141 results on '"Keshava SN"'
Search Results
2. Location of the Internal Mammary Arteries in Relation to the Lateral Border of the Sternum: A Key to Avoid Injury during Computed Tomography-Guided Biopsy of Anterior Mediastinal Masses
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Gurijala, PR, primary, Punnen, GE, additional, Mani, T, additional, and Keshava, SN, additional
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- 2022
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3. Transient Blindness after Endovascular Parent Artery Occlusion to Treat Giant Aneurysm of Internal Carotid Artery: a Case Report
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Padmanabhan, A, primary, Keshava, SN, additional, Ahmed, M, additional, and Moorthy, RK, additional
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- 2021
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4. Use of ultrasound for assessment of musculoskeletal disease in persons with haemophilia: Results of an International Prophylaxis Study Group global survey
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Ignas DM, Doria AS, von Drygalski A, Blanchette VS, Chang EY, Dover S, Fischer K, Gibikote S, Keshava SN, Querol F, Abad A, and Babyn P
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genetic structures ,haemarthrosis, haemophilia, outcome assessment, ultrasound - Abstract
The objective of this survey was to understand the global trends of imaging assessments in persons with haemophilia, focusing on point-of-care ultrasound (POCUS). Insights into the barriers impeding its widespread proliferation as a frontline imaging modality were obtained.
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- 2020
5. Aortic coarctation associated with an absent segment of the proximal right subclavian artery
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Jasper, A, primary and Keshava, SN, additional
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- 2014
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6. Evaluation of normal abdominal aortic diameters in the Indian population using computed tomography
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Jasper, A, primary, Harshe, G, additional, Keshava, SN, additional, Kulkarni, G, additional, Stephen, E, additional, and Agarwal, S, additional
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- 2014
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7. Gastrointestinal: Aortoenteric fistula
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Koshy, AK, primary, Simon, EG, additional, and Keshava, SN, additional
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- 2010
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8. Jejunal access loop cholangiogram and intervention using image guided access
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Amitha Vikrama, KS, primary, Keshava, SN, additional, Surendrababu, NRS, additional, Moses, V, additional, Joseph, P, additional, Vyas, F, additional, and Sitaram, V, additional
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- 2010
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9. Anatomical variations of the internal jugular veins and their relationship to the carotid arteries: A CT evaluation
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Lim, CL, primary, Keshava, SN, additional, and Lea, M, additional
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- 2006
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10. Endovascular management of posttraumatic arteriovenous fistulae.
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Koshy CG, Keshava SN, Surendrababu NR, Moses V, Stephen E, and Agarwal S
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- 2009
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11. Endovascular management of carotid-cavernous fistula in Ehlers-Danlos syndrome Type IV.
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Mammen S, Keshava SN, Danda S, Raju R, and Chacko AG
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- 2012
12. Cannula-assisted and transabdominal ultrasound-guided hepatic venous recanalization in Budd Chiari syndrome: a novel technique to avoid percutaneous transabdominal access.
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Keshava SN, Moses V, Surendrababu NR, Keshava, Shyamkumar N, Moses, Vinu, and Surendrababu, Narayanam R S
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We describe a technique for facilitating recanalization of hepatic veins via the transjugular approach in patients with Budd Chiari syndrome, where a transjugular liver biopsy cannula provides support to the catheter-glidewire combination and transabdominal ultrasound helps in positioning the tip of the cannula at the hepatic venous ostium. [ABSTRACT FROM AUTHOR]
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- 2009
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13. Radiology for the surgeon: Soft-tissue case 57. Superior mesenteric vein thrombosis.
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Irodi A, Keshava SN, Govil S, Mathew G, Stein LA, Irodi, Aparna, Keshava, Shyamkumar N, Govil, Shalini, and Mathew, George
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- 2005
14. In an era of EUS-guided interventions, direct glue injection remains relevant in management algorithm for bleeding isolated gastric varices -1.
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Bharadwaj PK, Kumar SE, Chowdhury SD, Simon EG, Keshava SN, Joseph AJ, Kurien RT, Zachariah UG, and Goel A
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- 2024
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15. International Prophylaxis Study Group (IPSG) haemophilia joint MRI scale version 2.0.
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Lundin B, Bakeer N, Dunn AL, Gibikote S, Keshava SN, Ljung RCR, Papakonstantinou O, Pergantou H, Strike K, Drygalski AV, Zhang N, Babyn P, Dover S, and Doria AS
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- Humans, Joints diagnostic imaging, Hemophilia A, Magnetic Resonance Imaging methods
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- 2024
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16. Surgical strategies in the management of aggressive spinal haemangiomas: Retrospective case series with literature review and a practical treatment algorithm.
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Swaminathan G, Jonathan GE, Mani SA, Keshava SN, Moses V, and Prabhu K
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Purpose: We studied the clinico-radiological features and treatment outcomes of patients with aggressive spinal haemangiomas., Methods: We undertook a retrospective review of 24 patients with aggressive spinal haemangiomas managed at our centre from 2004 to 2016. The cohort was divided into two groups. Group1 included patients managed from 2004 to 2009 while Group 2 was those treated between 2010 and 2016. Clinicoradiological features and treatment outcomes were studied., Results: Back pain (24/24) and myelopathy (18/24) were the most common presenting complaints. Over 80% (20/24) of patients, had involvement of the thoracic spine and more than 50% (13/24) had severe spasticity, being Nurick grade 4&5 at presentation. The various treatment modalities used were laminectomy with or without instrumented posterior fusion (10/24), corpectomy with instrumented fusion (10/24) and alcohol injection alone (4/24). Patients who were treated with surgery had significant clinical improvement at follow-up in both groups. Patients who underwent alcohol injection did not have any improvement in symptoms at follow-up. There was a change in our strategy in the later part of the series from a two staged anterior and posterior approach to a single staged posterior-only approach to address vertebral body disease with preoperative angioembolization., Conclusion: Haemangiomas are benign lesions with locally aggressive behavior in some cases. Results of conservative approaches such as alcohol injection in management of these lesions are discouraging. Aggressive surgical decompression combined with preoperative adjuncts such as angioembolization with or without stabilization reduces intra operative blood loss and results in good neurological recovery even in patients with severe myelopathy., Competing Interests: All authors certify that they have no affiliations with or involvement in any organization or entity with any financial interest (such as honoraria; educational grants; participation in speakers; bureaus; membership, employment, consultancies, stock ownership, or other equity interest; and expert testimony or patent-licensing arrangements), or non-financial interest (such as personal or professional relationships, affiliations, knowledge or beliefs) in the subject matter or materials discussed in this manuscript., (© 2023 The Authors.)
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- 2023
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17. UDHAVI Community Support During India's Second COVID-19 Wave: A Descriptive Study on a Tertiary Care Center's Pandemic Response Helpline.
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Sasidharan BK, James RI, Sathyendra S, Harsh R, Jeba Sundararaj J, Ravindran V, T HMT, Ashok N, Thirunavukkarasu MM, Punitha JV, George TK, Isaac BTJ, Zechariah AJ, David SNJ, Yesupatham DP, Irodi A, Aruldas V, Keshava SN, Zachariah A, Kang G, and Mammen JJ
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- Humans, Pandemics, Retrospective Studies, Community Support, Tertiary Care Centers, COVID-19 epidemiology
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Background: In April 2021, during the peak of the second wave of the COVID-19 pandemic in India, hospitals overflowed with COVID-19 patients, and people hesitated to seek necessary care due to fear of contracting the disease. The UDHAVI helpline was set up by a tertiary care hospital in Vellore with the help of district administration, nongovernmental organizations, and various supporting agencies to provide general information, medical advice, counseling, and logistics support to the community., Methods: This is a retrospective study of all the phone calls made to the UDHAVI helpline between mid-May and mid-June 2021 during the second wave of the COVID-19 pandemic. The calls were electronically captured as part of the process, and the information was subsequently retrieved and analyzed., Results: In all, 677 calls were received. The lines for general information, medical advice, counseling, and logistics support received 168 (25%), 377 (56%), 15 (2%), and 117 (17%) calls, respectively. Home care kits, oxygen concentrators, and food were delivered by volunteers from local nongovernmental organizations and hospitals., Conclusion: We believe the details of our experience would be useful in the preparedness and mobilization of resources in the event of any public health emergency. As a result of this initiative, we propose an integrated partnership model for emergency response to any pandemic situation., (© Sasidharan et al.)
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- 2023
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18. Correlation Between Post-Radiosurgery Perinidal Hyperintensity and AVM Obliteration Following LINAC-Based Stereotactic Radiosurgery.
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Ganesh S, Jasper A, Backianathan S, Moorthy RK, Balakrishnan R, Sebastian P, Moses V, Godson HF, Keshava SN, and Rajshekhar V
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- Humans, Male, Adolescent, Young Adult, Adult, Female, Follow-Up Studies, Treatment Outcome, Retrospective Studies, Radiosurgery adverse effects, Radiosurgery methods, Intracranial Arteriovenous Malformations diagnostic imaging, Intracranial Arteriovenous Malformations radiotherapy, Intracranial Arteriovenous Malformations surgery
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Objective: We studied the correlation between new-onset perinidal hyperintensity (PH) on T2-weighted magnetic resonance imaging and obliteration of intracranial arteriovenous malformation (AVM) after stereotactic radiosurgery (SRS)., Methods: A retrospective study of 148 patients with an intracranial AVM who underwent SRS between September 2005 and June 2018 and had ≥1 radiological follow-up (early magnetic resonance imaging) 12-18 months after SRS was performed to analyze the correlation between PH (graded from 0 to 2) and AVM obliteration., Results: Of the 148 patients, 95 were male. The mean patient age was 27.7 ± 12.4 years. Of the 148 AVMs, 105 (70.9%) were obliterated at a median follow-up of 27 months (interquartile range, 14-48 months). The cumulative 3-, 5-, 10-year obliteration rate was 51.8%, 70.8%, and 91.8%, respectively. New-onset PH was observed in 58 AVMs (39.2%; 50 obliterated and 8 not obliterated). No association was found between the pretreatment variables or dose delivered and the development of PH. Grade 2 PH was associated with the risk of symptoms developing compared with grade 1 PH (37.5% vs. 4%; P = 0.002). Symptomatic PH was more likely to develop in patients with a larger AVM (P = 0.05). On multivariate analysis, the presence of a single draining vein (odds ratio [OR], 2.9; 95% confidence interval [CI], 1.3-6.8), a lower median AVM volume (OR, 0.97; 95% CI, 0.6-0.89), a mean marginal radiation dose (OR, 1.29; 95% CI, 1.02-1.64), and the presence of PH (OR, 3.16; 95% CI, 1.29-7.71) were independent predictors of AVM obliteration., Conclusions: The incidence of PH after SRS for AVM was 39.2%. PH was an independent predictor of AVM obliteration after SRS. Grade 2 PH and a larger AVM volume were associated with symptomatic PH., (Copyright © 2023 Elsevier Inc. All rights reserved.)
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- 2023
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19. A Survey on Factors Influencing the Work-Family-Health Balance of an Interventional Radiologist.
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Haridass S, Kalva S, Yadav B, and Keshava SN
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Aim: Burnout and stress-related health disorders are on the rise among physicians. The aim of this study is to report the results of a survey on factors affecting the work-life balance of interventional radiologists (IR). Material: The survey consisted of 30 questions focusing on work, family, and personal health. The questionnaire addressed knowledge, attitude, and practice. This online survey was sent to IRs across the globe and the responses were analyzed by three IRs (SH, SNK, SK). Results: On univariate analysis, the major risk factors for burnout were presence of weekend duties ( n = 91, 98.9%, p = 0.02), absence of support group at workplace ( n = 36, 39.1%, p = 0.005), having tough time with administration ( n = 61, 66.3%, p = 0.001), not able to spend quality time on family ( n = 30, 32.6%, p = 0.035), and inability to find time to do things that one enjoys ( n = 53, 57.6%, p = 0.0002). However, multivariate analysis revealed that those having tough time with administration (odds ratio = 2.77 [95% confidence interval [CI]: 1.12-6.48], p = 0.02) and those who could not find time to do things one enjoys (odds ratio = 4.79 [95% CI: 1.42-16.1], p = 0.01) were only statistically significant. Conclusion: Burnout is common among IRs and is considered a significant issue that needs to be addressed. Teamwork, a support structure for major events, healthy lifestyle, and dedicated time for family may combat the burnout., Competing Interests: Conflict of Interest None declared., (Indian Radiological Association. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. ( https://creativecommons.org/licenses/by-nc-nd/4.0/ ).)
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- 2023
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20. Computed Tomography-Guided Spinal Biopsy in Suspected Infective Spondylodiscitis: An Institutional Review of Its Utility.
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Ravichandran RCA, Amritanand R, Moses V, Kandagaddala M, Krishnan V, David KS, Arockiaraj J, Kulasekaran H, Ganesan MP, Prabhu AJ, and Keshava SN
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Background Infectious spondylodiscitis is a debilitating condition and evidence-based medicine dictates confirming the diagnosis before treatment. Computed tomography-guided spinal biopsy plays a major role and hence we would like to determine its utility in current clinical practice. Purpose The purpose of this study is to determine the percentage of confirmatory positives of CT-guided spinal biopsy in patients who were clinicoradiologically diagnosed with infectious spondylitis. Material and Methods A retrospective analysis of patients who underwent CT-guided biopsy for suspected infectious spondylodiscitis from 2017 to 2021 in a tertiary medical center was done. The data were filtered and obtained from the electronic database of the institution. Results In all, 259 patients underwent CT-guided biopsy of the spine. The procedure provided confirmatory results in 149 (57.5%) biospecimens. Histopathology examination was confirmatory in 95 (36.6%) of the 241 biospecimens sent. The Mycobacteria Growth Indicator Tube (MGIT) was confirmatory in 51 (19.9%) of the 250 biospecimens sent and drug resistance was seen in 6/51 (11.7%) biospecimens. Xpert TB provided confirmatory results in 72 (27.8%) of the 254 biospecimens sent and rifampicin resistance was seen in 16/72 (22.2%) biospecimens. Bacterial culture was confirmatory in 29 (11.2%) of the 250 biospecimens sent. The complication documented in this study was 0.3%. Conclusion CT-guided spinal biopsy for suspected vertebral osteomyelitis is a safe and effective minimally invasive procedure. It demonstrates a positive yield in more than half of the patients. Knowing the outcome, the patients can be appropriately counseled prior to the procedure. CT-guided biopsy results were affected by prior administration of ATT (antitubercular therapy) in suspected tuberculous spondylitis patients., Competing Interests: Conflict of Interest None declared., (Indian Radiological Association. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. ( https://creativecommons.org/licenses/by-nc-nd/4.0/ ).)
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- 2023
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21. Society of Chest Imaging and Interventions Consensus Guidelines for the Interventional Radiology Management of Hemoptysis.
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Singhal R, K B SB, Naranje P, Kazimi J, Garg PK, Chandra D, Popat BA, Shetty NS, Gorsi U, Vimala LR, Khera PS, Irodi A, Kulkarni S, Keshava SN, and Bhalla AS
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The recommendations from the Society of Chest Imaging and Interventions expert group comprehensively cover all the aspects of management of hemoptysis, highlighting the role of diagnostic and interventional radiology. The diversity existing in etiopathology, imaging findings, and management of hemoptysis has been addressed. The management algorithm recommends the options for effective treatment while minimizing the chances of recurrence, based on the best evidence available and opinion from the experts., Competing Interests: Conflict of Interest None declared., (Indian Radiological Association. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. ( https://creativecommons.org/licenses/by-nc-nd/4.0/ ).)
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- 2023
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22. Efficacy of Shadow-Based Needle Positioning System in Performing CT Image-Guided Percutaneous Biopsy of Lung Lesions: Our Initial Experience.
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Keshava SN, Moses V, and Padmanabhan A
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Context Computerized tomography (CT) is widely used for various interventions and there is a need for an effective navigation tool, for best outcomes. Aim The study was performed to evaluate the efficacy of light- and shadow-based needle positioning assistance device, an innovative navigation tool over the conventional freehand technique, in performing CT image-guided percutaneous interventions. Settings and Design This randomized control trial was performed among patients undergoing CT-guided percutaneous intervention for lung pathologies. Methodology A total of 60 participants were randomized into an intervention group and a control group. The accuracy of needle insertion and other efficacy parameters were assessed for both groups. Post needle placement, CT images were used to evaluate the study endpoints. Statistical Analysis Statistical analysis was performed using SPSS ver. 20 software. Results The mean needle positioning accuracy was 2.1 mm in the experimental group compared with 7.2 mm in the control group freehand procedures. The average time to position the needle at the desired target location was 2.5 minutes in the assisted procedure as compared with 5.3 minutes in the freehand procedure ( p < 0.05). The total number of check scans required to position the needle was 1.3 for assisted procedures and 1.9 for freehand procedures. Conclusion The use of shadow-based assistance device for CT-guided interventions is proven to be efficient and safer with high needle positioning accuracy., Competing Interests: Conflicts of Interest None declared., (Indian Radiological Association. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. ( https://creativecommons.org/licenses/by-nc-nd/4.0/ ).)
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- 2022
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23. De novo arteriovenous malformations in post-thrombotic limbs.
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Kota PB, Kota AA, Agarwal S, and Keshava SN
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- Angioplasty, Female, Humans, Iliac Artery diagnostic imaging, Iliac Vein diagnostic imaging, Middle Aged, Arteriovenous Malformations complications, Arteriovenous Malformations diagnostic imaging, Arteriovenous Malformations surgery, Thrombosis
- Abstract
A 50-year-old woman presented with progressive, painful and disabling swelling of the left lower limb following a left ovarian cyst excision 2 years ago. She had gross oedema of the left lower limb with multiple pubic varices. Contrast-enhanced CT and digital subtraction imaging revealed diffuse arteriovenous malformation (AVM) with feeders from the left internal iliac artery and a short segment significant stenosis of the proximal left common iliac vein. She underwent angioplasty and stenting of the left iliac vein. Her symptoms dramatically improved following the procedure and her limb swelling regressed within 6 months. The occurrence of post-thrombotic AVMs has been long established in the dural and portal systems. This report deals with an analogous phenomenon following iatrogenic deep venous thrombosis of the left lower limb, its pathogenesis, natural history and a review of treatment options., Competing Interests: Competing interests: None declared., (© BMJ Publishing Group Limited 2022. No commercial re-use. See rights and permissions. Published by BMJ.)
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- 2022
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24. Biopsy with Side-Cutting Coaxial Needle-Knowing the "Cutting Length" and "Throw Length".
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Patra A and Keshava SN
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Image-guided Trucut biopsy is a well-established procedure. The length of the side notch in the stylet is the "cutting length," which entraps the tissue sample and contributes to the yield. The total distance by which the inner stylet protrudes from the outer cannula with the cutting notch open is the "throw length." It is inevitably longer than the cutting length does not add to the yield of the sample, but potentially to the complication of the procedure. The authors highlight the importance of knowing this distinction to minimize complications during the procedure., Competing Interests: Conflicts of Interest There are no conflicts of interest., (Indian Radiological Association. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. ( https://creativecommons.org/licenses/by-nc-nd/4.0/ ).)
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- 2022
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25. Technical and Medium-Term Clinical Outcomes of Transjugular Intrahepatic Portosystemic Shunt with Fluoroscopy and Additional Trans-abdominal Ultrasound Guidance.
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Keshava SN, Moses V, Sharma A, Ahmed M, Narayanan S, Padmanabhan A, Goel A, Zachariah U, and Eapen CE
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Background and Objective The aim of the study is to evaluate the technical and clinical outcomes of transjugular intrahepatic portosystemic shunt (TIPS) performed with additional transabdominal ultrasound guidance. Material and Methods Patients who underwent TIPS between January 2004 to January 2020 in our center were studied. Technical, hemodynamic, angiographic, and clinical outcome were recorded up to 1 year of follow-up. Results TIPS was attempted in 162 patients (median [range] age 37[3-69] years; 105 were males and 57 were females; Etiology: Budd-Chiari syndrome [BCS] 91, cirrhosis 65, symptomatic acute portal venous thrombosis [PVT] 3, veno-occlusive disease [VOD] 2, congenital portosystemic shunt [CPSS] 1) during the study period. Indication for TIPS was refractory ascites in 135 patients (BCS 86, cirrhosis 49) and variceal bleed in 21 patients (BCS 5, cirrhosis 16). Technical success was seen in 161 of the 162 (99.4%) patients. The tract was created from hepatic vein in 55 patients and inferior vena cava (IVC) in 106 patients. Complications within 1 week post TIPS were seen in 29 of the 162 (18%) patients, of whom one developed unexplained arrhythmia and hypotension and died. Of the patients with available follow-up, clinical success was noted in 120 (81%), while 14 (9%) patients had partial nonresponse and six (4%) had complete nonresponse. Eight (5%) patients died during the follow-up period. Conclusion The technical success of TIPS creation with additional transabdominal ultrasound guidance is very high with low peri-procedural complication rate. It has enabled the inclusion of a wider spectrum of cases like acute PVT and obliterated hepatic veins which were otherwise considered contraindications., Competing Interests: Conflict of Interest None declared., (Indian Radiological Association. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. ( https://creativecommons.org/licenses/by-nc-nd/4.0/ ).)
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- 2021
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26. Utility of spinal angiography and arterial embolization in patients undergoing CT guided alcohol injection of aggressive vertebral hemangiomas.
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Srinivasan G, Moses V, Padmanabhan A, Ahmed M, Keshava SN, Krishnan V, Joseph BV, Raju KP, and Rajshekhar V
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- Angiography, Decompression, Surgical, Humans, Retrospective Studies, Tomography, X-Ray Computed, Embolization, Therapeutic, Hemangioma surgery, Hemangioma therapy, Spinal Neoplasms surgery, Spinal Neoplasms therapy
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Purpose: The purpose of this study is to evaluate the role of spinal angiography and arterial embolization in avoiding spinal cord ischemia in patients undergoing CT-guided alcohol injection of aggressive vertebral hemangiomas., Methods: In this retrospective study, patients with vertebral hemangioma who underwent CT-guided direct alcohol injection between January 2007 and October 2018 were identified. Of 28 such patients, 26 had neurological deficits, and 2 had only back pain or radiculopathy. Direct alcohol injection without prior arterial embolization was done in 17 patients. Direct alcohol injection with prior arterial embolization was done in 11 patients. Clinical outcome was assessed immediately after the intervention and at follow-up., Results: Three patients, who underwent alcohol injection without trans-arterial embolization, had worsening of neurological deficits in the post procedure period due to spinal cord ischemia. No complications related to spinal cord ischemia were noted in the embolization group. There was no significant difference in the outcomes between the two groups if the three patients with complications are excluded (p = 0.34)., Conclusion: While CT-guided direct alcohol injection is effective in the management of symptomatic and aggressive vertebral hemangiomas, spinal angiography and trans-arterial embolization of the blood supply to the vertebral body hemangioma, prior to the direct transpedicular alcohol embolization of the lesion, improves the safety of the procedure., (© 2021. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)
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- 2021
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27. The "Inside-outside" Sign.
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Haridass S and Keshava SN
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We describe a radiological sign, "inside-outside sign," observed during the cannulation of an expandable contrast-filled tubular structure in the human body. In this optical illusion, a catheter or guidewire appears to be outside the lumen when it is inside the lumen in reality. Knowing this rare optical illusion is essential to avoid mistaking it for a catheter or guidewire outside the lumen., Competing Interests: There are no conflicts of interest., (© 2021 Published by Scientific Scholar on behalf of Journal of Clinical Imaging Science.)
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- 2021
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28. Musculoskeletal ultrasound in hemophilia: Results and recommendations from a global survey and consensus meeting.
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Bakeer N, Dover S, Babyn P, Feldman BM, von Drygalski A, Doria AS, Ignas DM, Abad A, Bailey C, Beggs I, Chang EY, Dunn A, Funk S, Gibikote S, Goddard N, Hilliard P, Keshava SN, Kruse-Jarres R, Li Y, Lobet S, Manco-Johnson M, Martinoli C, O'Donnell JS, Papakonstantinou O, Pergantou H, Poonnoose P, Querol F, Srivastava A, Steiner B, Strike K, Timmer M, Tyrrell PN, Vidarsson L, and Blanchette VS
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Introduction: For persons with hemophilia, optimization of joint outcomes is an important unmet need. The aim of this initiative was to determine use of ultrasound in evaluating arthropathy in persons with hemophilia, and to move toward consensus among hemophilia care providers regarding the preferred ultrasound protocols for global adaptation., Methods: A global survey of hemophilia treatment centers was conducted that focused on understanding how and why ultrasound was being used and endeavored to move toward consensus definitions of both point-of-care musculoskeletal ultrasound (POC-MSKUS) and full diagnostic ultrasound, terminology to describe structures being assessed by ultrasound, and how these assessments should be interpreted. Next, an in-person meeting of an international group of hemophilia health care professionals and patient representatives was held, with the objective of achieving consensus regarding the acquisition and interpretation of POC-MSKUS and full diagnostic ultrasound for use in the assessment of musculoskeletal (MSK) pathologies in persons with hemophilia., Results: The recommendations were that clear definitions of the types of ultrasound examinations should be adopted and that a standardized ultrasound scoring/measurement system should be developed, tested, and implemented. The scoring/measurement system should be tiered to allow for a range of complexity yet maintain the ability for comparison across levels., Conclusion: Ultrasound is an evolving technology increasingly used for the assessment of MSK outcomes in persons with hemophilia. As adoption increases globally for clinical care and research, it will become increasingly important to establish clear guidelines for image acquisition, interpretation, and reporting to ensure accuracy, consistency, and comparability across groups., (© 2021 The authors. Research and Practice in Thrombosis and Haemostasis published by Wiley Periodicals LLC on behalf of International Society on Thrombosis and Haemostasis(ISTH).)
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- 2021
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29. An Update on the Management of Budd-Chiari Syndrome.
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Sharma A, Keshava SN, Eapen A, Elias E, and Eapen CE
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- Angioplasty trends, Budd-Chiari Syndrome physiopathology, Endovascular Procedures trends, Humans, Liver Transplantation trends, Thrombolytic Therapy trends, Budd-Chiari Syndrome diagnostic imaging, Budd-Chiari Syndrome therapy, Disease Management
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Budd-Chiari syndrome (BCS) is an uncommon condition, caused by obstruction to hepatic venous outflow. It is largely underdiagnosed, and a high index of suspicion is required for any patient with unexplained portal hypertension. The understanding of its etiology and pathology is improving with advances in diagnostic techniques. Recent studies reported an identifiable etiology in > 80% of cases. Myeloproliferative neoplasm (MPN) is the most common etiology, and genetic studies help in diagnosing latent MPN. Better cross-sectional imaging helps delineate the site of obstruction accurately. The majority of BCS patients are now treated by endovascular intervention and anticoagulation which have improved survival in this disease. Angioplasty of hepatic veins/inferior vena cava remains under-utilized at present. While surgical porto-systemic shunts are no longer done for BCS, liver transplantation is reserved for select indications. Some of the unresolved issues in the current management of BCS are also discussed in this review.
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- 2021
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30. Imaging criteria to predict Shamblin group in carotid body tumors - revisited.
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Jasper A, Mammen S, Gowri MS, Keshava SN, and Selvaraj D
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- Blood Loss, Surgical, Humans, Retrospective Studies, Treatment Outcome, Vascular Surgical Procedures, Carotid Body Tumor diagnostic imaging, Carotid Body Tumor surgery
- Abstract
Purpose: This study aims to compare the imaging findings of carotid body tumors on contrast-enhanced computed tomography (CT) with the intraoperative Shamblin grade and to evolve an imaging-based scoring system that can accurately predict the Shamblin grade., Methods: Preoperative contrast-enhanced CT scans of 40 patients who underwent surgical excision of carotid body tumors in our institution between 2004 and 2017 were retrospectively reviewed. The angle of contact with the internal carotid artery (ICA), tumor volume, presence of peritumoral tuft of veins, loss of tumor adventitia interface and distance from the skull base were assessed and compared with the intraoperative Shamblin grades of the tumor. Ordinal logistic regression was used to determine which parameters could be predictors of the Shamblin grades. Receiver operator characteristic (ROC) curves were used to score the tumor volumes., Results: Among the 42 tumors evaluated, 6 (14.3%) were surgically classified as Shamblin I, 15 (35.7%) as Shamblin II, and 21 (50%) as Shamblin III tumors. Pairwise comparison between the three Shamblin groups showed a statistically significant difference for angle of contact with ICA, maximum tumor dimension, presence of peritumoral tuft of veins and loss of tumor adventitia interface (p = 0.001, p = 0.001, p = 0.038 and p = 0.003, respectively). However, tumor volumes and distance from skull base were not significantly different between the Shamblin groups (p = 0.136 and p = 0.682). A scoring system, including four of the above mentioned parameters (angle of contact with ICA, tumor volume, presence of peritumoral tuft of veins, and loss of tumor adventitia interface) was developed with a maximum score of 8 and a minimum of 2. A statistically significant difference was found between the final scores among the three Shamblin groups (p < 0.001). Using ROC curves, a final score of ≥6 was found to separate Shamblin grade III tumors from grade I and II tumors (sensitivity, 95.24%; specificity, 71.43%). All patients with documented intraoperative estimated blood loss of >1000 mL had Shamblin grade III tumors. Postoperative complications like stroke, ICA thrombosis and lower cranial nerve palsies were seen only with Shamblin grade II and III tumors., Conclusion: The simple scoring system we have proposed correlates well with the Shamblin grade and helps in identifying patients who have a higher risk of developing complications.
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- 2021
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31. Ultrasound and magnetic resonance imaging for the detection of blood: An ex-vivo study.
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Regi SS, Livingstone RS, Kandagaddala M, Poonnoose P, Gibikote S, Keshava SN, and Srivastava A
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- Humans, Magnetic Resonance Imaging, Reproducibility of Results, Ultrasonography, Hemarthrosis, Hemophilia A diagnostic imaging
- Abstract
Objectives: Early detection of bleeding into a joint is crucial in patients with haemophilia. This study was designed to evaluate the sensitivity of ultrasonography (USG) and magnetic resonance imaging (MRI) to detect the presence of blood in small concentrations in a simulated model to mimic joint bleeding., Materials and Methods: Different concentrations of blood in plasma, varying from 0.1% to 45%, were collected in 10-ml plastic syringes and imaged using 12 and 18 MHz USG transducers and with 1.5T and 3T MRI scanners, at different intervals of time following dilution. The images were scored for the presence of blood by four experienced radiologists who were blinded to the concentration of blood., Results: Within the first 2 h, the 18 MHz transducer was able to detect blood consistently up to 0.5%, whereas the 12 MHz transducer could consistently identify blood up to 1.4%. After the first 12 h, both transducers were able to detect blood up to 0.5% concentration. However, at concentrations below 0.5%, there was discordance in the ability to detect blood, with both transducers. There was no correlation between the signal intensities of MRI images and concentration of blood, at different time intervals, irrespective of the magnetic field strength., Conclusions: Detection of blood using the USG is dependent on variables such as the concentration of blood, frequency of the transducer used and timing of the imaging. As the concentration of blood decreases below 0.5%, the discordance between the observers increases, implying that the detection limit of USG affects its reliability at lower concentrations of blood. Caution is urged while interpreting USG imaging studies for the detection of blood in symptomatic joints., (© 2021 John Wiley & Sons Ltd.)
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- 2021
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32. Radiology Reporting Errors: Learning from Report Addenda.
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Patra A, Premkumar M, Keshava SN, Chandramohan A, Joseph E, and Gibikote S
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Background The addition of new information to a completed radiology report in the form of an "addendum" conveys a variety of information, ranging from less significant typographical errors to serious omissions and misinterpretations. Understanding the reasons for errors and their clinical implications will lead to better clinical governance and radiology practice. Aims This article assesses the common reasons which lead to addenda generation to completed reports and their clinical implications. Subjects and Methods Retrospective study was conducted by reviewing addenda to computed tomography (CT), ultrasound, and magnetic resonance imaging reports between January 2018 to June 2018, to note the frequency and classification of report addenda. Results Rate of addenda generation was 1.1% ( n = 1,076) among the 97,003 approved cross-sectional radiology reports. Errors contributed to 71.2% ( n = 767) of addenda, most commonly communication (29.3%, n = 316) and observational errors (20.8%, n = 224), and 28.7% were nonerrors aimed at providing additional clinically relevant information. Majority of the addenda (82.3%, n = 886) did not have a significant clinical impact. CT and ultrasound reports accounted for 36.9% ( n = 398) and 35.2% ( n = 379) share, respectively. A time gap of 1 to 7 days was noted for 46.8% ( n = 504) addenda and 37.6% ( n = 405) were issued in less than a day. Radiologists with more than 6-year experience created majority (1.5%, n = 456) of addenda. Those which were added to reports generated during emergency hours contributed to 23.2% ( n = 250) of the addenda. Conclusion The study has identified the prevalence of report addenda in a radiology practice involving picture archiving and communication system in a tertiary care center in India. The etiology included both errors and non-errors. Results of this audit were used to generate a checklist and put protocols that will help decrease serious radiology misses and common errors., Competing Interests: Conflict of Interest There are no conflicts of interest. Financial Support and Sponsorship None., (Indian Radiological Association. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/).)
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- 2021
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33. Indian College of Radiology and Imaging (ICRI) Consensus Guidelines for the Early Management of Patients with Acute Ischemic Stroke: Imaging and Intervention.
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Londhe SR, Gg SK, Keshava SN, and Mohan C
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The medical science has witnessed significant change in the management of acute stroke patients as a result of recent advances in the field of stroke imaging and endovascular mechanical thrombectomy in addition to intravenous thrombolysis and optimization of stroke services in balance with available resources. Despite initial negative trials, we witnessed the publication of five multicenter randomized clinical trials showing superiority of the endovascular approach over standard medical management in patients with large vessel occlusion. The aim of this study is to provide comprehensive set of evidence-based recommendations regarding imaging and endovascular interventions in acute ischemic stroke patients., Competing Interests: Conflicts of Interest There are no conflicts of interest. Financial Support and Sponsorship Nil., (Indian Radiological Association. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/).)
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- 2021
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34. Indian College of Radiology and Imaging Evidence-Based Guidelines for Percutaneous Image-Guided Biliary Procedures.
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Madhusudhan KS, Jineesh V, and Keshava SN
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Percutaneous biliary interventions are among the commonly performed nonvascular radiological interventions. Most common of these interventions is the percutaneous transhepatic biliary drainage for malignant biliary obstruction. Other biliary procedures performed include percutaneous cholecystostomy, biliary stenting, drainage for bile leaks, and various procedures like balloon dilatation, stenting, and large-bore catheter drainage for bilioenteric or post-transplant anastomotic strictures. Although these procedures are being performed for ages, no standard guidelines have been formulated. This article attempts at preparing guidelines for performing various percutaneous image-guided biliary procedures along with discussion on the published evidence in this field., Competing Interests: Conflict of Interest None declared. Remarks Surgical method of drainage is associated with higher morbidity and mortality and hence is used as a last resort, when other minimally invasive techniques have failed, in the palliative setting. 215 However, in patients with resectable tumors, this is the curative treatment of choice. 25 217, (Indian Radiological Association. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/).)
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- 2021
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35. The Status of Interventional Radiology as a Specialty among Medical Students in India-Knowledge, Interest, and Exposure.
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Sebastian B, Keshava SN, and Lakshminarayan R
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Purpose Interventional radiology (IR) is a young medical specialty where image guidance is utilized in minimally invasive procedures as a treatment option and/or as a diagnostic tool. There is an exponential increase in awareness and interest in IR amongst medical students. This trend is continuing despite lack of proportionate representation of IR in the current medical curriculum. This study aims to understand the exposure to IR as a specialty amongst medical students in India. Materials and Methods Anonymous, voluntary, online questionnaire was sent to medical students from different parts of the country. The survey comprised 15 questions regarding exposure and awareness on IR. Results The responses were obtained from 1,024 medical students from 98 medical colleges across the country, majority (57.0%) in the clinical years of their training. Thirty-six percent of them were interested in an IR career. Lack of awareness was the most (61.6%) cited reason for not choosing an IR career. Majority (57.9%) would consider IR as a clinical management option and believe that IR holds an important place in medical practice (68.4%). Conclusion There is an evident under-representation of IR in the medical curriculum. However, an increasing awareness and interest among medical students toward IR as a specialty is demonstrated. Incorporation of IR into current medical curriculum in a systematic way is the need of the hour. This would ultimately benefit a wide cohort of patients across multiple specialties., Competing Interests: Conflict of Interest None declared., (Indian Radiological Association. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/).)
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- 2021
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36. Endografts with mini-cuff-augmented fenestrations for endovascular repair of thoracoabdominal aortic and common iliac artery aneurysms.
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Joseph G, Kota A, Thomson VS, Perla HT, and Keshava SN
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- Aortic Aneurysm, Thoracic diagnostic imaging, Aortic Aneurysm, Thoracic physiopathology, Blood Vessel Prosthesis Implantation adverse effects, Endovascular Procedures adverse effects, Humans, Iliac Aneurysm diagnostic imaging, Iliac Aneurysm physiopathology, Male, Middle Aged, Prosthesis Design, Time Factors, Treatment Outcome, Vascular Patency, Aortic Aneurysm, Thoracic surgery, Blood Vessel Prosthesis, Blood Vessel Prosthesis Implantation instrumentation, Endovascular Procedures instrumentation, Iliac Aneurysm surgery, Stents
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Objective: To report a technique of creating mini-cuff-augmented fenestrations in endografts for use in endovascular aneurysm repair., Methods: Circular fenestrations are made in Dacron thoracic (Valiant Captivia, Medtronic) or tapered iliac limb (Endurant, Medtronic) endografts using thermal cautery and the edges are strengthened with radio-opaque wire sutured on with 6-0 polypropylene. Straight thin-wall expanded polytetrafluoroethylene vascular graft of the same diameter as the fenestration is affixed to its edge with nonlocking 5-0 polypropylene suture, everted, trimmed, balloon-dilated to its nominal diameter and prevented from invaginating by relaxed external stay sutures. Mini-cuff-augmented fenestrations are often pre-cannulated with looped or externalized nitinol guidewires to facilitate catheter crossing. Successful use of mini-cuff-augmented fenestrations is illustrated in a symptomatic patient with Crawford extent-3 thoracoabdominal aortic and bilateral common iliac artery aneurysm undergoing endovascular repair. Seven mini-cuff-augmented fenestrations were created to preserve flow into five visceral arteries (celiac, superior mesenteric, left and dual right renal; all arising from the aneurysm) and both internal iliac arteries (arising at the aneurysm edge)., Results: Effective sealing was achieved immediately at all mini-cuff-augmented fenestrations. At 6-month follow-up there were no endoleaks, all fenestration stents were patent and undistorted, and the aneurysm sac size had decreased., Conclusion: Mini-cuff-augmented fenestrations accomplish effective fenestration sealing, despite being in aneurysmal zones, while preserving the advantages of fenestrations over cuffed branches.
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- 2021
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37. Endovascular management of a patient with massive renal arteriovenous fistula: challenges and tricks.
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Balasubramanian K, Keshava SN, Lenin A, and Mukha R
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- Adult, Angiography, Digital Subtraction, Arteriovenous Fistula complications, Arteriovenous Fistula diagnostic imaging, Computed Tomography Angiography, Echocardiography, Humans, Male, Prosthesis Failure, Renal Artery abnormalities, Renal Veins abnormalities, Retreatment, Ventricular Dysfunction, Left diagnostic imaging, Ventricular Dysfunction, Left etiology, Arteriovenous Fistula therapy, Embolization, Therapeutic, Endovascular Procedures, Renal Artery diagnostic imaging, Renal Veins diagnostic imaging, Septal Occluder Device
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We describe the endovascular management of a patient with a massive renal arteriovenous fistula and a huge venous aneurysmal sac, who presented with features of cardiac failure and fever. The challenges faced and the outcomes are discussed with relevant literature review., Competing Interests: Competing interests: None declared., (© BMJ Publishing Group Limited 2021. No commercial re-use. See rights and permissions. Published by BMJ.)
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- 2021
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38. Clinical Radiology Case Presentation: Do's and Don'ts.
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Punnen GE, Keshava SN, and Gibikote S
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Clinical case presentation is part of daily routine for doctors to communicate with each other to facilitate learning, and ultimately patient management. Hence, the art of good clinical case presentation is a skill that needs to be mastered. Case presentations are a part of most undergraduate and postgraduate training programs aimed at nurturing oratory and presentation design skills. This article is an attempt at providing a trainee in radiology a guideline to good case presentation skills., Competing Interests: Conflicts of InterestFinancial Support and Sponsorship There are no conflicts of interest. Nil., (Indian Radiological Association. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/).)
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- 2021
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39. Interventional radiology and COVID-19: How to face the challenge?
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Chaluvashetty SB, Kalra N, Bhujade H, Keshava SN, and Mohan C
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With the sudden outbreak of Coronavirus disease-19 (COVID-19) in China, and its rapid spread across the continents over a short period of time, healthcare workers are posed with the challenge of managing these patients as well protecting themselves from getting infected. Since interventional radiology deals with both elective and emergency services, wherein close patient contact is a norm, there is a substantial risk of acquiring and transmitting infection. Given the circumstances, it is imperative to develop broadly applicable guidelines to utilize the available resources in an optimal fashion and limit transmission of disease. This brief review deals with infection control measures within the Interventional Radiology department or section and possible recommendations that can be adopted at the institutional level., Competing Interests: There are no conflicts of interest., (Copyright: © 2021 Indian Journal of Radiology and Imaging.)
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- 2021
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40. Clinical Profile of Overgrowth Syndromes Consistent with PROS ( PIK3CA -Related Overgrowth Syndromes)-A Case Series.
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Mathew L, George R, Sudhakar S, Keshava SN, and Fouzia NA
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Context: PIK3CA -related overgrowth syndrome (PROS) is characterized by focal and disproportionate growth of acral body structures in a mosaic pattern with varied phenotypes. Clinical diagnostic criteria are available and testing of the mutation is recommended for diagnosis. Cutaneous features described in these conditions include epidermal nevi and vascular malformations which form part of the diagnostic criteria., Aims: To detail the clinical profile of patients with presumptive PROS., Settings and Design: We conducted a retrospective study of 15 patients with focal overgrowth of the extremities or macrocephaly who presented to the department of dermatology at a tertiary care hospital in South India., Subjects and Methods: Data were collected through electronic medical records from July 2012 to April 2018 over 70 months. The criterion proposed by Keppler-Noreuil et al . was used for classifying them as presumptive PROS in the absence of genetic studies., Statistical Analysis Used: Descriptive analysis., Results: There were nine males and six females; mean age of 12.10 years (range: 8 months to 73 years) with clinical features consistent with PROS. There was a higher frequency of vascular malformations (9/15, 60%) and of epidermal nevi (7/15, 46.6%) than that reported in the literature. Unusual features included focal acrochordons, blaschkoid hypopigmentation and linear papillomatous growths in the oral mucosa., Conclusions: This study provides data on the clinical features of patients with PROS from the Indian subcontinent. In resource-poor settings, clinical criteria may be adequate for diagnosis due to restricted accessibility of technically challenging diagnostic tests., Competing Interests: There are no conflicts of interest., (Copyright: © 2020 Indian Dermatology Online Journal.)
- Published
- 2020
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41. Anticoagulating Budd-Chiari syndrome patients presenting with variceal bleed: A retrospective study.
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Sharma A, Goel A, Moses V, Keshava SN, Zachariah UG, Elias E, and Eapen CE
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- Adult, Endoscopy, Gastrointestinal, Endovascular Procedures, Esophageal and Gastric Varices etiology, Esophageal and Gastric Varices mortality, Female, Gastrointestinal Hemorrhage etiology, Gastrointestinal Hemorrhage mortality, Humans, Male, Recurrence, Retrospective Studies, Survival Rate, Young Adult, Anticoagulants therapeutic use, Budd-Chiari Syndrome complications, Esophageal and Gastric Varices drug therapy, Esophageal and Gastric Varices surgery, Gastrointestinal Hemorrhage drug therapy, Gastrointestinal Hemorrhage surgery
- Abstract
Background and Aim: This aims to study incidence of re-bleeding on anticoagulation and survival of Budd-Chiari syndrome (BCS) patients presenting with variceal bleeding., Methods: Budd-Chiari syndrome patients presenting with variceal bleed between 01/01/2007 and 01/05/2019 were retrospectively studied. Patients underwent endoscopic treatment ± endovascular therapy, followed by anticoagulation. Variceal re-bleed (on anticoagulation) and survival were studied., Results: Of 376 BCS patients diagnosed during the study period, 40 (10.7%) patients, presenting with variceal bleed (age 33 [25-40] years; male patients 70%; Rotterdam score 1.13 [0.63-1.22]), Group 1 were compared with 40 randomly selected age-matched BCS patients presenting with ascites, no bleeds (40 [23-42] years; male patients 42.5%; Rotterdam score 1.11 [1.09-1.16]), Group 2. The commonest site of obstruction was hepatic vein (65%) in Group 1 and combined hepatic veins and inferior vena cava (57.5%) in Group 2 (P < 0.01). Thirty-six Group 1 patients underwent endoscopic intervention (variceal ligation, 33; sclerotherapy, 2; glue injection, 1). Endovascular intervention was performed in 30 Group 1 patients (angioplasty ± stent, 22; endovascular shunt, 8) and in 34 Group 2 patients (angioplasty ± stent, 26; endovascular shunt, 8). All 80 patients were started on anticoagulation. Variceal bleed on anticoagulation occurred in five patients in Group 1 and three patients in Group 2. One-year and 5-year survival were 94.2% and 87.5%, respectively, in Group 1 and 100% and 80%, respectively, in Group 2., Conclusions: About one-tenth of BCS patients present with variceal bleed. On management with endoscopic ± endovascular therapy, followed by anticoagulation, variceal re-bleed in these patients were comparable with those in BCS patients presenting with ascites and survival was excellent at 1 and 5 years., (© 2020 Journal of Gastroenterology and Hepatology Foundation and John Wiley & Sons Australia, Ltd.)
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- 2020
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42. Critical appraisal of the International Prophylaxis Study Group magnetic resonance image scale for evaluating haemophilic arthropathy.
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Tolend M, Majeed H, Soliman M, Daruge P, Bordalo-Rodrigues M, Dertkigil SSJ, Gibikote S, Keshava SN, Stimec J, Dunn A, Li YJ, Blanchette V, Lundin B, and Doria AS
- Subjects
- Adolescent, Ankle Joint diagnostic imaging, Ankle Joint pathology, Child, Child, Preschool, Hemarthrosis etiology, Hemarthrosis pathology, Hemophilia A complications, Hemophilia A therapy, Hemosiderin analysis, Humans, Joint Diseases etiology, Knee Joint diagnostic imaging, Knee Joint pathology, Male, Observer Variation, Reproducibility of Results, Severity of Illness Index, Synovial Membrane metabolism, Synovial Membrane pathology, Hemarthrosis diagnosis, Hemarthrosis prevention & control, Joint Diseases diagnostic imaging, Magnetic Resonance Imaging methods
- Abstract
A goal of the International Prophylaxis Study Group (IPSG) is to provide an accurate instrument to measure MRI-based disease severity of haemophilic arthropathy at various time points, so that longitudinal changes in disease severity can be identified to support decisions on treatment management. We review and discuss in this paper the evaluative purpose of the IPSG MRI scale in relation to its development and validation processes so far. We also critically appraise the validity, reliability and responsiveness of using the IPSG MRI scale in different clinical and research settings, and whenever applicable, compare these clinimetric properties of the IPSG MRI scale with those of its precursors, the compatible additive and progressive MRI scales., (© 2020 John Wiley & Sons Ltd.)
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- 2020
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43. Retrieval of retained pigtail in the liver.
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Premkumar M, Chiramel GK, and Keshava SN
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The incidence of catheter breakage during percutaneous image-guided treatment of liver hydatid is very rare. A "telescoping" technique was used to retrieve the broken pigtail in this case report. Alternative options for pigtail retrieval are briefly discussed., Competing Interests: There are no conflicts of interest., (Copyright: © 2020 Indian Journal of Radiology and Imaging.)
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- 2020
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44. Peripheral Arteriovenous Malformations-A Case Series.
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Mathew L, George R, Meeniga RS, Moses V, and Keshava SN
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Context: Arteriovenous malformations (AVMs) are aggressive vascular malformations that often result in significant morbidity. Patients may present to a dermatologist due to associated skin changes. Early diagnosis is important as treatment is available to halt their progression toward irreversible destruction of adjacent tissues., Aims: To study the clinical profile of peripheral AVMs presenting to the dermatologist and to provide a diagnostic algorithm., Settings and Design: A retrospective study of patients of all age groups with peripheral AVMs who presented to the Department of Dermatology at a tertiary care hospital in India was performed. Syndromic forms were also included., Subjects and Methods: We conducted a search of patients with peripheral AVMs, which were seen over a period of 51 months, i.e., from July 2014 to September 2018, from electronic medical records and reviewed their clinical details., Statistical Analysis Used: Descriptive statistics such as frequency, mean, and median were computed., Results: We report a series of 13 patients with peripheral AVMs, which constituted 6.7% (13/193) of all vascular malformations during this period. Of these, 8.3% (1/12) belonged to Schobinger's stage 1, 41.7% (5/12) to stage 2, 50% (6/12) to stage 3, and one with subcutaneous involvement devoid of cutaneous changes. The most common location was the extremities, which was seen in 53.8% (7/13). Syndromic association was present in 46.2% (6/13). Management included embolization, surgery, and medical treatment., Conclusions: The proportion of peripheral AVMs out of all vascular malformations was similar to reported studies. The extremities were more frequently involved as compared to the head and neck. The diagnostic algorithm provided will help us to optimize investigations and direct early management., Competing Interests: There are no conflicts of interest., (Copyright: © 2020 Indian Dermatology Online Journal.)
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- 2020
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45. Role of Ultrasound Acoustic Radiation Force Impulse in Differentiating Benign from Malignant Superficial Lymph Nodes.
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Chanda R, Kandagaddala M, Moses V, Sigamani E, Keshava SN, and Janakiraman R
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Objective: The purpose of this study was to evaluate the diagnostic performance of acoustic radiation force impulse (ARFI) imaging in differentiating benign from malignant peripheral lymphadenopathy., Materials and Methods: This was a prospective study approved by the Institutional Review Board with financial grant for the same. Ultrasound and ARFI imaging of peripheral lymph nodes were performed and correlated with pathological results, which were used as the reference standard. The virtual touch tissue imaging and virtual touch tissue quantification parameters of ARFI were analyzed in 86 lymph nodes, of which 78 were included in the study. Using receiver operating characteristic curve analysis, the diagnostic usefulness of ARFI values were evaluated with respect to their sensitivity, specificity, and area under the curve., Results: The mean area ratio of benign lymph nodes was 0.88 (±0.2) and that of malignant lymph nodes was 1.17 (±0.14). The mean shear wave velocities (SWV) of benign and malignant lymph nodes were 2.02 m/s (±0.94) and 3.7 m/s (±2.27), respectively. The sensitivity and specificity of virtual touch imaging area ratio in differentiating benign from malignant lymph nodes was 97% and 77%, of SWV was 71% and 70%, and of SWV ratio was 68% and 79%, respectively., Conclusion: As ARFI was found to have a superior diagnostic performance over conventional ultrasound and color Doppler in the characterization of lymph nodes, we recommend its routine use in differentiating benign from malignant nodes., Competing Interests: There are no conflicts of interest., (© 2020 Published by Scientific Scholar on behalf of Journal of Clinical Imaging Science.)
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- 2020
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46. A new and simplified comprehensive ultrasound protocol of haemophilic joints: the Universal Simplified Ultrasound (US-US) protocol.
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Kandagaddala M, Sundaramoorthy M, Keshava SN, Gibikote S, Mahata KM, Kavitha ML, Poonnoose P, and Srivastava A
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- Adolescent, Cartilage Diseases diagnostic imaging, Cartilage Diseases pathology, Child, Clinical Protocols, Connective Tissue diagnostic imaging, Hemosiderin analysis, Humans, Hypertrophy diagnostic imaging, Magnetic Resonance Imaging, Osteochondrosis diagnostic imaging, Osteochondrosis pathology, Prospective Studies, Synovial Membrane diagnostic imaging, Synovial Membrane pathology, Temporomandibular Joint Disc pathology, Time Factors, Ultrasonography, Young Adult, Ankle Joint diagnostic imaging, Hemophilia A complications, Knee Joint diagnostic imaging, Temporomandibular Joint Disc diagnostic imaging
- Abstract
Aim: To present a new protocol to optimise ultrasound (US) assessment of haemophilic arthropathy., Materials and Methods: Ultrasound of haemophilic arthropathy joints was performed using three different ultrasound protocols, namely, the Toronto-Vellore Comprehensive Ultrasound (TVC-US) protocol, the Haemophilia Early Arthropathy Detection with Ultrasound (HEAD-US), and the newly developed Universal Simplified Ultrasound (US-US) protocol. Synovial hypertrophy, haemosiderin deposition, effusion, erosion, and cartilage loss were evaluated in 20 joints. The reliability and diagnostic efficiency of these protocols was compared using magnetic resonance imaging (MRI)., Results: The correlation between the TVC-US and US-US protocols for synovial hypertrophy was excellent: kappa significance (KS) was 1, but was substantial (KS=0.65) with the HEAD-US protocol. For effusion, both the TVC-US and the HEAD-US protocols had substantial correlation with the US-US protocol (KS=0.7 and 0.6 respectively). The correlation for erosion and cartilage loss was excellent between the TVC-US and the US-US with MRI (KS=1), but poor (KS=0) with the HEAD-US protocol. The US-US protocol also had good interobserver agreement (KS=1)., Conclusion: The accuracy of the US-US protocol is comparable to the TVC-US protocol and MRI and is superior to the HEAD-US protocol in the assessment of haemophilic arthropathy., (Copyright © 2019 The Royal College of Radiologists. Published by Elsevier Ltd. All rights reserved.)
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- 2019
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47. Radiation dose reference card for interventional radiology procedures: Experience in a tertiary referral centre.
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Varghese A, Keshava SN, Moses V, Koshy G, Mammen S, Ahmed M, and Livingstone RS
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Background: Fluoroscopy-guided interventions can potentially increase radiation risk to patients, if awareness on angiographic imaging technique and radiation dose is neglected., Aim: To develop patient radiation dose reference card from standardized imaging techniques for various radiology interventions performed using flat detector based angiography system., Materials and Methods: Real-time monitoring of angiographic exposure parameters and radiation dose were performed for 16 types of radiological interventions. Effective dose (ED) was estimated from dose area product (DAP) using PCXMC Monte Carlo simulation software. Radiation risk levels were estimated based on Biological Effects of Ionising radiation (BEIR) report VII predictive models for an Asian population., Results: Pulse rates of 7.5 pps and 0.6 mm Copper filtration during fluoroscopy and 4 frames per second (fps) and 0.1-0.3 mm Cu filtration during image acquisitions were found to reduce radiation dose. Owing to increased number of image acquisitions, DAP was highest during diagnostic spinal angiography 186.7 Gycm
2 (44.0-377.5). This resulted in highest ED of 59.4 mSv with moderate risk levels (1 in 1000 to 1 in 500). Most of the radiological interventions had low radiation risk levels (1 in 10,000 to 1 in 1000)., Conclusion: The patient radiation dose reference card is valuable to the medical community and can aid in patient counselling on radiation induced risk from radiological interventions., Competing Interests: There are no conflicts of interest., (Copyright: © 2019 Indian Journal of Radiology and Imaging.)- Published
- 2019
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48. What makes non-cirrhotic portal hypertension a common disease in India? Analysis for environmental factors.
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Goel A, Ramakrishna B, Zachariah U, Sajith KG, Burad DK, Kodiatte TA, Keshava SN, Balasubramanian KA, Elias E, and Eapen CE
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- Arsenic toxicity, Blood Platelets drug effects, Endothelium drug effects, Environment, Humans, Hypertension, Portal etiology, Hypertension, Portal pathology, India epidemiology, Liver drug effects, Liver Cirrhosis epidemiology, Liver Cirrhosis pathology, Poverty, Thrombophilia etiology, Thrombophilia pathology, Hypertension, Portal epidemiology, Liver pathology, Portal Vein pathology, Thrombophilia epidemiology
- Abstract
In India, an unexplained enteropathy is present in a majority of non-cirrhotic intrahepatic portal hypertension (NCIPH) patients. Small intestinal bacterial contamination and tropical enteropathy could trigger inflammatory stimuli and activate the endothelium in the portal venous system. Groundwater contaminated with arsenic is an environmental factor of epidemic proportions in large areas of India which has similar consequences. Von Willebrand factor (a sticky protein) expressed by activated endothelium may promote formation of platelet microthrombi and occlusion of intrahepatic portal vein branches leading to NCIPH. Environmental factors linked to suboptimal hygiene and sanitation, which enter through the gastrointestinal (GI) tract, predispose to platelet plugging onto activated endothelium in portal microcirculation. Thus, NCIPH, an example of poverty linked thrombophilia, is a disease mainly affecting the lower socio-economic strata of Indian population. Public health measures to improve sanitation, provide clean drinking water and eliminate arsenic contamination of drinking water are urgently needed. Till such time as these environmental factors are addressed, NCIPH is likely to remain 'an Indian disease'., Competing Interests: None
- Published
- 2019
- Full Text
- View/download PDF
49. Multiple Stab Incisions and Evacuation Technique for Contrast Extravasation of the Hand and Forearm.
- Author
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Raveendran S, Rajendra Benny K, Monica S, Pallapati SR, Keshava SN, and Thomas BP
- Subjects
- Compartment Syndromes etiology, Extravasation of Diagnostic and Therapeutic Materials complications, Humans, Compartment Syndromes prevention & control, Contrast Media adverse effects, Drainage methods, Extravasation of Diagnostic and Therapeutic Materials therapy, Forearm, Hand
- Abstract
Extravasation of intravenous contrast agents in the hand and forearm during computed tomography scanning is rising with the use of automated pressure injectors. The main concern in such a situation is progression to acute compartment syndrome and necrosis of the overlying skin. Management has been mainly nonsurgical comprising upper limb elevation and orthosis, with surgical techniques such as liposuction and saline evacuation mainly used for large volume (>50 mL) extravasations. We have developed a technique of multiple stab incisions and drainage for the treatment of contrast extravasations., (Copyright © 2019 American Society for Surgery of the Hand. Published by Elsevier Inc. All rights reserved.)
- Published
- 2019
- Full Text
- View/download PDF
50. Transjugular Intrahepatic Portosystemic Shunt Through the Strut of a Previously Placed Stent: Technical Feasibility and Long-Term Follow-Up Results.
- Author
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Ahmed M, Keshava SN, Moses V, Chiramel GK, Mammen S, Eapen CE, and Zachariah UG
- Subjects
- Adolescent, Adult, Aged, Feasibility Studies, Female, Follow-Up Studies, Hepatic Veins, Humans, Kaplan-Meier Estimate, Male, Middle Aged, Retrospective Studies, Treatment Outcome, Vascular Patency, Vena Cava, Inferior, Young Adult, Portasystemic Shunt, Transjugular Intrahepatic instrumentation, Stents
- Abstract
Aims and Objectives: To evaluate technical feasibility, long-term primary patency and clinical outcome of the transjugular intrahepatic portosystemic shunt (TIPS) through the struts of the previously placed stents., Materials and Methods: Retrospective evaluation of seven consecutive patients (three male and four female, age range 13-65 years, median 28) out of a total 95 patients, who underwent TIPS through the strut of the previously placed stents of hepatic vein (HV), inferior vena cava (IVC) or TIPS in a single tertiary care hospital. Six of the patients were diagnosed with Budd-Chiari syndrome (BCS) and one with alcohol-induced chronic liver disease (CLD). Kaplan-Meier test was used to calculate 18- and 60-month primary patency rate of TIPS stent., Results: TIPS through the strut of a previously placed stent was technically successful in all the patients (100%). The TIPS was direct intrahepatic portosystemic shunt (DIPS) in 5/7 cases, due to occluded HV. Mean portosystemic pressure gradient (PPG) reduced from 24 mmHg ± 5.9 (range, pre-TIPS 15-31 mmHg) to 8.57 mmHg ± 4.4 (range, post-TIPS, 3-14 mmHg). One patient required three sessions of TIPS revisions. Another patient needed TIPS revision after 5 years of TIPS creation. All the patients showed improvement in clinical symptoms and in mean Child-Turcotte-Pugh (CTP) score and modified end-stage liver disease (MELD) score during mean follow-up period 40.57 month ± 34.9 (range 3-100 month). Primary patency rates of TIPS stent measured with Kaplan-Meier estimate at 18- and 60-month follow-up were 80% (95% CI, 37-97%) and 40% (95% CI, 10-97%), respectively., Conclusion: TIPS through the strut of a previously placed stent is technically feasible with good long-term primary patency and clinical outcome.
- Published
- 2018
- Full Text
- View/download PDF
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