8 results on '"Kerstin U. Amann"'
Number of results to display per page
Search Results
2. Organ manifestations of COVID-19: what have we learned so far (not only) from autopsies?
- Author
-
Danny Jonigk, Christopher Werlein, Till Acker, Martin Aepfelbacher, Kerstin U. Amann, Gustavo Baretton, Peter Barth, Rainer M. Bohle, Andreas Büttner, Reinhard Büttner, Reinhard Dettmeyer, Philip Eichhorn, Sefer Elezkurtaj, Irene Esposito, Katja Evert, Matthias Evert, Falko Fend, Nikolaus Gaßler, Stefan Gattenlöhner, Markus Glatzel, Heike Göbel, Elise Gradhand, Torsten Hansen, Arndt Hartmann, Axel Heinemann, Frank L. Heppner, Julia Hilsenbeck, David Horst, Jan C. Kamp, Gita Mall, Bruno Märkl, Benjamin Ondruschka, Jessica Pablik, Susanne Pfefferle, Alexander Quaas, Helena Radbruch, Christoph Röcken, Andreas Rosenwald, Wilfried Roth, Martina Rudelius, Peter Schirmacher, Julia Slotta-Huspenina, Kevin Smith, Linna Sommer, Konrad Stock, Philipp Ströbel, Stephanie Strobl, Ulf Titze, Gregor Weirich, Joachim Weis, Martin Werner, Claudia Wickenhauser, Thorsten Wiech, Peter Wild, Tobias Welte, Saskia von Stillfried, and Peter Boor
- Subjects
pathology [Lung] ,SARS-CoV-2 ,COVID-19 ,Cell Biology ,General Medicine ,Pathology and Forensic Medicine ,Acute kidney damage ,Humans ,ddc:610 ,Autopsy ,Immune response ,Molecular Biology ,Lung ,Pandemics ,Diffuse alveolar damage - Abstract
Virchows Archiv (2022). doi:10.1007/s00428-022-03319-2, Published by Springer, Berlin
- Published
- 2022
3. First report from the German COVID-19 autopsy registry
- Author
-
Saskia von Stillfried, Roman David Bülow, Rainer Röhrig, Peter Boor, Jana Böcker, Jens Schmidt, Pauline Tholen, Raphael Majeed, Jan Wienströer, Joachim Weis, Juliane Bremer, Ruth Knüchel, Anna Breitbach, Claudio Cacchi, Benita Freeborn, Sophie Wucherpfennig, Oliver Spring, Georg Braun, Christoph Römmele, Bruno Märkl, Rainer Claus, Christine Dhillon, Tina Schaller, Eva Sipos, Klaus Hirschbühl, Michael Wittmann, Elisabeth Kling, Thomas Kröncke, Frank L. Heppner, Jenny Meinhardt, Helena Radbruch, Simon Streit, David Horst, Sefer Elezkurtaj, Alexander Quaas, Heike Göbel, Torsten Hansen, Ulf Titze, Johann Lorenzen, Thomas Reuter, Jaroslaw Woloszyn, Gustavo Baretton, Julia Hilsenbeck, Matthias Meinhardt, Jessica Pablik, Linna Sommer, Olaf Holotiuk, Meike Meinel, Nina Mahlke, Irene Esposito, Graziano Crudele, Maximilian Seidl, Kerstin U. Amann, Roland Coras, Arndt Hartmann, Philip Eichhorn, Florian Haller, Fabienne Lange, Kurt Werner Schmid, Marc Ingenwerth, Josefine Rawitzer, Dirk Theegarten, Christoph G. Birngruber, Peter Wild, Elise Gradhand, Kevin Smith, Martin Werner, Oliver Schilling, Till Acker, Stefan Gattenlöhner, Christine Stadelmann, Imke Metz, Jonas Franz, Lidia Stork, Carolina Thomas, Sabrina Zechel, Philipp Ströbel, Claudia Wickenhauser, Christine Fathke, Anja Harder, Benjamin Ondruschka, Eric Dietz, Carolin Edler, Antonia Fitzek, Daniela Fröb, Axel Heinemann, Fabian Heinrich, Anke Klein, Inga Kniep, Larissa Lohner, Dustin Möbius, Klaus Püschel, Julia Schädler, Ann-Sophie Schröder, Jan-Peter Sperhake, Martin Aepfelbacher, Nicole Fischer, Marc Lütgehetmann, Susanne Pfefferle, Markus Glatzel, Susanne Krasemann, Jakob Matschke, Danny Jonigk, Christopher Werlein, Peter Schirmacher, Lisa Maria Domke, Laura Hartmann, Isabel Madeleine Klein, Constantin Schwab, Christoph Röcken, Johannes Friemann, Dorothea Langer, Wilfried Roth, Stephanie Strobl, Martina Rudelius, Konrad Friedrich Stock, Wilko Weichert, Claire Delbridge, Atsuko Kasajima, Peer-Hendrik Kuhn, Julia Slotta-Huspenina, Gregor Weirich, Peter Barth, Eva Wardelmann, Katja Evert, Andreas Büttner, Johannes Manhart, Stefan Nigbur, Iris Bittmann, Falko Fend, Hans Bösmüller, Massimo Granai, Karin Klingel, Verena Warm, Konrad Steinestel, Vincent Gottfried Umathum, Andreas Rosenwald, Florian Kurz, Niklas Vogt, Weis, Joachim, Glatzel, Markus, Krasemann, Susanne, Matschke, Jakob, Jonigk, Danny, Werlein, Christopher, Schirmacher, Peter, Domke, Lisa Maria, Hartmann, Laura, Klein, Isabel Madeleine, Schwab, Constantin, Bremer, Juliane, Röcken, Christoph, Friemann, Johannes, Langer, Dorothea, Roth, Wilfried, Strobl, Stephanie, Rudelius, Martina, Stock, Konrad Friedrich, Weichert, Wilko, Delbridge, Claire, Kasajima, Atsuko, Knüchel-Clarke, Ruth, Kuhn, Peer-Hendrik, Slotta-Huspenina, Julia, Weirich, Gregor, Barth, Peter, Wardelmann, Eva, Evert, Katja, Büttner, Andreas, Manhart, Johannes, Nigbur, Stefan, Bittmann, Iris, Breitbach, Anna, Fend, Falko, Bösmüller, Hans, Granai, Massimo, Klingel, Karin, Warm, Verena, Steinestel, Konrad, Umathum, Vincent Gottfried, Rosenwald, Andreas, Kurz, Florian, Vogt, Niklas, Cacchi, Claudio, Freeborn, Benita, Wucherpfennig, Sophie, Spring, Oliver, Braun, Georg, Römmele, Christoph, Märkl, Bruno, Claus, Rainer, Dhillon, Christine, Schaller, Tina, Sipos, Eva, Hirschbühl, Klaus, Wittmann, Michael, Kling, Elisabeth, Kröncke, Thomas, Heppner, Frank L., Meinhardt, Jenny, Radbruch, Helena, Streit, Simon, Horst, David, Elezkurtaj, Sefer, Quaas, Alexander, Göbel, Heike, Hansen, Torsten, Titze, Ulf, Lorenzen, Johann, Reuter, Thomas, Woloszyn, Jaroslaw, Baretton, Gustavo, Hilsenbeck, Julia, Meinhardt, Matthias, Pablik, Jessica, Sommer, Linna, Holotiuk, Olaf, Meinel, Meike, Mahlke, Nina, Böcker, Jana, Esposito, Irene, Crudele, Graziano, Seidl, Maximilian, Amann, Kerstin U., Coras, Roland, Hartmann, Arndt, Eichhorn, Philip, Haller, Florian, Lange, Fabienne, Schmid, Kurt Werner, Schmidt, Jens, Ingenwerth, Marc, Rawitzer, Josefine, Theegarten, Dirk, Birngruber, Christoph G., Wild, Peter, Gradhand, Elise, Smith, Kevin, Werner, Martin, Schilling, Oliver, Acker, Till, Tholen, Pauline, Gattenlöhner, Stefan, Stadelmann, Christine, Metz, Imke, Franz, Jonas, Stork, Lidia, Thomas, Carolina, Zechel, Sabrina, Ströbel, Philipp, Wickenhauser, Claudia, Fathke, Christine, Majeed, Raphael, Harder, Anja, Ondruschka, Benjamin, Dietz, Eric, Edler, Carolin, Fitzek, Antonia, Fröb, Daniela, Heinemann, Axel, Heinrich, Fabian, Klein, Anke, Kniep, Inga, Wienströer, Jan, Lohner, Larissa, Möbius, Dustin, Püschel, Klaus, Schädler, Julia, Schröder, Ann-Sophie, Sperhake, Jan-Peter, Aepfelbacher, Martin, Fischer, Nicole, Lütgehetmann, Marc, and Pfefferle, Susanne
- Subjects
Oncology ,Health Policy ,Internal Medicine ,Medizin ,ddc:610 - Abstract
The lancet / Regional health. Europe 15, 100330 (2022). doi:10.1016/j.lanepe.2022.100330, Published by Elsevier, [Amsterdam]
- Published
- 2022
4. Lack of Intestinal Epithelial Atg7 Affects Paneth Cell Granule Formation but Does Not Compromise Immune Homeostasis in the Gut
- Author
-
Nadine Wittkopf, Claudia Günther, Eva Martini, Maximilian Waldner, Kerstin U. Amann, Markus F. Neurath, and Christoph Becker
- Subjects
Immunologic diseases. Allergy ,RC581-607 - Abstract
Genetic polymorphisms of autophagy-related genes have been associated with an increased risk to develop inflammatory bowel disease (IBD). Autophagy is an elementary process participating in several cellular events such as cellular clearance and nonapoptotic programmed cell death. Furthermore, autophagy may be involved in intestinal immune homeostasis due to its participation in the digestion of intracellular pathogens and in antigen presentation. In the present study, the role of autophagy in the intestinal epithelial layer was investigated. The intestinal epithelium is essential to maintain gut homeostasis, and defects within this barrier have been associated with the pathogenesis of IBD. Therefore, mice with intestinal epithelial deletion of Atg7 were generated and investigated in different mouse models. Knockout mice showed reduced size of granules and decreased levels of lysozyme in Paneth cells. However, this was dispensable for gut immune homeostasis and had no effect on susceptibility in mouse models of experimentally induced colitis.
- Published
- 2012
- Full Text
- View/download PDF
5. Oncofertility: combination of ovarian stimulation with subsequent ovarian tissue extraction on the day of oocyte retrieval
- Author
-
Ralf, Dittrich, Laura, Lotz, Andreas, Mueller, Inge, Hoffmann, David L, Wachter, Kerstin U, Amann, Matthias W, Beckmann, and Thomas, Hildebrandt
- Subjects
Adult ,endocrine system ,Time Factors ,Research ,Ovarian tissue ,Ovary ,Fertility Preservation ,Oocyte Retrieval ,Reproducibility of Results ,Ovarian tissue cryopreservation ,Fertilization in Vitro ,Medical Oncology ,Chorionic Gonadotropin ,Young Adult ,Ovulation Induction ,Oocyte cryopreservation ,IVF ,Neoplasms ,Humans ,Female ,Sperm Injections, Intracytoplasmic ,Ovarian stimulation ,Retrospective Studies - Abstract
Background New anticancer treatments have increased survival rates for cancer patients, but often at the cost of sterility. Several strategies are currently available for preserving fertility. However, the chances of achieving a pregnancy with one technique are still limited. A combination of methods is therefore recommended in order to maximize women’s chances of future fertility. In this retrospective study, ovarian stimulation with subsequent ovarian tissue extraction on the day of oocyte retrieval were combined and the quality of the ovarian tissue, the numbers and quality of oocytes, time requirements, and the safety of the strategy were examined. Methods Fourteen female patients suffering from malignant diseases underwent one in vitro fertilization cycle. Different stimulation protocols were used, depending on the menstrual cycle. Transvaginal oocyte retrieval was scheduled 34–36 h after human chorionic gonadotropin administration. Immediately afterwards, ovarian tissue was extracted laparoscopically. Results A mean of 10 oocytes were retrieved per patient, and 67% of the oocytes were successfully fertilized using intracytoplasmic sperm injection. No periprocedural complications and no complications leading to postponement of the start of chemotherapy occurred. The ovarian tissues were of good quality, with a normal age-related follicular distribution and without carcinoma cell invasion. Conclusions An approach using ovarian stimulation first, followed by laparoscopic collection of ovarian tissue, is a useful strategy for increasing the efficacy of fertility preservation techniques. The ovarian tissue is not affected by prior ovarian stimulation.
- Published
- 2012
6. Abstract 3406: Plaque Characterization Using Different X-ray Energy By Dual Source CT And Its Comparison With Histology
- Author
-
Sei Komatsu, Alexander Kuhlmann, Valentine Campean, Dieter Ropers, Ulrike Ropers, Martin Wechsel, Werner G Daniel, Kerstin U Amann, and Stephan Achenbach
- Subjects
Physiology (medical) ,Cardiology and Cardiovascular Medicine - Abstract
Background In addition to high spatial (0.4 mm) and temporal resolution (83 ms), Dual Source CT (DSCT) allows simultaneous imaging with two different x-ray energies. This may be beneficial for tissue characterization. Objectives. To determine the accuracy of ex vivo atherosclerotic plaque characterization with DSCT and to assess the CT attenuation of various plaque components depending on X-ray energy. Materials and Methods. 18 atherosclerotic vessels of coronary, carotid and iliac arteries obatined from autopsy were analyzed by DSCT. Each lumen of the vessels was filled with contrast media (30X Imeron 350). The collimation was 2X64X0.6 mm, rotation time was 330 msec., temporal resolution was 83 msec. Data sets were obtained using a tube voltage of 80, 100, 120, and 140 kV. The x.-ray attenuation of lipid-rich plaque, fibrous plaque, calcified plaque and contrast-enhanced lumen were determined for all x-ray energies by comparison to histology at 25 sites. In addition, cross-sectional images were reconstructed with 0.75 mm slice thickness and 0.4 mm increment. 26 slices at 10 mm interval were analyzed by comprehensive color-coding according to CT number. Results. There were significant differences among CT attenuations of lipid-rich, fibrous and calcified plaque using 80, 100, 120, and 140 kV (Table , p Conclusions. The relationships between lumen enhancement and each plaque component were different as changing the x-ray energy level. Using of varying x-ray energy, DSCT may able to detect atherosclerotic plaque and characterization of plaque components. The Attenuation on Different Energy
- Published
- 2007
7. Correlation of enhanced thrombospondin-1 expression, TGF-{beta} signalling and proteinuria in human type-2 diabetic nephropathy.
- Author
-
Bernd Hohenstein, Christoph Daniel, Birgit Hausknecht, Kirsten Boehmer, Regine Riess, Kerstin U. Amann, and Christian P. M. Hugo
- Subjects
PEOPLE with diabetes ,THROMBOSPONDINS ,KIDNEY diseases ,PROTEINURIA ,CELLULAR signal transduction ,FIBROSIS - Abstract
Background. Activation of the thrombospondin-1 (TSP-1)-TGF-β pathway by glucose and the relevance of TSP-1-dependent activation of TGF-β for renal matrix expansion, renal fibrosis and sclerosis have previously been demonstrated by our group in in vivo and in vitro studies. Design and methods. We investigated renal biopsies (n = 40) and clinical data (n = 30) of patients with diabetic nephropathy. Ten kidneys without evidence of renal disease served as controls. Glomerular and cortical expression of TSP-1, p-smad2/3, fibrosis and glomerular sclerosis (PAS) were assessed by immunhistochemical staining and related with clinical data. Results. Glomerular (g) and cortical (c) TSP-1 were increased during diabetic nephropathy (g: 2.62 ± 2.65; c: 4.5 ± 4.2) compared to controls (g: 0.67 ± 0.7; c: 1.5 ± 1.2). P-smad2/3 was significantly increased (g: 16.7 ± 12.9; c: 148.7 ± 92.8) compared to controls (g: 7.1 ± 3.6; c: 55 ± 25; P < 0.05). TSP-1 was coexpressed with p-smad2/3 as an indicator of TGF-β activation. TSP-1 correlated with enhanced tubulointerstitial p-smad2/3 positivity (r = 0.39 and r = 0.4, P < 0.05) and glomerular p-smad2/3 correlated with proteinuria (r = 0.35, P < 0.05). Conclusions. In summary, the present study suggests a functional activity of the TSP-1/TGF-β axis, especially in the tubulointerstitium of patients with diabetic nephropathy. The positive correlation of glomerular p-smad2/3 positivity with proteinuria further supports the importance of the TSP-1/TGF-β system as a relevant mechanism for progression of human type-2 diabetic nephropathy. [ABSTRACT FROM AUTHOR]
- Published
- 2008
- Full Text
- View/download PDF
8. A murine model of site-specific renal microvascular endothelial injury and thrombotic microangiopathy.
- Author
-
Bernd Hohenstein, Andrea Braun, Kerstin U. Amann, Richard J. Johnson, and Christian P. M. Hugo
- Subjects
CARDIOVASCULAR diseases ,KIDNEY diseases ,BLOOD coagulation ,THROMBOTIC microangiopathies - Abstract
Despite the importance of endothelial injury and healing for primary and secondary renal disease and the availability of genetically engineered mouse models, to date no generally applicable murine disease model with site-specific renal endothelial injury has been established. We induced specific microvascular renal injury via selective renal arterial perfusion of the lectin concanavalin A (Con A) followed by sheep anti-concanavalin A and harvested tissues after 4 h, 24 h, days 3 and 7. Compared to control kidneys, histological evaluation demonstrated endothelial cell injury with subsequent complement, and platelet activation and thrombosis by light and electron microscopy. Mouse kidneys showed histologic evidence of severe glomerular and peritubular microvascular thrombosis with acute tubular necrosis, proteinuria, increased BUN and presence of schistocytes. Initial cell death of intrinsic renal cells resulted in a decrease of the glomerular cell count by 50% after 4 h followed by a proliferative response of glomerular (day 3, PâPâ<â0.05) and tubular cells leading to increased total glomerular cell count by day 7. This study establishes the Con A anti-Con A model as specific endothelial injury model in the mouse kidney providing a novel tool for investigating endothelial injury and repair mechanisms as well as elucidating the role of platelets in genetically engineered mice. [ABSTRACT FROM AUTHOR]
- Published
- 2008
Catalog
Books, media, physical & digital resources
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.