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105 results on '"Kenna, T."'

5. Peat Archives in the Hudson Estuary - Marsh Formation, Carbon Storage and Release, and Resilience

Author

Peteet, Dorothy M, Corbett, L, Nichols, J, Chou, C, and Kenna, T

Subjects
Meteorology And Climatology
Abstract

We target deep peat stores (at least 8 meters) of carbon in the lower Hudson Estuary, which formed as the glacial fjord became an estuary with mid-Holocene sea level rise. These deep marshes play an extremely important role in the estuary health and stability in a changing climate. Never before have we faced the threats to coastal marshes that we are facing today, and the resulting sedimentation rates, inorganic/organic component histories, pollen, macrofossil, isotopic, and XRF data reveal critical information about past vegetation and climate change. Long-term shifts in organic/inorganic storage appear to be linked to drought, as watershed erosion results in more sand, silt and clay in the marshes. Climatic shifts often result in regional watershed shifts in vegetation, both locally and regionally. Understanding how these marshes are linked to human impact (disturbance, invasive species, higher nitrogen, heavy metal pollution, dams) over the last four centuries is critical to providing management of these key ecosystems, and their preservation as sea level rises. Quantification of processes that cause carbon degradation and release from these wetlands to the estuary is also key to this investigation. Peat loss would contribute to heavy metal pollution in the estuary as well as carbon loss. Young investigators from secondary schools in New York City participated in much of the fieldwork as part of the NASA/GISS NYC Research Initiative and the LDEO Secondary School Field Research Carbon Team.

Published
2017

6. The Potential of U-233/U-236 as a Water Mass Tracer in the Arctic Ocean

Author

Chamizo, E., Christl, M., López Lora, Mercedes, Casacuberta, N., Wefing, A. -M., Kenna, T. C., Chamizo, E., Christl, M., López Lora, Mercedes, Casacuberta, N., Wefing, A. -M., and Kenna, T. C.

Abstract

This study explores for the first time the possibilities that the U-233/U-236 atom ratio offers to distinguish waters of Atlantic or Pacific origin in the Arctic Ocean. Atlantic waters entering the Arctic Ocean often carry an isotopic signature dominantly originating from European reprocessing facilities with some smaller contribution from global fallout nuclides, whereas northern Pacific waters are labeled with nuclides released during the atmospheric nuclear testing period only. In the Arctic Ocean, U-233 originates from global fallout while U-236 carries both, a global fallout and a prominent nuclear reprocessing signal. Thus, the U-233/U-236 ratio provides a tool to identify water masses with distinct U sources. In this work, U-233 and U-236 were analyzed in samples from the GN01 GEOTRACES expedition to the western Arctic Ocean in 2015. The study of depth profiles and surface seawater samples shows that: (a) Pacific and Atlantic waters show enhanced signals of both radionuclides, which can be unraveled based on their U-233/U-236 signature; and (b) Deep and Bottom Waters show extremely low U-233 and U-236 concentrations close to or below analytical detection limits with isotopic ratios distinct from known anthropogenic U sources. The comparably high U-233/U-236 ratios are interpreted as a relative increase of naturally occurring U-233 and U-236 and thus for gradually reaching natural U-233/U-236 levels in the deep Arctic Ocean. Our results set the basis for future studies using the U-233/U-236 ratio to distinguish anthropogenic and pre-anthropogenic U in the Arctic Ocean and beyond., Funding Agencies|ETH Zurich Research GrantETH Zurich [ETH-06 16-1]; Swiss National Science FoundationSwiss National Science Foundation (SNSF)European Commission [PRIMA SNF PR00P2_193091]; Spanish Government (Ministerio de Ciencia, Innovacion y Universidades)Spanish Government [PGC2018-094546-B-I00]

Published
2022
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7. Supporting Information for The potential of 233U/236U as a water mass tracer in the Arctic Ocean

Author

Chamizo, Elena [echamizo@us.es], Christl, M. [mchristl@phys.ethz.ch], Chamizo, Elena, Christl, M., López-Lora, Mercedes, Casacuberta, Nuria, Wefing, A.-M., Kenna, T., Chamizo, Elena [echamizo@us.es], Christl, M. [mchristl@phys.ethz.ch], Chamizo, Elena, Christl, M., López-Lora, Mercedes, Casacuberta, Nuria, Wefing, A.-M., and Kenna, T.

Abstract

Dataset published as supplementary material of Chamizo et al. (2022), http://doi.org/10.1029/2021JC017790. This supporting material includes two Texts with further explanations on two points given in the manuscript: Text 1 explains the calculations used to model the input function of the 233U/236U ratio in the Atlantic Layer of the Arctic Ocean; Text 2 presents the adopted calculations to estimate the 233U/236U ratio in the surface of the rocks due to natural production processes, and the adopted number for the U present in Deep and Bottom Waters in the Amerasian Basin. Figure S1 compares the obtained ICP-MS 238U results in this work with the predicted ones based on salinity data using the empirical formula given in (Owens et al., 2011). Figure S2 shows how the modelled 233U/236U ratios for the Atlantic Layer in Text 2 compares with the obtained values in this work.

Published
2022

8. The Potential of 233U/236U as a Water Mass Tracer in the Arctic Ocean

Author

ETH Zurich, Swiss National Science Foundation, Ministerio de Ciencia, Innovación y Universidades (España), Chamizo, Elena, Christl, M., López-Lora, Mercedes, Casacuberta, Nuria, Wefing, A.-M., Kenna, T., ETH Zurich, Swiss National Science Foundation, Ministerio de Ciencia, Innovación y Universidades (España), Chamizo, Elena, Christl, M., López-Lora, Mercedes, Casacuberta, Nuria, Wefing, A.-M., and Kenna, T.

Abstract

This study explores for the first time the possibilities that the U/U atom ratio offers to distinguish waters of Atlantic or Pacific origin in the Arctic Ocean. Atlantic waters entering the Arctic Ocean often carry an isotopic signature dominantly originating from European reprocessing facilities with some smaller contribution from global fallout nuclides, whereas northern Pacific waters are labeled with nuclides released during the atmospheric nuclear testing period only. In the Arctic Ocean, U originates from global fallout while U carries both, a global fallout and a prominent nuclear reprocessing signal. Thus, the U/U ratio provides a tool to identify water masses with distinct U sources. In this work, U and U were analyzed in samples from the GN01 GEOTRACES expedition to the western Arctic Ocean in 2015. The study of depth profiles and surface seawater samples shows that: (a) Pacific and Atlantic waters show enhanced signals of both radionuclides, which can be unraveled based on their U/U signature; and (b) Deep and Bottom Waters show extremely low U and U concentrations close to or below analytical detection limits with isotopic ratios distinct from known anthropogenic U sources. The comparably high U/U ratios are interpreted as a relative increase of naturally occurring U and U and thus for gradually reaching natural U/U levels in the deep Arctic Ocean. Our results set the basis for future studies using the U/U ratio to distinguish anthropogenic and pre-anthropogenic U in the Arctic Ocean and beyond.

Published
2022

10. Additional file 1 of Distinctive gut microbiomes of ankylosing spondylitis and inflammatory bowel disease patients suggest differing roles in pathogenesis and correlate with disease activity

Author

Sternes, P. R., Brett, L., Phipps, J., Ciccia, F., Kenna, T., de Guzman, E., Zimmermann, K., Morrison, M., Holtmann, G., Klingberg, E., Mauro, D., McIvor, C., Forsblad-d’Elia, H., and Brown, M. A.

Subjects
musculoskeletal diseases, respiratory system, human activities
Abstract

Additional file 1: Supplementary Figure 1. Comparison of microbiome composition in the Swedish cohort, consisting of stool samples which were sampled from some patients twice at a five-year interval. Composition was measured according to BASDAI and FCP levels. A. sPLSDA visualisation of microbiome composition (beta diversity) according to BASDAI. B. PERMANOVA significance testing of beta diversity according to BASDAI. C. Comparison of species richness (alpha diversity) according to BASDAI. D. sPLSDA visualisation of microbiome composition (beta diversity) according to FCP level. E. PERMANOVA significance testing of beta diversity according to FCP level. F. Comparison of species richness (alpha diversity) according to FCP level.

Published
2022
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11. Surgical Mask Disguises in Eyewitness Identification Procedures: Matching Encoding and Retrieval Conditions

Author

Rudominer, Kenna T and Levett, Lora M

Subjects
FOS: Psychology, Sociology, Psychology, FOS: Law, Criminology, Social and Behavioral Sciences, FOS: Sociology
Abstract

Inaccurate eyewitness identifications are exacerbated by disguised perpetrators. While some research has focused on the ways in which disguise impacts identification accuracy, few studies have found ways to attenuate the negative effects that disguise creates. In the present study, I employ an experimental paradigm to examine how matching encoding and lineup disguise conditions affects eyewitness identification accuracy. This research will provide insight on how to potentially mitigate the detrimental effects of disguises in identification procedures in the context of increased mask-wearing behavior resulting from the COVID-19 pandemic.

Published
2022
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13. Discovery of widespread transcription initiation at microsatellites predictable by sequence-based deep neural network

Author

Grapotte M., Saraswat M., Bessiere C., Menichelli C., Ramilowski J. A., Severin J., Hayashizaki Y., Itoh M., Tagami M., Murata M., Kojima-Ishiyama M., Noma S., Noguchi S., Kasukawa T., Hasegawa A., Suzuki H., Nishiyori-Sueki H., Frith M. C., Abugessaisa I., Aitken S., Aken B. L., Alam I., Alam T., Alasiri R., Alhendi A. M. N., Alinejad-Rokny H., Alvarez M. J., Andersson R., Arakawa T., Araki M., Arbel T., Archer J., Archibald A. L., Arner E., Arner P., Asai K., Ashoor H., Astrom G., Babina M., Baillie J. K., Bajic V. B., Bajpai A., Baker S., Baldarelli R. M., Balic A., Bansal M., Batagov A. O., Batzoglou S., Beckhouse A. G., Beltrami A. P., Beltrami C. A., Bertin N., Bhattacharya S., Bickel P. J., Blake J. A., Blanchette M., Bodega B., Bonetti A., Bono H., Bornholdt J., Bttcher M., Bougouffa S., Boyd M., Breda J., Brombacher F., Brown J. B., Bult C. J., Burroughs A. M., Burt D. W., Busch A., Caglio G., Califano A., Cameron C. J., Cannistraci C. V., Carbone A., Carlisle A. J., Carninci P., Carter K. W., Cesselli D., Chang J. -C., Chen J. C., Chen Y., Chierici M., Christodoulou J., Ciani Y., Clark E. L., Coskun M., Dalby M., Dalla E., Daub C. O., Davis C. A., de Hoon M. J. L., de Rie D., Denisenko E., Deplancke B., Detmar M., Deviatiiarov R., Di Bernardo D., Diehl A. D., Dieterich L. C., Dimont E., Djebali S., Dohi T., Dostie J., Drablos F., Edge A. S. B., Edinger M., Ehrlund A., Ekwall K., Elofsson A., Endoh M., Enomoto H., Enomoto S., Faghihi M., Fagiolini M., Farach-Carson M. C., Faulkner G. J., Favorov A., Fernandes A. M., Ferrai C., Forrest A. R. R., Forrester L. M., Forsberg M., Fort A., Francescatto M., Freeman T. C., Frith M., Fukuda S., Funayama M., Furlanello C., Furuno M., Furusawa C., Gao H., Gazova I., Gebhard C., Geier F., Geijtenbeek T. B. H., Ghosh S., Ghosheh Y., Gingeras T. R., Gojobori T., Goldberg T., Goldowitz D., Gough J., Greco D., Gruber A. J., Guhl S., Guigo R., Guler R., Gusev O., Gustincich S., Ha T. J., Haberle V., Hale P., Hallstrom B. M., Hamada M., Handoko L., Hara M., Harbers M., Harrow J., Harshbarger J., Hase T., Hashimoto K., Hatano T., Hattori N., Hayashi R., Herlyn M., Hettne K., Heutink P., Hide W., Hitchens K. J., Sui S. H., 't Hoen P. A. C., Hon C. C., Hori F., Horie M., Horimoto K., Horton P., Hou R., Huang E., Huang Y., Hugues R., Hume D., Ienasescu H., Iida K., Ikawa T., Ikemura T., Ikeo K., Inoue N., Ishizu Y., Ito Y., Ivshina A. V., Jankovic B. R., Jenjaroenpun P., Johnson R., Jorgensen M., Jorjani H., Joshi A., Jurman G., Kaczkowski B., Kai C., Kaida K., Kajiyama K., Kaliyaperumal R., Kaminuma E., Kanaya T., Kaneda H., Kapranov P., Kasianov A. S., Katayama T., Kato S., Kawaguchi S., Kawai J., Kawaji H., Kawamoto H., Kawamura Y. I., Kawasaki S., Kawashima T., Kempfle J. S., Kenna T. J., Kere J., Khachigian L., Kiryu H., Kishima M., Kitajima H., Kitamura T., Kitano H., Klaric E., Klepper K., Klinken S. P., Kloppmann E., Knox A. J., Kodama Y., Kogo Y., Kojima M., Kojima S., Komatsu N., Komiyama H., Kono T., Koseki H., Koyasu S., Kratz A., Kukalev A., Kulakovskiy I., Kundaje A., Kunikata H., Kuo R., Kuo T., Kuraku S., Kuznetsov V. A., Kwon T. J., Larouche M., Lassmann T., Law A., Le-Cao K. -A., Lecellier C. -H., Lee W., Lenhard B., Lennartsson A., Li K., Li R., Lilje B., Lipovich L., Lizio M., Lopez G., Magi S., Mak G. K., Makeev V., Manabe R., Mandai M., Mar J., Maruyama K., Maruyama T., Mason E., Mathelier A., Matsuda H., Medvedeva Y. A., Meehan T. F., Mejhert N., Meynert A., Mikami N., Minoda A., Miura H., Miyagi Y., Miyawaki A., Mizuno Y., Morikawa H., Morimoto M., Morioka M., Morishita S., Moro K., Motakis E., Motohashi H., Mukarram A. K., Mummery C. L., Mungall C. J., Murakawa Y., Muramatsu M., Nagasaka K., Nagase T., Nakachi Y., Nakahara F., Nakai K., Nakamura K., Nakamura Y., Nakazawa T., Nason G. P., Nepal C., Nguyen Q. H., Nielsen L. K., Nishida K., Nishiguchi K. M., Nishiyori H., Nitta K., Notredame C., Ogishima S., Ohkura N., Ohno H., Ohshima M., Ohtsu T., Okada Y., Okada-Hatakeyama M., Okazaki Y., Oksvold P., Orlando V., Ow G. S., Ozturk M., Pachkov M., Paparountas T., Parihar S. P., Park S. -J., Pascarella G., Passier R., Persson H., Philippens I. H., Piazza S., Plessy C., Pombo A., Ponten F., Poulain S., Poulsen T. M., Pradhan S., Prezioso C., Pridans C., Qin X. -Y., Quackenbush J., Rackham O., Ramilowski J., Ravasi T., Rehli M., Rennie S., Rito T., Rizzu P., Robert C., Roos M., Rost B., Roudnicky F., Roy R., Rye M. B., Sachenkova O., Saetrom P., Sai H., Saiki S., Saito M., Saito A., Sakaguchi S., Sakai M., Sakaue S., Sakaue-Sawano A., Sandelin A., Sano H., Sasamoto Y., Sato H., Saxena A., Saya H., Schafferhans A., Schmeier S., Schmidl C., Schmocker D., Schneider C., Schueler M., Schultes E. A., Schulze-Tanzil G., Semple C. A., Seno S., Seo W., Sese J., Sheng G., Shi J., Shimoni Y., Shin J. W., SimonSanchez J., Sivertsson A., Sjostedt E., Soderhall C., Laurent G. S., Stoiber M. H., Sugiyama D., Summers K. M., Suzuki A. M., Suzuki K., Suzuki M., Suzuki N., Suzuki T., Swanson D. J., Swoboda R. K., Taguchi A., Takahashi H., Takahashi M., Takamochi K., Takeda S., Takenaka Y., Tam K. T., Tanaka H., Tanaka R., Tanaka Y., Tang D., Taniuchi I., Tanzer A., Tarui H., Taylor M. S., Terada A., Terao Y., Testa A. C., Thomas M., Thongjuea S., Tomii K., Triglia E. T., Toyoda H., Tsang H. G., Tsujikawa M., Uhlen M., Valen E., van de Wetering M., van Nimwegen E., Velmeshev D., Verardo R., Vitezic M., Vitting-Seerup K., von Feilitzen K., Voolstra C. R., Vorontsov I. E., Wahlestedt C., Wasserman W. W., Watanabe K., Watanabe S., Wells C. A., Winteringham L. N., Wolvetang E., Yabukami H., Yagi K., Yamada T., Yamaguchi Y., Yamamoto M., Yamamoto Y., Yamanaka Y., Yano K., Yasuzawa K., Yatsuka Y., Yo M., Yokokura S., Yoneda M., Yoshida E., Yoshida Y., Yoshihara M., Young R., Young R. S., Yu N. Y., Yumoto N., Zabierowski S. E., Zhang P. G., Zucchelli S., Zwahlen M., Chatelain C., Brehelin L., Grapotte, M., Saraswat, M., Bessiere, C., Menichelli, C., Ramilowski, J. A., Severin, J., Hayashizaki, Y., Itoh, M., Tagami, M., Murata, M., Kojima-Ishiyama, M., Noma, S., Noguchi, S., Kasukawa, T., Hasegawa, A., Suzuki, H., Nishiyori-Sueki, H., Frith, M. C., Abugessaisa, I., Aitken, S., Aken, B. L., Alam, I., Alam, T., Alasiri, R., Alhendi, A. M. N., Alinejad-Rokny, H., Alvarez, M. J., Andersson, R., Arakawa, T., Araki, M., Arbel, T., Archer, J., Archibald, A. L., Arner, E., Arner, P., Asai, K., Ashoor, H., Astrom, G., Babina, M., Baillie, J. K., Bajic, V. B., Bajpai, A., Baker, S., Baldarelli, R. M., Balic, A., Bansal, M., Batagov, A. O., Batzoglou, S., Beckhouse, A. G., Beltrami, A. P., Beltrami, C. A., Bertin, N., Bhattacharya, S., Bickel, P. J., Blake, J. A., Blanchette, M., Bodega, B., Bonetti, A., Bono, H., Bornholdt, J., Bttcher, M., Bougouffa, S., Boyd, M., Breda, J., Brombacher, F., Brown, J. B., Bult, C. J., Burroughs, A. M., Burt, D. W., Busch, A., Caglio, G., Califano, A., Cameron, C. J., Cannistraci, C. V., Carbone, A., Carlisle, A. J., Carninci, P., Carter, K. W., Cesselli, D., Chang, J. -C., Chen, J. C., Chen, Y., Chierici, M., Christodoulou, J., Ciani, Y., Clark, E. L., Coskun, M., Dalby, M., Dalla, E., Daub, C. O., Davis, C. A., de Hoon, M. J. L., de Rie, D., Denisenko, E., Deplancke, B., Detmar, M., Deviatiiarov, R., Di Bernardo, D., Diehl, A. D., Dieterich, L. C., Dimont, E., Djebali, S., Dohi, T., Dostie, J., Drablos, F., Edge, A. S. B., Edinger, M., Ehrlund, A., Ekwall, K., Elofsson, A., Endoh, M., Enomoto, H., Enomoto, S., Faghihi, M., Fagiolini, M., Farach-Carson, M. C., Faulkner, G. J., Favorov, A., Fernandes, A. M., Ferrai, C., Forrest, A. R. R., Forrester, L. M., Forsberg, M., Fort, A., Francescatto, M., Freeman, T. C., Frith, M., Fukuda, S., Funayama, M., Furlanello, C., Furuno, M., Furusawa, C., Gao, H., Gazova, I., Gebhard, C., Geier, F., Geijtenbeek, T. B. H., Ghosh, S., Ghosheh, Y., Gingeras, T. R., Gojobori, T., Goldberg, T., Goldowitz, D., Gough, J., Greco, D., Gruber, A. J., Guhl, S., Guigo, R., Guler, R., Gusev, O., Gustincich, S., Ha, T. J., Haberle, V., Hale, P., Hallstrom, B. M., Hamada, M., Handoko, L., Hara, M., Harbers, M., Harrow, J., Harshbarger, J., Hase, T., Hashimoto, K., Hatano, T., Hattori, N., Hayashi, R., Herlyn, M., Hettne, K., Heutink, P., Hide, W., Hitchens, K. J., Sui, S. H., 't Hoen, P. A. C., Hon, C. C., Hori, F., Horie, M., Horimoto, K., Horton, P., Hou, R., Huang, E., Huang, Y., Hugues, R., Hume, D., Ienasescu, H., Iida, K., Ikawa, T., Ikemura, T., Ikeo, K., Inoue, N., Ishizu, Y., Ito, Y., Ivshina, A. V., Jankovic, B. R., Jenjaroenpun, P., Johnson, R., Jorgensen, M., Jorjani, H., Joshi, A., Jurman, G., Kaczkowski, B., Kai, C., Kaida, K., Kajiyama, K., Kaliyaperumal, R., Kaminuma, E., Kanaya, T., Kaneda, H., Kapranov, P., Kasianov, A. S., Katayama, T., Kato, S., Kawaguchi, S., Kawai, J., Kawaji, H., Kawamoto, H., Kawamura, Y. I., Kawasaki, S., Kawashima, T., Kempfle, J. S., Kenna, T. J., Kere, J., Khachigian, L., Kiryu, H., Kishima, M., Kitajima, H., Kitamura, T., Kitano, H., Klaric, E., Klepper, K., Klinken, S. P., Kloppmann, E., Knox, A. J., Kodama, Y., Kogo, Y., Kojima, M., Kojima, S., Komatsu, N., Komiyama, H., Kono, T., Koseki, H., Koyasu, S., Kratz, A., Kukalev, A., Kulakovskiy, I., Kundaje, A., Kunikata, H., Kuo, R., Kuo, T., Kuraku, S., Kuznetsov, V. A., Kwon, T. J., Larouche, M., Lassmann, T., Law, A., Le-Cao, K. -A., Lecellier, C. -H., Lee, W., Lenhard, B., Lennartsson, A., Li, K., Li, R., Lilje, B., Lipovich, L., Lizio, M., Lopez, G., Magi, S., Mak, G. K., Makeev, V., Manabe, R., Mandai, M., Mar, J., Maruyama, K., Maruyama, T., Mason, E., Mathelier, A., Matsuda, H., Medvedeva, Y. A., Meehan, T. F., Mejhert, N., Meynert, A., Mikami, N., Minoda, A., Miura, H., Miyagi, Y., Miyawaki, A., Mizuno, Y., Morikawa, H., Morimoto, M., Morioka, M., Morishita, S., Moro, K., Motakis, E., Motohashi, H., Mukarram, A. K., Mummery, C. L., Mungall, C. J., Murakawa, Y., Muramatsu, M., Nagasaka, K., Nagase, T., Nakachi, Y., Nakahara, F., Nakai, K., Nakamura, K., Nakamura, Y., Nakazawa, T., Nason, G. P., Nepal, C., Nguyen, Q. H., Nielsen, L. K., Nishida, K., Nishiguchi, K. M., Nishiyori, H., Nitta, K., Notredame, C., Ogishima, S., Ohkura, N., Ohno, H., Ohshima, M., Ohtsu, T., Okada, Y., Okada-Hatakeyama, M., Okazaki, Y., Oksvold, P., Orlando, V., Ow, G. S., Ozturk, M., Pachkov, M., Paparountas, T., Parihar, S. P., Park, S. -J., Pascarella, G., Passier, R., Persson, H., Philippens, I. H., Piazza, S., Plessy, C., Pombo, A., Ponten, F., Poulain, S., Poulsen, T. M., Pradhan, S., Prezioso, C., Pridans, C., Qin, X. -Y., Quackenbush, J., Rackham, O., Ramilowski, J., Ravasi, T., Rehli, M., Rennie, S., Rito, T., Rizzu, P., Robert, C., Roos, M., Rost, B., Roudnicky, F., Roy, R., Rye, M. B., Sachenkova, O., Saetrom, P., Sai, H., Saiki, S., Saito, M., Saito, A., Sakaguchi, S., Sakai, M., Sakaue, S., Sakaue-Sawano, A., Sandelin, A., Sano, H., Sasamoto, Y., Sato, H., Saxena, A., Saya, H., Schafferhans, A., Schmeier, S., Schmidl, C., Schmocker, D., Schneider, C., Schueler, M., Schultes, E. A., Schulze-Tanzil, G., Semple, C. A., Seno, S., Seo, W., Sese, J., Sheng, G., Shi, J., Shimoni, Y., Shin, J. W., Simonsanchez, J., Sivertsson, A., Sjostedt, E., Soderhall, C., Laurent, G. S., Stoiber, M. H., Sugiyama, D., Summers, K. M., Suzuki, A. M., Suzuki, K., Suzuki, M., Suzuki, N., Suzuki, T., Swanson, D. J., Swoboda, R. K., Taguchi, A., Takahashi, H., Takahashi, M., Takamochi, K., Takeda, S., Takenaka, Y., Tam, K. T., Tanaka, H., Tanaka, R., Tanaka, Y., Tang, D., Taniuchi, I., Tanzer, A., Tarui, H., Taylor, M. S., Terada, A., Terao, Y., Testa, A. C., Thomas, M., Thongjuea, S., Tomii, K., Triglia, E. T., Toyoda, H., Tsang, H. G., Tsujikawa, M., Uhlen, M., Valen, E., van de Wetering, M., van Nimwegen, E., Velmeshev, D., Verardo, R., Vitezic, M., Vitting-Seerup, K., von Feilitzen, K., Voolstra, C. R., Vorontsov, I. E., Wahlestedt, C., Wasserman, W. W., Watanabe, K., Watanabe, S., Wells, C. A., Winteringham, L. N., Wolvetang, E., Yabukami, H., Yagi, K., Yamada, T., Yamaguchi, Y., Yamamoto, M., Yamamoto, Y., Yamanaka, Y., Yano, K., Yasuzawa, K., Yatsuka, Y., Yo, M., Yokokura, S., Yoneda, M., Yoshida, E., Yoshida, Y., Yoshihara, M., Young, R., Young, R. S., Yu, N. Y., Yumoto, N., Zabierowski, S. E., Zhang, P. G., Zucchelli, S., Zwahlen, M., Chatelain, C., Brehelin, L., Institute of Biotechnology, Biosciences, Institut de Génétique Moléculaire de Montpellier (IGMM), Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Institut de Biologie Computationnelle (IBC), Institut National de Recherche en Informatique et en Automatique (Inria)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Méthodes et Algorithmes pour la Bioinformatique (MAB), Laboratoire d'Informatique de Robotique et de Microélectronique de Montpellier (LIRMM), Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), RIKEN Center for Integrative Medical Sciences [Yokohama] (RIKEN IMS), RIKEN - Institute of Physical and Chemical Research [Japon] (RIKEN), National Institute of Advanced Industrial Science and Technology (AIST), SANOFI Recherche, University of British Columbia (UBC), Experimental Immunology, Infectious diseases, AII - Infectious diseases, Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM), Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM), and Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Institut National de Recherche en Informatique et en Automatique (Inria)-Université de Montpellier (UM)

Subjects
0301 basic medicine, General Physics and Astronomy, Genome, Mice, 0302 clinical medicine, Transcription (biology), Promoter Regions, Genetic, Transcription Initiation, Genetic, 0303 health sciences, Multidisciplinary, 1184 Genetics, developmental biology, physiology, High-Throughput Nucleotide Sequencing, Neurodegenerative Diseases, 222 Other engineering and technologies, Genomics, [SDV.BIBS]Life Sciences [q-bio]/Quantitative Methods [q-bio.QM], humanities, Enhancer Elements, Genetic, Microsatellite Repeat, Transcription Initiation Site, Sequence motif, Transcription Initiation, Human, Enhancer Elements, Neural Networks, Science, 610 Medicine & health, Computational biology, Biology, Article, General Biochemistry, Genetics and Molecular Biology, Promoter Regions, 03 medical and health sciences, Computer, Deep Learning, Tandem repeat, Genetic, Clinical Research, [SDV.BBM.GTP]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Genomics [q-bio.GN], Machine learning, Genetics, Animals, Humans, Polymorphism, Enhancer, Transcriptomics, Gene, A549 Cell, 030304 developmental biology, Polymorphism, Genetic, Neurodegenerative Disease, Base Sequence, Animal, Genome, Human, Human Genome, Computational Biology, Promoter, General Chemistry, 113 Computer and information sciences, Cap analysis gene expression, 030104 developmental biology, [SDV.GEN.GH]Life Sciences [q-bio]/Genetics/Human genetics, Cardiovascular and Metabolic Diseases, A549 Cells, Minion, Generic health relevance, 3111 Biomedicine, Neural Networks, Computer, 610 Medizin und Gesundheit, 030217 neurology & neurosurgery, FANTOM consortium, Microsatellite Repeats
Abstract

Using the Cap Analysis of Gene Expression (CAGE) technology, the FANTOM5 consortium provided one of the most comprehensive maps of transcription start sites (TSSs) in several species. Strikingly, ~72% of them could not be assigned to a specific gene and initiate at unconventional regions, outside promoters or enhancers. Here, we probe these unassigned TSSs and show that, in all species studied, a significant fraction of CAGE peaks initiate at microsatellites, also called short tandem repeats (STRs). To confirm this transcription, we develop Cap Trap RNA-seq, a technology which combines cap trapping and long read MinION sequencing. We train sequence-based deep learning models able to predict CAGE signal at STRs with high accuracy. These models unveil the importance of STR surrounding sequences not only to distinguish STR classes, but also to predict the level of transcription initiation. Importantly, genetic variants linked to human diseases are preferentially found at STRs with high transcription initiation level, supporting the biological and clinical relevance of transcription initiation at STRs. Together, our results extend the repertoire of non-coding transcription associated with DNA tandem repeats and complexify STR polymorphism., Nature Communications, 12 (1), ISSN:2041-1723

Published
2020
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14. Reference material for radionuclides in sediment IAEA-384 (Fangataufa Lagoon sediment)

Author

Povinec, P. P., Pham, M. K., Sanchez-Cabeza, J. A., Barci-Funel, G., Bojanowski, R., Boshkova, T., Burnett, W. C., Carvalho, F., Chapeyron, B., Cunha, I. L., Dahlgaard, H., Galabov, N., Fifield, L. K., Gastaud, J., Geering, J. -J., Gomez, I. F., Green, N., Hamilton, T., Ibanez, F. L., Ibn Majah, M., John, M., Kanisch, G., Kenna, T. C., Kloster, M., Korun, M., Liong Wee Kwong, L., La Rosa, J., Lee, S. -H., Levy-Palomo, I., Malatova, M., Maruo, Y., Mitchell, P., Murciano, I. V., Nelson, R., Nouredine, A., Oh, J. -S., Oregioni, B., Le Petit, G., Pettersson, H. B. L., Reineking, A., Smedley, P. A., Suckow, A., van der Struijs, T. D. B., Voors, P. I., Yoshimizu, K., and Wyse, E.

Published
2007
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15. 236U, 237Np and 239,240Pu as complementary fingerprints of radioactiveeffluents in the western Mediterranean Sea and in the Canada Basin (Arctic Ocean)

Author

Ministerio de Economía y Competitividad (España), Agencia Estatal de Investigación (España), Ministerio de Ciencia, Innovación y Universidades (España), Fundación Cámara Sevilla, National Science Foundation (US), Principality of Monaco, López-Lora, Mercedes, Chamizo, Elena, Levy, Isabelle, Christl, M., Casacuberta, Nuria, Kenna, T., Ministerio de Economía y Competitividad (España), Agencia Estatal de Investigación (España), Ministerio de Ciencia, Innovación y Universidades (España), Fundación Cámara Sevilla, National Science Foundation (US), Principality of Monaco, López-Lora, Mercedes, Chamizo, Elena, Levy, Isabelle, Christl, M., Casacuberta, Nuria, and Kenna, T.

Abstract

The aim of this study was to assess the potential of combining the conservatively behaving anthropogenic radionuclides 236U and 237Np to gain information on the origin of water masses tagged with liquid effluents from Nuclear Reprocessing Plants. This work includes samples collected from three full-depth water columns in two areas: i) the Arctic Ocean, where Atlantic waters carry the signal of Sellafield (United Kingdom) and La Hague (France) nuclear reprocessing facilities; and ii) the western Mediterranean Sea, directly impacted by Marcoule reprocessing plant (France). This work is complemented by the study of the particle-reactive Pu isotopes as an additional fingerprint of the source region. In the Canada Basin, Atlantic waters showed the highest concentrations and 237Np/236U ratios in agreement with the estimated values for North Atlantic waters entering the Arctic Ocean and tagged with the signal of European Nuclear Reprocessing Plants. These results may reflect the impact of the documented releases for the 1990s. In the Mediterranean Sea, an excess of 236U presumably caused by Marcoule is reflected in the lower 237Np/236U ratios compared to the Global Fallout signal in all the studied samples. On the contrary, the 239,240Pu profiles were mainly governed by the Global Fallout. The impact of Marcoule as a local source is further corroborated when comparing the temporal evolution of these ratios between 2001 and 2013. The lowest 237Np/236U ratios observed in 2001 at the surface reflect a previous local input that is no longer observed in 2013 as it had been homogenized through the whole water column. This work presents the use of 237Np as a new ocean tracer. A more accurate characterization of the main sources is still needed to optimize the use of 236U-237Np as a new tool to understand transient oceanographic processes.

Published
2021

19. SAT0361 HEALTHY HUMAN SPINAL PROCESSES PERI-ENTHESEAL T-CELLS EXHIBIT A TR1 RATHER THAN A FOXP3 REGULATORY PHENOTYPE

Author

Rowe, H., primary, Watad, A., additional, Russell, T., additional, Sharif, K., additional, Newton, D., additional, Wittmann, M., additional, Zhou, Q., additional, Khan, A., additional, Loughenbury, P., additional, Dunsmuir, R., additional, Rao, A. S., additional, Millner, P., additional, Kenna, T., additional, Brown, M., additional, Bridgewood, C., additional, and Mcgonagle, D., additional

Published
2020
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21. The Potential of 233U/236U as a Water Mass Tracer in the Arctic Ocean.

Author

Chamizo, E., Christl, M., López‐Lora, M., Casacuberta, N., Wefing, A.‐M., and Kenna, T. C.

Subjects
WATER masses, RADIOISOTOPES, NUCLEAR weapons testing, RADIOACTIVE fallout, OCEAN, ARCTIC exploration, NUCLEAR energy, URANIUM isotopes
Abstract

This study explores for the first time the possibilities that the 233U/236U atom ratio offers to distinguish waters of Atlantic or Pacific origin in the Arctic Ocean. Atlantic waters entering the Arctic Ocean often carry an isotopic signature dominantly originating from European reprocessing facilities with some smaller contribution from global fallout nuclides, whereas northern Pacific waters are labeled with nuclides released during the atmospheric nuclear testing period only. In the Arctic Ocean, 233U originates from global fallout while 236U carries both, a global fallout and a prominent nuclear reprocessing signal. Thus, the 233U/236U ratio provides a tool to identify water masses with distinct U sources. In this work, 233U and 236U were analyzed in samples from the GN01 GEOTRACES expedition to the western Arctic Ocean in 2015. The study of depth profiles and surface seawater samples shows that: (a) Pacific and Atlantic waters show enhanced signals of both radionuclides, which can be unraveled based on their 233U/236U signature; and (b) Deep and Bottom Waters show extremely low 233U and 236U concentrations close to or below analytical detection limits with isotopic ratios distinct from known anthropogenic U sources. The comparably high 233U/236U ratios are interpreted as a relative increase of naturally occurring 233U and 236U and thus for gradually reaching natural 233U/236U levels in the deep Arctic Ocean. Our results set the basis for future studies using the 233U/236U ratio to distinguish anthropogenic and pre‐anthropogenic U in the Arctic Ocean and beyond. Plain Language Summary: We study the presence of 233U and 236U in seawater samples taken in the Arctic Ocean from the GN01 GEOTRACES expedition in 2015. Both long‐lived manmade U isotopes were introduced worldwide during the open‐air testing of nuclear weapons (mainly in the 1960s). 236U is also linked to the civil uses of nuclear energy, particularly to the liquid effluents from Sellafield (United Kingdom) and La Hague (France) reprocessing plants (starting in the 1950s). Atlantic Waters flowing into the Arctic Ocean carry both the bomb‐tests and the reprocessing plants signals. Pacific Waters entering the Arctic Ocean carry the bomb‐tests signal only. Thus, they show different 233U and 236U compositions. We demonstrate that the 233U/236U ratio and the 236U composition can be used to identify water masses of Pacific and Atlantic origin in the upper waters of the western Arctic Ocean. Deep and Bottom Waters, where an anthropogenic influence is not expected, exhibit extremely low 233U and 236U concentrations but 233U/236U ratios above the ones observed in the upper Arctic Ocean. These features can be explained by the presence of naturally produced uranium isotopes of lithogenic origin. This study demonstrates the potential of the 233U/236U ratio to distinguish anthropogenic and natural U in the Arctic Ocean and beyond. Key Points: The 233U/236U ratio and the 236U composition unravel Pacific and Atlantic waters in Polar Surface Waters of the western Arctic OceanThe Atlantic Layer exhibit distinct 233U and 236U signals from Polar Surface WatersDeep and Bottom Waters show extremely low 233U and 236U concentrations with isotopic ratios distinct from known anthropogenic U sources [ABSTRACT FROM AUTHOR]

Published
2022
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24. Brief Report: Intestinal dysbiosis in ankylosing spondylitis

Author

Costello, M., Willner, D., Warrington, N., Robinson, P., Gardiner, B., Marshall, M., Kenna, T., Brown, M., CICCIA, Francesco, TRIOLO, Giovanni, Costello, M., Ciccia, Francesco, Willner, D., Warrington, N., Robinson, P., Gardiner, B., Marshall, M., Kenna, T., Triolo, Giovanni, Brown, M., Ciccia, F., and Triolo, G.

Subjects
Ankylosing spondyliti, Ankylosing spondylitis, Community profiling, Intestinal microbiome, Immunology, Immunology and Allergy, Rheumatology
Abstract

Objective Ankylosing spondylitis (AS) is a common, highly heritable immune-mediated arthropathy that occurs in genetically susceptible individuals exposed to an unknown but likely ubiquitous environmental trigger. There is a close relationship between the gut and spondyloarthritis, as exemplified in patients with reactive arthritis, in whom a typically self-limiting arthropathy follows either a gastrointestinal or urogenital infection. Microbial involvement in AS has been suggested; however, no definitive link has been established. The aim of this study was to determine whether the gut in patients with AS carries a distinct microbial signature compared with that in the gut of healthy control subjects. Methods Microbial profiles for terminal ileum biopsy specimens obtained from patients with recent-onset tumor necrosis factor antagonist-naive AS and from healthy control subjects were generated using culture-independent 16S ribosomal RNA gene sequencing and analysis techniques. Results Our results showed that the terminal ileum microbial communities in patients with AS differ significantly (P < 0.001) from those in healthy control subjects, driven by a higher abundance of 5 families of bacteria (Lachnospiraceae [P = 0.001], Ruminococcaceae [P = 0.012], Rikenellaceae [P = 0.004], Porphyromonadaceae [P = 0.001], and Bacteroidaceae [P = 0.001]) and a decrease in the abundance of 2 families of bacteria (Veillonellaceae [P = 0.01] and Prevotellaceae [P = 0.004]). Conclusion We show evidence for a discrete microbial signature in the terminal ileum of patients with AS compared with healthy control subjects. The microbial composition was demonstrated to correlate with disease status, and greater differences were observed between disease groups than within disease groups. These results are consistent with the hypothesis that genes associated with AS act, at least in part, through effects on the gut microbiome.

Published
2015

25. A first transect of 236U at the Equatorial Pacific

Author

Chamizo, Elena, Villa-Alfageme, María, López-Lora, Mercedes, Casacuberta, Nuria, Kenna, T., Masqué, Pere, Christl, M., Chamizo, Elena [0000-0001-8266-6129], Villa-Alfageme, María [0000-0001-7157-8588], Christl, M. [0000-0002-3131-6652], Chamizo, Elena, Villa-Alfageme, María, and Christl, M.

Abstract

Trabajo presentado en la 14th International conference on Accelerator Mass Spectrometry, celebrada en Ottawa (Canadá), del 14 al 18 de agosto de 2017, The 2013 U.S. GEOTRACES East Pacific Zonal Transect (EPZT) between Peru and Tahiti chosen to encompass a range of processes that influence the supply, removal, and internal cycling of trace metals in the ocean, including from east to west a productivity gradient, a large oxygen minimum zone, and the largest known hydrothermal plume. With respect to 236U and other anthropogenic radionuclides, the major source to the Eastern Tropical South Pacific has been global stratospheric fallout. In addition to this, nuclear tests conducted in the Pacific Ocean also generated tropospheric fallout. Here we present dissolved 236U profiles collected at 4 full-depth stations along the EPZT. After pre-concentration of 4L samples (LDEO) and purification (CNA), 236U was analyzed by AMS at one of two facilities depending on collection depth. Surface samples (first 400m depth) were analyzed at the 1MV CNA facility. In this case 236U /238U atom ratios were expected to be at the 1010 level, so the parameters of the CNA system were optimized to achieve the necessary abundance sensitivity. Deeper samples were measured at the 600kV ETH facility. The most relevant conclusions are the following. a) Concentrations of 236U range from 0.02x106 to 6.5x106 atoms/kg, showing a typical distribution associated to a conservative element for which the atmospheric input to the ocean dominates. b) Inventories of 236U range from 1.45x1012 to 2x1012 at/m2 , in agreement with the expected values for global fallout. c) Below 1000 m depth, the four profiles presented 236U / 238U atom ratios at the 1012 level, which are among the lowest ratios reported so far in seawater. d) A slight enhancement of 236U at the bottom layers, near the seafloor, might be detected and most especially close to the hydrothermal plume. e) No influence of the local fallout from the French Polynesia is observed. These results will be presented and discussed.

Published
2017

26. Measurement of 236U at the GEOTRACES East Pacific zonal transect

Author

Villa-Alfageme, María, Chamizo, Elena, López-Lora, Mercedes, Kenna, T., Casacuberta, Nuria, Masqué, Pere, and Christl, M.

Abstract

Trabajo presentado a la II International Conference on Radioecological Concentration Processes (50 years later), celebrada en Sevilla (España) del 6 al 9 de noviembre de 2016., During October-December 2013 U.S. GEOTRACES sampled the East Pacific Zonal Transect (EPZT). The transect went from Peru (12°S, 77°W) to Tahiti (17°S, 149°W) and included the in-depth analysis of the Peru Margin upwelling and oxygen minimum zone (OMZ), and the large hydrothermal plume (HP) originating from the southern East Pacific Rise. Respectively St. 11 (12°S,94°W) and St. 18 (15°S,113°W). That area might have been influenced by the US and French nuclear weapon testing sites at the Pacific Ocean.Several water profiles were collected for the analysis of 236U. Surface samples, i.e. above 400 m, were measured on the1 MV AMS system at the Centro Nacional de Aceleradores (CNA, Sevilla, Spain) because the 236U/238U atom ratio (AR) was at the order of 10-10, and the maximum sensitivity achieved on this system is 7x10-11. In deeper samples the expected AR was at the 10-12-10-11 level, and for that reason they were measured on the 600 KV Tandy facility at the ETH Laboratory of Ion Beam Physics (Zürich,Switzerland), with a lower background (at the order of 10-14)., We present here the results for stations 11 and 18. Our results show that: i) Samples above 1000 m presented 236U concentrations from 0.02·106 to 7·106 at kg-1, lower than the activity concentrations at the Equatorial North Atlantic (NA), from 2·106 to 6·106 at kg-1, above 1000 m. The data indicated the presence of anthropogenic 236U, but no additional sources than global fallout were identified here. In contrast,deep samples in the North Atlantic showed the presence of 236U from European nuclear reprocessing plants. ii) Most of the samples between 600 and 2000 m presented very low values, close to the lithogenic/natural ratios (i.e. at the 10-12 level). To the best of our knowledge, these ratios are the lowest ones measured so far in seawater. Below 2000 m it might detected a slight increase in the 236Uconcentration in both OMZ and HP stations.iii) Regarding the biogeochemical behaviour, similar 236U/238U profiles were obtained in the upper 1300 m in both OMZ and HP. The analysis of other radionuclides sampled during the cruise, e.g. 237Np and 129I, and of additional EPZT profiles will provide insights of the origin of 236U fluctuations in depth.

Published
2016

27. A first transect of 236U at the Equatorial Pacific

Author

Chamizo, Elena [0000-0001-8266-6129], Villa-Alfageme, María [0000-0001-7157-8588], Christl, M. [0000-0002-3131-6652], Chamizo, Elena, Villa-Alfageme, María, López-Lora, Mercedes, Casacuberta, Nuria, Kenna, T., Masqué, Pere, Christl, M., Chamizo, Elena [0000-0001-8266-6129], Villa-Alfageme, María [0000-0001-7157-8588], Christl, M. [0000-0002-3131-6652], Chamizo, Elena, Villa-Alfageme, María, López-Lora, Mercedes, Casacuberta, Nuria, Kenna, T., Masqué, Pere, and Christl, M.

Abstract

The 2013 U.S. GEOTRACES East Pacific Zonal Transect (EPZT) between Peru and Tahiti chosen to encompass a range of processes that influence the supply, removal, and internal cycling of trace metals in the ocean, including from east to west a productivity gradient, a large oxygen minimum zone, and the largest known hydrothermal plume. With respect to 236U and other anthropogenic radionuclides, the major source to the Eastern Tropical South Pacific has been global stratospheric fallout. In addition to this, nuclear tests conducted in the Pacific Ocean also generated tropospheric fallout. Here we present dissolved 236U profiles collected at 4 full-depth stations along the EPZT. After pre-concentration of 4L samples (LDEO) and purification (CNA), 236U was analyzed by AMS at one of two facilities depending on collection depth. Surface samples (first 400m depth) were analyzed at the 1MV CNA facility. In this case 236U /238U atom ratios were expected to be at the 1010 level, so the parameters of the CNA system were optimized to achieve the necessary abundance sensitivity. Deeper samples were measured at the 600kV ETH facility. The most relevant conclusions are the following. a) Concentrations of 236U range from 0.02x106 to 6.5x106 atoms/kg, showing a typical distribution associated to a conservative element for which the atmospheric input to the ocean dominates. b) Inventories of 236U range from 1.45x1012 to 2x1012 at/m2 , in agreement with the expected values for global fallout. c) Below 1000 m depth, the four profiles presented 236U / 238U atom ratios at the 1012 level, which are among the lowest ratios reported so far in seawater. d) A slight enhancement of 236U at the bottom layers, near the seafloor, might be detected and most especially close to the hydrothermal plume. e) No influence of the local fallout from the French Polynesia is observed. These results will be presented and discussed.

Published
2017

28. 129I concentrations in the Southern Hemisphere

Author

López-Gutiérrez, J. M. [0000-0001-8672-8075], Villa-Alfageme, María [0000-0001-7157-8588], López-Gutiérrez, J. M., Villa-Alfageme, María, Ceballos Romero, E., Kenna, T., López-Gutiérrez, J. M. [0000-0001-8672-8075], Villa-Alfageme, María [0000-0001-7157-8588], López-Gutiérrez, J. M., Villa-Alfageme, María, Ceballos Romero, E., and Kenna, T.

Published
2017

29. The statistical geometry of transcriptome divergence in cell-type evolution and cancer

Author

Liang, C, Alam, I, Albanese, D, Altschuler, G, Andersson, R, Arakawa, T, Archer, J, Arner, E, Arner, P, Babina, M, Baillie, K, Bajic, V, Baker, S, Balic, A, Balwierz, P, Beckhouse, A, Bertin, N, Blake, Ja, Blumenthal, A, Bodega, B, Bonetti, A, Briggs, J, Brombacher, F, Burroughs, M, Califano, A, Cannistraci, C, Carbajo, D, Carninci, P, Chen, Yang, Chierici, M, Ciani, Y, Clevers, H, Dalla, Emiliano, Daub, C, Davis, C, De Hoon, M, De Lima Morais, D, Dermar, M, Diehl, A, Dimont, E, Dohl, T, Drabros, F, Edge, A, Edinger, M, Ekwall, K, Endoh, M, Enomoto, H, Fagiolini, M, Fairbairn, L, Fang, H, Farach Carson, Mc, Faulkner, G, Favorov, A, Fisher, M, Forrest, A, Francescatto, M, Freeman, T, Frith, M, Fujita, R, Fukuda, S, Furlanello, C, Furuno, M, Furusawa, J, Geijtenbeek, Tb, Gibson, A, Gingeras, T, Goldowithz, D, Gough, J, Guhl, S, Guler, R, Gustincich, Stefano, Ha, T, Haberle, V, Hamaguchi, M, Hara, M, Harbers, M, Harshbarger, J, Hasegawa, A, Hasegawa, Y, Hashimoto, T, Hayashizaki, Y, Herlyn, M, Heutink, P, Hide, W, Hitchens, K, Ho Sui, S, Hofmann, O, Hoof, I, Hori, F, Hume, D, Huminiecki, L, Iida, K, Ikawa, T, Ishizu, Y, Itoh, M, Jankovic, B, Jia, H, Jorgensen, M, Joshi, A, Jurman, G, Kaczkowski, B, Kai, C, Kaida, K, Kaiho, A, Kajiyama, K, Kanamori Katayama, M, Kasianov, A, Kasukawa, T, Katayama, S, Kato Ishikawa, S, Kawaguchi, S, Kawai, J, Kawaji, H, Kawamoto, H, Kawamura, Y, Kawashima, T, Kempfle, J, Kenna, T, Kere, J, Khachigian, L, Kitamura, T, Klinken, P, Knox, A, Kojima, M, Kojima, S, Kondo, N, Koseki, H, Koyasu, S, Krampitz, S, Kubosaki, A, Kulakovskiy, I, Kwon, At, Laros, J, Lassmann, T, Lenhard, B, Lennartsson, A, Li, K, Lilji, B, Lipovich, L, Lizio, M, Mackay Sim, A, Makeev, V, Manabe, R, Mar, J, Marchand, B, Mathelier, A, Medvedeva, Y, Meehan, Tf, Mejhert, N, Meynert, A, Mizuno, Y, Morikawa, H, Morimoto, M, Moro, K, Motakis, E, Motohashi, H, Mummery, C, Mungall, Cj, Murata, M, Nagao Sato, S, Nakachi, Y, Nakahara, F, Nakamura, T, Nakamura, Y, Nakazato, K, Ninomiya Fukuda, N, Nishiyori Sueki, H, Noma, S, Nozaki, T, Ogishima, S, Ohkura, N, Ohmiya, H, Ohno, H, Ohshima, M, Okada Hatakeyama, M, Okazaki, Y, Orlando, V, Ovchinnikov, D, Pain, A, Passier, R, Persson, H, Piazza, Silvano, Plessy, C, Pradhan Bhatt, S, Prendergast, J, Rackham, O, Ramilowski, J, Rashid, M, Ravasi, T, Rehli, M, Rizzu, P, Roncador, M, Roy, S, Rye, M, Saijyo, E, Sajantila, A, Saka, A, Sakaguchi, S, Sakai, M, Sandelin, A, Sato, H, Satoh, H, Suzana, S, Alka, S, Schaefer, U, Schmeier, S, Schmidl, C, Schneider, C, Schultes, Ea, Schulze Tanzil, G, Schwegmann, A, Semple, C, Sengstag, T, Severin, J, Sheng, G, Shimoji, H, Shimoni, Y, Shin, J, Simon, C, Sugiyama, D, Sugiyama, T, Summers, K, Suzuki, H, Suzuki, M, Suzuki, N, Swoboda, R, Hoen P, T, Tagami, M, Takahashi, N, Takai, J, Tanaka, H, Tatsukawa, H, Tatum, Z, Taylor, M, Thompson, M, Toyoda, H, Toyoda, T, Valen, E, Van De Wetering, M, Van Den Berg, L, Van Nimwegen, E, Verardo, R, Vijayan, D, Vitezic, M, Vorontzov, I, Wasserman, W, Watanabe, S, Wells, C, Winteringham, L, Wolvetang, E, Wood, Ej, Yamaguchi, Y, Yamamoto, M, Yoneda, M, Yonekura, Y, Yoshida, Shin'Ichirou, Young, R, Zabierowski, Se, Zhang, P, Zhao, X, Zucchelli, Silvia, Forrest, Ar, Wagner, Gp, Hubrecht Institute for Developmental Biology and Stem Cell Research, AII - Amsterdam institute for Infection and Immunity, Infectious diseases, and Experimental Immunology

Subjects
Cell type, General Physics and Astronomy, rna-seq data, phylogenetic networks, Biology, ENCODE, General Biochemistry, Genetics and Molecular Biology, Divergence, Transcriptome, Models, Settore BIO/13 - Biologia Applicata, Neoplasms, Humans, Genetics, Models, Statistical, Multidisciplinary, Statistical model, General Chemistry, Statistical, Biological Evolution, Body plan, Tree structure, Evolutionary biology, Cancer cell
Abstract

In evolution, body plan complexity increases due to an increase in the number of individualized cell types. Yet, there is very little understanding of the mechanisms that produce this form of organismal complexity. One model for the origin of novel cell types is the sister cell-type model. According to this model, each cell type arises together with a sister cell type through specialization from an ancestral cell type. A key prediction of the sister cell-type model is that gene expression profiles of cell types exhibit tree structure. Here we present a statistical model for detecting tree structure in transcriptomic data and apply it to transcriptomes from ENCODE and FANTOM5. We show that transcriptomes of normal cells harbour substantial amounts of hierarchical structure. In contrast, cancer cell lines have less tree structure, suggesting that the emergence of cancer cells follows different principles from that of evolutionary cell-type origination.

Published
2015
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30. Intercalibration of selected anthropogenic radionuclides for the Geotraces

Author

Kenna, T., Masqué, Pere, Mas, José Luis, Cámara Mor, Patricia, Chamizo, Elenas, Scholten, J., Eriksson, M., Sanchez-Cabeza, Joan-Albert, Gastaud, J., Levy, Isabelle, Herrmann, Jürgen, Lindahl, P., Hong, Gi-Hoon, Nielsen, Sven, National Science Foundation (US), Generalitat de Catalunya, Principality of Monaco, Ministerio de Ciencia e Innovación (España), and European Commission

Abstract

As part of the GEOTRACES Program, six laboratories participated in an intercalibration exercise on several anthropogenic radionuclides of interest. The effort was successful for 239,240Pu activity, 240Pu/239Pu isotope ratio, and 137Cs activity measured in filtered seawater samples from the Bermuda Atlantic Time Series station (BATS) and a site on the continental slope of the Northeastern U.S. A limited number of analyses were reported for 237Np, 241Am, 90Sr, and 238Pu in filtered seawater. Intercalibration of any of the isotopes of interest in filtered particulate matter was unsuccessful due to insufficient size of the samples distributed. Methods used were based on traditional radio-counting techniques and inductively coupled plasma mass spectrometry (ICP-MS). Although the majority of analyses were performed on samples ≥ 60 L, one lab demonstrated the ability to analyze several of the anthropogenic radionuclides on 10–20 L sample volumes using ICP-MS., Support for the research of Pere Masqué was received through the prize ICREA Academia, funded by the Generalitat de Catalunya, and project CTM2010-10267-E funded by MCINN. The International Atomic Energy Agency is grateful to the government of the Principality of Monaco for the support provided to its Environment Laboratories. Support for the research of Patric Lindahl was received from the European Commission seventh Framework, Marie Curie International Out going Fellowship Research Project PIOF-GA-2008-219625“PLUTOTRACE.” This work was supported by the U.S. National Science Foundation through award OCE 0752402. This is LDEO Contribution 7566.

Published
2012

32. Epigenetic and expression analysis of ankylosing spondylitis association loci point to key cell types driving disease

Author

Li, Z., Haynes, K., Thomas, G.P., Kenna, T., Leo, P., Brown, M.A., Li, Z., Haynes, K., Thomas, G.P., Kenna, T., Leo, P., and Brown, M.A.

Abstract

Introduction Susceptibility to ankylosing spondylitis (AS) is primarily genetic; thus far 113 susceptibility variants for AS have been identified. However, most of the AS associated SNPs do not directly affect protein-coding genes. Studies of disease- and trait-associated SNPs suggest they may act by affecting gene regulatory regions in specific cell types or tissues. Therefore, identifying the AS relevant cell types is crucial for further mechanistic studies. Material and Methods We applied several bioinformatics methods to utilize epigenetic, gene and protein expression information to identify the primary relevant cell types through which genetic variants associated with AS operate. In total, there are 113 AS associated loci; 39 of them show genome-wide significance in AS-only analyses, whereas the remainder are genome-wide significant in analyses leveraging pleiotrophy with other related diseases (inflammatory bowel disease (IBD), psoriasis, primary sclerosing cholangitis (PSC) and ulcerative colitis (UC)) (1). Results Epigenetic analysis suggests that AS-associated SNPs operate primarily in immune cell types including monocytes, CD4+ and CD8+ T cells, NK cells, regulatory T cells, and B cells. Gene expression studies showed enrichment of AS associated loci in genes specifically expressed in monocytes and NK cells while protein expression study shows protein products of AS associated loci were significantly enriched in CD8+ T cells. Epigenetic analyses also showed evidence that AS-associated signals operate in gut cell types including in mucosa from the small intestine, sigmoid colon and rectum. These findings particularly relate to leiotropic loci also associated with IBD, psoriasis, and PSC. Conclusions These findings highlight the role of key immune cell types in the mechanism by which genetic associations with AS drive the disease, as well as providing further evidence for the involvement of the gut in the pathogenesis of AS.

Published
2013

33. Anthropogenic radionuclides in the Atlantic GEOTRACES sections A11 and A02

Author

Kenna, T. C., Masque, P., Camara-Mor, P., Puigcorbe, P., Garcia-Orellana, J., Frank, Martin, Rijkenberg, M., Gerringa, L., de Baar, H., Henry, C. L., Kenna, T. C., Masque, P., Camara-Mor, P., Puigcorbe, P., Garcia-Orellana, J., Frank, Martin, Rijkenberg, M., Gerringa, L., de Baar, H., and Henry, C. L.

Abstract

ID: 11526 PosterID: A0020 We are focused on determining the total concentrations of the anthropogenic radionuclides 239Pu, 240Pu, 237Np, and 137Cs in depth profiles from 2010 Atlantic GEOTRACES sections. Data from the equatorial region (A11) compared to GEOSECS data indicate water column inventories of 137Cs have increased over the last 40 years, while those of Pu are variable. By comparison, Pu and 237Np water column inventories are similar to regional soil core inventories, whereas 137Cs inventories are significantly higher, further suggesting continued supply of 137Cs to the open ocean. Water column 240Pu/239Pu inventory ratios are indicative of global fallout (~0.18). Deviations of the water column 237Np/239Pu inventory ratio from the average global fallout value (~0.48) can be used to estimate Pu-particulate fluxes, which are comparable to sediment trap data and may be used to assess scavenging at different locations along the cruise track. Data from mid and high latitude regions (A02) will be compare them to GEOSECS data; inventories and ratios will be used to identify additional contaminant sources, as water mass tracers, and to elucidate important processes such as scavenging and remineralization.

Published
2012

34. Intercalibration of selected anthropogenic radionuclides for the Geotraces

Author

National Science Foundation (US), Generalitat de Catalunya, Principality of Monaco, Ministerio de Ciencia e Innovación (España), European Commission, Kenna, T., Masqué, Pere, Mas, José Luis, Cámara Mor, Patricia, Chamizo, Elena, Scholten, J., Eriksson, M., Sánchez-Cabeza, Joan-Albert, Gastaud, J., Levy, Isabelle, Herrmann, Jürgen, Lindahl, P., Hong, Gi-Hoon, Nielsen, Sven, National Science Foundation (US), Generalitat de Catalunya, Principality of Monaco, Ministerio de Ciencia e Innovación (España), European Commission, Kenna, T., Masqué, Pere, Mas, José Luis, Cámara Mor, Patricia, Chamizo, Elena, Scholten, J., Eriksson, M., Sánchez-Cabeza, Joan-Albert, Gastaud, J., Levy, Isabelle, Herrmann, Jürgen, Lindahl, P., Hong, Gi-Hoon, and Nielsen, Sven

Abstract

As part of the GEOTRACES Program, six laboratories participated in an intercalibration exercise on several anthropogenic radionuclides of interest. The effort was successful for 239,240Pu activity, 240Pu/239Pu isotope ratio, and 137Cs activity measured in filtered seawater samples from the Bermuda Atlantic Time Series station (BATS) and a site on the continental slope of the Northeastern U.S. A limited number of analyses were reported for 237Np, 241Am, 90Sr, and 238Pu in filtered seawater. Intercalibration of any of the isotopes of interest in filtered particulate matter was unsuccessful due to insufficient size of the samples distributed. Methods used were based on traditional radio-counting techniques and inductively coupled plasma mass spectrometry (ICP-MS). Although the majority of analyses were performed on samples ≥ 60 L, one lab demonstrated the ability to analyze several of the anthropogenic radionuclides on 10–20 L sample volumes using ICP-MS.

Published
2012

35. Reference material for radionuclides in sediment. IAEA-384 (Fangataufa lagoon sediment).

Author

Povinec, Pavel, Pham, M.K., Sanchez-Cabeza, J. A., Barci-Funel, G., Bojanowski, R., Boshkova, T., Burnett, W. C., Carvalho, F., Chapeyron, B., Cunha, I. L., Dahlgaard, H., Galabov, N., Fifield, L. K., Gastaud, J., Geering, J.-J., Gomez, I. F., Green, N., Hamilton, T., Ibanez, F. L., Ibn Majah, M., John, M., Kanisch, G., Kenna, T. C., Kloster, M., Korun, M., Liong Wee Kwong, L., La Rosa, J., Lee, S.-H., Levy-Palomo, I., Malatova, M., Maruo, Y., Mitchell, P., Murciano, I. V., Nelson, R., Nouredine, A., Oh, J.-S., Oregioni, B., Le Petit, G., Pettersson, Håkan, Reineking, A., Smedley, P. A., Suckow, A., van der Struijs, T. D. B., Voors, P. I., Yoshimizu, K., Wyse, E., Povinec, Pavel, Pham, M.K., Sanchez-Cabeza, J. A., Barci-Funel, G., Bojanowski, R., Boshkova, T., Burnett, W. C., Carvalho, F., Chapeyron, B., Cunha, I. L., Dahlgaard, H., Galabov, N., Fifield, L. K., Gastaud, J., Geering, J.-J., Gomez, I. F., Green, N., Hamilton, T., Ibanez, F. L., Ibn Majah, M., John, M., Kanisch, G., Kenna, T. C., Kloster, M., Korun, M., Liong Wee Kwong, L., La Rosa, J., Lee, S.-H., Levy-Palomo, I., Malatova, M., Maruo, Y., Mitchell, P., Murciano, I. V., Nelson, R., Nouredine, A., Oh, J.-S., Oregioni, B., Le Petit, G., Pettersson, Håkan, Reineking, A., Smedley, P. A., Suckow, A., van der Struijs, T. D. B., Voors, P. I., Yoshimizu, K., and Wyse, E.

Abstract

A reference material designed for the determination of anthropogenic and natural radionuclides in sediment, IAEA-384 (Fangataufa Lagoon sediment), is described and the results of certification are presented. The material has been certified for 8 radionuclides (40K, 60Co, 155Eu, 230Th, 238U, 238Pu, 239+240Pu and 241Am). Information values are given for 12 radionuclides (90Sr, 137Cs, 210Pb (210Po), 226Ra, 228Ra, 232Th, 234U, 235U, 239Pu, 240Pu and 241Pu). Less reported radionuclides include 228Th, 236U, 239Np and 242Pu. The reference material may be used for quality management of radioanalytical laboratories engaged in the analysis of radionuclides in the environment, as well as for the development and validation of analytical methods and for training purposes. The material is available from IAEA in 100 g units.

Published
2007
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36. A potent nonporphyrin class of photodynamic therapeutic agent: Cellular localisation, cytotoxic potential and influence of hypoxia

Author

Gallagher, W. M., Allen, L. T., O'Shea, C., Kenna, T., Hall, M., Gorman, A., Killoran, J., O'Shea, D. F., Gallagher, W. M., Allen, L. T., O'Shea, C., Kenna, T., Hall, M., Gorman, A., Killoran, J., and O'Shea, D. F.

Abstract

We have developed a totally new class of nonporphyrin photodynamic therapeutic agents with a specific focus on two lead candidates azadipyrromethene (ADPM)01 and ADPM06. Confocal laser scanning microscopy imaging showed that these compounds are exclusively localised to the cytosolic compartment, with specific accumulation in the endoplasmic reticulum and to a lesser extent in the mitochondria. Light-induced toxicity assays, carried out over a broad range of human tumour cell lines, displayed EC50 values in the micro-molar range for ADPM01 and nano-molar range for ADPM06, with no discernable activity bias for a specific cell type. Strikingly, the more active agent, ADPM06, even retained significant activity under hypoxic conditions. Both photosensitisers showed low to nondeterminable dark toxicity. Flow cytometric analysis revealed that ADPM01 and ADPM06 were highly effective at inducing apoptosis as a mode of cell death. The photophysical and biological characteristics of these PDT agents suggest that they have potential for the development of new anticancer therapeutics. © 2005 Cancer Research UK.

Published
2005

41. Rakeeragil

Author

Rakeeragil, Murray, P., Cormack, Michael Mc, Coy, James Mc, Court, Patrick Mc, Ward, W., Court, P. Mc, Macduinnslebe, Michael J., and Kenna, T. P. Mc

Subjects
History, Historic sites, Legal status, laws, etc, Giants, Manners and customs, Riddles, Curses, Weather, Folklore, Treasure troves, legendary creatures, Jokes, Schools, Traditional medicine, Agriculture, Bread, Supernatural beings, Rites and ceremonies, Death, Famine, 1845-1852, Clothing and dress, Food, Land use, Dissenters, Religious, Butter, Recreation, Wake services, Proverbs, Ireland
Abstract

A collection of folklore and local history stories from Rakeeragil (school) (Rakeeragh, Co. Monaghan), collected as part of the Schools' Folklore Scheme, 1937-1938 under the supervision of teacher P. Murray., Ancient Crucifix Found / Cormack, Michael Mc -- Story / Coy, James Mc -- Hidden Treasure / Court, Patrick Mc -- Things Unlucky -- Riddles -- Local Heroes / Ward, W. -- Local Heroes, McKenna / Court, P. Mc -- There was once a man and every Sunday... -- Boxty Bread -- Flax -- Beaghbarton / Macduinnslebe, Michael J. -- Beaghbarton / Macduinnslebe, Michael J. -- Charms and Cures / Macduinnslebe, Michael J. -- Of all the natures of this country for miles.... -- This is a version of the story of the... -- Curse on the Rush -- Proverbs -- When the Israelites were in Egypt... -- Story of Dardria -- Old Story / Kenna, T. P. Mc -- Riddles -- Priest Hunting in this District -- Famine -- Funerals -- Local Cures -- Signs of Weather -- Famine -- Churning -- Wakes -- Story -- Story -- Rakeeragh School -- Coolmain House -- Ancient Customs -- Story -- Story -- Story -- Story -- Story -- Story, Supported by funding from the Department of Arts, Heritage and the Gaeltacht (Ireland), University College Dublin, and the National Folklore Foundation (Fondúireacht Bhéaloideas Éireann), 2014-2016.

Published
1937
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44. Distribution of 236U in the U.S. GEOTRACES Eastern Pacific Zonal Transect and its use as a water mass tracer

Author

<p>Funding information available at: <a href="https://doi.org/10.1016/j.chemgeo.2019.04.003" target="_blank" title="Link to publication">https://doi.org/10.1016/j.chemgeo.2019.04.003 </a></p>, Villa-Alfageme, M., Chamizo, E., Kenna, T. C., López-Lora, M., Casacuberta, N., Chang, C., Masque´, Pere, Christl, M., <p>Funding information available at: <a href="https://doi.org/10.1016/j.chemgeo.2019.04.003" target="_blank" title="Link to publication">https://doi.org/10.1016/j.chemgeo.2019.04.003 </a></p>, Villa-Alfageme, M., Chamizo, E., Kenna, T. C., López-Lora, M., Casacuberta, N., Chang, C., Masque´, Pere, and Christl, M.

Abstract

Villa-Alfageme, M., Chamizo, E., Kenna, T. C., López-Lora, M., Casacuberta, N., Chang, C., ... Christl, M. (2019). Distribution of 236U in the US GEOTRACES Eastern Pacific Zonal Transect and its use as a water mass tracer. Chemical Geology, 517, 44-57. Available here

45. CALLING ALL HUMAN GUINEA PIGS.

Author

Kenna, T. C.

Subjects
*LETTERS to the editor, *MILITARY weapons
Abstract

A letter to the editor is presented in response to the article published in the September 18, 2006 issue about the domestic testing of new weaponry of the U.S. armed forces.

Published
2006

46. Prostaglandin E2/EP4 axis is upregulated in Spondyloarthritis and contributes to radiographic progression

Author

Daniele Mauro, Archita Srinath, Giuliana Guggino, Vicky Nicolaidou, Stefania Raimondo, Jonathan J. Ellis, Jessica Whyte, Maria Maddalena Nicoletti, Marco Romano, Tony John Kenna, Juan D. Cañete, Riccardo Alessandro, Aroldo Rizzo, Matthew Arthur Brown, Nicole J. Horwood, Nigil Haroon, Francesco Ciccia, Mauro, D., Srinath, A., Guggino, G., Nicolaidou, V., Raimondo, S., Ellis, J. J., Whyte, J., Nicoletti, M. M., Romano, M., Kenna, T. J., Canete, J. D., Alessandro, R., Rizzo, A., Brown, M. A., Horwood, N. J., Haroon, N., and Ciccia, F.

Subjects
Ankylosing spondyliti, PTGER4, Radiographic progression, EP4, Prostaglandin, Immunology, Immunology and Allergy, Monocyte
Abstract

Ankylosing spondylitis (AS) is an inflammatory disease leading to spine ankylosis; however, the mechanisms behind new bone formation are still not fully understood. Single Nucleotide Polymorphisms (SNPs) in PTGER4, encoding for the receptor EP4 of prostaglandin E2 (PGE2), are associated with AS. Since the PGE2-EP4 axis participates in inflammation and bone metabolism, this work aims at investigating the influence of the prostaglandin-E2 axis on radiographic progression in AS. In 185 AS (97 progressors), baseline serum PGE2 predicted progression, and PTGER4 SNP rs6896969 was more frequent in progressors. Increased EP4/PTGER4 expression was observed in AS circulating immune cells, synovial tissue, and bone marrow. CD14highEP4 + cells frequency correlated with disease activity, and when monocytes were cocultured with mesenchymal stem cells, the PGE2/EP4 axis induced bone formation. In conclusion, the Prostaglandin E2 axis is involved in bone remodelling and may contribute to the radiographic progression in AS due to genetic and environmental upregulation.

Published
2023

48. Unremitting pro-inflammatory T-cell phenotypes, and macrophage activity, following paediatric burn injury.

Author

Langley D, Zimmermann K, Krenske E, Stefanutti G, Kimble RM, Holland AJ, Fear MW, Wood FM, Kenna T, and Cuttle L

Abstract

Objectives: The aim of this study was to characterise the dynamic immune profile of paediatric burn patients for up to 18 months post-burn., Methods: Flow cytometry was used to measure 25 cell markers, chemokines and cytokines which reflected both pro-inflammatory and anti-inflammatory immune profiles. Peripheral blood mononuclear cells from 6 paediatric burn patients who had returned for repeated burn and scar treatments for > 4 timepoints within 12 months post-burn were compared to four age-matched healthy controls., Results: While overall proportions of T cells, NK cells and macrophages remained relatively constant, over time percentages of these immune cells differentiated into effector and proinflammatory cell phenotypes including Th17 and activated γδ T cells. Circulating proportions of γδ T cells increased their expression of pro-inflammatory mediators throughout the burn recovery, with a 3-6 fold increase of IL-17 at 1-3 weeks, and NFκβ 9-18 months post-burn. T-regulatory cell plasticity was also observed, and Treg phenotype proportions changed from systemically reduced skin-homing T-regs (CCR4 + ) and increased inflammatory (CCR6 + ) at 1-month post-burn, to double-positive cell types (CCR4 + CCR6 + ) elevated in circulation for 18 months post-burn. Furthermore, Tregs were observed to proportionally express less IL-10 but increased TNF-α over 18 months., Conclusion: Overall, these results indicate the circulating percentages of immune cells do not increase or decrease over time post-burn, instead they become highly specialised, inflammatory and skin-homing. In this patient population, these changes persisted for at least 18 months post-burn, this 'immune distraction' may limit the ability of immune cells to prioritise other threats post-burn, such as respiratory infections., Competing Interests: The authors have no conflicts of interest to declare., (© 2024 The Authors. Clinical & Translational Immunology published by John Wiley & Sons Australia, Ltd on behalf of Australian and New Zealand Society for Immunology, Inc.)

Published
2024
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49. Lactate dehydrogenase contribution to symptom persistence in long COVID: A pooled analysis.

Author

Udeh R, Utrero-Rico A, Dolja-Gore X, Rahmati M, McEVoy M, and Kenna T

Subjects
Humans, L-Lactate Dehydrogenase, Plasma, PubMed, Post-Acute COVID-19 Syndrome, COVID-19 diagnosis
Abstract

There's critical need for risk predictors in long COVID. This meta-analysis evaluates the evidence for an association between plasma lactate dehydrogenase (LDH) and long COVID and explores the contribution of LDH to symptoms persistent across the distinct post-acute sequelae of COVID-19 (PASC) domains. PubMed, EMBASE, Web of Science, and Google Scholar were searched for articles published up to 20 March 2023 for studies that reported data on LDH levels in COVID-19 survivors with and without PASC. Random-effect meta-analysis was employed to estimate the standardized mean difference (SMD) with corresponding 95% confidence interval of each outcome. There were a total of 8289 study participants (3338 PASC vs. 4951 controls) from 46 studies. Our meta-analysis compared to the controls showed a significant association between LDH elevation and Resp-PASC [SMD = 1.07, 95%CI = 0.72, 1.41, p = 0.01] but not Cardio-PASC [SMD = 1.79, 95%CI = -0.02, 3.61, p = 0.05], Neuro-PASC [SMD = 0.19, 95%CI = -0.24, 0.61, p = 0.40], and Gastrointestinal-PASC [SMD = 0.45, 95%CI = -1.08, 1.98, p = 0.56]. This meta-analysis suggests elevated LDH can be used for predicting Resp-PASC, but not Cardio-PASC, Neuro-PASC or gastrointestinal-PASC. Thus, elevated plasma LDH following COVID infection may be considered as a disease biomarker., (© 2023 The Authors. Reviews in Medical Virology published by John Wiley & Sons Ltd.)

Published
2023
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50. A systematic review and meta-analysis of long-term sequelae of COVID-19 2-year after SARS-CoV-2 infection: A call to action for neurological, physical, and psychological sciences.

Author

Rahmati M, Udeh R, Yon DK, Lee SW, Dolja-Gore X, McEVoy M, Kenna T, Jacob L, López Sánchez GF, Koyanagi A, Shin JI, and Smith L

Subjects
Humans, Female, Male, Post-Acute COVID-19 Syndrome, SARS-CoV-2, Anxiety epidemiology, Carbon Monoxide, Disease Progression, COVID-19 complications, COVID-19 epidemiology
Abstract

Long-term sequelae conditions of COVID-19 at least 2-year following SARS-CoV-2 infection are unclear and little is known about their prevalence, longitudinal trajectory, and potential risk factors. Therefore, we conducted a comprehensive meta-analysis of survivors' health-related consequences and sequelae at 2-year following SARS-CoV-2 infection. PubMed/MEDLINE, CENTRAL, and EMBASE were systematically searched up to February 10, 2023. A systematic review and meta-analysis were performed to calculate the pooled effect size, expressed as event rate (ER) with corresponding 95% confidence interval (CI) of each outcome. Twelve studies involving 1 289 044 participants from 11 countries were included. A total of 41.7% of COVID-19 survivors experienced at least one unresolved symptom and 14.1% were unable to return to work at 2-year after SARS-CoV-2 infection. The most frequent symptoms and investigated findings at 2-year after SARS-CoV-2 infection were fatigue (27.4%; 95% CI 17%-40.9%), sleep difficulties (25.1%; 95% CI 22.4%-27.9%), impaired diffusion capacity for carbon monoxide (24.6%; 95% CI 10.8%-46.9%), hair loss (10.2%; 95% CI 7.3%-14.2%), and dyspnea (10.1%; 95% CI 4.3%-21.9%). Individuals with severe infection suffered more from anxiety (OR = 1.69, 95% CI 1.17-2.44) and had more impairments in forced vital capacity (OR = 9.70, 95% CI 1.94-48.41), total lung capacity (OR = 3.51, 95% CI 1.77-6.99), and residual volume (OR = 3.35, 95% CI 1.85-6.07) after recovery. Existing evidence suggest that participants with a higher risk of long-term sequelae were older, mostly female, had pre-existing medical comorbidities, with more severe status, underwent corticosteroid therapy, and higher inflammation at acute infection. Our findings suggest that 2-year after recovery from SARS-CoV-2 infection, 41.7% of survivors still suffer from either neurological, physical, and psychological sequela. These findings indicate that there is an urgent need to preclude persistent or emerging long-term sequelae and provide intervention strategies to reduce the risk of long COVID., (© 2023 Wiley Periodicals LLC.)

Published
2023
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