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1. 1002 Single cell transcriptomics in kidney tissue from African American patients enrolled in the accelerating medicines partnership (AMP) implicates tubular cells in the pathogenesis of APOL1 associated lupus nephritis

Author

Richard Furie, Brad Rovin, Michelle Petri, Judith A James, Kenneth Kalunian, Maria Dall’Era, Jill Buyon, Chaim Putterman, Peter Izmirly, Betty Diamond, David Wofsy, Ming Wu, Soumya Raychaudhuri, Philip M Carlucci, Qian Xiao, Nir Hacohen, Jennifer Anolik, H Michael Belmont, Robert Clancy, Kelly Ruggles, ANNE DAVIDSON, Deepak Rao, Celine C Berthier, Andrea Fava, Diane Kamen, Joel Guthridge, Arnon Arazi, Jose Monroy-Trujillo, Kristin Haag, William Apruzzese, Fernanda Payan-Schober, Kerry Cho, Joseph Mears, Wade DeJager, Paul Hoover, Kristina Deonaraine, Siddarth Gurajala, Derek Fine, Devyn Zaminski, Jasmine Shwetar, Katie Preisinger, and Sethu Madhavan

Subjects
Immunologic diseases. Allergy, RC581-607
Published
2024
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2. 1702 Patients enrolled in the accelerating medicines partnership (AMP) RA/SLE network with isolated renal disease report minimal quality of life impairment on PROMIS-29 compared to patients with extrarenal symptoms

Author

Richard Furie, Michelle Petri, Judith A James, Kenneth Kalunian, Maria Dall’Era, Jill Buyon, Chaim Putterman, Peter Izmirly, Betty Diamond, Jessica Li, Jennifer Anolik, H Michael Belmont, Philip Carlucci, Deepak Rao, Andrea Fava, Diane Kamen, Celine Berthier, Jose Monroy-Trujillo, Kristin Haag, William Apruzzese, Sean Connery, Fernanda Payan-Schober, Kerry Cho, Kristina Deonaraine, Derek Fine, Heather T Gold, and Susana Serrate-Sztein

Subjects
Immunologic diseases. Allergy, RC581-607
Published
2022
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3. Safety of procuring research tissue during a clinically indicated kidney biopsy from patients with lupus: data from the Accelerating Medicines Partnership RA/SLE Network

Author

Andrew Filer, Michael H Weisman, Judith A James, Kenneth Kalunian, Michelle A Petri, Chaim Putterman, H Michael Belmont, Ilfita Sahbudin, Karim Raza, Maria Dall'Era, Jill P Buyon, Diane L Kamen, Karen Salomon-Escoto, Kazuyoshi Ishigaki, Patrick Dunn, David Wofsy, Michele Bombardieri, Vivian Bykerk, Myles Lewis, Ming Wu, Soumya Raychaudhuri, Hemant Suryawanshi, Thomas Tuschl, Christopher Ritchlin, Maureen McMahon, Jennifer Grossman, Philip M Carlucci, Alessandra Nerviani, Peter M Izmirly, Fan Zhang, Felice Rivellese, Joan Bathon, Zhu Zhu, Qian Xiao, Jessica Li, Holden Maecker, Nir Hacohen, Rong Mao, Jennifer Anolik, Javier Rangel-Moreno, Nida Meednu, Susan Goodman, Lindsy Forbess, Mariko Ishimori, Kevin Deane, David Hildeman, Yuhong Li, Laura Hughes, Robert Clancy, ANNE DAVIDSON, Matthias Kretzler, Larry Moreland, Harris Perlman, Peter Gregersen, Celine C Berthier, Andrea Fava, David Boyle, Derek M Fine, Ami Ben-Artzi, P J Utz, Melanie Smith, Beatrice Goilav, Carla Cuda, Andrew McDavid, Deepak A Rao, Joshua Keegan, Ilya Korsunsky, Joel Guthridge, Kevin Wei, Arnon Arazi, Thomas Eisenhaure, Michael Brenner, Susan Macwana, Pavel Morozov, Manjunath Kustagi, Gerald Watts, Kristina K Deonaraine, Jose Monroy-Trujillo, Mohamed G Atta, Kristin Haag, William Apruzzese, Sean Connery, Fernanda Payan-Schober, Kerry Cho, Jennifer Goff, Aparna Nathan, Joseph Mears, Nghia Millard, Kathryn Weinand, Saori Sakaue, Bill Robinson, Wade DeJager, Louis Bridges, Laura Donlin, Edward DiCarlo, Amit Lakhanpal, Heather Sherman, Anvita Singaraju, Lorien Shakib, Brendan Boyce, Darren Tabechian, Jen Albrecht, James Lederer, A Helena Jonsson, Daimon Simmons, Gregory Keras, Adam Chicoine, Zhihan Jian Li, Mandy McGeachy, Gary Firestein, Arnold Ceponis, Diane Horowitz, Salina Dominguez, Arthur Mandelin, Anjali Thakrar, Mike Holers, Jennifer Seifert, Constanino Pitzalis, Ellen Gravallese, Jennifer Barnas, Raymond Hsu, Steven Woodle, Paul Hoover, Michael Peters, Tony Jones, David Lieb, Jeffrey Hodgin, and Raji Menon

Subjects
Immunologic diseases. Allergy, RC581-607
Abstract

Objectives In lupus nephritis the pathological diagnosis from tissue retrieved during kidney biopsy drives treatment and management. Despite recent approval of new drugs, complete remission rates remain well under aspirational levels, necessitating identification of new therapeutic targets by greater dissection of the pathways to tissue inflammation and injury. This study assessed the safety of kidney biopsies in patients with SLE enrolled in the Accelerating Medicines Partnership, a consortium formed to molecularly deconstruct nephritis.Methods 475 patients with SLE across 15 clinical sites in the USA consented to obtain tissue for research purposes during a clinically indicated kidney biopsy. Adverse events (AEs) were documented for 30 days following the procedure and were determined to be related or unrelated by all site investigators. Serious AEs were defined according to the National Institutes of Health reporting guidelines.Results 34 patients (7.2%) experienced a procedure-related AE: 30 with haematoma, 2 with jets, 1 with pain and 1 with an arteriovenous fistula. Eighteen (3.8%) experienced a serious AE requiring hospitalisation; four patients (0.8%) required a blood transfusion related to the kidney biopsy. At one site where the number of cores retrieved during the biopsy was recorded, the mean was 3.4 for those who experienced a related AE (n=9) and 3.07 for those who did not experience any AE (n=140). All related AEs resolved.Conclusions Procurement of research tissue should be considered feasible, accompanied by a complication risk likely no greater than that incurred for standard clinical purposes. In the quest for targeted treatments personalised based on molecular findings, enhanced diagnostics beyond histology will likely be required.

Published
2021
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4. High incidence of proliferative and membranous nephritis in SLE patients with low proteinuria in the Accelerating Medicines Partnership

Author

Philip M, Carlucci, Jessica, Li, Andrea, Fava, Kristina K, Deonaraine, David, Wofsy, Judith A, James, Chaim, Putterman, Betty, Diamond, Anne, Davidson, Derek M, Fine, Jose, Monroy-Trujillo, Mohamed G, Atta, Wade, DeJager, Joel M, Guthridge, Kristin, Haag, Deepak A, Rao, Michael B, Brenner, James A, Lederer, William, Apruzzese, H Michael, Belmont, Peter M, Izmirly, Devyn, Zaminski, Ming, Wu, Sean, Connery, Fernanda, Payan-Schober, Richard, Furie, Maria, Dall'Era, Kerry, Cho, Diane, Kamen, Kenneth, Kalunian, Jennifer, Anolik, Jennifer, Barnas, Mariko, Ishimori, Michael H, Weisman, Jill P, Buyon, and Raji, Menon

Subjects
Proteinuria, Rheumatology, Incidence, Humans, Pharmacology (medical), Prospective Studies, Clinical Science, Kidney Function Tests, Kidney, Lupus Nephritis
Abstract

Objective Delayed detection of LN associates with worse outcomes. There are conflicting recommendations regarding a threshold level of proteinuria at which biopsy will likely yield actionable management. This study addressed the association of urine protein:creatinine ratios (UPCR) with clinical characteristics and investigated the incidence of proliferative and membranous histology in patients with a UPCR between 0.5 and 1. Methods A total of 275 SLE patients (113 first biopsy, 162 repeat) were enrolled in the multicentre multi-ethnic/racial Accelerating Medicines Partnership across 15 US sites at the time of a clinically indicated renal biopsy. Patients were followed for 1 year. Results At biopsy, 54 patients had UPCR Conclusion In this prospective study, three-quarters of patients with UPCR

Published
2021

5. Quantifying Severity of Chronic Kidney Disease as a Risk Factor for Acute Kidney Injury

Author

Chi-yuan Hsu and Kerry Cho

Subjects
medicine.medical_specialty, Proteinuria, urogenital system, business.industry, Acute kidney injury, Renal function, Sequela, General Medicine, Odds ratio, urologic and male genital diseases, medicine.disease, Comorbidity, female genital diseases and pregnancy complications, Nephrology, Internal medicine, medicine, medicine.symptom, Risk factor, business, Kidney disease
Abstract

Acute kidney injury (AKI) may be the real epidemic kidney disease,1 and practicing nephrologists have long known that patients with reduced GFR are more likely to experience AKI, particularly in the elderly.2 Surprisingly, this relationship had not been quantified rigorously until recently. For example, the widely disseminated Clinical Practice Guidelines for Chronic Kidney Disease by the National Kidney Foundation devote specific chapters describing the association of levels of GFR with various sequelae of chronic kidney disease (CKD) such as anemia,3 but there is no discussion of the association of level of GFR with AKI. A publication in 2008 quantified the risk for dialysis-requiring AKI among a large cohort of patients who were receiving usual medical care in a Northern California integrated health care delivery system.4 The observed magnitude of the increase in odds ratio of AKI with progressively more severe CKD—up to 20- to 30-fold higher adjusted risk—suggests that AKI may be the sequela of CKD most tightly linked with estimated GFR (eGFR). This study also noted that proteinuria, a valuable screening marker for CKD,5 was also an important independent risk factor for AKI.4 Patients with documented dipstick proteinuria seem to be two to three times as likely to develop AKI, independent of eGFR. Notably, the relationship between proteinuria and risk …

Published
2010

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