.5 mg/kg per 3 mL levobupivacaine; group late c (late control): 3 mL isotonic saline; group late l1.25 (late levobupivacaine 1.25): 1.25 mg/kg per 3 mL levobupivacaine; and group late l2.5 (late levobupivacaine 2.5): 2.5 mg/kg per 3 mL levobupivacaine. Rats in groups early c to early l2.5 were euthanized on the 8th day. Rats in groups late c to late l2.5 were euthanized on the 21st day. Wound tension strength, tissue hydroxyproline, and fibrotic index levels of the tissue samples from the early c and early l2.5 and late c and late l2.5 groups, respectively, on the 8th and 21st days were examined., Results: Levobupivacaine decreased wound tension strength on the 8th day, especially a 2.5 mg/kg dose (P<0.001), and increased it on the 21st day (P<0.001). It also increased the inflammatory response (P<0.001) and collagen synthesis (8th day, P=0.109; 21st day, P=0.103) on both the 8th and 21st days., Conclusions: While levobupivacaine had a positive effect on wound healing during the early period, negative effects were observed thereafter. Additional studies at the molecular level are necessary to determine the cause of these apparently opposite effects.
- Published
- 2013
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29. Cystic duct cyst: Report of one case.
- Author
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Kesici U, Kesici S, and Tüten A
- Subjects
- Bile Duct Diseases complications, Cholangiopancreatography, Magnetic Resonance, Cysts complications, Humans, Male, Middle Aged, Pancreatitis etiology, Pancreatitis therapy, Bile Duct Diseases diagnosis, Cystic Duct, Cysts diagnosis
- Abstract
Cystic duct cyst is an extremely rare anomaly. The classification developed by Tadoni is used for the other bile duct anomalies, but cystic duct cysts are excluded from this classification. In this case report, acute pancreatitis was diagnosed based on the clinical and laboratory findings of the patient, who presented with a complaint of nonspecific abdominal pain. Cystic duct cyst was determined with magnetic resonance cholangiopancreatography performed after determination of a cystic lesion on the neck of the gallbladder by abdominal ultrasonography. Cystic duct cyst is an extremely rare anomaly, and advanced examination is required for the diagnosis.
- Published
- 2013
- Full Text
- View/download PDF
30. A Case of Traumatic Asphyxia due to Motorcycle Accident.
- Author
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Kamali S, Kesici S, Gunduz I, and Kesici U
- Abstract
Background. Perthe's syndrome (traumatic asphyxia) is rare, which is caused by sudden compressive chest trauma and characterized by subconjunctival hemorrhage, facial edema, craniocervical cyanosis, and petechiae on the upper chest and face and should always be kept in mind as a possible complication of injuries of the chest and abdomen. Case Report. In this case report a 36-years-old male patient brought to the emergency room due to thorax trauma related to motorcycle accident was discussed. Distinct cyanotic, edematous, and multiple petechiae were present on the face, neck, and upper thorax regions of the patient. Bilateral subconjunctival hemorrhage was determined. Conclusion. Treatment for traumatic asphyxia is supportive and patient recovery is related to the generally associated injuries. Prognosis of the patients is quite good with effective and timely treatment.
- Published
- 2013
- Full Text
- View/download PDF
31. Effects of enteral and parenteral glutamine on intestinal mucosa and on levels of blood glutamine, tumor necrosis factor-alpha, and interleukin-10 in an experimental sepsis model.
- Author
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Kesici S, Turkmen UA, Kesici U, Altan A, and Polat E
- Subjects
- Animals, Enzyme-Linked Immunosorbent Assay, Female, Glutamine administration & dosage, Glutamine blood, Injections, Intraperitoneal, Rats, Rats, Wistar, Disease Models, Animal, Glutamine pharmacology, Interleukin-1 blood, Intestinal Mucosa drug effects, Sepsis blood, Tumor Necrosis Factor-alpha blood
- Abstract
Objective: To investigate the effects of enteral and parenteral glutamine (Gln) usage on rats in sepsis., Methods: This study was conducted in Istanbul University Experimental Medical Research Institution (DETAE) laboratory, Istanbul University, Istanbul, Turkey between June and September 2009. The levels of blood Gln, tumor necrosis-alpha (TNF-alpha) and interleukin (IL)-10 was measured. Samples of tissue were obtained from the mesenteric lymph nodes, liver, and lower lobe of the right lung to evaluate the reproduction of bacteria, and samples of tissue were also obtained from the small intestine to evaluate blood and villus atrophy., Results: Bacteremia of Group EP (combined group) were found lower than Group C (control) (p=0.007). Villous atrophy rates of all groups were lower than Group C: between Group E (enteral) and C (p=0.003); between Group P (parenteral alanine) and C (p=0.019); and between Group EP and C (p=0.001). The values of serum TNF-alpha and IL-10 of Group EP and P were lower than the other groups at the 24th and 96th hours (p=0.000)., Conclusion: In this study we found that the most efficient Gln administration technique in sepsis was enteral administration together with parenteral administration due to trophic effect on the intestinal mucosa, decrease of reproduction in tissue and blood cultures, immunomodulator effect, and approximately the same cost as parenteral application.
- Published
- 2012
32. Primary cutaneous umbilical endometriosis.
- Author
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Kesici U, Yenisolak A, Kesici S, and Siviloglu C
- Subjects
- Adult, Endometriosis surgery, Female, Humans, Skin Diseases surgery, Endometriosis diagnosis, Skin Diseases diagnosis, Umbilicus surgery
- Abstract
Introduction: Primary umbilical endometriosis a rare case. It is mostly seen in women in the reproductive age group., Case Report: In this case report, a 38 year old woman is discussed who received antibiotherapy for omphalitis diagnosis established due to many complaints of umbilical secretion but who was diagnosed with primary umbilical endometriosis after histopathological examination., Conclusion: Endometriosis must be certainly considered in differential diagnosis in especially inflammatory lesions resistant to noncyclic treatment, determined in umbilical region.
- Published
- 2012
- Full Text
- View/download PDF
33. Effects of intra-abdominal pressure increase on intestinal ischemia and bacterial translocation in experimental sepsis model.
- Author
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Kesici U, Kesici S, Polat E, Agca B, Turkmen UA, Ozcan D, and Sari MK
- Subjects
- Animals, Female, Laparoscopy adverse effects, Peritonitis, Rats, Rats, Wistar, Bacterial Translocation, Intestines blood supply, Ischemia etiology, Pneumoperitoneum, Artificial adverse effects, Pressure adverse effects
- Abstract
Objective: To investigate the safety of laparoscopic intervention for diagnosis and treatment at 8 mm Hg pressure in one-hour period on acute peritonitis related intra-abdominal sepsis model., Methods: In this study, we included 32 female Wistar-Albino rats, weighing 250 +/- 20 g, and divided them into 4 groups. This study was conducted in Istanbul University Experimental Medical Research Institution (DETAE) laboratory from April to May 2009. Intra-abdominal sepsis was created with intraperitoneal (i.p.) one mL (109 CFU/mL) Escherichia coli (E. coli) injection, and pneumoperitoneum was formed with CO2 insufflation at 8 mm Hg pressure for one hour i.p. The rats were administered with: Group 1 - one mL i.p. isotonic saline; Group 2 - one mL i.p. isotonic saline + pneumoperitoneum; Group 3 - i.p E. coli; and Group 4 - i.p. E.coli + pneumoperitoneum. Data were analyzed using the Statistical Package for Social Sciences version 15 for Windows (SPSS Inc, Chicago, IL, USA)., Results: Fever and leukocyte values were considered high in Groups 3 and 4 compared with Groups 1 and 2 (p=0.001). The administered reproduction ratio of the E. coli strain was determined as 0% in Groups 1 and 2, and 100% in Groups 3 and 4., Conclusion: In this study, as pneumoperitoneum was formed for one hour at 8 mm Hg pressure, in case of intra-abdominal derived sepsis where emergency intervention is needed, we consider that laparoscopic approaches with low pressure may be used safely for diagnosis and treatment.
- Published
- 2011
34. Primary cyst hydatid in the neck; report of one case.
- Author
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Kesici U, Kesici S, Türkmen ÜA, Ulusoy H, Duman A, Burakgazi G, and Yavuz E
- Subjects
- Adolescent, Albendazole therapeutic use, Anthelmintics therapeutic use, Diagnosis, Differential, Echinococcosis drug therapy, Echinococcosis surgery, Female, Humans, Echinococcosis diagnosis, Neck Muscles parasitology
- Abstract
Hydatid cyst is a parasitic disease that has been recognized endemically in many countries. Although the liver and lung are the most common organs involved by the disease, it may appear rarely in other tissues as a primary disease. In the ultrasonography of the neck taken from a 17 year old case who attended with a complaint of swelling in the neck, a partly regular, bounded cystic lesion of 33x28 mm in size was reported. When the cyst was thought to be hydatid during surgical exploration, this diagnosis was confirmed by histopathological verification of the specimen obtained. Whole abdomen ultrasonography and PA Chest Radiography were taken in order to determine whether there was another focus during the postoperative period. The Echinococcus ELISA test was performed as an immunological parameter. Treatment with Albendazole began after diagnosis during the postoperative period. Although hydatid cyst most commonly involves the liver and lung, it may be detected in all body tissues. Therefore hydatid cyst must be considered in the differential diagnosis in cystic lesions that are rarely encountered in body localizations in human, living in endemic regions.
- Published
- 2011
- Full Text
- View/download PDF
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