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45 results on '"Kent, Sandra"'

2. Hand hygiene

Author

Storr, Julie and Clayton-Kent, Sandra

Published
2004

4. Inhibition of the early asthmatic response to inhaled allergen by the 5-lipoxygenase activating protein inhibitor GSK2190915: a dose–response study

Author

Singh,Dave, Boyce,Malcolm, Norris,Virginia, Kent,Sandra E, Bentley,Jane H, Singh,Dave, Boyce,Malcolm, Norris,Virginia, Kent,Sandra E, and Bentley,Jane H

Abstract

Dave Singh,1 Malcolm Boyce,2 Virginia Norris,3 Sandra E Kent,3 Jane H Bentley31University of Manchester, Medicines Evaluation Unit, University Hospital of South Manchester, Manchester, UK; 2Hammersmith Medicines Research, London, UK; 3GlaxoSmithKline, Middlesex, UKBackground: GSK2190915, a 5-lipoxygenase activating protein inhibitor, inhibits the production of cysteinyl leukotrienes and leukotriene B4 and 5-oxo-6,8,11,14-eicosatetraenoic acid. We have previously reported that GSK2190915 100 mg daily inhibits early and late asthmatic responses to inhaled allergen; the effects of lower doses have not been reported. This study assessed the dose–response effects of GSK2190915 10 mg and 50 mg on the early asthmatic response (EAR) to inhaled allergen.Methods: Nineteen subjects with mild asthma and an EAR were enrolled in a randomized, double-blind, three-way crossover study of GSK2190915 10 mg, 50 mg, and placebo orally once-daily for 3 days. Allergen challenge was performed 2 hours after the third dose.Results: Compared with placebo, GSK2190915 10 mg and 50 mg caused significant, dose-dependent attenuation of the minimum forced expiratory volume at 1 second (FEV1) absolute change from baseline; mean treatment differences were 0.21 L (95% confidence interval [CI] 0.04 L, 0.38 L) and 0.41 L (95% CI 0.24 L, 0.58 L), respectively. GSK2190915 50 mg was more effective than 10 mg; mean difference between treatments was 0.20 L, (95% CI 0.03 L, 0.36 L). Compared with placebo, GSK2190915 50 mg, but not 10 mg, significantly inhibited the weighted mean FEV1 absolute change from baseline.Conclusion: GSK2190915 50 mg attenuated the EAR similarly to GSK2190915 100 mg in our previous study, suggesting 50 mg is at the top of the dose–response curve. GSK2190915 10 mg is a suboptimal dose. The EAR can be used to assess the therapeutic dose of a new treatment for asthma.Keywords: GSK2190915, FLAP inhibitor, early asthmatic response

Published
2013

5. Half-century mark isn't what it used to be

Author

Kent, Sandra

Abstract

Byline: SANDRA KENT Madonna - singer, dancer, actress, exhibitionist, children's book author and relentless self-inventor - brings her "Sticky & Sweet" tour to TD Banknorth Garden tonight and tomorrow. As […]

Published
2008

7. Kids honor military parents in heartfelt 'My Hero'

Author

Kent, Sandra

Subjects
Soldiers
Abstract

Byline: SANDRA KENT "My Hero: Military Kids Write About Their Moms and Dads," edited by Allen Appel and Mike Rothmiller ($12.95, St. Martin's Press) You've seen them in news photos […]

Published
2008

8. Cine-matchmake your perfect movie date

Author

Kent, Sandra

Abstract

Byline: SANDRA KENT With nearly a dozen films opening today, this is a perfect weekend for a movie date - but which kind? Are you trying to rev up a […]

Published
2008

9. Carrie-ing on about 'Prom' horrors

Author

Kent, Sandra

Abstract

Byline: SANDRA KENT As any slasher-flick fan knows, the real dangers of prom night aren't drunken teen drivers, but vengeful ghosts and ax-wielding maniacs. What is it about a rented […]

Published
2008

10. Authors take a page from Austen's powers

Author

Kent, Sandra

Subjects
Austen, Jane
Abstract

Byline: SANDRA KENT The film "Becoming Jane," which opens tomorrow starring Anne Hathaway, is just the tip of this year's Jane Austen-orama. Here are a few notable books to satisfy […]

Published
2007

11. Even before Remy, cartoon rodents ruled - and cooked, too

Author

Kent, Sandra and Kincaid, Linda G.

Subjects
Rodents
Abstract

Byline: SANDRA KENT and LINDA G. KINCAID As Remy, the four-legged foodie of "Ratatouille," nibbles his way to fame, we can't help but recall other renowned cartoon rodents. These animated, […]

Published
2007

12. A salute to female soldiers

Author

Kent, Sandra

Subjects
Soldiers -- Appreciation, Women -- Appreciation
Abstract

Byline: SANDRA KENT As Americans get ready to celebrate July Fourth, much attention will be paid to the military personnel serving our country. With a release coinciding with the holiday, […]

Published
2007

13. Bask in the glow of these hot summer reads

Author

Kent, Sandra

Abstract

Byline: SANDRA KENT Whether you're baking in the sun or lolling in a lounge chair - summer's sublime supine moments were made for a good, or good 'n' dishy, book. […]

Published
2007

14. 'Ted Williams at War' hits all the bases

Author

Kent, Sandra

Subjects
Williams, Ted
Abstract

Byline: SANDRA KENT "TED WILLIAMS AT WAR" By Bill Nowlin (Rounder Books, $24.95) Steroid and cheating scandals have rocked the sports world in recent years, and so it may be […]

Published
2007

15. Beyond chick-lit: New books explore women's diverse lives

Author

Kent, Sandra

Subjects
Book publishing
Abstract

Byline: SANDRA KENT The diverse lives of women inform a trio of April books, highlighting the Palestinian-American immigrant experience, extraordinary African-Americans and a humorous memoir by a writer labeled the […]

Published
2007

16. Dishing on the new Julia Child bio

Author

Kent, Sandra

Subjects
Child, Julia
Abstract

Byline: SANDRA KENT "JULIA CHILD" By Laura Shapiro (Viking, $19.95). Available April 9. Before Giada and Emeril and Rachael and Martha, there was Julia. With a jaunty "Bon appetit!" Cambridge-based […]

Published
2007

17. Convenient truths to help save planet

Author

Kent, Sandra

Abstract

Byline: SANDRA KENT Why wait until Earth Day to raise your ecological awareness? Two books, debuting in early April, offer facts and tips for wannabe tree-huggers. ** "True Green: 100 […]

Published
2007

19. Peter O'Toole, Superstar

Author

Kent, Sandra

Abstract

Byline: SANDRA KENT 79th Academy Awards February 25, 2007. Best Actor nominee Peter O'Toole has played some high-profile roles in his 74 years: King Henry II, Lawrence of Arabia, Caesar […]

Published
2007

20. That Dame Judi Dench is a rat!

Author

Kent, Sandra

Subjects
Dench, Judi
Abstract

Byline: SANDRA KENT 79th Academy Awards Feb 25, 2007. Playing a manipulative schoolteacher in "Notes on a Scandal," Dame Judi Dench gave her character a certain ratlike cunning. But it […]

Published
2007

21. GIFTS FOR . . . THE STYLISH MAN

Author

Kent, Sandra

Abstract

Byline: SANDRA KENT Can recognize a "European cut" suit. Can't wait for Thom Browne's collection to arrive at Brooks Brothers. Gets his hair trimmed at a salon, not a barbershop. […]

Published
2006

22. Gifts for ... the animal rescuer

Author

Kent, Sandra

Abstract

Byline: SANDRA KENT Has Save the Wolves/Whales/Whatever Web sites bookmarked for regular e-giving. Cried when Shakespeare didn't return to "Meerkat Manor." ** Help Fundacion Ecolombia care for a rescued Colombian […]

Published
2006

23. WHAT THEY'RE READING NOW

Author

Kent, Sandra

Subjects
Book publishing, Simon & Schuster Inc.
Abstract

Byline: SANDRA KENT Brits get personal "They Call Me Naughty Lola: Personal Ads from the London Review of Books" Edited by David Rose (Simon & Schuster, $16) Intimidated when describing […]

Published
2006

24. Get the truth about Katz and 'Dog'

Author

Kent, Sandra

Subjects
Katz, Jon
Abstract

Byline: SANDRA KENT "A GOOD DOG: The Story of Orson, Who Changed My Life" By Jon Katz (Villard Books, $21.95) Fans of Jon Katz (the ironically named author of several […]

Published
2006

25. READ; Wedding books help you walk the aisle with a smile

Author

Kent, Sandra

Subjects
Books
Abstract

Byline: SANDRA KENT The bridal path can be fraught with drama, if one is to believe the spate of reality TV shows spotlighting nuptials-gone-nuclear. How can a happy couple put […]

Published
2006

26. These words of wisdom are more likely to make you laugh

Author

Kent, Sandra

Abstract

Byline: SANDRA KENT Advice books are thick on the ground, covering everything from home decor to emotional housekeeping, love, lust and weight loss. At this point, only a few provoke […]

Published
2006

27. Get your yearly calendar fix

Author

Kent, Sandra

Subjects
Automobile industry, Automobile Industry
Abstract

Byline: SANDRA KENT In the log-flume ride that is the week between Christmas and New Year's, you're probably starting to think of 2006 beyond Jan. 1. Birthdays, parties, dental appointments […]

Published
2005

29. Seeking 'Inspirations'? Try Madonna, Dylan compilations

Author

Kent, Sandra

Abstract

Byline: Sandra Kent "Madonna: Inspirations," ($14.95, Andrews McMeel Publishing) "Bob Dylan: Inspirations," ($14.95, Andrews McMeel Publishing) "Well, as Madonna once said . . ." Did you ever want to stun […]

Published
2005

30. Every picture tells a story

Author

Kent, Sandra

Abstract

Byline: Sandra Kent A picture is worth a thousand words, and Clinton pulls out the stops in his choice of photographs for "My Life," crafting a montage of Innocent, Poignant […]

Published
2004

31. Do-it-yourself Peeps leaves her squawking

Author

Kent, Sandra

Abstract

Byline: SANDRA KENT Peeps - their arrival in stores is arguably as stalwart a harbinger of spring as the first crocus or chirpy robin. The sweet, squishy little marshmallow chicks […]

Published
2004

32. Wardrobe functions: From lovely to ugly

Author

Kent, Sandra

Abstract

Byline: SANDRA KENT Some Grammy attendees must have gotten an invite that said "formal attire," some decided to "come as you are," and some heeded the call to resurrect Halloween. […]

Published
2004

33. [0] Wardrobe functions: From lovely to ugly

Author

Kent, Sandra

Abstract

Byline: Sandra Kent Some Grammy attendees must have gotten an invite that said "formal attire," some decided to "come as you are," and some heeded the call to resurrect Halloween. […]

Published
2004

34. Changing places: Your guide to moving

Author

Kent, Sandra

Subjects
Moving, Household -- Personal narratives, Storage and moving industry -- Evaluation, Travel, recreation and leisure
Published
1987

35. Celebrity style crimes of 2003

Author

Kent, Sandra

Abstract

Byline: Sandra Kent The Fashion Police has seen it all this year - from misdemeanors to serious style scams. And when it comes to Fashion Felonies, celebrities are often the […]

Published
2003

36. Most Clever Excuse for Kudos Award goes to . .

Author

Kent, Sandra

Abstract

Byline: Sandra Kent Tomorrow night, Jenny McCarthy will bring her teeth and tresses to a Los Angeles podium to host the DVD Exclusive Awards. You know, where the industry honors […]

Published
2003

37. Paris on $10 a day

Author

Kent, Sandra

Abstract

Byline: SANDRA KENT She's young, pretty and super-rich, with her own reality show and Internet infamy as an "alternative movie" star. Who wouldn't want to be Paris Hilton? Well, unless […]

Published
2003

38. Stunners and stinkers

Author

Kent, Sandra and Kincaid, Linda G.

Abstract

Byline: Sandra Kent and Linda G. Kincaid Hmm. . . is "Emmy fashion" a contradiction in terms? We found ourselves wondering that last night as style disasters piled up on […]

Published
2003

39. FASHION: Clothes-captioned for the flair-impaired

Author

Kincaid, Linda and Kent, Sandra

Abstract

Byline: LINDA KINCAID and SANDRA KENT The tickets flew fast and furious this week - as fashionistas big and small crossed the double yellow line of style. But, with few […]

Published
2003

40. Bling it on: Beantown KOs pop stars

Author

Kent, Sandra and Kincaid, Linda

Abstract

Byline: by SANDRA KENT and LINDA KINCAID Pop quiz: If Boston fashionistas had a style smackdown with the superstars of the recording industry, who would win? Congratulations, Hubsters. This week […]

Published
2003

41. Reality TV's dim bulbs outshine Hollywood celebrities

Author

Kent, Sandra

Abstract

Byline: SANDRA KENT Is it just me, or is this season's spate of celebrity shenanigans decidedly tepid? Britney Spears dyes her hair brown, then back to blond; Madonna flogs togs […]

Published
2003

42. Girls gone bad answer to 'Sandy'

Author

Kent, Sandra

Subjects
Duncan, Sandy
Abstract

Byline: SANDRA KENT It was about 15 minutes into the "Law & Order: Criminal Intent" episode when she showed up. Tall, blond, a former stripper, she was being questioned about […]

Published
2003

43. Inhibition of the early asthmatic response to inhaled allergen by the 5-lipoxygenase activating protein inhibitor GSK2190915: a dose-response study.

Author

Singh, Dave, Boyce, Malcolm, Norris, Virginia, Kent, Sandra E., and Bentley, Jane H.

Subjects
ARACHIDONATE 5-lipoxygenase, ALLERGENS, ASTHMATICS, REACTION time, ASTHMA treatment
Abstract

Background: GSK2190915, a 5-lipoxygenase activating protein inhibitor, inhibits the production of cysteinyl leukotrienes and leukotriene B4 and 5-oxo-6,8,11,14-eicosatetraenoic acid. We have previously reported that GSK2190915 100 mg daily inhibits early and late asthmatic responses to inhaled allergen; the effects of lower doses have not been reported. This study assessed the dose-response effects of GSK2190915 10 mg and 50 mg on the early asthmatic response (EAR) to inhaled allergen. Methods: Nineteen subjects with mild asthma and an EAR were enrolled in a randomized, double-blind, three-way crossover study of GSK2190915 10 mg, 50 mg, and placebo orally once-daily for 3 days. Allergen challenge was performed 2 hours after the third dose. Results: Compared with placebo, GSK2190915 10 mg and 50 mg caused significant, dosedependent attenuation of the minimum forced expiratory volume at 1 second (FEV1) absolute change from baseline; mean treatment differences were 0.21 L (95% confidence interval [CI] 0.04 L, 0.38 L) and 0.41 L (95% CI 0.24 L, 0.58 L), respectively. GSK2190915 50 mg was more effective than 10 mg; mean difference between treatments was 0.20 L, (95% CI 0.03 L, 0.36 L). Compared with placebo, GSK2190915 50 mg, but not 10 mg, significantly inhibited the weighted mean FEV1 absolute change from baseline. Conclusion: GSK2190915 50 mg attenuated the EAR similarly to GSK2190915 100 mg in our previous study, suggesting 50 mg is at the top of the dose-response curve. GSK2190915 10 mg is a suboptimal dose. The EAR can be used to assess the therapeutic dose of a new treatment for asthma. [ABSTRACT FROM AUTHOR]

Published
2013
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45. Cancer Care Delivery Research: Building the Evidence Base to Support Practice Change in Community Oncology.

Author

Kent EE, Mitchell SA, Castro KM, DeWalt DA, Kaluzny AD, Hautala JA, Grad O, Ballard RM, McCaskill-Stevens WJ, Kramer BS, and Clauser SB

Subjects
Humans, Research, Delivery of Health Care methods, Health Services Research methods, Medical Oncology methods
Abstract

Understanding how health care system structures, processes, and available resources facilitate and/or hinder the delivery of quality cancer care is imperative, especially given the rapidly changing health care landscape. The emerging field of cancer care delivery research (CCDR) focuses on how organizational structures and processes, care delivery models, financing and reimbursement, health technologies, and health care provider and patient knowledge, attitudes, and behaviors influence cancer care quality, cost, and access and ultimately the health outcomes and well-being of patients and survivors. In this article, we describe attributes of CCDR, present examples of studies that illustrate those attributes, and discuss the potential impact of CCDR in addressing disparities in care. We conclude by emphasizing the need for collaborative research that links academic and community-based settings and serves simultaneously to accelerate the translation of CCDR results into practice. The National Cancer Institute recently launched its Community Oncology Research Program, which includes a focus on this area of research., (© 2015 by American Society of Clinical Oncology.)

Published
2015
Full Text
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