7 results on '"Kerepesi, L."'
Search Results
2. IL-4(-/-) mice with lethal Mesocestoides corti infections--reduced Th2 cytokines and alternatively activated macrophages.
- Author
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O'Connell, A. E., Kerepesi, L. A., Vandergrift, G. L., Herbert, D. R., VAN Winkle, T J., Hooper, D. C., Pearce, E J., Abraham, D., O'Connell, A. E., Kerepesi, L. A., Vandergrift, G. L., Herbert, D. R., VAN Winkle, T J., Hooper, D. C., Pearce, E J., and Abraham, D.
- Abstract
Protection against Mesocestoides corti, a cestode that invades vital organs, is dependent on the production of IL-4, as IL-4(-/-) mice were found to have higher parasite burdens when compared with wild-type mice. The goal of this study was to investigate the role of IL-4 in immunity to M. corti, focusing on the immunological profile and on potential mediators of pathology. IL-4(-/-) mice infected with M. corti showed 100% mortality by 32 days, whereas wild-type mice survived for approximately 1 year. Parasite burdens were significantly increased in the liver, peritoneal, and thoracic cavities of IL-4(-/-) mice, associated with impaired recruitment of inflammatory cells and a reduction in monocytes and macrophages. IL-5 production by splenocytes and expression in liver tissue was decreased in infected IL-4(-/-) mice compared with wild-type mice. In contrast, IL-4(-/-) mice produced increased amounts of IFNgamma and TNFalpha. Alternatively activated macrophages were a major feature of liver granulomas in wild-type mice evidenced by Arginase I expression, while livers from infected IL-4(-/-) mice showed impaired alternative macrophage activation without increased classical macrophage activation. Thus, lethality during M. corti infection of IL-4(-/-) mice is associated with decreased Th2 cytokines, increased Th1 cytokines and impairment of alternatively activated macrophages.
- Published
- 2009
3. IL-4−/−mice with lethalMesocestoides cortiinfections - reduced Th2 cytokines and alternatively activated macrophages
- Author
-
O’CONNELL, A. E., primary, KEREPESI, L. A., additional, VANDERGRIFT, G. L., additional, HERBERT, D. R., additional, VAN WINKLE, T. J., additional, HOOPER, D. C., additional, PEARCE, E. J., additional, and ABRAHAM, D., additional
- Published
- 2009
- Full Text
- View/download PDF
4. IL-4−/− mice with lethal Mesocestoides corti infections – reduced Th2 cytokines and alternatively activated macrophages.
- Author
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O'CONNELL, A. E., KEREPESI, L. A., VANDERGRIFT, G. L., HERBERT, D. R., VAN WINKLE, T. J., HOOPER, D. C., PEARCE, E. J., and ABRAHAM, D.
- Subjects
- *
MESOCESTOIDES , *MACROPHAGES , *KILLER cells , *CYTOKINES , *CELLULAR immunity - Abstract
Protection against Mesocestoides corti, a cestode that invades vital organs, is dependent on the production of IL-4, as IL-4−/− mice were found to have higher parasite burdens when compared with wild-type mice. The goal of this study was to investigate the role of IL-4 in immunity to M. corti, focusing on the immunological profile and on potential mediators of pathology . IL-4−/− mice infected with M. corti showed 100% mortality by 32 days, whereas wild-type mice survived for approximately 1 year. Parasite burdens were significantly increased in the liver, peritoneal, and thoracic cavities of IL-4−/− mice, associated with impaired recruitment of inflammatory cells and a reduction in monocytes and macrophages. IL-5 production by splenocytes and expression in liver tissue was decreased in infected IL-4−/− mice compared with wild-type mice. In contrast, IL-4−/− mice produced increased amounts of IFNγ and TNFα. Alternatively activated macrophages were a major feature of liver granulomas in wild-type mice evidenced by Arginase I expression, while livers from infected IL-4−/− mice showed impaired alternative macrophage activation without increased classical macrophage activation. Thus, lethality during M. corti infection of IL-4−/− mice is associated with decreased Th2 cytokines, increased Th1 cytokines and impairment of alternatively activated macrophages. [ABSTRACT FROM AUTHOR]
- Published
- 2009
- Full Text
- View/download PDF
5. Effects of betahistine on patient-reported outcomes in routine practice in patients with vestibular vertigo and appraisal of tolerability: Experience in the OSVaLD study
- Author
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Benecke, H., Pérez-Garrigues, H., Bin Sidek, D., Uloziene, I., Kuessner, D., Sondag, E., Theeuwes, A., Boari, L., Chaves, A. G., Dorigueto, R. S., Ganança, F. F., Gonçalves, D. U., Hyppolito, M. A., Korn, G. P., Munhoz, M. S., Oliveira, J. A., Ajisafe, O., Angilleta, B., Bracalenti, I., Carlos, J. M., Dada, O., Ho, M., Kopyto, A., Laliberté, A., Lau, Y., Medina, X., Mercier, C., Nijmeh, P., Pietraszek, B., Roberge, C., Vincent, S., Zeitouni, A., Aras, I., Bencic, I., Bonifacic, M., Branica, S., Dovzak-Kokic, D., Drvis, P., Gortan, D., Grdinic, B., Grigic, J., Handzic, I., Ivkovic, M., Juros, V., Kovacic, J., Krstic, E., Lucin, Z., Maksimovic, Z., Maslovara, S., Rak, I., Resler Seks, A., Ries, M., Trotic, R., Rosenberg, A., Gaal, A., Badacsonyi, M., Balogh, G., Bandula, M., Baranya, E., Jeges, B., Brajnovits, T., Bucsai, A., Tubony, C., Csill, R., Czegledi, I., Olah, L., Draveczky, E., Vaszkun, L., Siro, E., Fain, A., Foth, A., Gerlinger, I., Gestelyi, G., Getachen, K., Ghayada, R., Gilincsek, L., Guth, I., Hegedus, E., Hegyi, I., Jofeju, E., Kerepesi, L., Krisan, I., Laszlo, K., Lorincz, T., Marisch, I., Mihalecz, K., Breznyan, M., Mori, I., Nagy, L., Manhalter, N., Pal, A., Papp, M., Peter, J., Prunk Eger, F., Radai, F., Szihalmy, I., Torma, E., Torok, K., Trencsenyi, G., Varga, E., Vincze, A., Vogel, R., Szakolczay, Z., Zsilinszky, Z., Rovo, Z., Tamas, L., Mester, B., Hudak, I., Toth, L., Merczel, A., Agarwal, V. K., Bhatia, R., Bhimani, B., Biswal, R. N., Biswas, A., Chowdary, V. S., Dhond, P., Dube, T. N., Gopakumar, G., Kansara, A., Khound, G., Kirtane, M. V., Mukherjee, A., Nagpal, T., Ravikumar, A., Reddy, V., Sampat, N., Shaikh, S., Sinha, S., Vaid, N., Valsangkar, S., Vasnoi, S., Vishwanathan, A., Blumberga, I., Bucina, B., Cakule, G., Demidova, L., Dolge, A., Dzirgause, M., Freimane, A., Fricbergs, J., Frolova, V., Ganus, I., Gavare, I., Grigs, V., Grusle, M., Levins, E., Veidule, I., Indrane, M., Saihulova, I., Jeca, A., Jegere, D., Ivanova, A., Kalitas, N., Kalnina, Z., Kanepe, K., Karlovska, M., Kokina, I., Krigere, R., Krisjane, D., Kukurane, S., Kundrate, G., Kukaine, S., Kukute, I., Lagzdina, L., Lapsa-Arenta, S., Madre, S., Matusevica, A., Mežale, I., Melnika, V., Mickevica, S., Morlata, N., Naudina, M. S., Nimroda, L., Norina, D., Opelte, V., Pavlovska, I., Priede, Z., Proskurna, T., Purina, J., Kamsa, I., Raumane, D., Kenina, V., Roska-Levina, D., Rozenbaha, A., Rozkalne, A., Ruta, A., Sendze, G., Silins, A., Skrupska, D., Skurule, I., Sokalska, A., Stepko, Z., Supe, I., Telezenko, I., Tretjaka, N., Turlaja, V., Uzbeka, I., Valucka, T., Vancans, J., Vasilevskis, U., Veinberga, V., Viba, Z., Vitkovska, M., Vitolina, A., Voitovica, L., Zigure, I., Zilite, I., Bakstiene, J., Balkaitiene, R., Basinskiene, V., Beinaraviciene, R., Bertasiene, Z., Bieliauskiene, I., Budrikiene, N., Butkus, A., Butkus, E., Butkus, R., Cholomskiene, V., Dainius, K., Degteriova, R., Deveikyte, A., Dirzauskiene, J., Einoriene, D., Gadeikis, E., Gircys, P., Grazeviciute, L., Ivaskevicius, A., Janciute, J., Jankauskiene, D., Jersova, J., Jociene, I., Jokimaitiene, J., Jukneliene, R., Kanapeckiene, V., Karaliene, V., Kazlauskas, A., Kicas, R., Kiskuniene, I., Kiudelis, A., Kizlaitiene, R., Kuriene, A., Lukaseviciene, N., Lukosaitis, A., Malikeniene, T., Markeleviciene, R., Mazonyte, S., Nadusauskiene, M., Narkeviciene, V., Naumcik, J., Navickiene, E., Pancyreva, I., Pavydyte, J., Persidskaja, O., Petkiniene, V. R., Petrileviciene, R., Petrosiute, B., Pliopliene, I., Puckiene, Z., Razukiene, J., Remeikiene, S., Rudzeviciene, E., Sceponaviciute, S., Scerbickiene, L., Sersniova, I., Sinkuniene, N., Skerneviciute, I., Snureviciute, V., Sostakiene, N., Tunkulas, E., Vitkauskiene, V., Zakarauskiene, R., Zorjan, N., Zurauskiene, R., Sani, A., Mohamad, A., Abdullah, A., Abdullah, B., Hassan, F., Selvarajah, G., See, G. B., Mann, G. S., Singh, H., Hj Ahmad, H. A., Hailani, I., Mohd Yusof, I., Gopalan Nair, K., Sathananthar, K. S., Singh, K., Saim, L., Abdul Ghani, M. H., Herg, M., Jalaludin, M. A., Md Daud, M. K., Khir Abdullah, M., Noor, N. H., Mohamed, N. R., Esa, N. K., Jusoh, N. M., Narayanan, P., Choo, P. K., Al Konee, R. A., Rajagopalan, R., Ismail, R., Mohd Hashim, S. S., Kumarasamy, S., Suan, T. L., Kamalden, T. M., Sang, T. T., Ambu, V. K., Leman, W. I., Abidin, Z. A., Salahuddin, Z., Yusof, Z., Burduk, P., Chmura, H., Czecior, E., Dabrowski, P., Diechota, L., Dietrich, G., Domagata, M., Durko, M., Frak, W., Franczuk-Gwiazda, M., Galbarczyk, D., Gaweowicz, J., Kabacinska, A., Kadej, G. Z., Kapuscinski, J., Kolebacz, B., Korpus-Kaminska, I., Lachowicz, M., Mielnik, E., Mihutka, S., Nilewski, J., Nouinska, E., Obzebowska-Karszania, Z., Oleksiak, M., Palasik, W., Paradowski, B., Paskal, J., Pospiech, L., Pres, K., Rynio, E., Schneider, K., Siger, M., Stoniewska-Piackus, M., Szczuto, J., Wilczynski, K., Wojcick, P., Woynowski, W., Tomasz Zatonski, Ziolkowska-Kochan, M., Zygadlo, E. N., Alaicescu, M., Augustin, A., Bădescu, A., Baltag, D., Bărbos, C., Becuşi, T., Bucan, L., Călăraşu, R., Cămpeanu, A., Chirileanhu, R. D., Comşa, G. I., Constantinescu, D., Cotulbea, S., Cozma, S., Cucoş, L., Docu, A. A., Dulămea, A., Enache, N., Ene, A., Fischer, T. S., Floare, L., Frăsineanu, A., Geană, I., Georgescu, E., Georgescu, M., Georgescu, M. J., Gherman, E., Hăncu, A., Iliescu, I., Ionescu-Mihăiţă, E. R., Ionita, E., Ionita, I., Iovănescu, D., Ladea, M., Loghin, V., Marceanu, L., Mărginean, I., Mariam, G., Marin, M., Mariş, C., Mârţu, D., Matcău, L., Muhlfay, G., Muică, L., Naconecinîi, D., Nirestean, A., Niţă, A., Niţu, L., Oană, N., Oancea, A., Oşanu, M., Panea, N., Pascu, A., Pastia, M., Pavel, R., Pendefunda, L., Petrutiu, S., Plăviţu, I., Poenaru, M., Popa, G. C., Popa, G., Popi, S., Popovivci, A., Prelipceanu, D., Radu, L., Rădulescu, L., Roceanu, A., Rusu, A., Sabău, M. S., Safta, D., Sarafoleanu, D., Stanciu, M., Stănciulescu, R., Ştefanache, F., Stefanescu, E. H., Szatmari, S., Szocs, Tomescu, L., Tudorache, B., Tudose, C., Ursu, C., Vasilescu, L., Vasu, I., Vioreanu, M., Zaboş, D., Zaharia, C., Zainea, V., Zarie, G., Alekseeva, N., Amelin, A., Artemova, I., Batysheva, T., Bobyreva, S., Boyko, A., Buldakova, N., Ganzhula, P., Gaponova, O., Hanevich, T., Hozova, A., Isachenkova, O., Ismailov, A., Zhuravleva, E., Kostenko, E., Lilenko, S., Lisenker, L., Makarova, G., Manevich, T., Matsnev, E., Melnikov, O., Morozova, S., Nesterova, O., Nikulina, I., Otcheskaya, O., Pivovarova, V., Rotor, L., Rylskiy, A., Shalabanova, I., Shinkarev, S., Sorokoumov, V., Vdovichenko, T., Vinetskiy, Y., Vostricova, I., Zadorozhnaya, T., Breznik Farkas, B., Felbabic, J., Geczy Buljovcic, B., Grad, A., Hoenigman, B., Kurent, Z., Krek, B. P., Rok, B., Spindler, M., Vatovec, J., Zorn, A., Zupan, L., Aguila, A. A., Caballero, B. M., Garcia, V. C., Cruellas, T. F., Munoz, P. C., Domenech, J. I., Donderis, S. J., Estevez, G. M., Pallas, P. E., Grani, M. F., Gonzalez, C. F., Galindo, O. J., Garcia, A. A., Garcia, G. B., Gonzalez, G. I., Hernandez Ade, S., Hijano, E. R., Lopez, E. J., Saiz, A. J., Izquierdo, L. J., Perez, L. L., Paya, P. L., Mesa, M. M., Molina, P. M., Navarrete, A. L., Marti, G. L., Melgarejo, M. F., Orts, A. M., Suarez, G. P., Perez, M. P., Perez, G. H., Perez, G. V., Rodriguez, R. S., Santos, P. S., Soto, V. A., Malluguiza, C. J., Ramirez, L. R., Jimenez, M. R., Barona Guzmán, R., Escamilla, C. Y., Saiz, M. V., Gisbert, A. F., Provedo, P. C., Pardo, S. E., Alemán, L. O., Martin, S. E., and Marco, A. J.
6. IL-4(-/-) mice with lethal Mesocestoides corti infections--reduced Th2 cytokines and alternatively activated macrophages.
- Author
-
O'Connell AE, Kerepesi LA, Vandergrift GL, Herbert DR, VAN Winkle TJ, Hooper DC, Pearce EJ, and Abraham D
- Subjects
- Animals, Cestode Infections metabolism, Cestode Infections parasitology, Host-Parasite Interactions immunology, Interferon-gamma biosynthesis, Interleukin-4 genetics, Interleukin-5 biosynthesis, Liver immunology, Liver parasitology, Macrophage Activation, Mice, Mice, Inbred BALB C, Mice, Knockout, Spleen immunology, Spleen metabolism, Th2 Cells metabolism, Tumor Necrosis Factor-alpha biosynthesis, Cestode Infections immunology, Host-Parasite Interactions physiology, Interleukin-4 immunology, Macrophages immunology, Mesocestoides, Th2 Cells immunology
- Abstract
Protection against Mesocestoides corti, a cestode that invades vital organs, is dependent on the production of IL-4, as IL-4(-/-) mice were found to have higher parasite burdens when compared with wild-type mice. The goal of this study was to investigate the role of IL-4 in immunity to M. corti, focusing on the immunological profile and on potential mediators of pathology. IL-4(-/-) mice infected with M. corti showed 100% mortality by 32 days, whereas wild-type mice survived for approximately 1 year. Parasite burdens were significantly increased in the liver, peritoneal, and thoracic cavities of IL-4(-/-) mice, associated with impaired recruitment of inflammatory cells and a reduction in monocytes and macrophages. IL-5 production by splenocytes and expression in liver tissue was decreased in infected IL-4(-/-) mice compared with wild-type mice. In contrast, IL-4(-/-) mice produced increased amounts of IFNgamma and TNFalpha. Alternatively activated macrophages were a major feature of liver granulomas in wild-type mice evidenced by Arginase I expression, while livers from infected IL-4(-/-) mice showed impaired alternative macrophage activation without increased classical macrophage activation. Thus, lethality during M. corti infection of IL-4(-/-) mice is associated with decreased Th2 cytokines, increased Th1 cytokines and impairment of alternatively activated macrophages.
- Published
- 2009
- Full Text
- View/download PDF
7. Cytotoxicity and gene expression profiles in cell cultures exposed to whole smoke from three types of cigarettes.
- Author
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Lu B, Kerepesi L, Wisse L, Hitchman K, and Meng QR
- Subjects
- Animals, BALB 3T3 Cells, Biomarkers, Cell Proliferation drug effects, Cell Survival drug effects, Gene Expression Profiling, Glutathione genetics, Lysosomes drug effects, Lysosomes metabolism, Mice, Neutral Red metabolism, Nicotine toxicity, Oligonucleotide Array Sequence Analysis, Smoke adverse effects, Nicotiana
- Abstract
The purpose of this study was to evaluate and compare the cytotoxicity and gene expression profiles in cell cultures exposed to whole smoke generated from a full flavor cigarette (Test 1), a low tar cigarette (Test 2), and an ultra-low tar cigarette (Test 3). In addition, a reference cigarette 2R4F was evaluated for cytotoxicity. Neutral red (NR) cytotoxicity assay was performed to determine relative cell death at each exposure concentration (n = 6). LC(50) was generated using wet total particular matter (WTPM), cigarette number, or nicotine concentrations. The overall order of cytotoxicity was Test 1 >> 2R4F approximately Test 2 > Test 3. Cell culture samples were collected for RNA extraction at WTPM concentrations of each cigarette that gave similar nicotine concentrations. Affymetrix mouse whole genome 430 2.0 array was used to characterize the gene expression profiles for each cigarette. A total of 598 genes in Test 1, 176 genes in Test 2, and 234 genes in Test 3 samples were differentially expressed compared to the concurrent sham controls. The major biological processes associated with the changed genes in Test 1 samples were down-regulated DNA replication and cell proliferation; the same biological processes were much less affected in Test 2 and Test 3 samples. The common findings in all three cigarettes types were increased glutathione biosynthesis/consumption and inflammatory response, which are known biological effects caused by smoke exposure. The most significantly up-regulated genes were CYP1A1, GSTs, Hmox1, and Procr in smoke-exposed samples, which are either related to well-studied mechanisms of smoke exposure-related diseases or potential new biomarkers for assessing and monitoring biological effects of cigarette smoke exposure in vivo and in smokers. In summary, both the NR cytotoxicity assay and gene expression profiling were able to differentiate the three types of test cigarettes, and the results demonstrated reduced biological effects for the Test 2 and Test 3 cigarettes compared to the Test 1 cigarette in BALB/c-3T3 Cells.
- Published
- 2007
- Full Text
- View/download PDF
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