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2. Outcomes of Skull Base Reconstruction

Author

Hernandez, Stephen C., Papagiannopoulos, Peter, Senior, Brent A., Kennedy, David W., AlQahtani, Abdulaziz A., editor, Castelnuovo, Paolo, editor, Casiano, Roy, editor, and Carrau, Ricardo L., editor

Published
2022
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4. Broncho‐Vaxom® (OM‐85 BV) soluble components stimulate sinonasal innate immunity

Author

Triantafillou, Vasiliki, Workman, Alan D, Patel, Neil N, Maina, Ivy W, Tong, Charles CL, Kuan, Edward C, Kennedy, David W, Palmer, James N, Adappa, Nithin D, Waizel‐Haiat, Salomon, and Cohen, Noam A

Subjects
Medical Physiology, Biomedical and Clinical Sciences, Infectious Diseases, Lung, Nutrition, Good Health and Well Being, Adjuvants, Immunologic, Cell Extracts, Cells, Cultured, Cilia, Epithelial Cells, Humans, Immunity, Innate, Nasal Mucosa, Nitric Oxide, sinusitis, ciliary motility, therapeutics, immunotherapy, innate immunity, rhinosinusitis, Immunology, Clinical sciences
Abstract

BackgroundBroncho-Vaxom® (OM-85 BV) is an extract of infectious respiratory bacteria that is used as an immunostimulant outside of the United States for the prevention and treatment of bronchitis and rhinosinusitis. Prior studies have shown that use of OM-85 BV is associated with reduction in frequency of respiratory infection and decreased duration of antibiotic usage. However, the effects of OM-85 BV on respiratory mucosal innate immunity are unknown.MethodsHuman sinonasal epithelial cells were grown at an air-liquid interface (ALI). Ciliary beat frequency (CBF) and nitric oxide (NO) production in response to stimulation with OM-85 BV was measured in vitro. Pharmacologic inhibitors of bitter taste receptor (T2R) signaling were used to determine if this pathway was taste-receptor-mediated.ResultsApical application of OM-85 BV resulted in an NO-mediated increase in CBF (p

Published
2019

11. List of contributors

Author

Akar-Ghibril, Nicole, primary, Ale, Hanadys, additional, Anaya, Juan-Manuel, additional, Anstey, Karen M., additional, Awasthi, Smita, additional, Baker, Mary Grace, additional, Chambliss, Jeffrey M., additional, Chang, Christopher, additional, Chen, Meng, additional, Cheung, Hei Lam Helena, additional, Chitty-Lopez, Maria, additional, Chrisant, Maryanne, additional, Chu, Ka Hou, additional, Cosme-Blanco, Wilfredo, additional, Daley, Aparna, additional, Dimitriades, Victoria R., additional, Dowden, Amy, additional, Elsayed-Ali, Omar, additional, Feuille, Elizabeth J., additional, Fonacier, Luz, additional, Freij, Joudeh B., additional, Fung, Maxwell A., additional, Gaytán, Armando Partida, additional, Ge, Xiang, additional, Gebba, Jennifer, additional, Ghaffari, Gisoo, additional, Golpanian, Rachel Shireen, additional, Hathaway, Kathleen, additional, Heimall, Jennifer, additional, Hein, Nina, additional, Herrera Guerra, Angel A., additional, Horton, Rachel K, additional, Huang, Ke, additional, Hwang, Samuel T., additional, Kennedy, David W., additional, Kleiner, Gary, additional, Kline, Ahnika, additional, Kobrynski, Lisa J., additional, Kostandy, Erini Nessim, additional, Kuruvilla, Merin, additional, Lachmann, Helen J., additional, Lam, Wai Ching, additional, Lee, Gerald B., additional, Lee, Joyce S., additional, Lee, Min J., additional, Lehman, Heather K., additional, Leiding, Jennifer W., additional, Lejeune, Stéphanie, additional, Leung, Nicki Y.H., additional, Leung, Patrick S.C., additional, Liburd, Kyndra, additional, Lipman, Zoe Morgan, additional, Lu, Qianjin, additional, Lugo Reyes, Saul O., additional, Lyons, Jonathan J., additional, Lyu, Aiping, additional, Makol, Richika, additional, Mawhirt, Stephanie L., additional, McGrath, Eric, additional, Medina, Renata, additional, Nadeau, Kari, additional, Nkamba, Iris, additional, Nomula, Kranthi, additional, Ong, Peck Y., additional, Oriel, Roxanne C., additional, Otani, Iris M., additional, Park, Young Hwan, additional, Patkar, Rasika, additional, Peet, Claire J., additional, Permaul, Perdita, additional, Phipatanakul, Wanda, additional, Poowuttikul, Pavadee, additional, Ramirez, Lourdes, additional, Ranganathan Ganakammal, S., additional, Restrepo, Lucas, additional, Rodriguez, Marlen, additional, Rodríguez, Yhojan, additional, Rose, Nevenda Velikova, additional, Rush, Nia, additional, Sabella, Colleen M., additional, Sandhu, Amandeep, additional, Sani, Sonam, additional, Secord, Elizabeth, additional, Seth, Divya, additional, Shao, Tihong, additional, Shenderov, Faina, additional, Shih, Jennifer, additional, Shu, Shang An, additional, Sicherer, Scott H., additional, Simpson, Jessica, additional, Squire, Jacqueline D., additional, Sriaroon, Panida, additional, Stern, Heather, additional, Summerfield, Daniel D., additional, Sun, JinLyu, additional, Sweis, Auddie M., additional, Tison, Katherine L., additional, Vadakal, Siena, additional, Valentini, Kelly, additional, Vanijcharoenkarn, Kristine, additional, Viqar, Sehrish, additional, Wai, Christine Y.Y., additional, Walkiewicz, M., additional, Walter, Jolan E., additional, Wang, Julie, additional, Wiers-Shamir, Kristina, additional, Winters, Jeffrey L., additional, Wu, Haijing, additional, Xirasagar, S., additional, Xu, Jennifer, additional, Yosipovitch, Gil, additional, Zerbe, Christa, additional, Zhong, Lidan Linda, additional, Zhou, Suqing, additional, and Zhou, Xiaoying, additional

Published
2022
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12. Ectopic Pituitary Adenomas Presenting as Sphenoid or Clival Lesions: Case Series and Management Recommendations

Author

Tajudeen, Bobby A, Kuan, Edward C, Adappa, Nithin D, Han, Joseph K, Chandra, Rakesh K, Palmer, James N, Kennedy, David W, Wang, Marilene B, and Suh, Jeffrey D

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Clinical Research, Prevention, Neurosciences, pituitary adenoma, ectopic pituitary tumors, sphenoid tumors, clival tumors, Neurology & Neurosurgery, Dentistry
Abstract

Background An ectopic pituitary adenoma presenting as a clival or sphenoid mass is a rare clinical occurrence that may mislead the clinician and result in unnecessary interventions or potential medicolegal consequences. Here, we present one of the largest multi-institutional case series and review the literature with an emphasis on radiological findings and critical preoperative workup. Methods Retrospective chart review. Results Nine patients were identified with ectopic pituitary adenomas of the sphenoid or clivus. There were four females and five males. Median age was 60 years old (range, 36-73 years). The most common presenting symptom was headache (56%). Five (56%) patients presented with a mass arising from the clivus while four (44%) presented with a mass in the sphenoid. Six (67%) patients demonstrated biochemical evidence of hypersecretion on full endocrinology panel. All masses showed evidence of enhancement with gadolinium with a propensity for adjacent bone involvement. Lesions also had a predilection for growth toward the cavernous sinus, carotid artery, or sellar floor. Surgical intervention was performed in eight patients (89%). In eight patients (89%), tumors demonstrated immunoreactivity to prolactin. Conclusions Pituitary adenomas can rarely present as an isolated sphenoid or clival mass. Lesions displayed similar magnetic resonance imaging findings with an erosive growth pattern toward the sellar floor, cavernous sinus, or adjacent carotid artery. Patients with clival or parasellar lesions with comparable features should have a preoperative workup which includes prolactin level and alert the physician to consider an ectopic pituitary adenoma in the differential to prevent unnecessary surgery and potential complications.

Published
2017

13. Common Cold Coronavirus 229E Induces Higher Interferon Stimulating Gene Responses in Human Nasal Epithelial Cells from Patients with Chronic Rhinosinusitis with Polyposis.

Author

Sell, Elizabeth A., Tan, Li Hui, Renner, David M., Douglas, Jennifer, Lee, Robert J., Kohanski, Michael A., Bosso, John V., Kennedy, David W., Palmer, James N., Adappa, Nithin D., Weiss, Susan R., and Cohen, Noam A.

Abstract

Background: Viral infections have long been implicated in the development of chronic rhinosinusitis with nasal polyps (CRSwNP). Given widespread exposure to the common cold coronavirus 229E (HCoV229E), we sought to investigate how HCoV-229E is cleared and stimulates interferon pathways in air–liquid interface (ALI) cultures from patients with CRSwNP. Objective: The objective of this study was to identify whether viral clearance and ISG expression is different in ALI cultures from donors with CRSwNP compared with controls. Methods: Plaque assays were used to quantify infectious virus released by infected air–liquid interface (ALI) cultures derived from patients with CRSwNP compared to patients without CRS (controls). Additionally, mock and induced levels of Interferon Stimulated Genes (ISGs) mRNA following HCoV-229E infection were quantified by RT-qPCR. Results: Quantification of infectious virus by plaque assay reveals that CRSwNP ALI cultures were equally susceptible to HCoV-229E infection, and surprisingly viral titers dropped significantly faster than in the control ALI cultures. We further demonstrate that this accelerated viral clearance correlates with increased mRNA expression of at least 4 ISGs following viral infection in the CRSwNP ALIs compared to the control ALIs. Conclusion: This study paradoxically demonstrates that ALI cultures from patients with CRSwNP are more efficient at clearing the common cold HCoV-229E virus compared to controls. We also demonstrate significantly increased ISG mRNA expression following HCoV-229E infection in CRSwNP. These findings call for further investigation into the effect of unimpaired interferon signaling on the type 2 inflammatory environment in patients with CRSwNP. [ABSTRACT FROM AUTHOR]

Published
2025
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21. International consensus statement on allergy and rhinology: Sinonasal tumors

Author

Kuan, Edward C., primary, Wang, Eric W., additional, Adappa, Nithin D., additional, Beswick, Daniel M., additional, London, Nyall R., additional, Su, Shirley Y., additional, Wang, Marilene B., additional, Abuzeid, Waleed M., additional, Alexiev, Borislav, additional, Alt, Jeremiah A., additional, Antognoni, Paolo, additional, Alonso‐Basanta, Michelle, additional, Batra, Pete S., additional, Bhayani, Mihir, additional, Bell, Diana, additional, Bernal‐Sprekelsen, Manuel, additional, Betz, Christian S., additional, Blay, Jean‐Yves, additional, Bleier, Benjamin S., additional, Bonilla‐Velez, Juliana, additional, Callejas, Claudio, additional, Carrau, Ricardo L., additional, Casiano, Roy R., additional, Castelnuovo, Paolo, additional, Chandra, Rakesh K., additional, Chatzinakis, Vasileios, additional, Chen, Simon B., additional, Chiu, Alexander G., additional, Choby, Garret, additional, Chowdhury, Naweed I., additional, Citardi, Martin J., additional, Cohen, Marc A., additional, Dagan, Roi, additional, Dalfino, Gianluca, additional, Dallan, Iacopo, additional, Dassi, Camila Soares, additional, de Almeida, John, additional, Tos, Angelo P. Dei, additional, DelGaudio, John M., additional, Ebert, Charles S., additional, El‐Sayed, Ivan H., additional, Eloy, Jean Anderson, additional, Evans, James J., additional, Fang, Christina H., additional, Farrell, Nyssa F., additional, Ferrari, Marco, additional, Fischbein, Nancy, additional, Folbe, Adam, additional, Fokkens, Wytske J., additional, Fox, Meha G., additional, Lund, Valerie J., additional, Gallia, Gary L., additional, Gardner, Paul A., additional, Geltzeiler, Mathew, additional, Georgalas, Christos, additional, Getz, Anne E., additional, Govindaraj, Satish, additional, Gray, Stacey T., additional, Grayson, Jessica W., additional, Gross, Bradley A., additional, Grube, Jordon G., additional, Guo, Ruifeng, additional, Ha, Patrick K., additional, Halderman, Ashleigh A., additional, Hanna, Ehab Y., additional, Harvey, Richard J., additional, Hernandez, Stephen C., additional, Holtzman, Adam L., additional, Hopkins, Claire, additional, Huang, Zhigang, additional, Huang, Zhenxiao, additional, Humphreys, Ian M., additional, Hwang, Peter H., additional, Iloreta, Alfred M., additional, Ishii, Masaru, additional, Ivan, Michael E., additional, Jafari, Aria, additional, Kennedy, David W., additional, Khan, Mohemmed, additional, Kimple, Adam J., additional, Kingdom, Todd T., additional, Knisely, Anna, additional, Kuo, Ying‐Ju, additional, Lal, Devyani, additional, Lamarre, Eric D., additional, Lan, Ming‐Ying, additional, Le, Hien, additional, Lechner, Matt, additional, Lee, Nancy Y., additional, Lee, Jivianne K., additional, Lee, Victor H., additional, Levine, Corinna G., additional, Lin, Jin‐Ching, additional, Lin, Derrick T., additional, Lobo, Brian C., additional, Locke, Tran, additional, Luong, Amber U., additional, Magliocca, Kelly R., additional, Markovic, Svetomir N., additional, Matnjani, Gesa, additional, McKean, Erin L., additional, Meço, Cem, additional, Mendenhall, William M., additional, Michel, Loren, additional, Na'ara, Shorook, additional, Nicolai, Piero, additional, Nuss, Daniel W., additional, Nyquist, Gurston G., additional, Oakley, Gretchen M., additional, Omura, Kazuhiro, additional, Orlandi, Richard R., additional, Otori, Nobuyoshi, additional, Papagiannopoulos, Peter, additional, Patel, Zara M., additional, Pfister, David G., additional, Phan, Jack, additional, Psaltis, Alkis J., additional, Rabinowitz, Mindy R., additional, Ramanathan, Murugappan, additional, Rimmer, Ryan, additional, Rosen, Marc R., additional, Sanusi, Olabisi, additional, Sargi, Zoukaa B., additional, Schafhausen, Philippe, additional, Schlosser, Rodney J., additional, Sedaghat, Ahmad R., additional, Senior, Brent A., additional, Shrivastava, Raj, additional, Sindwani, Raj, additional, Smith, Timothy L., additional, Smith, Kristine A., additional, Snyderman, Carl H., additional, Solares, C. Arturo, additional, Sreenath, Satyan B., additional, Stamm, Aldo, additional, Stölzel, Katharina, additional, Sumer, Baran, additional, Surda, Pavol, additional, Tajudeen, Bobby A., additional, Thompson, Lester D. R., additional, Thorp, Brian D., additional, Tong, Charles C. L., additional, Tsang, Raymond K., additional, Turner, Justin H., additional, Turri‐Zanoni, Mario, additional, Udager, Aaron M., additional, van Zele, Thibaut, additional, VanKoevering, Kyle, additional, Welch, Kevin C., additional, Wise, Sarah K., additional, Witterick, Ian J., additional, Won, Tae‐Bin, additional, Wong, Stephanie N., additional, Woodworth, Bradford A., additional, Wormald, Peter‐John, additional, Yao, William C., additional, Yeh, Chien‐Fu, additional, Zhou, Bing, additional, Palmer, James N., additional, Abiri, Arash, additional, Adams, Carrie D., additional, Ayoub, Noel F., additional, Bitner, Benjamin F., additional, Boyd, Jacob T., additional, Chang, Michael T., additional, Chapurin, Nikita, additional, Chaskes, Mark B., additional, Chua, Andy, additional, Chung, Sei Y., additional, Contrera, Kevin J., additional, Dilley, Katelyn K., additional, Dutra, André Zanette, additional, Eide, Jacob G., additional, Fenberg, Rachel, additional, Godse, Neal R., additional, Jawad, Basit, additional, Johnson, Jared, additional, Johnson, B. Jake, additional, Judd, Ryan, additional, Khalife, Sarah, additional, Khosravi, Pooya, additional, Kolarski, Mirko Manojlovic, additional, Kong, Keonho A., additional, Kshirsagar, Rijul S., additional, Lee, Joseph S., additional, Lin, Tian‐Yun, additional, McCormick, Justin P., additional, Melder, Katie, additional, Morse, Elliot, additional, Nguyen, Theodore V., additional, Norwood, Timothy G., additional, Pang, Jonathan C., additional, Parsel, Sean M., additional, Patel, Prayag S., additional, Ringel, Barak, additional, Schneider, Alexander L., additional, Spielman, Daniel B., additional, Spock, Todd, additional, and Vasudev, Milind, additional

Published
2023
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31. A Metagenomic Analysis of the Virome of Inverted Papilloma and Squamous Cell Carcinoma

Author

Tong, Charles C. L., primary, Lin, Xiang, additional, Seckar, Tyler, additional, Koptyra, Mateusz, additional, Kohanski, Michael A., additional, Cohen, Noam A., additional, Kennedy, David W., additional, Adappa, Nithin D., additional, Papagiannopoulos, Peter, additional, Kuan, Edward C., additional, Baranov, Esther, additional, Jalaly, Jalal B., additional, Feldman, Michael D., additional, Storm, Phillip B., additional, Resnick, Adam C., additional, Palmer, James N., additional, Wei, Zhi, additional, and Robertson, Erle S., additional

Published
2023
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34. Orbital resection by intranasal technique (ORBIT): A new classification system for reporting endoscopically resectable primary benign orbital tumors.

Author

Jafari, Aria, Adappa, Nithin D., Anagnos, Vincent J., Campbell, Raewyn G., Castelnuovo, Paolo, Chalian, Ara, Chambers, Christopher B., Chitguppi, Chandala, Dallan, Iacopo, El Rassi, Edward, Freitag, Suzanne K., Fernandez Miranda, Juan C., Ferreira, Manuel, Gardner, Paul A., Gudis, David A., Harvey, Richard J., Huang, Qian, Humphreys, Ian M., Kennedy, David W., and Lee, John Y. K.

Published
2023
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37. Open Access: Is There a Predator at the Door?

Author

Chandra, Rakesh, Fisher, Edward W., Jones, Terry M., Kennedy, David W., Kraus, Dennis H., Krouse, John H., Link, Michael, Lustig, Lawrence R., O’Malley, Bert W., Jr, Piccirillo, Jay F., Ruben, Robert, Sataloff, Robert T., Schwartz, Sandra, Sindwani, Raj, Smith, Richard J., Stewart, Michael G., Weber, Peter C., Welling, D. Bradley, and Youngs, Robin

Published
2018
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