Search

Your search keyword '"Kerkmeijer, Linda G W"' showing total 170 results
Start Over Author "Kerkmeijer, Linda G W"
170 results on '"Kerkmeijer, Linda G W"'

1. Delphi consensus on stereotactic ablative radiotherapy for oligometastatic and oligoprogressive renal cell carcinoma—a European Society for Radiotherapy and Oncology study endorsed by the European Association of Urology

Author

Marvaso, Giulia, Jereczek-Fossa, Barbara Alicja, Zaffaroni, Mattia, Vincini, Maria Giulia, Corrao, Giulia, Andratschke, Nicolaus, Balagamwala, Ehsan H, Bedke, Jens, Blanck, Oliver, Capitanio, Umberto, Correa, Rohann J M, De Meerleer, Gert, Franzese, Ciro, Gaeta, Aurora, Gandini, Sara, Garibaldi, Cristina, Gerszten, Peter C, Gillessen, Silke, Grubb, William R, Guckenberger, Matthias, Hannan, Raquibul, Jhaveri, Pavan M, Josipovic, Mirjana, Kerkmeijer, Linda G W, Lehrer, Eric J, Lindskog, Magnus, Louie, Alexander V, Nguyen, Quynh-Nhu, Ost, Piet, Palma, David A, Procopio, Giuseppe, Rossi, Maddalena, Staehler, Michael, Tree, Alison C, Tsang, Yat Man, Van As, Nicholas, Zaorsky, Nicholas G, Zilli, Thomas, Pasquier, David, and Siva, Shankar

Published
2024
Full Text
View/download PDF

3. Dose evaluation of fast synthetic-CT generation using a generative adversarial network for general pelvis MR-only radiotherapy

Author

Maspero, Matteo, Savenije, Mark H. F., Dinkla, Anna M., Seevinck, Peter R., Intven, Martijn P. W., Jurgenliemk-Schulz, Ina M., Kerkmeijer, Linda G. W., and Berg, Cornelis A. T. van den

Subjects
Physics - Medical Physics
Abstract

To enable magnetic resonance (MR)-only radiotherapy and facilitate modelling of radiation attenuation in humans, synthetic-CT (sCT) images need to be generated. Considering the application of MR-guided radiotherapy and online adaptive replanning, sCT generation should occur within minutes. This work aims at assessing whether an existing deep learning network can rapidly generate sCT images to be used for accurate MR-based dose calculations in the entire pelvis. A study was conducted on data of 91 patients with prostate, rectal and cervical cancer who underwent external beam radiotherapy acquiring both CT and MRI for patients' simulation. Dixon reconstructed water, fat and in-phase images obtained from a conventional dual gradient-recalled echo sequence were used to generate sCT images. A conditional generative adversarial network (cGAN) was trained in a paired fashion on 2D transverse slices of 32 prostate cancer patients. The trained network was tested on the remaining patients to generate sCT images. For 30 patients in the test set, dose recalculations of the clinical plan were performed on sCT images. Dose distributions were evaluated comparing voxel-based dose differences, gamma and dose-volume histogram (DVH) analysis. The sCT generation required 5.6 s and 21 s for a single patient volume on a GPU and CPU, respectively. On average, sCT images resulted in a higher dose to the target of maximum 0.3%. Results suggest that accurate MR-based dose calculation using sCT images generated with a cGAN trained on prostate cancer patients is feasible for the entire pelvis. The sCT generation was sufficiently fast to be integrated into an MR-guided radiotherapy workflow., Comment: Accepted for publication in Physics in Medicine and Biology, in press (2018)

Published
2018
Full Text
View/download PDF

4. MRI-guided radiotherapy in twenty fractions for localised prostate cancer: results from the MOMENTUM study

Author

MS CGO, Cancer, Trialbureau Beeld, MS Radiotherapie, Sritharan, Kobika, Daamen, Lois, Pathmanathan, Angela, Schytte, Tine, Pos, Floris, Choudhury, Ananya, van der Voort van Zyp, Jochem R N, Kerkmeijer, Linda G W, Hall, William, Hall, Emma, Verkooijen, Helena M, Herbert, Trina, Hafeez, Shaista, Mitchell, Adam, Tree, Alison C, MS CGO, Cancer, Trialbureau Beeld, MS Radiotherapie, Sritharan, Kobika, Daamen, Lois, Pathmanathan, Angela, Schytte, Tine, Pos, Floris, Choudhury, Ananya, van der Voort van Zyp, Jochem R N, Kerkmeijer, Linda G W, Hall, William, Hall, Emma, Verkooijen, Helena M, Herbert, Trina, Hafeez, Shaista, Mitchell, Adam, and Tree, Alison C

Published
2024

5. Recommendations for improved reproducibility of ADC derivation on behalf of the Elekta MRI-linac consortium image analysis working group

Author

Klinische Fysica RT, MS Radiotherapie, Cancer, Bisgaard, Anne L H, Keesman, Rick, van Lier, Astrid L H M W, Coolens, Catherine, van Houdt, Petra J, Tree, Alison, Wetscherek, Andreas, Romesser, Paul B, Tyagi, Neelam, Lo Russo, Monica, Habrich, Jonas, Vesprini, Danny, Lau, Angus Z, Mook, Stella, Chung, Peter, Kerkmeijer, Linda G W, Gouw, Zeno A R, Lorenzen, Ebbe L, van der Heide, Uulke A, Schytte, Tine, Brink, Carsten, Mahmood, Faisal, Klinische Fysica RT, MS Radiotherapie, Cancer, Bisgaard, Anne L H, Keesman, Rick, van Lier, Astrid L H M W, Coolens, Catherine, van Houdt, Petra J, Tree, Alison, Wetscherek, Andreas, Romesser, Paul B, Tyagi, Neelam, Lo Russo, Monica, Habrich, Jonas, Vesprini, Danny, Lau, Angus Z, Mook, Stella, Chung, Peter, Kerkmeijer, Linda G W, Gouw, Zeno A R, Lorenzen, Ebbe L, van der Heide, Uulke A, Schytte, Tine, Brink, Carsten, and Mahmood, Faisal

Published
2023

6. From once-weekly to semi-weekly whole prostate gland stereotactic radiotherapy with focal boosting: Primary endpoint analysis of the multicenter phase II hypo-FLAME 2.0 trial

Author

MS Radiotherapie, Cancer, Klinische Fysica RT, De Cock, Lisa, Draulans, Cédric, Pos, Floris J, Isebaert, Sofie, De Roover, Robin, van der Heide, Uulke A, Smeenk, Robert J, Kunze-Busch, Martina, van der Voort van Zyp, Jochem, de Boer, Hans, Kerkmeijer, Linda G W, Haustermans, Karin, MS Radiotherapie, Cancer, Klinische Fysica RT, De Cock, Lisa, Draulans, Cédric, Pos, Floris J, Isebaert, Sofie, De Roover, Robin, van der Heide, Uulke A, Smeenk, Robert J, Kunze-Busch, Martina, van der Voort van Zyp, Jochem, de Boer, Hans, Kerkmeijer, Linda G W, and Haustermans, Karin

Published
2023

7. Magnetic Resonance-Guided Adaptive Radiation therapy for Prostate Cancer: The First Results from the MOMENTUM study-An International Registry for the Evidence-Based Introduction of Magnetic Resonance-Guided Adaptive Radiation Therapy

Author

Cancer, Onderzoek Radiotherapie, Arts-assistenten Radiotherapie, MS Radiotherapie, Trialbureau Beeld, Teunissen, Frederik R, Willigenburg, Thomas, Tree, Alison C, Hall, William A, Choi, Seungtaek L, Choudhury, Ananya, Christodouleas, John P, de Boer, Johannes C J, Groot-van Breugel, Eline N de, Kerkmeijer, Linda G W, Pos, Floris J, Schytte, Tine, Vesprini, Danny, Verkooijen, Helena M, Voort van Zyp, Jochem R N van der, Cancer, Onderzoek Radiotherapie, Arts-assistenten Radiotherapie, MS Radiotherapie, Trialbureau Beeld, Teunissen, Frederik R, Willigenburg, Thomas, Tree, Alison C, Hall, William A, Choi, Seungtaek L, Choudhury, Ananya, Christodouleas, John P, de Boer, Johannes C J, Groot-van Breugel, Eline N de, Kerkmeijer, Linda G W, Pos, Floris J, Schytte, Tine, Vesprini, Danny, Verkooijen, Helena M, and Voort van Zyp, Jochem R N van der

Published
2023

8. An ESTRO-ACROP guideline on quality assurance and medical physics commissioning of online MRI guided radiotherapy systems based on a consensus expert opinion

Author

Tanadini-Lang, Stephanie, Budgell, Geoff, Bohoudi, Omar, Corradini, Stefanie, Cusumano, Davide, Güngör, Görkem, Kerkmeijer, Linda G W, Mahmood, Faisal, Nill, Simeon, Palacios, Miguel A, Reiner, Michael, Thorwarth, Daniela, Wilke, Lotte, Wolthaus, Jochem, Tanadini-Lang, Stephanie, Budgell, Geoff, Bohoudi, Omar, Corradini, Stefanie, Cusumano, Davide, Güngör, Görkem, Kerkmeijer, Linda G W, Mahmood, Faisal, Nill, Simeon, Palacios, Miguel A, Reiner, Michael, Thorwarth, Daniela, Wilke, Lotte, and Wolthaus, Jochem

Abstract

OBJECTIVE The goal of this consensus expert opinion was to define quality assurance (QA) tests for online magnetic resonance image (MRI) guided radiotherapy (oMRgRT) systems and to define the important medical physics aspects for installation and commissioning of an oMRgRT system. MATERIALS AND METHODS Ten medical physicists and two radiation oncologists experienced in oMRgRT participated in the survey. In the first round of the consensus expert opinion, ideas on QA and commissioning were collected. Only tests and aspects different from commissioning of a CT guided radiotherapy (RT) system were considered. In the following two rounds all twelve participants voted on the importance of the QA tests, their recommended frequency and their suitability for the two oMRgRT systems approved for clinical use as well as on the importance of the aspects to consider during medical physics commissioning. RESULTS Twenty-four QA tests were identified which are potentially important during commissioning and routine QA on oMRgRT systems compared to online CT guided RT systems. An additional eleven tasks and aspects related to construction, workflow development and training were collected. Consensus was found for most tests on their importance, their recommended frequency and their suitability for the two approved systems. In addition, eight aspects mostly related to the definition of workflows were also found to be important during commissioning. CONCLUSIONS A program for QA and commissioning of oMRgRT systems was developed to support medical physicists to prepare for safe handling of such systems.

Published
2023

12. Adaptive magnetic resonance image guided radiation for intact localized prostate cancer how to optimally test a rapidly emerging technology

Author

Hall, William A., primary, Kishan, Amar U., additional, Hall, Emma, additional, Nagar, Himanshu, additional, Vesprini, Danny, additional, Paulson, Eric, additional, Van der Heide, Uulke A., additional, Lawton, Colleen A. F., additional, Kerkmeijer, Linda G. W., additional, and Tree, Alison C., additional

Published
2022
Full Text
View/download PDF

14. 'Who needs a mean dose if you can FLAME?'

Author

Cancer, Epi Kanker Team C, JC onderzoeksprogramma Kanker, Guricová, Karolína, van der Heide, Uulke A, Kerkmeijer, Linda G W, Pos, Floris, Monninkhof, Evelyn, Haustermans, Karin, Cancer, Epi Kanker Team C, JC onderzoeksprogramma Kanker, Guricová, Karolína, van der Heide, Uulke A, Kerkmeijer, Linda G W, Pos, Floris, Monninkhof, Evelyn, and Haustermans, Karin

Published
2022

15. Urethral and bladder dose-effect relations for late genitourinary toxicity following external beam radiotherapy for prostate cancer in the FLAME trial

Author

Trialbureau Beeld, Cancer, MS Radiotherapie, Biostatistiek Onderzoek, Other research (not in main researchprogram), Epi Kanker Team C, JC onderzoeksprogramma Kanker, Groen, Veerle H, van Schie, Marcel, Zuithoff, Nicolaas P A, Monninkhof, Evelyn M, Kunze-Busch, Martina, de Boer, Johannes C J, van der Voort van Zijp, Jochem, Pos, Floris J, Smeenk, Robert Jan, Haustermans, Karin, Isebaert, Sofie, Draulans, Cédric, Depuydt, Tom, Verkooijen, Helena M, van der Heide, Uulke A, Kerkmeijer, Linda G W, Trialbureau Beeld, Cancer, MS Radiotherapie, Biostatistiek Onderzoek, Other research (not in main researchprogram), Epi Kanker Team C, JC onderzoeksprogramma Kanker, Groen, Veerle H, van Schie, Marcel, Zuithoff, Nicolaas P A, Monninkhof, Evelyn M, Kunze-Busch, Martina, de Boer, Johannes C J, van der Voort van Zijp, Jochem, Pos, Floris J, Smeenk, Robert Jan, Haustermans, Karin, Isebaert, Sofie, Draulans, Cédric, Depuydt, Tom, Verkooijen, Helena M, van der Heide, Uulke A, and Kerkmeijer, Linda G W

Published
2022

19. Focal Boost to the Intraprostatic Tumor in External Beam Radiotherapy for Patients With Localized Prostate Cancer: Results From the FLAME Randomized Phase III Trial

Author

MS Radiotherapie, Cancer, Trialbureau Beeld, Epi Kanker Team A, JC onderzoeksprogramma Kanker, Klinische Fysica RT, Kerkmeijer, Linda G W, Groen, Veerle H, Pos, Floris J, Haustermans, Karin, Monninkhof, Evelyn M, Smeenk, Robert Jan, Kunze-Busch, Martina, de Boer, Johannes C J, van der Voort van Zijp, Jochem, van Vulpen, Marco, Draulans, Cédric, van den Bergh, Laura, Isebaert, Sofie, van der Heide, Uulke A, MS Radiotherapie, Cancer, Trialbureau Beeld, Epi Kanker Team A, JC onderzoeksprogramma Kanker, Klinische Fysica RT, Kerkmeijer, Linda G W, Groen, Veerle H, Pos, Floris J, Haustermans, Karin, Monninkhof, Evelyn M, Smeenk, Robert Jan, Kunze-Busch, Martina, de Boer, Johannes C J, van der Voort van Zijp, Jochem, van Vulpen, Marco, Draulans, Cédric, van den Bergh, Laura, Isebaert, Sofie, and van der Heide, Uulke A

Published
2021

21. Focal Boost to the Intraprostatic Tumor in External Beam Radiotherapy for Patients With Localized Prostate Cancer: Results From the FLAME Randomized Phase III Trial

Author

Kerkmeijer, Linda G. W., primary, Groen, Veerle H., additional, Pos, Floris J., additional, Haustermans, Karin, additional, Monninkhof, Evelyn M., additional, Smeenk, Robert Jan, additional, Kunze-Busch, Martina, additional, de Boer, Johannes C. J., additional, van der Voort van Zijp, Jochem, additional, van Vulpen, Marco, additional, Draulans, Cédric, additional, van den Bergh, Laura, additional, Isebaert, Sofie, additional, and van der Heide, Uulke A., additional

Published
2021
Full Text
View/download PDF

24. Deep learning-based MR-to-CT synthesis : The influence of varying gradient echo-based MR images as input channels

Author

Florkow, Mateusz C, Zijlstra, Frank, Willemsen, Koen, Maspero, Matteo, van den Berg, Cornelis A T, Kerkmeijer, Linda G W, Castelein, René M, Weinans, Harrie, Viergever, Max A, van Stralen, Marijn, Seevinck, Peter R, Florkow, Mateusz C, Zijlstra, Frank, Willemsen, Koen, Maspero, Matteo, van den Berg, Cornelis A T, Kerkmeijer, Linda G W, Castelein, René M, Weinans, Harrie, Viergever, Max A, van Stralen, Marijn, and Seevinck, Peter R

Published
2020

25. Deep learning-based MR-to-CT synthesis: The influence of varying gradient echo-based MR images as input channels

Author

Beeldverwerking ISI, Cancer, Orthopaedie Onderzoek, Computational Imaging, MS Radiotherapie, Regenerative Medicine and Stem Cells, MS Orthopaedie Spine, MS Orthopaedie Algemeen, Florkow, Mateusz C, Zijlstra, Frank, Willemsen, Koen, Maspero, Matteo, van den Berg, Cornelis A T, Kerkmeijer, Linda G W, Castelein, René M, Weinans, Harrie, Viergever, Max A, van Stralen, Marijn, Seevinck, Peter R, Beeldverwerking ISI, Cancer, Orthopaedie Onderzoek, Computational Imaging, MS Radiotherapie, Regenerative Medicine and Stem Cells, MS Orthopaedie Spine, MS Orthopaedie Algemeen, Florkow, Mateusz C, Zijlstra, Frank, Willemsen, Koen, Maspero, Matteo, van den Berg, Cornelis A T, Kerkmeijer, Linda G W, Castelein, René M, Weinans, Harrie, Viergever, Max A, van Stralen, Marijn, and Seevinck, Peter R

Published
2020

26. Primary endpoint analysis of the multicentre phase II hypo-FLAME trial for intermediate and high risk prostate cancer

Author

MS Radiotherapie, Cancer, Klinische Fysica RT, Trialbureau Beeld, Epi Kanker Team A, JC onderzoeksprogramma Kanker, Draulans, Cédric, van der Heide, Uulke A, Haustermans, Karin, Pos, Floris J, van der Voort van Zyp, Jochem, De Boer, Hans, Groen, Veerle H, Monninkhof, Evelyn M, Smeenk, Robert J, Kunze-Busch, Martina, De Roover, Robin, Depuydt, Tom, Isebaert, Sofie, Kerkmeijer, Linda G W, MS Radiotherapie, Cancer, Klinische Fysica RT, Trialbureau Beeld, Epi Kanker Team A, JC onderzoeksprogramma Kanker, Draulans, Cédric, van der Heide, Uulke A, Haustermans, Karin, Pos, Floris J, van der Voort van Zyp, Jochem, De Boer, Hans, Groen, Veerle H, Monninkhof, Evelyn M, Smeenk, Robert J, Kunze-Busch, Martina, De Roover, Robin, Depuydt, Tom, Isebaert, Sofie, and Kerkmeijer, Linda G W

Published
2020

27. Knowledge-Based Assessment of Focal Dose Escalation Treatment Plans in Prostate Cancer

Author

MS Radiotherapie, Klinische Fysica RT, Cancer, Epi Kanker Team A, JC onderzoeksprogramma Kanker, van Schie, Marcel A, Janssen, Tomas M, Eekhout, Dave, Walraven, Iris, Pos, Floris J, de Ruiter, Peter, Kotte, Alexis N T J, Monninkhof, Evelyn M, Kerkmeijer, Linda G W, Draulans, Cédric, de Roover, Robin, Haustermans, Karin, Kunze-Busch, Martina, Smeenk, Robert Jan, van der Heide, Uulke A, MS Radiotherapie, Klinische Fysica RT, Cancer, Epi Kanker Team A, JC onderzoeksprogramma Kanker, van Schie, Marcel A, Janssen, Tomas M, Eekhout, Dave, Walraven, Iris, Pos, Floris J, de Ruiter, Peter, Kotte, Alexis N T J, Monninkhof, Evelyn M, Kerkmeijer, Linda G W, Draulans, Cédric, de Roover, Robin, Haustermans, Karin, Kunze-Busch, Martina, Smeenk, Robert Jan, and van der Heide, Uulke A

Published
2020

29. Quantitative MRI Changes During Weekly Ultra-Hypofractionated Prostate Cancer Radiotherapy With Integrated Boost

Author

van Schie, Marcel A., primary, van Houdt, Petra J., additional, Ghobadi, Ghazaleh, additional, Pos, Floris J., additional, Walraven, Iris, additional, de Boer, Hans C. J., additional, van den Berg, Cornelis A. T., additional, Smeenk, Robert Jan, additional, Kerkmeijer, Linda G. W., additional, and van der Heide, Uulke A., additional

Published
2019
Full Text
View/download PDF

30. Deep learning–based MR‐to‐CT synthesis: The influence of varying gradient echo–based MR images as input channels

Author

Florkow, Mateusz C., primary, Zijlstra, Frank, additional, Willemsen, Koen, additional, Maspero, Matteo, additional, Berg, Cornelis A. T., additional, Kerkmeijer, Linda G. W., additional, Castelein, René M., additional, Weinans, Harrie, additional, Viergever, Max A., additional, Stralen, Marijn, additional, and Seevinck, Peter R., additional

Published
2019
Full Text
View/download PDF

31. Visualization of gold fiducial markers in the prostate using phase-cycled bSSFP imaging for MRI-only radiotherapy

Author

Shcherbakova, Yulia, primary, Bartels, Lambertus W, additional, Mandija, Stefano, additional, Beld, Ellis, additional, Seevinck, Peter R, additional, van der Voort van Zyp, Jochem R N, additional, Kerkmeijer, Linda G W, additional, Moonen, Chrit T W, additional, Lagendijk, Jan J W, additional, and van den Berg, Cornelis A T, additional

Published
2019
Full Text
View/download PDF

34. Adaptive radiotherapy : The Elekta Unity MR-linac concept

Author

Winkel, Dennis, Bol, Gijsbert H, Kroon, Petra S, van Asselen, Bram, Hackett, Sara S, Werensteijn-Honingh, Anita M, Intven, Martijn P W, Eppinga, Wietse S C, Tijssen, Rob H N, Kerkmeijer, Linda G W, de Boer, Hans C J, Mook, Stella, Meijer, Gert J, Hes, Jochem, Willemsen-Bosman, Mirjam, de Groot-van Breugel, Eline N, Jürgenliemk-Schulz, Ina M, Raaymakers, Bas W, Winkel, Dennis, Bol, Gijsbert H, Kroon, Petra S, van Asselen, Bram, Hackett, Sara S, Werensteijn-Honingh, Anita M, Intven, Martijn P W, Eppinga, Wietse S C, Tijssen, Rob H N, Kerkmeijer, Linda G W, de Boer, Hans C J, Mook, Stella, Meijer, Gert J, Hes, Jochem, Willemsen-Bosman, Mirjam, de Groot-van Breugel, Eline N, Jürgenliemk-Schulz, Ina M, and Raaymakers, Bas W

Published
2019

35. Soft-tissue prostate intrafraction motion tracking in 3D cine-MR for MR-guided radiotherapy

Author

de Muinck Keizer, Daan M, Kerkmeijer, Linda G W, Maspero, Matteo, Andreychenko, Anna, van der Voort van Zyp, Jochem R N, Van den Berg, Cornelis A T, Raaymakers, Bas W, Lagendijk, Jan J W, de Boer, J C J, de Muinck Keizer, Daan M, Kerkmeijer, Linda G W, Maspero, Matteo, Andreychenko, Anna, van der Voort van Zyp, Jochem R N, Van den Berg, Cornelis A T, Raaymakers, Bas W, Lagendijk, Jan J W, and de Boer, J C J

Published
2019

36. MRI-Guided Ultrafocal HDR Brachytherapy for Localized Prostate Cancer: Median 4-Year Results of a feasibility study

Author

Peters, Max, van Son, Marieke J., Moerland, Marinus A., Kerkmeijer, Linda G. W., Eppinga, Wietse S. C., Meijer, Richard P., Lagendijk, Jan J. W., Shah, Taimur T., Ahmed, Hashim U., van Zijp, Jochem R. N. van der Voort, Peters, Max, van Son, Marieke J., Moerland, Marinus A., Kerkmeijer, Linda G. W., Eppinga, Wietse S. C., Meijer, Richard P., Lagendijk, Jan J. W., Shah, Taimur T., Ahmed, Hashim U., and van Zijp, Jochem R. N. van der Voort

Published
2019

37. Gross Tumor Delineation in Esophageal Cancer on MRI Compared With 18F-FDG-PET/CT

Author

Vollenbrock, Sophie E, Nowee, Marlies E, Voncken, Francine E M, Kotte, Alexis N T J, Goense, Lucas, van Rossum, Peter S N, van Lier, Astrid L H M W, Heijmink, Stijn W, Bartels-Rutten, Annemarieke, Wessels, Frank J, Aleman, Berthe M P, Dewit, Luc, Kerkmeijer, Linda G W, Jansen, Edwin P M, Intven, Martijn, Lips, Irene M, Meijer, Gert J, Nijkamp, Jasper, Vollenbrock, Sophie E, Nowee, Marlies E, Voncken, Francine E M, Kotte, Alexis N T J, Goense, Lucas, van Rossum, Peter S N, van Lier, Astrid L H M W, Heijmink, Stijn W, Bartels-Rutten, Annemarieke, Wessels, Frank J, Aleman, Berthe M P, Dewit, Luc, Kerkmeijer, Linda G W, Jansen, Edwin P M, Intven, Martijn, Lips, Irene M, Meijer, Gert J, and Nijkamp, Jasper

Published
2019

38. Quantitative MRI Changes During Weekly Ultra-Hypofractionated Prostate Cancer Radiotherapy With Integrated Boost

Author

van Schie, Marcel A, van Houdt, Petra J, Ghobadi, Ghazaleh, Pos, Floris J, Walraven, Iris, de Boer, Hans C J, van den Berg, Cornelis A T, Smeenk, Robert Jan, Kerkmeijer, Linda G W, van der Heide, Uulke A, van Schie, Marcel A, van Houdt, Petra J, Ghobadi, Ghazaleh, Pos, Floris J, Walraven, Iris, de Boer, Hans C J, van den Berg, Cornelis A T, Smeenk, Robert Jan, Kerkmeijer, Linda G W, and van der Heide, Uulke A

Published
2019

39. Visualization of gold fiducial markers in the prostate using phase-cycled bSSFP imaging for MRI-only radiotherapy

Author

Shcherbakova, Yulia, Bartels, Lambertus Wilbert, Mandija, Stefano, Beld, Ellis, Seevinck, Peter R, van der Voort van Zyp, Jochem R N, Kerkmeijer, Linda G W, Moonen, Chrit T W, Lagendijk, Jan J W, Van den Berg, Cornelis A T, Shcherbakova, Yulia, Bartels, Lambertus Wilbert, Mandija, Stefano, Beld, Ellis, Seevinck, Peter R, van der Voort van Zyp, Jochem R N, Kerkmeijer, Linda G W, Moonen, Chrit T W, Lagendijk, Jan J W, and Van den Berg, Cornelis A T

Published
2019

41. Gross Tumor Delineation in Esophageal Cancer on MRI Compared With 18F-FDG-PET/CT

Author

Klinische Fysica RT, Cancer, MS CGO, Arts-assistenten Radiotherapie, MS Radiologie, MS Radiotherapie, Vollenbrock, Sophie E, Nowee, Marlies E, Voncken, Francine E M, Kotte, Alexis N T J, Goense, Lucas, van Rossum, Peter S N, van Lier, Astrid L H M W, Heijmink, Stijn W, Bartels-Rutten, Annemarieke, Wessels, Frank J, Aleman, Berthe M P, Dewit, Luc, Kerkmeijer, Linda G W, Jansen, Edwin P M, Intven, Martijn, Lips, Irene M, Meijer, Gert J, Nijkamp, Jasper, Klinische Fysica RT, Cancer, MS CGO, Arts-assistenten Radiotherapie, MS Radiologie, MS Radiotherapie, Vollenbrock, Sophie E, Nowee, Marlies E, Voncken, Francine E M, Kotte, Alexis N T J, Goense, Lucas, van Rossum, Peter S N, van Lier, Astrid L H M W, Heijmink, Stijn W, Bartels-Rutten, Annemarieke, Wessels, Frank J, Aleman, Berthe M P, Dewit, Luc, Kerkmeijer, Linda G W, Jansen, Edwin P M, Intven, Martijn, Lips, Irene M, Meijer, Gert J, and Nijkamp, Jasper

Published
2019

42. Quantitative MRI Changes During Weekly Ultra-Hypofractionated Prostate Cancer Radiotherapy With Integrated Boost

Author

MS Radiotherapie, Klinische Fysica RT, Cancer, Computational Imaging, van Schie, Marcel A, van Houdt, Petra J, Ghobadi, Ghazaleh, Pos, Floris J, Walraven, Iris, de Boer, Hans C J, van den Berg, Cornelis A T, Smeenk, Robert Jan, Kerkmeijer, Linda G W, van der Heide, Uulke A, MS Radiotherapie, Klinische Fysica RT, Cancer, Computational Imaging, van Schie, Marcel A, van Houdt, Petra J, Ghobadi, Ghazaleh, Pos, Floris J, Walraven, Iris, de Boer, Hans C J, van den Berg, Cornelis A T, Smeenk, Robert Jan, Kerkmeijer, Linda G W, and van der Heide, Uulke A

Published
2019

43. MRI-Guided Ultrafocal HDR Brachytherapy for Localized Prostate Cancer: Median 4-Year Results of a feasibility study

Author

Arts-assistenten Radiotherapie, Onderzoek Radiotherapie, Klinische Fysica RT, Cancer, MS Radiotherapie, MS Urologische Oncologie, Urologie Medisch volwassenen, Fysica Radiotherapie Research, Peters, Max, van Son, Marieke J., Moerland, Marinus A., Kerkmeijer, Linda G. W., Eppinga, Wietse S. C., Meijer, Richard P., Lagendijk, Jan J. W., Shah, Taimur T., Ahmed, Hashim U., van Zijp, Jochem R. N. van der Voort, Arts-assistenten Radiotherapie, Onderzoek Radiotherapie, Klinische Fysica RT, Cancer, MS Radiotherapie, MS Urologische Oncologie, Urologie Medisch volwassenen, Fysica Radiotherapie Research, Peters, Max, van Son, Marieke J., Moerland, Marinus A., Kerkmeijer, Linda G. W., Eppinga, Wietse S. C., Meijer, Richard P., Lagendijk, Jan J. W., Shah, Taimur T., Ahmed, Hashim U., and van Zijp, Jochem R. N. van der Voort

Published
2019

44. Visualization of gold fiducial markers in the prostate using phase-cycled bSSFP imaging for MRI-only radiotherapy

Author

Beeldverwerking ISI, Cancer, Researchgr. Beeldg. Moleculaire Interv., Computational Imaging, Circulatory Health, Experimentele klinische fysica, Regenerative Medicine and Stem Cells, MS Radiotherapie, Fysica Radiotherapie Research, Klinische Fysica RT, Shcherbakova, Yulia, Bartels, Lambertus Wilbert, Mandija, Stefano, Beld, Ellis, Seevinck, Peter R, van der Voort van Zyp, Jochem R N, Kerkmeijer, Linda G W, Moonen, Chrit T W, Lagendijk, Jan J W, Van den Berg, Cornelis A T, Beeldverwerking ISI, Cancer, Researchgr. Beeldg. Moleculaire Interv., Computational Imaging, Circulatory Health, Experimentele klinische fysica, Regenerative Medicine and Stem Cells, MS Radiotherapie, Fysica Radiotherapie Research, Klinische Fysica RT, Shcherbakova, Yulia, Bartels, Lambertus Wilbert, Mandija, Stefano, Beld, Ellis, Seevinck, Peter R, van der Voort van Zyp, Jochem R N, Kerkmeijer, Linda G W, Moonen, Chrit T W, Lagendijk, Jan J W, and Van den Berg, Cornelis A T

Published
2019

45. Adaptive radiotherapy: The Elekta Unity MR-linac concept

Author

Cancer, Fysica Radiotherapie Research, Klinische Fysica RT, Onderzoek Radiotherapie, MS Radiotherapie, Experimentele klinische fysica, Winkel, Dennis, Bol, Gijsbert H, Kroon, Petra S, van Asselen, Bram, Hackett, Sara S, Werensteijn-Honingh, Anita M, Intven, Martijn P W, Eppinga, Wietse S C, Tijssen, Rob H N, Kerkmeijer, Linda G W, de Boer, Hans C J, Mook, Stella, Meijer, Gert J, Hes, Jochem, Willemsen-Bosman, Mirjam, de Groot-van Breugel, Eline N, Jürgenliemk-Schulz, Ina M, Raaymakers, Bas W, Cancer, Fysica Radiotherapie Research, Klinische Fysica RT, Onderzoek Radiotherapie, MS Radiotherapie, Experimentele klinische fysica, Winkel, Dennis, Bol, Gijsbert H, Kroon, Petra S, van Asselen, Bram, Hackett, Sara S, Werensteijn-Honingh, Anita M, Intven, Martijn P W, Eppinga, Wietse S C, Tijssen, Rob H N, Kerkmeijer, Linda G W, de Boer, Hans C J, Mook, Stella, Meijer, Gert J, Hes, Jochem, Willemsen-Bosman, Mirjam, de Groot-van Breugel, Eline N, Jürgenliemk-Schulz, Ina M, and Raaymakers, Bas W

Published
2019

46. Soft-tissue prostate intrafraction motion tracking in 3D cine-MR for MR-guided radiotherapy

Author

Radiotherapie, Fysica Radiotherapie Research, MS Radiotherapie, Cancer, Computational Imaging, Experimentele klinische fysica, Klinische Fysica RT, de Muinck Keizer, Daan M, Kerkmeijer, Linda G W, Maspero, Matteo, Andreychenko, Anna, van der Voort van Zyp, Jochem R N, Van den Berg, Cornelis A T, Raaymakers, Bas W, Lagendijk, Jan J W, de Boer, J C J, Radiotherapie, Fysica Radiotherapie Research, MS Radiotherapie, Cancer, Computational Imaging, Experimentele klinische fysica, Klinische Fysica RT, de Muinck Keizer, Daan M, Kerkmeijer, Linda G W, Maspero, Matteo, Andreychenko, Anna, van der Voort van Zyp, Jochem R N, Van den Berg, Cornelis A T, Raaymakers, Bas W, Lagendijk, Jan J W, and de Boer, J C J

Published
2019

47. A dual-purpose MRI acquisition to combine 4D-MRI and dynamic contrast-enhanced imaging for abdominal radiotherapy planning

Author

Computational Imaging, Cancer, Fysica Radiotherapie Research, MS Radiotherapie, Klinische Fysica RT, Stemken, Bjorn, Prins, Fieke M., Bruijnen, Tom, Kerkmeijer, Linda G. W., Lagendijk, Jan J. W., van den Ber, Cornelis A. T., Tijssen, Rob H. N., Computational Imaging, Cancer, Fysica Radiotherapie Research, MS Radiotherapie, Klinische Fysica RT, Stemken, Bjorn, Prins, Fieke M., Bruijnen, Tom, Kerkmeijer, Linda G. W., Lagendijk, Jan J. W., van den Ber, Cornelis A. T., and Tijssen, Rob H. N.

Published
2019

48. Magnetic Resonance Imaging-Guided Adaptive Radiation Therapy: A 'Game Changer' for Prostate Treatment?

Author

Pathmanathan, Angela U, van As, Nicholas J, Kerkmeijer, Linda G W, Christodouleas, John, Lawton, Colleen A F, Vesprini, Danny, van der Heide, Uulke A, Frank, Steven J, Nill, Simeon, Oelfke, Uwe, van Herk, Marcel, Li, X Allen, Mittauer, Kathryn, Ritter, Mark, Choudhury, Ananya, Tree, Alison C, Other departments, and CCA - Imaging and biomarkers

Subjects
Manchester Cancer Research Centre, ResearchInstitutes_Networks_Beacons/mcrc, Journal Article, Review
Abstract

Radiation therapy to the prostate involves increasingly sophisticated delivery techniques and changing fractionation schedules. With a low estimated α/β ratio, a larger dose per fraction would be beneficial, with moderate fractionation schedules rapidly becoming a standard of care. The integration of a magnetic resonance imaging (MRI) scanner and linear accelerator allows for accurate soft tissue tracking with the capacity to replan for the anatomy of the day. Extreme hypofractionation schedules become a possibility using the potentially automated steps of autosegmentation, MRI-only workflow, and real-time adaptive planning. The present report reviews the steps involved in hypofractionated adaptive MRI-guided prostate radiation therapy and addresses the challenges for implementation.

Published
2018
Full Text
View/download PDF

49. R-IDEAL: A Framework for Systematic Clinical Evaluation of Technical Innovations in Radiation Oncology

Author

Verkooijen, Helena M., Kerkmeijer, Linda G. W., Fuller, Clifton D., Huddart, Robbert, Faivre-Finn, Corinne, Verheij, Marcel, Mook, Stella, Sahgal, Arjun, Hall, Emma, and Schultz, Chris

Subjects
evaluation, Oncology, MRI-guided linear accelerator, design, methodology, innovation
Abstract

The pace of innovation in radiation oncology is high and the window of opportunity for evaluation narrow. Financial incentives, industry pressure, and patients’ demand for high-tech treatments have led to widespread implementation of innovations before, or even without, robust evidence of improved outcomes has been generated. The standard phase I–IV framework for drug evaluation is not the most efficient and desirable framework for assessment of technological innovations. In order to provide a standard assessment methodology for clinical evaluation of innovations in radiotherapy, we adapted the surgical IDEAL framework to fit the radiation oncology setting. Like surgery, clinical evaluation of innovations in radiation oncology is complicated by continuous technical development, team and operator dependence, and differences in quality control. Contrary to surgery, radiotherapy innovations may be used in various ways, e.g., at different tumor sites and with different aims, such as radiation volume reduction and dose escalation. Also, the effect of radiation treatment can be modeled, allowing better prediction of potential benefits and improved patient selection. Key distinctive features of R-IDEAL include the important role of predicate and modeling studies (Stage 0), randomization at an early stage in the development of the technology, and long-term follow-up for late toxicity. We implemented R-IDEAL for clinical evaluation of a recent innovation in radiation oncology, the MRI-guided linear accelerator (MR-Linac). MR-Linac combines a radiotherapy linear accelerator with a 1.5-T MRI, aiming for improved targeting, dose escalation, and margin reduction, and is expected to increase the use of hypofractionation, improve tumor control, leading to higher cure rates and less toxicity. An international consortium, with participants from seven large cancer institutes from Europe and North America, has adopted the R-IDEAL framework to work toward coordinated, evidence-based introduction of the MR-Linac. R-IDEAL holds the promise for timely, evidence-based introduction of radiotherapy innovations with proven superior effectiveness, while preventing unnecessary exposure of patients to potentially harmful interventions.

Published
2017
Full Text
View/download PDF

50. Deep learning–based MR‐to‐CT synthesis: The influence of varying gradient echo–based MR images as input channels.

Author

Florkow, Mateusz C., Zijlstra, Frank, Willemsen, Koen, Maspero, Matteo, Berg, Cornelis A. T., Kerkmeijer, Linda G. W., Castelein, René M., Weinans, Harrie, Viergever, Max A., Stralen, Marijn, and Seevinck, Peter R.

Subjects
MAGNETIC resonance imaging, TRANSPOSONS, DEEP learning, PELVIS, POPULATION, MODEL railroads
Abstract

Purpose: To study the influence of gradient echo–based contrasts as input channels to a 3D patch‐based neural network trained for synthetic CT (sCT) generation in canine and human populations. Methods: Magnetic resonance images and CT scans of human and canine pelvic regions were acquired and paired using nonrigid registration. Magnitude MR images and Dixon reconstructed water, fat, in‐phase and opposed‐phase images were obtained from a single T1‐weighted multi‐echo gradient‐echo acquisition. From this set, 6 input configurations were defined, each containing 1 to 4 MR images regarded as input channels. For each configuration, a UNet‐derived deep learning model was trained for synthetic CT generation. Reconstructed Hounsfield unit maps were evaluated with peak SNR, mean absolute error, and mean error. Dice similarity coefficient and surface distance maps assessed the geometric fidelity of bones. Repeatability was estimated by replicating the training up to 10 times. Results: Seventeen canines and 23 human subjects were included in the study. Performance and repeatability of single‐channel models were dependent on the TE‐related water–fat interference with variations of up to 17% in mean absolute error, and variations of up to 28% specifically in bones. Repeatability, Dice similarity coefficient, and mean absolute error were statistically significantly better in multichannel models with mean absolute error ranging from 33 to 40 Hounsfield units in humans and from 35 to 47 Hounsfield units in canines. Conclusion: Significant differences in performance and robustness of deep learning models for synthetic CT generation were observed depending on the input. In‐phase images outperformed opposed‐phase images, and Dixon reconstructed multichannel inputs outperformed single‐channel inputs. [ABSTRACT FROM AUTHOR]

Published
2020
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results