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1. Development of Prostate Bed Delineation Consensus Guidelines for Magnetic Resonance Image-Guided Radiotherapy and Assessment of Its Effect on Interobserver Variability

Author

MS Radiotherapie, Cancer, Sritharan, K, Akhiat, A, Cahill, D, Choi, S, Choudhury, A, Chung, P, Diaz, J, Dysager, L, Hall, W, Huddart, R, Kerkmeijer, L G W, Lawton, C, Mohajer, J, Murray, J, Nyborg, C J, Pos, F J, Rigo, M, Schytte, T, Sidhom, M, Sohaib, A, Tan, A, van der Voort van Zyp, J, Vesprini, D, Zelefsky, M J, Tree, A C, MS Radiotherapie, Cancer, Sritharan, K, Akhiat, A, Cahill, D, Choi, S, Choudhury, A, Chung, P, Diaz, J, Dysager, L, Hall, W, Huddart, R, Kerkmeijer, L G W, Lawton, C, Mohajer, J, Murray, J, Nyborg, C J, Pos, F J, Rigo, M, Schytte, T, Sidhom, M, Sohaib, A, Tan, A, van der Voort van Zyp, J, Vesprini, D, Zelefsky, M J, and Tree, A C

Published
2024

3. PO-1941 Feasibility of a focal boost in MRI-guided online adaptive SBRT for locally advanced prostate cancer

Author

Dassen, M., primary, Betgen, A., additional, De Ruiter, P., additional, Van Der Linden, J., additional, Wiersema, L., additional, Neijndorff, B., additional, Janssen, T., additional, Abbenhuis, L., additional, Van Kollenburg, P., additional, Reijnen, C., additional, Kerkmeijer, L., additional, Pos, F., additional, Van Der Heide, U., additional, and Brunenberg, E., additional

Published
2023
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7. 1388P Interim safety analysis of nivolumab 3mg/kg and ipilimumab 1mg/kg (nivo3/ipi1) in molecular-selected patients (pts) with metastastic castration-resistant prostate cancer (mCRPC)

Author

van Wilpe, S., primary, Westdorp, H., additional, Kloots, I.S.H., additional, Slootbeek, P., additional, den Brok, M., additional, Adema, G., additional, Kerkmeijer, L., additional, Smeenk, R.J., additional, Coskunturk, M., additional, Bloemendal, H., additional, Schalken, J., additional, Erp, N.V., additional, Gerritsen, W.R., additional, and Mehra, N., additional

Published
2022
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8. Salvage stereotactic body radiotherapy (SBRT) for intraprostatic relapse after prostate cancer radiotherapy: An ESTRO ACROP Delphi consensus

Author

Jereczek-Fossa, B, Marvaso, G, Zaffaroni, M, Gugliandolo, S, Zerini, D, Corso, F, Gandini, S, Alongi, F, Bossi, A, Cornford, P, De Bari, B, Fonteyne, V, Hoskin, P, Pieters, B, Tree, A, Arcangeli, S, Fuller, D, Franzese, C, Hannoun-Levi, J, Janoray, G, Kerkmeijer, L, Kwok, Y, Livi, L, Loi, M, Miralbell, R, Pasquier, D, Pinkawa, M, Scher, N, Scorsetti, M, Shelan, M, Toledano, A, van As, N, Vavassori, A, Zilli, T, Pepa, M, Ost, P, Jereczek-Fossa B. A., Marvaso G., Zaffaroni M., Gugliandolo S. G., Zerini D., Corso F., Gandini S., Alongi F., Bossi A., Cornford P., De Bari B., Fonteyne V., Hoskin P., Pieters B. R., Tree A. C., Arcangeli S., Fuller D. B., Franzese C., Hannoun-Levi J. -M., Janoray G., Kerkmeijer L., Kwok Y., Livi L., Loi M., Miralbell R., Pasquier D., Pinkawa M., Scher N., Scorsetti M., Shelan M., Toledano A., van As N., Vavassori A., Zilli T., Pepa M., Ost P., Jereczek-Fossa, B, Marvaso, G, Zaffaroni, M, Gugliandolo, S, Zerini, D, Corso, F, Gandini, S, Alongi, F, Bossi, A, Cornford, P, De Bari, B, Fonteyne, V, Hoskin, P, Pieters, B, Tree, A, Arcangeli, S, Fuller, D, Franzese, C, Hannoun-Levi, J, Janoray, G, Kerkmeijer, L, Kwok, Y, Livi, L, Loi, M, Miralbell, R, Pasquier, D, Pinkawa, M, Scher, N, Scorsetti, M, Shelan, M, Toledano, A, van As, N, Vavassori, A, Zilli, T, Pepa, M, Ost, P, Jereczek-Fossa B. A., Marvaso G., Zaffaroni M., Gugliandolo S. G., Zerini D., Corso F., Gandini S., Alongi F., Bossi A., Cornford P., De Bari B., Fonteyne V., Hoskin P., Pieters B. R., Tree A. C., Arcangeli S., Fuller D. B., Franzese C., Hannoun-Levi J. -M., Janoray G., Kerkmeijer L., Kwok Y., Livi L., Loi M., Miralbell R., Pasquier D., Pinkawa M., Scher N., Scorsetti M., Shelan M., Toledano A., van As N., Vavassori A., Zilli T., Pepa M., and Ost P.

Abstract

Background and purpose: Between 30% and 47% of patients treated with definitive radiotherapy (RT) for prostate cancer are at risk of intraprostatic recurrence during follow-up. Re-irradiation with stereotactic body RT (SBRT) is emerging as a feasible and safe therapeutic option. However, no consensus or guidelines exist on this topic. The purpose of this ESTRO ACROP project is to investigate expert opinion on salvage SBRT for intraprostatic relapse after RT. Materials and Methods: A 40-item questionnaire on salvage SBRT was prepared by an internal committee and reviewed by a panel of leading radiation oncologists plus a urologist expert in prostate cancer. Following the procedure of a Delphi consensus, 3 rounds of questionnaires were sent to selected experts on prostate re-irradiation. Results: Among the 33 contacted experts, 18 (54.5%) agreed to participate. At the end of the final round, participants were able to find consensus on 14 out of 40 questions (35% overall) and major agreement on 13 questions (32.5% overall). Specifically, the consensus was reached regarding some selection criteria (no age limit, ECOG 0–1, satisfactory urinary flow), diagnostic procedures (exclusion of metastatic disease, SBRT target defined on the MRI) and therapeutic approach (no need for concomitant ADT, consideration of the first RT dose, validity of Phoenix criteria for salvage SBRT failure). Conclusion: While awaiting the results of ongoing studies, our ESTRO ACROP Delphi consensus may serve as a practical guidance for salvage SBRT. Future research should address the existing disagreements on this promising approach.

Published
2021

9. PO-1371 Dose-adaptive MR-linac workflow for hypofractionated focal boost radiotherapy in prostate cancer

Author

Kerkmeijer, L., primary, Kunze-Busch, M., additional, Smeenk, R.J., additional, Van Kollenburg, P., additional, Abbenhuis, L., additional, Scheenstra, T., additional, Engels, L., additional, Van der Sande, C., additional, Verheyden-Beckers, N., additional, Spee, L., additional, Hinke, L., additional, Brunenberg, E., additional, and Van der Bijl, E., additional

Published
2022
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10. PD-0571 Determining interobserver variability in prostate bed CTV target delineation using MRI

Author

Sritharan, K., primary, Akhiat, H., additional, Cahill, D., additional, Choi, S.L., additional, Choudhury, A., additional, Chung, P., additional, Diaz, J., additional, Dysager, L., additional, Hall, W., additional, Kerkmeijer, L., additional, Lawton, C.A., additional, Murray, J., additional, Nyborg, C.J., additional, Pos, F.J., additional, Rigo, M., additional, Schytte, T., additional, Sidhom, M., additional, Sohaib, A., additional, Tan, A., additional, van der Voort van Zyp, J., additional, Vesprini, D., additional, Zelefsky, M.J., additional, and Tree, A., additional

Published
2022
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11. PO-1754 Delineation-related ADC variation between centres in the Elekta Unity MR linac Consortium

Author

Bisgaard, A., primary, van Lier, A., additional, Coolens, C., additional, Keesman, R., additional, Tree, A., additional, Wetscherek, A., additional, Romesser, P., additional, Tyagi, N., additional, Lo Russo, M., additional, Habrich, J., additional, Vespirini, D., additional, Lau, A., additional, Mook, S., additional, Chung, P., additional, Kerkmeijer, L., additional, Nowee, M., additional, Schytte, T., additional, Lorenzen, E., additional, Brink, C., additional, Van der Heide, U., additional, and Mahmood, F., additional

Published
2022
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12. SP-0917 Patterns of failure in the phase III randomized controlled FLAME trial for localized prostate cancer

Author

Groen, V.H., primary, Haustermans, K., additional, Pos, F.J., additional, Draulans, C., additional, Isebaert, S., additional, Monninkhof, E.M., additional, Smeenk, R.J., additional, Kunze-Busch, M., additional, De Boer, H.C., additional, Van der Voort van Zyp, J.R., additional, Kerkmeijer, L., additional, and Van der Heide, U.A., additional

Published
2022
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14. 642TiP Phase II CA184-585 (INSPIRE) trial of ipilimumab with nivolumab for molecular-selected patients with castration-resistant prostate cancer

Author

Mehra, N., primary, Kloots, I., additional, Slootbeek, P., additional, Brok, M. den, additional, Adema, G., additional, Kerkmeijer, L., additional, Smeenk, R.J., additional, Westdorp, H., additional, Bloemendal, H., additional, Schalken, J., additional, van Erp, N.P., additional, Binder, M., additional, De Vries, J., additional, and Gerritsen, W., additional

Published
2021
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15. PO-1374 MR-guided SBRT for localized prostate cancer: the first results from the MOMENTUM study

Author

Teunissen, F., primary, Willigenburg, T., additional, Tree, A., additional, Hall, W., additional, Choi, S., additional, Choudhury, A., additional, Christodouleas, J., additional, de Boer, J., additional, de Groot-van Breugel, E., additional, Kerkmeijer, L., additional, Pos, F., additional, Vesprini, D., additional, Verkooijen, H., additional, and van der Voort van Zyp, J., additional

Published
2021
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16. MR-guided SBRT for localized prostate cancer: the first results from the MOMENTUM study

Author

Onderzoek Radiotherapie, Cancer, Klinische Fysica RT, MS Radiotherapie, Trialbureau Beeld, Teunissen, F., Willigenburg, T., Tree, A., Hall, W., Choi, S., Choudhury, A., Christodouleas, J., de Boer, J., de Groot-van Breugel, E., Kerkmeijer, L., Pos, F., Vesprini, D., Verkooijen, H., van Zyp, J. van der Voort, Onderzoek Radiotherapie, Cancer, Klinische Fysica RT, MS Radiotherapie, Trialbureau Beeld, Teunissen, F., Willigenburg, T., Tree, A., Hall, W., Choi, S., Choudhury, A., Christodouleas, J., de Boer, J., de Groot-van Breugel, E., Kerkmeijer, L., Pos, F., Vesprini, D., Verkooijen, H., and van Zyp, J. van der Voort

Published
2021

17. Urethra and bladder dose-effect relations for genitourinary toxicity after EBRT for prostate cancer

Author

Trialbureau Beeld, Cancer, MS Radiotherapie, Biostatistiek Onderzoek, Other research (not in main researchprogram), Epi Kanker Team C, JC onderzoeksprogramma Kanker, Klinische Fysica RT, Groen, V., van Schie, M., Zuithoff, N. P., Monninkhof, E. M., Kunze-Busch, M., de Boer, J. C., van Zijp, J. van der Voort, Pos, F. J., Smeenk, R. J., Haustermans, K., Isebaert, S., Draulans, C., Verkooijen, H. M., van der Heide, U. A., Kerkmeijer, L. G., Trialbureau Beeld, Cancer, MS Radiotherapie, Biostatistiek Onderzoek, Other research (not in main researchprogram), Epi Kanker Team C, JC onderzoeksprogramma Kanker, Klinische Fysica RT, Groen, V., van Schie, M., Zuithoff, N. P., Monninkhof, E. M., Kunze-Busch, M., de Boer, J. C., van Zijp, J. van der Voort, Pos, F. J., Smeenk, R. J., Haustermans, K., Isebaert, S., Draulans, C., Verkooijen, H. M., van der Heide, U. A., and Kerkmeijer, L. G.

Published
2021

19. Dosimetric impact of soft-tissue based intrafraction motion from 3D cine-MR in prostate SBRT

Author

Fysica Radiotherapie Research, Klinische Fysica RT, Cancer, MS Radiotherapie, Computational Imaging, Experimentele klinische fysica, AIOS Psychiatrie, de Muinck Keizer, D M, Kontaxis, C, Kerkmeijer, L G W, van der Voort van Zyp, J R N, van den Berg, C A T, Raaymakers, B W, Lagendijk, J J W, de Boer, J C J, Fysica Radiotherapie Research, Klinische Fysica RT, Cancer, MS Radiotherapie, Computational Imaging, Experimentele klinische fysica, AIOS Psychiatrie, de Muinck Keizer, D M, Kontaxis, C, Kerkmeijer, L G W, van der Voort van Zyp, J R N, van den Berg, C A T, Raaymakers, B W, Lagendijk, J J W, and de Boer, J C J

Published
2020

20. Prostate intrafraction motion during the preparation and delivery of MR-guided radiotherapy sessions on a 1.5T MR-Linac

Author

Fysica Radiotherapie Research, Cancer, MS Radiotherapie, Onderzoek Radiotherapie, Klinische Fysica RT, Arts-assistenten Radiotherapie, Experimentele klinische fysica, de Muinck Keizer, D. M., Kerkmeijer, L. G.W., Willigenburg, T., van Lier, A. L.H.M.W., Hartogh, M. D.den, van der Voort van Zyp, J. R.N., de Groot-van Breugel, E. N., Raaymakers, B. W., Lagendijk, J. J.W., de Boer, J. C.J., Fysica Radiotherapie Research, Cancer, MS Radiotherapie, Onderzoek Radiotherapie, Klinische Fysica RT, Arts-assistenten Radiotherapie, Experimentele klinische fysica, de Muinck Keizer, D. M., Kerkmeijer, L. G.W., Willigenburg, T., van Lier, A. L.H.M.W., Hartogh, M. D.den, van der Voort van Zyp, J. R.N., de Groot-van Breugel, E. N., Raaymakers, B. W., Lagendijk, J. J.W., and de Boer, J. C.J.

Published
2020

21. 68Ga-PSMA-11-PET, 18F-PSMA-1007-PET and MRI for Gross Tumor Volume Delineation in Primary Prostate Cancer: Intermodality and Inter-tracer Variability

Author

Draulans, C., primary, Pos, F.J., additional, Smeenk, R.J., additional, Kerkmeijer, L., additional, Vogel, W., additional, Nagarajah, J., additional, Janssen, M., additional, Mai, C., additional, Heijmink, S., additional, van der Leest, M., additional, Zámecnik, P., additional, Isebaert, S., additional, Maes, F., additional, Joniau, S., additional, Kunze-Busch, M., additional, De Roover, R., additional, Defraene, G., additional, van der Heide, U., additional, Goffin, K., additional, and Haustermans, K., additional

Published
2020
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22. Five-Year Toxicity after EBRT for Localized Prostate Cancer with or without a Simultaneously Integrated Focal Boost up to 95Gy: Results of a Randomized Controlled Trial

Author

Kerkmeijer, L., primary, Groen, V., additional, Pos, F.J., additional, Monninkhof, E., additional, Smeenk, R.J., additional, Kunze-Busch, M., additional, de Boer, H., additional, Van der Voort vanZyp, J., additional, van Vulpen, M., additional, Draulans, C., additional, Van Den Bergh, L., additional, Isebaert, S., additional, van der Heide, U., additional, and Haustermans, K., additional

Published
2020
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23. Impact of diabetes mellitus on 2-year outcomes of Absorb BVS compared to Xience EES: a pooled analysis of the COMPARE-ABSORB and AIDA trial

Author

Gao, C, primary, Kerkmeijer, L, additional, Tijssen, R.Y.G, additional, Kraak, R, additional, Tijssen, J, additional, Onuma, Y, additional, Chevalier, B, additional, West, N, additional, Morice, M.C, additional, De Winter, R, additional, Smits, P, additional, Wykrzykowska, J.J, additional, and Van Geuns, R.J, additional

Published
2020
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24. PH-0114: Dose-volume effects for GI toxicity following EBRT for prostate cancer in the FLAME trial

Author

Groen, V., primary, Zuithoff, P., additional, Van Schie, M., additional, Monninkhof, E., additional, Kunze-Busch, M., additional, De Boer, H., additional, Van der Voort van Zijp, J., additional, Pos, F., additional, Smeenk, R.J., additional, Haustermans, K., additional, Isebaert, S., additional, Depuydt, T., additional, Verkooijen, H.M., additional, Van der Heide, U.A., additional, and Kerkmeijer, L., additional

Published
2020
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26. OC-0315: Quality of life after EBRT with or without focal boost for prostate cancer in the FLAME trial

Author

Groen, V., primary, Monninkhof, E., additional, Verkooijen, H.M., additional, Kunze-Busch, M., additional, De Boer, H., additional, Van der Voort van Zijp, J., additional, Pos, F., additional, Smeenk, R.J., additional, Haustermans, K., additional, Isebaert, S., additional, Depuydt, T., additional, Van der Heide, U.A., additional, and Kerkmeijer, L., additional

Published
2020
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30. Gross tumour delineation on computed tomography and positron emission tomography-computed tomography in oesophageal cancer: A nationwide study

Author

Nowee, M. E., Voncken, F. E. M., Kotte, A. N. T. J., Goense, L., van Rossum, P. S. N., van Lier, A. L. H. M. W., Heijmink, S. W., Aleman, B. M. P., Nijkamp, J., Meijer, G. J., Lips, I. M., Braam, P. M., Buijsen, J., Ceha, H. M., Dewit, L., Franssen, J. H., van Gestel, K., Grootenboers, D. A. R. H., Intven, M., Jansen, E. P. M., Kerkmeijer, L. G. W., Mul, V. E., Muller, K., Neelis, K. J., Oppedijk, V, Rozema, T., Spruit, P. H., Nowee, M. E., Voncken, F. E. M., Kotte, A. N. T. J., Goense, L., van Rossum, P. S. N., van Lier, A. L. H. M. W., Heijmink, S. W., Aleman, B. M. P., Nijkamp, J., Meijer, G. J., Lips, I. M., Braam, P. M., Buijsen, J., Ceha, H. M., Dewit, L., Franssen, J. H., van Gestel, K., Grootenboers, D. A. R. H., Intven, M., Jansen, E. P. M., Kerkmeijer, L. G. W., Mul, V. E., Muller, K., Neelis, K. J., Oppedijk, V, Rozema, T., and Spruit, P. H.

Published
2019

32. Fiducial marker based intra-fraction motion assessment on cine-MR for MR-linac treatment of prostate cancer

Author

Fysica Radiotherapie Research, Cancer, MS Radiotherapie, Computational Imaging, Klinische Fysica RT, Keizer, D. M. de Muinck, Pathmanathan, A. U., Andreychenko, A., Kerkmeijer, L. G. W., van Zyp, J. R. N. van der Voort, Tree, A. C., van den Berg, C. A. T., de Boer, J. C. J., Fysica Radiotherapie Research, Cancer, MS Radiotherapie, Computational Imaging, Klinische Fysica RT, Keizer, D. M. de Muinck, Pathmanathan, A. U., Andreychenko, A., Kerkmeijer, L. G. W., van Zyp, J. R. N. van der Voort, Tree, A. C., van den Berg, C. A. T., and de Boer, J. C. J.

Published
2019

33. Gross tumour delineation on computed tomography and positron emission tomography-computed tomography in oesophageal cancer: A nationwide study

Author

Arts-assistenten Radiotherapie, Klinische Fysica RT, Cancer, Onderzoek Radiotherapie, MS Verloskunde, MS Mondziekten/Kaakchirurgie, MS Radiotherapie, Nowee, M. E., Voncken, F. E. M., Kotte, A. N. T. J., Goense, L., van Rossum, P. S. N., van Lier, A. L. H. M. W., Heijmink, S. W., Aleman, B. M. P., Nijkamp, J., Meijer, G. J., Lips, I. M., Braam, P. M., Buijsen, J., Ceha, H. M., Dewit, L., Franssen, J. H., van Gestel, K., Grootenboers, D. A. R. H., Intven, M., Jansen, E. P. M., Kerkmeijer, L. G. W., Mul, V. E., Muller, K., Neelis, K. J., Oppedijk, V, Rozema, T., Spruit, P. H., Arts-assistenten Radiotherapie, Klinische Fysica RT, Cancer, Onderzoek Radiotherapie, MS Verloskunde, MS Mondziekten/Kaakchirurgie, MS Radiotherapie, Nowee, M. E., Voncken, F. E. M., Kotte, A. N. T. J., Goense, L., van Rossum, P. S. N., van Lier, A. L. H. M. W., Heijmink, S. W., Aleman, B. M. P., Nijkamp, J., Meijer, G. J., Lips, I. M., Braam, P. M., Buijsen, J., Ceha, H. M., Dewit, L., Franssen, J. H., van Gestel, K., Grootenboers, D. A. R. H., Intven, M., Jansen, E. P. M., Kerkmeijer, L. G. W., Mul, V. E., Muller, K., Neelis, K. J., Oppedijk, V, Rozema, T., and Spruit, P. H.

Published
2019

34. Intrafraction Motion Management of Renal Cell Carcinoma With Magnetic Resonance Imaging-Guided Stereotactic Body Radiation Therapy

Author

Onderzoek Radiotherapie, Cancer, Computational Imaging, MS Radiotherapie, Urologie Medisch volwassenen, Klinische Fysica RT, MS Radiologie, Circulatory Health, Fysica Radiotherapie Research, Prins, F M, Stemkens, B, Kerkmeijer, L G W, Barendrecht, M M, de Boer, J C J, Vonken, E P A, Lagendijk, J J W, Tijssen, R H N, Onderzoek Radiotherapie, Cancer, Computational Imaging, MS Radiotherapie, Urologie Medisch volwassenen, Klinische Fysica RT, MS Radiologie, Circulatory Health, Fysica Radiotherapie Research, Prins, F M, Stemkens, B, Kerkmeijer, L G W, Barendrecht, M M, de Boer, J C J, Vonken, E P A, Lagendijk, J J W, and Tijssen, R H N

Published
2019

35. 'First in man' treatments with the MRI-linac provide clinical proof of the concept

Author

Jurgenliemk-Schulz, I. M., Raaymakers, B. W., Van Asselen, B., Bol, G. H., Brown, K. J., Doornaert, P., De Groot-van Breugel, E. N., Hackett, S. L., Kasperts, N., Kiekebosch, I. H., Kerkmeijer, L. G. W., Kok, J. G. M., Kotte, A. N. T., Meijers, L. T. C., Nomden, C. N., Pais, B. R., Philippens, M. E. P., Sikkes, G. G., Tersteeg, J. H. A., Tijssen, R. H. N., Wolthaus, J. W. H., Woodings, S. J., and Lagendijk, J. J. W.

Published
2018

36. P2798Final 5-year outcomes of the TRIAS High Risk of Restenosis; a multi-centre, randomized trial comparing endothelial progenitor cell capturing stent with drug-eluting stents

Author

Kerkmeijer, L S M, primary, Woudstra, P, additional, Klomp, M, additional, Kalkman, D N, additional, Varma, C, additional, Koolen, J J, additional, Teiger, E, additional, Florian, B, additional, Verouden, N J, additional, Tijssen, J G, additional, Beijk, M A, additional, and De Winter, R J, additional

Published
2019
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37. 126Clinical outcomes at two years of the Absorb BRS vs. the Xience metallic DES in patients presenting with ACS vs. stable coronary disease - AIDA trial substudy

Author

Tijssen, R Y G, primary, Van Der Schaaf, R J, additional, Vink, M A, additional, Kraak, R P, additional, Hofma, S H, additional, Arkenbout, E K, additional, Weevers, A P J D, additional, Kerkmeijer, L S, additional, Onuma, Y, additional, Serruys, P W J C, additional, Piek, J J, additional, Tijssen, J G P, additional, Henriques, J P, additional, De Winter, R J, additional, and Wykrzykowska, J J, additional

Published
2019
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45. Magnetic Resonance-based Response Assessment and Dose Adaptation in Human Papilloma Virus Positive Tumors of the Oropharynx treated with Radiotherapy (MR-ADAPTOR): An R-IDEAL stage 2a-2b/Bayesian phase II trial

Author

Bahig, H, Yuan, Y, Mohamed, ASR, Brock, KK, Ng, SP, Wang, J, Ding, Y, Hutcheson, K, McCulloch, M, Balter, PA, Lai, SY, Al-Mamgani, A, Sonke, J-J, van der Heide, UA, Nutting, C, Li, XA, Robbins, J, Awan, M, Karam, I, Newbold, K, Harrington, K, Oelfke, U, Bhide, S, Philippens, MEP, Terhaard, CHJ, McPartlin, AJ, Blanchard, P, Garden, AS, Rosenthal, DI, Gunn, GB, Phan, J, Cazoulat, G, Aristophanous, M, McSpadden, KK, Garcia, JA, van den Berg, CAT, Raaijmakers, CPJ, Kerkmeijer, L, Doornaert, P, Blinde, S, Frank, SJ, Fuller, CD, Bahig, H, Yuan, Y, Mohamed, ASR, Brock, KK, Ng, SP, Wang, J, Ding, Y, Hutcheson, K, McCulloch, M, Balter, PA, Lai, SY, Al-Mamgani, A, Sonke, J-J, van der Heide, UA, Nutting, C, Li, XA, Robbins, J, Awan, M, Karam, I, Newbold, K, Harrington, K, Oelfke, U, Bhide, S, Philippens, MEP, Terhaard, CHJ, McPartlin, AJ, Blanchard, P, Garden, AS, Rosenthal, DI, Gunn, GB, Phan, J, Cazoulat, G, Aristophanous, M, McSpadden, KK, Garcia, JA, van den Berg, CAT, Raaijmakers, CPJ, Kerkmeijer, L, Doornaert, P, Blinde, S, Frank, SJ, and Fuller, CD

Abstract

BACKGROUND: Current standard radiotherapy for oropharynx cancer (OPC) is associated with high rates of severe toxicities, shown to adversely impact patients' quality of life. Given excellent outcomes of human papilloma virus (HPV)-associated OPC and long-term survival of these typically young patients, treatment de-intensification aimed at improving survivorship while maintaining excellent disease control is now a central concern. The recent implementation of magnetic resonance image - guided radiotherapy (MRgRT) systems allows for individual tumor response assessment during treatment and offers possibility of personalized dose-reduction. In this 2-stage Bayesian phase II study, we propose to examine weekly radiotherapy dose-adaptation based on magnetic resonance imaging (MRI) evaluated tumor response. Individual patient's plan will be designed to optimize dose reduction to organs at risk and minimize locoregional failure probability based on serial MRI during RT. Our primary aim is to assess the non-inferiority of MRgRT dose adaptation for patients with low risk HPV-associated OPC compared to historical control, as measured by Bayesian posterior probability of locoregional control (LRC). METHODS: Patients with T1-2 N0-2b (as per AJCC 7th Edition) HPV-positive OPC, with lymph node <3 cm and <10 pack-year smoking history planned for curative radiotherapy alone to a dose of 70 Gy in 33 fractions will be eligible. All patients will undergo pre-treatment MRI and at least weekly intra-treatment MRI. Patients undergoing MRgRT will have weekly adaptation of high dose planning target volume based on gross tumor volume response. The stage 1 of this study will enroll 15 patients to MRgRT dose adaptation. If LRC at 6 months with MRgRT dose adaptation is found sufficiently safe as per the Bayesian model, stage 2 of the protocol will expand enrollment to an additional 60 patients, randomized to either MRgRT or standard IMRT. DISCUSSION: Multiple methods for safe treatment de-esc

Published
2018

46. 'First in man' treatments with the MRI-linac provide clinical proof of the concept

Author

MS Radiotherapie, Cancer, Experimentele klinische fysica, Klinische Fysica RT, Fysica Radiotherapie Research, Jurgenliemk-Schulz, I. M., Raaymakers, B. W., Van Asselen, B., Bol, G. H., Brown, K. J., Doornaert, P., De Groot-van Breugel, E. N., Hackett, S. L., Kasperts, N., Kiekebosch, I. H., Kerkmeijer, L. G. W., Kok, J. G. M., Kotte, A. N. T., Meijers, L. T. C., Nomden, C. N., Pais, B. R., Philippens, M. E. P., Sikkes, G. G., Tersteeg, J. H. A., Tijssen, R. H. N., Wolthaus, J. W. H., Woodings, S. J., Lagendijk, J. J. W., MS Radiotherapie, Cancer, Experimentele klinische fysica, Klinische Fysica RT, Fysica Radiotherapie Research, Jurgenliemk-Schulz, I. M., Raaymakers, B. W., Van Asselen, B., Bol, G. H., Brown, K. J., Doornaert, P., De Groot-van Breugel, E. N., Hackett, S. L., Kasperts, N., Kiekebosch, I. H., Kerkmeijer, L. G. W., Kok, J. G. M., Kotte, A. N. T., Meijers, L. T. C., Nomden, C. N., Pais, B. R., Philippens, M. E. P., Sikkes, G. G., Tersteeg, J. H. A., Tijssen, R. H. N., Wolthaus, J. W. H., Woodings, S. J., and Lagendijk, J. J. W.

Published
2018

47. Accelerating multi-modal image registration using a supervoxel-based variational framework

Author

Experimentele klinische fysica, Cancer, MS Radiotherapie, Researchgr. Beeldg. Moleculaire Interv., Lafitte, L, Zachiu, C, Kerkmeijer, L G W, Ries, M, Denis de Senneville, B, Experimentele klinische fysica, Cancer, MS Radiotherapie, Researchgr. Beeldg. Moleculaire Interv., Lafitte, L, Zachiu, C, Kerkmeijer, L G W, Ries, M, and Denis de Senneville, B

Published
2018

50. First patients treated with a 1.5 T MRI-Linac: clinical proof of concept of a high-precision, high-field MRI guided radiotherapy treatment

Author

Raaymakers, B W, primary, Jürgenliemk-Schulz, I M, additional, Bol, G H, additional, Glitzner, M, additional, Kotte, A N T J, additional, van Asselen, B, additional, de Boer, J C J, additional, Bluemink, J J, additional, Hackett, S L, additional, Moerland, M A, additional, Woodings, S J, additional, Wolthaus, J W H, additional, van Zijp, H M, additional, Philippens, M E P, additional, Tijssen, R, additional, Kok, J G M, additional, de Groot-van Breugel, E N, additional, Kiekebosch, I, additional, Meijers, L T C, additional, Nomden, C N, additional, Sikkes, G G, additional, Doornaert, P A H, additional, Eppinga, W S C, additional, Kasperts, N, additional, Kerkmeijer, L G W, additional, Tersteeg, J H A, additional, Brown, K J, additional, Pais, B, additional, Woodhead, P, additional, and Lagendijk, J J W, additional

Published
2017
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