1. Spontaneous-timed versus controlled noninvasive ventilation in chronic hypercapnia – a crossover trial
- Author
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Kerl J, Höhn E, Köhler D, and Dellweg D
- Subjects
noninvasive mechanical ventilation ,clinical trials ,respiratory failure ,reversible hypercapnia ,ventilator mode ,controlled ventilation ,Medical technology ,R855-855.5 - Abstract
Jens Kerl, Ekkehard Höhn, Dieter Köhler, Dominic DellwegDepartment for Pulmonary Medicine, Intensive Care Medicine and Sleep Medicine, Fachkrankenhaus Kloster Grafschaft GmbH, Schmallenberg, 57392, GermanyBackground: There is an ongoing debate about optimal ventilator modes and settings during noninvasive ventilation (NIV).Objectives: To compare the effect of spontaneous-timed (ST) and controlled NIV on carbon dioxide reduction in patients suffering from chronic hypercapnia.Methods: Night and daytime blood gas analysis, lung function tests and 6 minute walking distance tests (6MWD) were done before and after every 6-week treatment.Results: This randomized prospective crossover trial included 42 patients. Pooled data analysis showed a decrease of nocturnal CO2 from 54.8±5.9 mmHg to 41.6±5.5 mmHg during ST ventilation (p
- Published
- 2019