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1. Effects of a combined exercise and dietary intervention on body composition, physical functioning and fatigue in patients with ovarian cancer: results of the PADOVA trial

Author

Kenkhuis, Marlou-Floor, Stelten, Stephanie, Hartman, Yvonne AW., Brouwer, Calvin G., ten Tusscher, Marieke R., van Lonkhuijzen, Luc RCW., Kenter, Gemma G., van Driel, Willemien J., Winkels, Renate M., Bekkers, Ruud LM., Ottevanger, Nelleke PB., Hoedjes, Meeke, and Buffart, Laurien M.

Published
2024
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3. Tailoring of exercise and dietary interventions to adverse effects and existing comorbidities in patients with ovarian cancer receiving chemotherapy: a clinical vignettes study among expert physical therapists and dietitians.

Author

Stelten, Stephanie, ten Tusscher, Marieke R., Stuiver, Martijn M., Hartman, Yvonne A. W., van Lonkhuijzen, Luc R. C. W., Kenter, Gemma G., van der Leeden, Marike, Hoedjes, Meeke, and Buffart, Laurien M.

Subjects
MEDICAL logic, PATIENT education, PATIENT safety, RESEARCH funding, OVARIAN tumors, EXERCISE therapy, CANCER patients, DECISION making in clinical medicine, CANCER chemotherapy, COMBINED modality therapy, ADVERSE health care events, CASE studies, COMORBIDITY, DIET therapy
Abstract

Purpose: This study aims to capture the complex clinical reasoning process during tailoring of exercise and dietary interventions to adverse effects and comorbidities of patients with ovarian cancer receiving chemotherapy. Methods: Clinical vignettes were presented to expert physical therapists (n = 4) and dietitians (n = 3). Using the think aloud method, these experts were asked to verbalize their clinical reasoning on how they would tailor the intervention to adverse effects of ovarian cancer and its treatment and comorbidities. Clinical reasoning steps were categorized in questions raised to obtain additional information; anticipated answers; and actions to be taken. Questions and actions were labeled according to the evidence-based practice model. Results: Questions to obtain additional information were frequently related to the patients' capacities, safety or the etiology of health issues. Various hypothetical answers were proposed which led to different actions. Suggested actions by the experts included extensive monitoring of symptoms and parameters, specific adaptations to the exercise protocol and dietary-related patient education. Conclusions: Our study obtained insight into the complex process of clinical reasoning, in which a variety of patient-related variables are used to tailor interventions. This insight can be useful for description and fidelity assessment of interventions and training of healthcare professionals. IMPLICATIONS FOR REHABILITATION: The delivery of exercise and dietary programs is not a one-size fits all approach but involves a complex clinical reasoning process. Therefore, protocols should not only describe the intervention content, but also the strategy on how to tailor the intervention to individual adverse effects and pre-existing comorbidities. Education of healthcare professionals delivering the intervention is important as these professionals need to have good clinical reasoning skills to adequately tailor the intervention. [ABSTRACT FROM AUTHOR]

Published
2024
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7. Tailoring of exercise and dietary interventions to adverse effects and existing comorbidities in patients with ovarian cancer receiving chemotherapy: a clinical vignettes study among expert physical therapists and dietitians

Author

Stelten, Stephanie, primary, ten Tusscher, Marieke R., additional, Stuiver, Martijn M., additional, Hartman, Yvonne A. W., additional, van Lonkhuijzen, Luc R. C. W., additional, Kenter, Gemma G., additional, van der Leeden, Marike, additional, Hoedjes, Meeke, additional, and Buffart, Laurien M., additional

Published
2023
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8. Cost-effectiveness of laparoscopy as diagnostic tool before primary cytoreductive surgery in ovarian cancer

Author

van de Vrie, Roelien, van Meurs, Hannah S., Rutten, Marianne J., Naaktgeboren, Christiana A., Opmeer, Brent C., Gaarenstroom, Katja N., van Gorp, Toon, Ter Brugge, Henk G., Hofhuis, Ward, Schreuder, Henk W.R., Arts, Henriette J.G., Zusterzeel, Petra L.M., Pijnenborg, Johanna M.A., van Haaften, Maarten, Engelen, Mirjam J.A., Boss, Erik A., Vos, M. Caroline, Gerestein, Kees G., Schutter, Eltjo M.J., Kenter, Gemma G., Bossuyt, Patrick M.M., Mol, Ben Willem, and Buist, Marrije R.

Published
2017
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10. Tailoring of exercise and dietary interventions to adverse effects and existing comorbidities in patients with ovarian cancer receiving chemotherapy: a clinical vignettes study among expert physical therapists and dietitians

Author

Stelten, S., Tusscher, M. ten, Stuiver, M.M., Hartman, Y.A.W., Lonkhuijzen, L.R. van, Kenter, Gemma G., Hoedjes, Meeke, Buffart, L.M., Stelten, S., Tusscher, M. ten, Stuiver, M.M., Hartman, Y.A.W., Lonkhuijzen, L.R. van, Kenter, Gemma G., Hoedjes, Meeke, and Buffart, L.M.

Abstract

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Published
2023

11. Randomized Phase III Study Comparing Neoadjuvant Chemotherapy Followed by Surgery Versus Chemoradiation in Stage IB2-IIB Cervical Cancer: EORTC-55994.

Author

Kenter, Gemma G., Greggi, Stefano, Vergote, Ignace, Katsaros, Dionyssios, Kobierski, Juliusz, van Doorn, Heleen, Landoni, Fabio, van der Velden, Jacobus, Reed, Nicholas, Coens, Corneel, van Luijk, Iske, Colombo, Nicoletta, Steen-Banasik, Elzbietta van der, Ottevanger, Nelleke, Casado, Antonio, Schratter-Sehn, Annemarie, Vermorken, Jan Baptist, Altintas, Sevilay, Kridelka, Frederic, and Goffin, Frédéric

Published
2023
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14. Figure S2 from Adenocarcinoma of the Uterine Cervix Shows Impaired Recruitment of cDC1 and CD8+ T Cells and Elevated β-Catenin Activation Compared with Squamous Cell Carcinoma

Author

Rotman, Jossie, primary, Heeren, A. Marijne, primary, Gassama, Awa A., primary, Lougheed, Sinead M., primary, Pocorni, Noëlle, primary, Stam, Anita G.M., primary, Bleeker, Maaike C.G., primary, Zijlmans, Henry J.M.A.A, primary, Mom, Constantijne H., primary, Kenter, Gemma G., primary, Jordanova, Ekaterina S., primary, and de Gruijl, Tanja D., primary

Published
2023
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15. Figure S1 from Delta-Like Ligand–Notch1 Signaling Is Selectively Modulated by HPV16 E6 to Promote Squamous Cell Proliferation and Correlates with Cervical Cancer Prognosis

Author

Khelil, Maryam, primary, Griffin, Heather, primary, Bleeker, Maaike C.G., primary, Steenbergen, Renske D.M., primary, Zheng, Ke, primary, Saunders-Wood, Taylor, primary, Samuels, Sanne, primary, Rotman, Jossie, primary, Vos, Wim, primary, van den Akker, Brendy E., primary, de Menezes, Renée X., primary, Kenter, Gemma G., primary, Doorbar, John, primary, and Jordanova, Ekaterina S., primary

Published
2023
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16. Table S2 from Delta-Like Ligand–Notch1 Signaling Is Selectively Modulated by HPV16 E6 to Promote Squamous Cell Proliferation and Correlates with Cervical Cancer Prognosis

Author

Khelil, Maryam, primary, Griffin, Heather, primary, Bleeker, Maaike C.G., primary, Steenbergen, Renske D.M., primary, Zheng, Ke, primary, Saunders-Wood, Taylor, primary, Samuels, Sanne, primary, Rotman, Jossie, primary, Vos, Wim, primary, van den Akker, Brendy E., primary, de Menezes, Renée X., primary, Kenter, Gemma G., primary, Doorbar, John, primary, and Jordanova, Ekaterina S., primary

Published
2023
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17. Data from Delta-Like Ligand–Notch1 Signaling Is Selectively Modulated by HPV16 E6 to Promote Squamous Cell Proliferation and Correlates with Cervical Cancer Prognosis

Author

Khelil, Maryam, primary, Griffin, Heather, primary, Bleeker, Maaike C.G., primary, Steenbergen, Renske D.M., primary, Zheng, Ke, primary, Saunders-Wood, Taylor, primary, Samuels, Sanne, primary, Rotman, Jossie, primary, Vos, Wim, primary, van den Akker, Brendy E., primary, de Menezes, Renée X., primary, Kenter, Gemma G., primary, Doorbar, John, primary, and Jordanova, Ekaterina S., primary

Published
2023
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18. Supplementary Materials and Methods from Delta-Like Ligand–Notch1 Signaling Is Selectively Modulated by HPV16 E6 to Promote Squamous Cell Proliferation and Correlates with Cervical Cancer Prognosis

Author

Khelil, Maryam, primary, Griffin, Heather, primary, Bleeker, Maaike C.G., primary, Steenbergen, Renske D.M., primary, Zheng, Ke, primary, Saunders-Wood, Taylor, primary, Samuels, Sanne, primary, Rotman, Jossie, primary, Vos, Wim, primary, van den Akker, Brendy E., primary, de Menezes, Renée X., primary, Kenter, Gemma G., primary, Doorbar, John, primary, and Jordanova, Ekaterina S., primary

Published
2023
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19. Table S1 from Adenocarcinoma of the Uterine Cervix Shows Impaired Recruitment of cDC1 and CD8+ T Cells and Elevated β-Catenin Activation Compared with Squamous Cell Carcinoma

Author

Rotman, Jossie, primary, Heeren, A. Marijne, primary, Gassama, Awa A., primary, Lougheed, Sinead M., primary, Pocorni, Noëlle, primary, Stam, Anita G.M., primary, Bleeker, Maaike C.G., primary, Zijlmans, Henry J.M.A.A, primary, Mom, Constantijne H., primary, Kenter, Gemma G., primary, Jordanova, Ekaterina S., primary, and de Gruijl, Tanja D., primary

Published
2023
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20. Supplementary Materials from Vaccination against Oncoproteins of HPV16 for Noninvasive Vulvar/Vaginal Lesions: Lesion Clearance Is Related to the Strength of the T-Cell Response

Author

van Poelgeest, Mariëtte I.E., primary, Welters, Marij J.P., primary, Vermeij, Renee, primary, Stynenbosch, Linda F.M., primary, Loof, Nikki M., primary, Berends-van der Meer, Dorien M.A., primary, Löwik, Margriet J.G., primary, Hamming, Ineke L.E., primary, van Esch, Edith M.G., primary, Hellebrekers, Bart W.J., primary, van Beurden, Marc, primary, Schreuder, Henk W., primary, Kagie, Marjolein J., primary, Trimbos, J. Baptist M.Z., primary, Fathers, Lorraine M., primary, Daemen, Toos, primary, Hollema, Harry, primary, Valentijn, A. Rob P.M., primary, Oostendorp, Jaap, primary, Oude Elberink, J. Hanneke N.G., primary, Fleuren, Gertjan J., primary, Bosse, Tjalling, primary, Kenter, Gemma G., primary, Stijnen, Theo, primary, Nijman, Hans W., primary, Melief, Cornelis J.M., primary, and van der Burg, Sjoerd H., primary

Published
2023
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23. Supplementary Figure Legend from An Unexpectedly Large Polyclonal Repertoire of HPV-Specific T Cells Is Poised for Action in Patients with Cervical Cancer

Author

de Vos van Steenwijk, Peggy J., primary, Heusinkveld, Moniek, primary, Ramwadhdoebe, Tamara H., primary, Löwik, Margriet J., primary, van der Hulst, Jeanette M., primary, Goedemans, Renske, primary, Piersma, Sytse J., primary, Kenter, Gemma G., primary, and van der Burg, Sjoerd H., primary

Published
2023
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26. HPV16 E7 DNA tattooing: safety, immunogenicity, and clinical response in patients with HPV-positive vulvar intraepithelial neoplasia

Author

Samuels, Sanne, Marijne Heeren, A., Zijlmans, Henry J. M. A. A., Welters, Marij J. P., van den Berg, Joost H., Philips, Daisy, Kvistborg, Pia, Ehsan, Ilina, Scholl, Suzy M. E., Nuijen, Bastiaan, Schumacher, Ton N. M., van Beurden, Marc, Jordanova, Ekaterina S., Haanen, John B. A. G., van der Burg, Sjoerd H., and Kenter, Gemma G.

Published
2017
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33. Association between Energy Balance-Related Factors and Clinical Outcomes in Patients with Ovarian Cancer: A Systematic Review and Meta-Analysis

Author

Stelten, Stephanie, primary, Schofield, Christelle, additional, Hartman, Yvonne A. W., additional, Lopez, Pedro, additional, Kenter, Gemma G., additional, Newton, Robert U., additional, Galvão, Daniel A., additional, Hoedjes, Meeke, additional, Taaffe, Dennis R., additional, van Lonkhuijzen, Luc R. C. W., additional, McIntyre, Carolyn, additional, and Buffart, Laurien M., additional

Published
2022
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34. Clinical Regression of High-Grade Cervical Intraepithelial Neoplasia Is Associated With Absence of FAM19A4/miR124-2 DNA Methylation (CONCERVE Study)

Author

Kremer, Wieke W., primary, Dick, Stèfanie, additional, Heideman, Daniëlle A.M., additional, Steenbergen, Renske D.M., additional, Bleeker, Maaike C.G., additional, Verhoeve, Harold R., additional, van Baal, W. Marchien, additional, van Trommel, Nienke, additional, Kenter, Gemma G., additional, Meijer, Chris J.L.M., additional, and Berkhof, Johannes, additional

Published
2022
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41. FAM19A4/miR124-2 Methylation Testing and Human Papillomavirus (HPV) 16/18 Genotyping in HPV-Positive Women Under the Age of 30 Years

Author

Vink, Frederique J, primary, Meijer, Chris J L M, additional, Hesselink, Albertus T, additional, Floore, Arno N, additional, Lissenberg-Witte, Birgit I, additional, Bonde, Jesper H, additional, Pedersen, Helle, additional, Cuschieri, Kate, additional, Bhatia, Ramya, additional, Poljak, Mario, additional, Oštrbenk Valenčak, Anja, additional, Hillemanns, Peter, additional, Quint, Wim G V, additional, del Pino, Marta, additional, Kenter, Gemma G, additional, Steenbergen, Renske D M, additional, Heideman, Daniëlle A M, additional, and Bleeker, Maaike C G, additional

Published
2022
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43. Success or failure of vaccination for HPV16-positive vulvar lesions correlates with kinetics and phenotype of induced T-cell responses

Author

Welters, Marij J. P., Kenter, Gemma G., de Vos van Steenwijk, Peggy J., Löwik, Margriet J. G., der Meer, Dorien M. A. Berends-van, Essahsah, Farah, Stynenbosch, Linda F. M., Vloon, Annelies P. G., Ramwadhdoebe, Tamara H., Piersma, Sytse J., van der Hulst, Jeanette M., Valentijn, A. Rob P. M., Fathers, Lorraine M., Drijfhout, Jan W., Franken, Kees L. M. C., Oostendorp, Jaap, Fleuren, Gert Jan, Melief, Cornelis J. M., van der Burg, Sjoerd H., and van Rood, Johannes J.

Published
2010

44. Association between energy balance-related factors and clinical outcomes in patients with ovarian cancer: A systematic review and meta-analysis

Author

Stelten, Stephanie, Schofield, Christelle, Hartman, Yvonne A. W., Lopez, Pedro, Kenter, Gemma G., Newton, Robert U., Galvão, Daniel A., Hoedjes, Meeke, Taaffe, Dennis R., van Lonkhuijzen, Luc R. C. W., McIntyre, Carolyn, Buffart, Laurien M., Stelten, Stephanie, Schofield, Christelle, Hartman, Yvonne A. W., Lopez, Pedro, Kenter, Gemma G., Newton, Robert U., Galvão, Daniel A., Hoedjes, Meeke, Taaffe, Dennis R., van Lonkhuijzen, Luc R. C. W., McIntyre, Carolyn, and Buffart, Laurien M.

Abstract

Background: This systematic review and meta-analysis synthesized evidence in patients with ovarian cancer at diagnosis and/or during first-line treatment on; (i) the association of body weight, body composition, diet, exercise, sedentary behavior, or physical fitness with clinical outcomes; and (ii) the effect of exercise and/or dietary interventions. Methods: Risk of bias assessments and best-evidence syntheses were completed. Meta-analyses were performed when ≥ 3 papers presented point estimates and variability measures of associations or effects. Results: Body mass index (BMI) at diagnosis was not significantly associated with survival. Although the following trends were not supported by the best-evidence syntheses, the meta-analyses revealed that a higher BMI was associated with a higher risk of post-surgical complications (n = 5, HR: 1.63, 95 % CI: 1.06 – 2.51, p = 0.030), a higher muscle mass was associated with a better progression-free survival (n = 3, HR: 1.41, 95 % CI: 1.04 – 1.91, p = 0.030) and a higher muscle density was associated with a better overall survival (n = 3, HR: 2.12, 95 % CI: 1.62 – 2.79, p < 0.001). Muscle measures were not significantly associated with surgical or chemotherapy-related outcomes. Conclusions: The prognostic value of baseline BMI for clinical outcomes is limited, but muscle mass and density may have more prognostic potential. High-quality studies with comprehensive reporting of results are required to improve our understanding of the prognostic value of body composition measures for clinical outcomes. Systematic review registration number: PROSPERO identifier CRD42020163058.

Published
2022

49. The long-term immune response after HPV16 peptide vaccination in women with low-grade pre-malignant disorders of the uterine cervix: a placebo-controlled phase II study

Author

de Vos van Steenwijk, Peggy J., van Poelgeest, Mariette I. E., Ramwadhdoebe, Tamara H., Löwik, Margriet J. G., Berends-van der Meer, Dorien M. A., van der Minne, Caroline E., Loof, Nikki M., Stynenbosch, Linda F. M., Fathers, Lorraine M., Valentijn, A. Rob P. M., Oostendorp, Jaap, Osse, Elisabeth M., Fleuren, Gert Jan, Nooij, Linda, Kagie, Marjolein J., Hellebrekers, Bart W. J., Melief, Cornelis J. M., Welters, Marij J. P., van der Burg, Sjoerd H., and Kenter, Gemma G.

Published
2014
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