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Statement of the Problem: The tunnel technique has shown promising results in treatment of gingival recession. Plasma rich in growth factors (PRGF) is considered effective for soft tissue regeneration since it is a rich source of growth factors. Purpose: This clinical trial aimed to assess the efficacy of PRGF along with the tunnel technique and connective tissue graft for treatment of gingival recession. Materials and Method: In this controlled clinical trial, 20 areas around anterior and posterior teeth in 3 patients with gingival recession were bilaterally selected. The tunnel technique was used with and without PRGF in the test and control groups, respectively (10 areas in each group). The keratinized gingival width (KGW), clinical attachment level (CAL), clinical probing depth (PD), cementoenamel junction (CEJ) to mucogingival junction (MGJ) distance, and the esthetic visual analog scale (EVAS) score were evaluated preoperatively and at 6 weeks and 3 months, postoperatively. The gingival recession width (RW) and vertical recession depth (VRD) were assessed preoperatively and at 2 weeks and 3 months, postoperatively. The pain visual analog scale (PVAS) score was measured at 1, 3 and 7 days, post-treatment and the healing index (HI) was measured at 1, 3 and 7 days and 1 month, postoperatively. The root coverage percentage was assessed during 3 months. Paired t-test and repeated measures ANOVA were used for statistical analyses. p Value< 0.05 was considered statistically significant. Results: Significant improvements were noted in all tested parameters in both groups (p < 0.05). The mean root coverage percentage after 6 months was 88.68% ± 20.69% and 78.77% ± 24.94% in the test and control groups, respectively. None of the tested parameters were significantly different between the two groups (p > 0.05). Conclusion: Treatment of gingival recession with the tunnel technique can yield favorable clinical outcome, irrespective of the use/no use of PRGF. [ABSTRACT FROM AUTHOR]

Objective: Diabetes mellitus (DM) as an ongoing metabolic disorder worldwide is a major public health concern. Diagnosis of DM is depended on clinical symptoms and laboratory findings. Fasting blood glucose (FBG) monitoring is currently the most common diagnostic method, which is an invasive and stressful procedure. Most recently, the use of non-invasive, convenient methods like fasting salivary glucose (FSG) has been highly regarded among researchers. The aim of present study was to evaluate the correlation of FSG with FBG in T2DM patients and healthy subjects. Materials and Methods: In this cross sectional study, glucose level was measured using the glucose oxidase/peroxidase method in blood and unstimulated saliva in 50 T2DM patients and 50 nondiabetic subjects. After determining the normality of the data, Pearson's correlation coefficient was done to assess the correlation between FBG and FSG. Results: The mean level of FBG, FSG and HbA1c of diabetic group were 161.00±5.6, 12.80±0.80 and 8.00±0.3 which were significantly higher than non-diabetic subjects (74.75±4.3, 6.5±0.75, 5.2±0.2.7, Pvalue: 0.001). The Pearson's correlation coefficient showed significantly strong relationship between FBS and FSG in both groups (P-value: 0.005). Conclusion: This study demonstrated the presence of a significant correlation between FSG and FBG. Therefore, FSG level may be used as a non- invasive method to evaluate blood glucose in T2DM patients and healthy subjects. [ABSTRACT FROM AUTHOR]

Objective: Dental caries is considered as one of the major complication of diabetes mellitus. Patients with type 2 diabetes mellitus (T2DM) demonstrate evidence of oxidant-antioxidant imbalances in their biological fluids such as saliva. The aim of this study was to evaluate the correlation of oral health status and salivary total antioxidant capacity (TAC) in T2DM. Materials and Methods: Fifty T2DM patients and 50 healthy subjects were selected as study sample. Oral examination to assess the dental caries experience was carried out according decayed, missing and filled teeth (DMFT) index. Unstimulated whole saliva specimens were collected in the morning. TAC of saliva was evaluated by spectrophotometric assay. Statistical analysis was performed using an independent two-sample t test and Pearson's correlation test, by SPSS 18. Results: The mean level of TAC in T2DM was lower than healthy people (P-value: 0.0001). The mean of DMFT scores in T2DM were significantly higher than non-diabetics (P-value: 0.0001). Moreover, there was a significant negative correlation between TAC level and DMFT scores in both groups (P-value: 0.006). Conclusion: TAC of saliva could be a marker of dental caries activity among T2DM and healthy adults. Therefore, in order to decrease the risk of oxidative damage, it is recommended that T2DM patients take more natural antioxidant food. [ABSTRACT FROM AUTHOR]

Background: The aim of this study was to compare the clinical, histological, and histomorphometrical outcomes of CenoBone® allograft with and without plasma rich in growth factor (PRGF) for the preservation of edentulous ridge in the dental sockets. Materials and Methods: This study is experimental clinical trial that 14 dental sockets were included the sockets required ridge preservation followed by implant placement in the premolar and molar of the mandible. After extraction of the teeth, the CenoBone® allograft and PRGF were used in the test group and CenoBone® allograft was used alone in the control group. During the first stage of surgery and 5 months later, in the second stage of surgery (implant placement), the vertical changes of the ridge were measured. Furthermore, using Core-Biopsy in the second stage of surgery, criteria of histologic and histomorphometric were determined. Data were analyzed with t-test, Mann–Whitney U-test, and Fisher's exact test at the level of significance of P < 0.05. Results: The mean trabecular thickness in the test group (52.18 ± 5.53) was significantly higher than that in the control group (41.53 ± 10.40) (P = 0.344). However, there were no significant differences in the mean values of vertical bone absorption, bone percentage, remaining biomaterials, inflammation, and blood vessels between the two groups. There was no case of foreign body reaction and the bone was vital in all the cases and in direct contact with the biomaterial. Conclusion: Although CenoBone® allograft with PRGF was effective in some histomorphometric factors such as trabecular thickness, it did not lead to significant clinical changes. [ABSTRACT FROM AUTHOR]

Background: The aim of this study was to compare the clinical, histological, and histomorphometrical outcomes of CenoBone ® allograft with and without plasma rich in growth factor (PRGF) for the preservation of edentulous ridge in the dental sockets., Materials and Methods: This study is experimental clinical trial that 14 dental sockets were included the sockets required ridge preservation followed by implant placement in the premolar and molar of the mandible. After extraction of the teeth, the CenoBone ® allograft and PRGF were used in the test group and CenoBone ® allograft was used alone in the control group. During the first stage of surgery and 5 months later, in the second stage of surgery (implant placement), the vertical changes of the ridge were measured. Furthermore, using Core-Biopsy in the second stage of surgery, criteria of histologic and histomorphometric were determined. Data were analyzed with t -test, Mann-Whitney U -test, and Fisher's exact test at the level of significance of P < 0.05., Results: The mean trabecular thickness in the test group (52.18 ± 5.53) was significantly higher than that in the control group (41.53 ± 10.40) ( P = 0.344). However, there were no significant differences in the mean values of vertical bone absorption, bone percentage, remaining biomaterials, inflammation, and blood vessels between the two groups. There was no case of foreign body reaction and the bone was vital in all the cases and in direct contact with the biomaterial., Conclusion: Although CenoBone ® allograft with PRGF was effective in some histomorphometric factors such as trabecular thickness, it did not lead to significant clinical changes., Competing Interests: The authors of this manuscript declare that they have no conflicts of interest, real or perceived, financial or nonfinancial in this article., (Copyright: © 2023 Dental Research Journal.)