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Abstract The pathophysiology of immune checkpoint inhibitor-related pneumonitis remains incompletely understood. We conducted single-cell and T-cell receptor transcriptomic sequencing on the bronchoalveolar lavage fluid from five patients with grade ≥2 immune checkpoint inhibitor-related pneumonitis. Our analyses revealed a prominent enrichment of T cells in the bronchoalveolar lavage fluid of patients with immune checkpoint inhibitor-related pneumonitis. Within the CD4 + T cell subset, Tfh-like T cells were highly enriched and exhibited signatures associated with inflammation and clonal expansion. Regulatory T cells were also enriched and displayed enhanced inhibitory functions. Within the CD8 + T-cell subset, effector memory/tissue-resident memory T cells with an elevated cytotoxic phenotype were highly infiltrated. Among myeloid cells, alveolar macrophages were depleted, while pro-inflammatory intermediate monocytes were elevated. Dendritic cells demonstrated enhanced antigen presentation capabilities. Cytokines CXCR4, CXCL13, TNF-α, IFN-α, IFN-γ, and TWEAK were elevated. Through a comprehensive single-cell analysis, we depicted the landscape of immune checkpoint inhibitor-related pneumonitis.

Abstract The oversized TE11 mode bend is able to make the transmission direction of electromagnetic wave to turn 90°, and it is one of the key components in the high‐power microwave system. The mode coupling characteristics between the TE11 and parasitic modes under two different polarisations in the bending waveguide are analysed, and it is found that the TE11 suffers less interferences from parasitic modes when its polarisation direction is perpendicular to the bending plane, and the corresponding 90° TE11 bend is easier to realise high performance. To verify this analysis, an oversized 90° TE11 bend waveguide working at 10 GHz is designed, and its structural length is only 7.5 times the central working wavelength. Simulated results indicate that its relative bandwidth is 15.6% when the transmission efficiency is over 98%, and its maximum power handling capacity reaches 5.6 GW at short microwave pulse duration (less than 100 ns). The S‐parameters indicate that its S21 is about −0.1 dB from 9.5 to 10.5 GHz, and its S11 is under −25 dB in the same frequency range. Meanwhile, the high power test indicates that the bend works stably when the injected power is 3 GW.

Summary: Background: Checkpoint inhibitor pneumonitis (CIP) is a potentially fatal adverse event characterized by new pulmonary infiltrates in cancer patients receiving immune checkpoint inhibitor therapy. This study aims to explore the interplay between lung microbiota, dysregulated metabolites, and host immunity in CIP. Methods: We recruited thirteen hospitalized CIP patients, eleven idiopathic pulmonary fibrosis (IPF) patients, and ten new-onset non-small cell lung cancer patients. Bronchoalveolar lavage fluid samples were collected for 16S rRNA gene sequencing. The percentages of immune cells were determined using manual counting and flow cytometry. Interactions among microbiota, metabolites, and lymphocytes were analyzed using cultured mouse splenocytes and human T cells. Findings: Proteobacteria emerged as the dominant phylum, notably abundant in both the CIP and IPF groups. Vibrio, Halomonas, Mangrovibacter, and Salinivibrio were the predominant microbiota because of their discriminative abundance patterns. Vibrio (r = 0.72, P-adj = 0.007) and Halomonas (r = 0.65, P-adj = 0.023) demonstrated strong correlations with lymphocytes. Vibrio metschnikovii and Mangrovibacter plantisponsors were more abundant in the CIP group than in the IPF group. Lauroylcarnitine, a key intermediary metabolite co-occurring with the predominant microbiota, exhibited a potent effect on cytokine secretion by mouse and human T cells, notably enhancing IFN-γ and TNF-α production from CD4 and CD8 cells in vitro. Interpretation: Lauroylcarnitine, co-occurring with the predominant lung microbiota in CIP, could activate T cells in vitro. These findings suggest potential involvement of lung microbiota and acylcarnitine metabolism dysregulation in the pathogenesis of CIP. Funding: This work was supported by Peking University People’s Hospital Scientific Research Development Funds (RDJ2022-15) and Provincial Key Clinical Specialty Capacity Building Project 2020 (Department of the Respiratory Medicine).

Abstract Background Paclitaxel liposome (Lipusu) is known to be effective in non-small cell lung cancer (NSCLC) as first-line treatment. This study aimed to evaluate the effectiveness and safety of paclitaxel liposome based chemotherapy plus PD-1/PD-L1 inhibitor in patients with advanced NSCLC. Methods In this multicenter, retrospective, real-world study, patients with advanced NSCLC who were administered paclitaxel liposome based chemotherapy plus PD-1/PD-L1 inhibitor in three centers (Peking University People’s Hospital as the lead center) in China between 2016 and 2022 were included. Progression-free survival (PFS), overall survival (OS), objective response rate, disease control rate, and adverse events (AEs) were evaluated. Results A total of 49 patients were included, with 33 (67.3%) receiving paclitaxel liposome based chemotherapy plus PD-1/PD-L1 inhibitor as first-line treatment. There were 34 patients (69.4%) diagnosed with squamous cell carcinoma and 15 (30.6%) with adenocarcinoma. The median follow-up was 20.5 (range: 3.1–41.1) months. The median PFS and OS of all patients were 9.7 months (95% confidence interval [CI], 7.0-12.4) and 30.5 months (95% CI, not evaluable-not evaluable), respectively. Patients with squamous cell carcinoma and adenocarcinoma had median PFS of 11 months (95%CI, 6.5–15.5) and 9.3 months (95%CI, 7.0-12.4), respectively. The median PFS was 9.9 months (95%CI, 7.1–12.7) in patients who received the combined regimen as first-line treatment. Treatment-related AEs of any grade were observed in 25 (51.0%) patients, and AEs of grade 3 or worse were observed in nine patients (18.4%). The most common treatment-related AEs were myelosuppression (14.3%) and fever (10.2%). Conclusions Paclitaxel liposome based chemotherapy plus PD-1/PD-L1 inhibitor prolonged the PFS in advanced NSCLC with acceptable safety, which was worthy of clinical application.

Since its initial release in 2001, the human reference genome has undergone continuous improvement in quality, and the recently released telomere-to-telomere (T2T) version — T2T-CHM13 — reaches its highest level of continuity and accuracy after 20 years of effort by working on a simplified, nearly homozygous genome of a hydatidiform mole cell line. Here, to provide an authentic complete diploid human genome reference for the Han Chinese, the largest population in the world, we assembled the genome of a male Han Chinese individual, T2T-YAO, which includes T2T assemblies of all the 22 + X + M and 22 + Y chromosomes in both haploids. The quality of T2T-YAO is much better than those of all currently available diploid assemblies, and its haploid version, T2T-YAO-hp, generated by selecting the better assembly for each autosome, reaches the top quality of fewer than one error per 29.5 Mb, even higher than that of T2T-CHM13. Derived from an individual living in the aboriginal region of the Han population, T2T-YAO shows clear ancestry and potential genetic continuity from the ancient ancestors. Each haplotype of T2T-YAO possesses ∼ 330-Mb exclusive sequences, ∼ 3100 unique genes, and tens of thousands of nucleotide and structural variations as compared with CHM13, highlighting the necessity of a population-stratified reference genome. The construction of T2T-YAO, an accurate and authentic representative of the Chinese population, would enable precise delineation of genomic variations and advance our understandings in the hereditability of diseases and phenotypes, especially within the context of the unique variations of the Chinese population.

This is an essay in the field of ceramics and composites. In order to improve the utilization rate of rare earth tailings, this study designed and prepared C30 recycled aggregate concrete with rare earth tailings as fine aggregate. The influence of tailing sand content on workability, mechanical properties and durability of recycled aggregate concrete was studied. The results show that C30 and C40 concrete can be prepared by using rare earth tailing sand as fine aggregate to meet the requirements of the standard. With the increase of tailing sand content, the workability of concrete decreases, but the workability of concrete using tailing sand as fine aggregate can meet the requirements of use. With the increase of tailing sand content, the micro-pore structure of concrete becomes densified and the compressive strength is improved. When tailing sand content is 100%, the 28 d compressive strength of concrete is increased by 34.9%. The addition of tailing sand improves the frost resistance and carbonation resistance of concrete.

Land use conflicts (LUCs) have become a significant global issue. Accurately identifying potential LUCs is crucial for mediating these conflicts, optimizing land use structure, and enhancing land use function. The necessary conditions of LUCs are land use multi-suitability (LUMS), land resource scarcity (LRS), and diversity of demands (DD). However, few studies have approached LUC identification from these three dimensions simultaneously. In addition, when assessing the diversity of demand, only human needs are considered and wildlife needs are ignored. In order to address this gap in the research, this paper constructs a novel framework for LUC identification and proposes an induction-oriented governance path. LUMS was evaluated from three aspects: construction suitability, cultivation suitability, and ecological suitability. LRS is measured from three dimensions: construction land, cultivated land, and ecological land scarcity. The DD is expanded into human and wildlife demand diversity. By analyzing the combination of LUMS, LRS, and DD, LUCs are classified using the potential LUC identification Rubik’s cube model, and corresponding governance paths are suggested. In Shandong Province, potential LUCs are relatively high, with strong, medium, and weak conflicts accounting for 27.39%, 57.10%, and 13.06%, respectively. Potential strong conflicts are mainly distributed in the metropolitan suburbs and in the western plain of Shandong Province. Cultivated land is the main potential land use conflict space. The new framework of LUC identification proposed in this paper can effectively identify potential LUCs. Our research provides scientific reference for sustainable land use.

Abstract Human peripheral blood T lymphocytes are classified into alpha–beta T (αβΤ) cells and gamma–delta T (γδΤ) cells based on the difference in T cell receptors (TCRs). αβT cells are crucial for the acquired immune response, while γδΤ cells, though only a small subset, can recognize antigenic substances. These antigens do not need to be processed and presented and are not restricted by MHC. This distinguishes γδΤ cells from αβT cells and highlights their distinct role in innate immunity. Despite their small number, γδΤ cells hold significant significance in anti-tumor, anti-infection and immune regulation. Glioblastoma (GBM) represents one of the most prevalent malignant tumors within the central nervous system (CNS). Surgical resection alone proves to be an ineffective method for curing this type of cancer. Even with the combination of surgical resection, radiotherapy, and chemotherapy, the prognosis of some individuals with glioblastoma is still poor, and the recurrence rate is high. In this research, the classification, biological, and immunological functions of γδT cells and their research progress in anti-glioblastoma were reviewed.

The expansion of the construction land scale has been vital in supporting rapid economic development and meeting social needs. However, the spatial heterogeneity in the effect of construction land scale on carbon emission intensity at the county level remains underexplored. Therefore, comprehensively investigating the relation between the construction land transfer scale and carbon emission intensity holds substantial research value. Using panel data from 2007 to 2021, this study analyzes the spatiotemporal differentiation characteristics of carbon emission intensity and the effect of construction land scale on carbon emission intensity at the county level in Jiangsu Province, China. The findings reveal that carbon emission intensity at the county level in Jiangsu Province generally exhibits a continuous downward trend over time and a spatial distribution characterized by a gradual decrease from the southern counties to the central and northern counties. Moreover, there is a significant positive relation between the construction land transfer scale and carbon emission intensity, a conclusion supported by robustness tests. Furthermore, mediating analysis indicates that reduction of the construction land transfer scale exhibits a significant promoting effect on green technology innovation and industrial structure upgrading, which, in turn, has a significant inhibitory effect on carbon emission intensity. The impact of the construction land transfer scale from different sources, supply methods, types, and of county economic strength on carbon emission intensity has significant heterogeneity.

The power capacity of reflectarray antennas (RAs) is investigated through full-wave simulations and high-power microwave (HPM) experiments in this paper. In order to illustrate the results in detail, two RA elements are designed. The simulated power handling capacity of two RA elements are 7.17 MW/m2 and 2.3 GW/m2, respectively. To further study the HPM RA, two RA prototypes operating at 2.8 GHz are constructed with the aperture size of 1 m × 1 m. Simulations and experimental measurements are conducted for the two prototypes. The experimental results demonstrate that, even when subjected to 1 GW of power, the radiation beam of the RA with the second elements can still propagate in the intended direction. This research will establish a basis for advancing the practicality of RAs in HPM applications.

Agricultural land protection is vital for the realization of national food security and an ecological civilization. From the perspective of agricultural ecological value and landscape value, perfecting the theory of agricultural land rent is beneficial to the construction of an ecological civilization. Based on Marx’s land rent theory of agricultural production, the analytical framework of the agricultural decision support systems (DSS) was constructed; then, the agricultural land rent in suburbs was theoretically accounted for via a numerical example, and its realization rules were simulated according to the conditions of China (i.e., the specific solutions in force). Some interesting conclusions were found: (1) Agricultural production in suburbs involves both natural reproduction and social reproduction. (2) Agricultural land rent should include production land rent, ecological land rent, and landscape land rent. (3) The promotion of an ecological civilization and the development of the economy and society will lead to an increase in the comprehensive coefficient of agricultural land rent. (4) With the development of the economy, ecological land rent and landscape land rent should be gradually charged from zero payment to full payment. Based on these conclusions, five corresponding policy implications are proposed to improve the land profit of agricultural land owners to promote agricultural production, food security, and an ecological civilization.

Human γδT cells are a special immune cell type which exist in small quantities in the body, do not require processing and presentation for antigen recognition, and have non-major histocompatibility complex (MHC)-restricted immune response. They play an important role in the body’s anti-tumor, anti-infection, immune regulation, immune surveillance and maintenance of immune tolerance. This article reviews the generation and development of human γδT cells, genetic characteristics, classification, recognition and role of antigens, and research progress in tumor immunotherapy.

In this paper, a novel X-band TM01–TE01 mode converter for high-power microwave (HPM) system is proposed. To realize the compact design, a helical corrugated waveguide with large deformation is employed to convert the TM01 mode into TE01 mode. By optimizing the structure parameters, the simulation results demonstrate that the maximum conversion efficiency of the proposed TM01–TE01 mode converter reaches 98.8% at 9.2 GHz. Moreover, this mode converter exhibits a conversion efficiency of over 95% in the operation band from 8.7 to 9.42 GHz, and the power capacity of the mode converter reaches GW-level in theory. More importantly, the overall longitudinal and transverse dimensions of the mode converter are less than three wavelengths. The results show the compact structure and high conversion efficiency of this mode converter, which has great potential application value in the HPM system.

Empirical research was conducted on green credit asset securitized products issued by commercial banks in 2014 and 2016. By establishing an Autoregression moving average (ARMA) model, the paper analyzed the relationship between the Industrial Bank's implementation of green credit asset securitization and its capital adequacy ratio. The results showed that the implementation of green credit asset securitization improved the bank's capital adequacy ratio and reduced its nonperforming loan ratio. Then, an empirical study based on carbon finance market operating mechanisms was conducted on Chinese commercial banks that have adopted the “Equator Principles” (EPs). An event study method was used to observe the impact of adoption on the banks. The results indicate that, after the industrial bank adopted the “Equator Principles '', its asset scale increased from 2006 to 2009, whereas its nonperforming loan ratio decreased from 2006 to 2011. After commercial banks adopted the “Equator Principles '', the cumulative average excess return reached its maximum on the eighth day after the event and was significantly higher than the industry average. It is important to promote the awareness of banks of their close links with environmental protection and encourage them to adopt the “Equator Principles” to significantly improve their risk management awareness, business processes, technical systems, and performance in the carbon financial market. By adopting the “Equator Principles”, developing financial derivatives for carbon trading, and promoting the development of structured products for carbon trading, commercial banks can contribute to environmental protection while gaining commercial benefits.

In this paper, refined sugar wastewater (RSW) is treated by electrodialysis (ED) coupled with an upflow anaerobic sludge blanket (UASB) and membrane bioreactor (MBR). The salt in RSW was first removed by ED, and then the remaining organic components in RSW were degraded by a combined UASB and MBR system. In the batch operation of ED, the RSW was desalinated to a certain level (conductivity < 6 mS·cm−1) at different dilute to concentrated stream volume ratios (VD/VC). At the volume ratio of 5:1, the salt migration rate JR and COD migration rate JCOD were 283.9 g·h−1·m−2 and 13.84 g·h−1·m−2, respectively, and the separation factor α (defined as JCOD/JR) reached a minimum value of 0.0487. The ion exchange capacity (IEC) of ion exchange membranes (IEMs) after 5 months of usage showed a slight change from 2.3 mmol·g−1 to 1.8 mmol·g−1. After the ED treatment, the effluent from the tank of the dilute stream was introduced into the combined UASB-MBR system. In the stabilization stage, the average COD of UASB effluent was 2048 mg·L−1, and the effluent COD of MBR was maintained below 44–69 mg·L−1, which met the discharge standard of water contaminants for the sugar industry. The coupled method reported here provides a viable idea and an effective reference for treating RSW and other similar industrial wastewaters with high salinity and organic contents.

The development of intelligent Internet of vehicles (IoV) is based on communication technology, especially the quantum communication of hybrid entangled states based on orbital angular momentum (OAM). The quantum key distribution (QKD) method is demonstrated using hybrid entangled states with multi-degree of freedom and high purity based on OAM. First, the polarization entangled photon pairs are produced by two type I BBO crystals by means of spontaneous parametric down-conversion (SPDC). The polarization-OAM hybrid entangled states are created by q-plate (QP) to realize QKD. It is found that the polarization entangled photon pairs have the characteristics of OAM. A single mode fiber (SMF) is proposed to filter the topological charge non-zero photons and purify the polarization entangled photon pairs. Then the purification setup with M-Z interferometer and beam rotator (BR) is presented which can purify the polarization-OAM hybrid entangled states. The high purity polarization-OAM hybrid entangled states are implemented, and the QP conversion rate of 3 secondary feedbacks is 99.84% theoretically. Analysis indicates that precise purity polarization-OAM hybrid entangled state can increase the fidelity of information and improve the anti-interference ability in this program without mutually unbiased bases (MUBs). The photon utilization rate, energy-efficient and low-latency communication can be greatly improved by using the OAM carrying information.

Introduction. Mucormycosis is a rare, invasive disease caused by opportunistic pathogens related to the Mucorales order with high fatality rates in immunocompromised hosts, especially in recipients of allogeneic hematopoietic stem cell transplantation (allo-HSCT). Diagnosis and treatment of pulmonary mucormycosis in recipients of allo-HSCT remains challenging. Purpose. The aim of this study is to summarize and analyze the clinical features of pulmonary mucormycosis in recipients of allo-HSCT to explore further clinical research directions for this rare fungal infection in the particular populations. Methods. We retrospectively reviewed pulmonary mucormycosis in patients who received allo-HSCT in our hospital from January 2010 to December 2020. A total of 21 patients fulfilled the diagnostic criteria for pulmonary mucormycosis according to the European Organization for Research and Treatment of Cancer and Mycoses Study Group (EORTC/MSG) criteria. Demographic and clinical data, mycological and histopathological records, and treatment and prognosis data were collected. Clinical variables were compared between survivors and nonsurvivors. The survival days of patients with and without graft-versus-host disease (GVHD) and hemoptysis were compared separately. Results. Most of the recipients of allo-HSCT were male patients with a mean age of 43 years. Acute myeloid leukemia (AML) was the most common primary hematologic malignancy. Extrapulmonary involvement accounted for 28.6%, of the cases, including central nervous system (n = 5) and skin and soft tissue (n = 1). The median time to infection was 96 days after allo-HSCT. Clinical presentations were nonspecific, including fever (76.2%) and cough (85.7%), as well as dyspnea (19.0%), chest pain (38.1%), and hemoptysis (61.9%). Ground-glass infiltrates (95.0%) and nodules/masses (80%) were the most common radiographic patterns on chest CT. The most common pathogen was Rhizopus (63.2%), and breakthrough infection accounted for 90.5%. Fifteen of the patients died within one year, and the median time from diagnosis to death was 47 days. Conclusion. Mucormycosis is a fatal infection disease. Opportunistic infections in recipients of allo-HSCT are mainly breakthrough infections and may have a seasonal distribution (summer and autumn) and more cases of death in autumn. The marked reversed halo sign can be seen both in the initial stage of infection and after antifungal treatment. In our case series, patients with pulmonary mucormycosis with extrapulmonary involvement 100% died within one year. There are more patients with GVHD before infection and hemoptysis in nonsurvivors than survivors within 100 days. Patients with GVHD before infection and hemoptysis have a shorter survival time than those without.

Nowadays, the contradiction between strict construction land supply restriction and excessive construction land demand is extremely prominent. Construction land reduction (CLR) is a policy innovation for economically developed regions designed to solve the tight constraints of the construction land quota as urban development continues in China, however, it leads to a lack of spatial justice. In this study, we address a gap in land use regulation literature regarding regional economic development in fast-developing nations by presenting a quantitative investigation of spatial justice in Shanghai, China. We theoretically analyze the connotation of spatial justice in CLR and its influence on residents’ policy acceptance of CLR. Based on theoretical analysis and using household questionnaires from JJ Town in W District, Shanghai, China, we investigate how spatial justice affects residents’ policy acceptance of CLR through an ordered probit model. The results show that (1) spatial justice strengthens residents’ policy acceptance of CLR; (2) both policy familiarity and participation are important influencing factors that contribute to residents’ policy acceptance of CLR; (3) age, education, household income, the contracting land scale and household population structure also affect residents’ policy acceptance of CLR. (4) Robustness tests support the above findings. Thus, in the process of CLR, it is essential to fully consider the realization of spatial justice to ensure the development of remote suburbs, especially the regions experiencing a net reduction in their construction land.

Construction land reduction (CLR) was implemented in China to improve the efficiency of construction land use. CLR also limited the development of net reduction areas of CLR. By analyzing the Task-Quota-Financial-Benefit flow of CLR, this paper proposes three typical compensation schemes and uses the multivariate probit model to study residents’ selection behavior for these schemes. It is found that (1) in order to compensate for the losses caused by CLR to the reduced direct subjects, there can be three types of possible schemes: direct economic compensation (Scheme I), in situ (Scheme II) and off-site (Scheme III) enhancement of development capacity. (2) The more reasonable the compensation standard, the greater the employment pressure in the township and the greater the township’s location disadvantage, which is why more residents prefer Scheme III. (3) The higher their family income and their family support pressure, the more they prefer Scheme III. (4) At this stage, there is no significant difference in the choice of compensation schemes between cadres and non-cadres. (5) The net planning reduction area prefers Scheme I, while other areas prefer Scheme II. The conclusions may provide insight into the demand for more reasonable compensation policies to ensure the sustainability of CLR.

Abstract Background Accurate segmentation of brain tumors is vital for the gross tumor volume (GTV) definition in radiotherapy. Functional MR images like apparent diffusion constant (ADC) and fractional anisotropy (FA) images can provide more comprehensive information for sensitive detection of the GTV. We synthesize anatomical and functional MRI for accurate and semi-automatic segmentation of GTVs and improvement of clinical efficiency. Methods Four MR image sets including T1-weighted contrast-enhanced (T1C), T2-weighted (T2), apparent diffusion constant (ADC) and fractional anisotropy (FA) images of 5 glioma patients were acquired and registered. A new potential field segmentation (PFS) method was proposed based on the concept of potential field in physics. For T1C, T2 and ADC images, global potential field segmentation (global-PFS) was used on user defined region of interest (ROI) for rough segmentation and then morphologically processed for accurate delineation of the GTV. For FA images, white matter (WM) was removed using local potential field segmentation (local-PFS), and then tumor extent was delineated with region growing and morphological methods. The individual segmentations of multi-parametric images were ensembled into a fused segmentation, considered as final GTV. GTVs were compared with manually delineated ground truth and evaluated with segmentation quality measure (Q), Dice’s similarity coefficient (DSC) and Sensitivity and Specificity. Results Experimental study with the five patients’ data and new method showed that, the mean values of Q, DSC, Sensitivity and Specificity were 0.80 (±0.07), 0.88 (±0.04), 0.92 (±0.01) and 0.88 (±0.05) respectively. The global-PFS used on ROIs of T1C, T2 and ADC images can avoid interferences from skull and other non-tumor areas. Similarity to local-PFS on FA images, it can also reduce the time complexity as compared with the global-PFS on whole image sets. Conclusions Efficient and semi-automatic segmentation of the GTV can be achieved with the new method. Combination of anatomical and functional MR images has the potential to provide new methods and ideas for target definition in radiotherapy.

To realize multi-band mode conversion in a high-power microwave incoherent power combination system, a tri-band conversion system (at X-, Ku-, and Ka-bands) is proposed in this paper. The tri-band conversion system mainly consists of three parts: a dual-band multiplexer, a circular waveguide with a 90° bend, and a tri-band mode converter. To investigate the mode coupling characteristics in the system, every part is carefully analyzed and verified. Numerical and simulation results show that the final conversion efficiencies of the conversion system are 98.9% [coaxial transverse electromagnetic (TEM) mode–coaxial TE11 mode at 10.16 GHz], 99.1% (coaxial TEM mode–coaxial TE11 mode at 14.45 GHz), and 99.6% (circular TM01–circular TE11 at 30.5 GHz). Meanwhile, its maximum power handling capacities reached 1.5 GW, 957.6 MW, and 726.2 MW. The good agreement between theoretical analyses and simulation results demonstrates that the proposed tri-band system is feasible in high-power microwave applications.

In order to safely operate the electric transmission lines, to monitoring the crossed span distance of the overhead lines is one of the key measures. Since the current measurement methods of crossed span distance of overhead line has high cost, low accuracy, and traditional measurement methods has low efficiency, the monitoring model of overhead line in three-dimensional space is constructed, and based on oblique parabola equation. The algorithm for detecting the crossed span distance based on three-dimensional inclination under the windless and windy conditions is studied, which are applied to the on-line monitoring system. Through actual measurement, the accuracy and practicability of the three-dimensional model and algorithm are verified which provides reliable algorithm support for traverse crossing distance measurement and on-line monitoring system, and improves work efficiency.

Lubricant leakage will inevitably occur during the working process of wellbore trajectory control tools. Even including the lubricant compensation system, serious leakage will still cause lacks lubrication of the internal mechanical structure as well as electronic system damaged by external infiltration fluid, especially when it comes to battery sub and other electronic equipment. Seal system leakage prediction method was presented based on the assumption of steady gap flow. It is assumed that there is a constant gap between the lip seal and the rotating shaft, the gap height is determined by oil film thickness, and the length of the gap was determined by the contact analysis using the Mooney–Rivlin constitutive model. The analysis results show that the contact length between the primary seal lip and the rotary shaft is about 0.1 mm under the condition of ensuring the contact between the deputy seal lip and the rotary shaft. The overall lubricant leakage finite element analysis model was established, and the relationship between the internal lubricant pressure of the tool and the total leakage was obtained. The results of analysis indicate that under the internal pressure of 0.03 MPa, the lubricant leakage is approximately 6 mL/h, which was verified by experiments.

Schizophrenia (SCZ) is associated with aberrant redox regulation in the early stages of brain development. There is growing evidence that the antioxidant defense system is closely associated with the therapeutic response to antipsychotics in SCZ patients. The aim of this study was to examine the effect of risperidone monotherapy on total antioxidant status (TAS) and the relationship between symptom improvement and changes in TAS in patients with antipsychotic-naïve first-episode (ANFE) SCZ. Clinical symptoms were evaluated using the Positive and Negative Syndrome Scale (PANSS). Two hundred and forty-six ANFE patients were treated with risperidone for 3 months. PANSS and TAS levels were assessed at baseline and at a 3-month follow-up. Relative to healthy controls, ANFE patients had higher TAS levels, which increased even further during the treatment. Moreover, baseline TAS levels were a predictor of symptom reduction after risperidone treatment. In addition, there was a significant association between increased TAS levels and the decreased cognitive factor. Our findings suggest that antioxidant protection is possibly associated with clinical improvement in ANFE patients after risperidone treatment.

Abstract Background This study aimed to determine whether community-acquired pneumonia (CAP) had a metabolic profile and whether this profile can be used for disease severity assessment. Methods A total of 175 individuals including 119 CAP patients and 56 controls were enrolled and divided into two cohorts. Serum samples from a discovery cohort (n = 102, including 38 non-severe CAP, 30 severe CAP, and 34 age and sex-matched controls) were determined by untargeted ultra-high-performance liquid chromatography with tandem mass spectrometry (LC-MS/MS)-based metabolomics. Selected differential metabolites between CAP patients versus controls, and between the severe CAP group versus non-severe CAP group, were confirmed by targeted mass spectrometry assays in a validation cohort (n = 73, including 32 non-severe CAP, 19 severe CAP and 22 controls). Pearson’s correlation analysis was performed to assess relationships between the identified metabolites and clinical severity of CAP. The area under the curve (AUC), sensitivity and specificity of the metabolites for predicting the severity of CAP were also investigated. Results The metabolic signature was markedly different between CAP patients and controls. Fifteen metabolites were found to be significantly dysregulated in CAP patients, which were mainly mapped to the metabolic pathways of sphingolipid, arginine, pyruvate and inositol phosphate. The alternation trends of five metabolites among the three groups including sphinganine, p-Cresol sulfate, dehydroepiandrosterone sulfate (DHEA-S), lactate and l-arginine in the validation cohort were consistent with those in the discovery cohort. Significantly lower concentrations of sphinganine, p-Cresol sulfate and DHEA-S were observed in CAP patients than in controls (p 65 years (CURB-65), pneumonia severity index (PSI) and Acute Physiology and Chronic Health Evaluation II (APACHE II) scores, while DHEA-S inversely correlated with the three scoring systems. Combining lactate, sphinganine and DHEA-S as a metabolite panel for discriminating severe CAP from non-severe CAP exhibited a better AUC of 0.911 (95% confidence interval 0.825–0.998) than CURB-65, PSI and APACHE II scores. Conclusions This study demonstrates that serum metabolomics approaches based on the LC-MS/MS platform can be applied as a tool to reveal metabolic changes during CAP and establish a metabolite signature related to disease severity. Trial registration ClinicalTrials.gov, NCT03093220. Registered retrospectively on 28 March 2017.

The rising frequency of extreme disaster events seriously threatens the safe and secure operation of the regional integrated electricity-natural gas system (RIENGS). With the growing level of coupling between electric and natural gas systems, it is critical to enhance the load restoration capability of both systems. This paper proposes a coordinated optimization strategy for resilience-enhanced RIENGS load restoration and repair scheduling and transforms it into a mixed integer second-order cone programming (MISOCP) model. The proposed model considers the distribution network reconfiguration and the coordinated repair strategy between the two systems, minimizing the total system load loss cost and repair time. In addition, a bi-directional gas flow model is used to describe the natural gas system, which can provide the RIENGS with more flexibility for load restoration during natural gas system failure. Finally, the effectiveness of the proposed approach is verified by conducting case studies on the test systems RIENGS E13-G7 and RIENGS E123-G20. [ABSTRACT FROM AUTHOR]