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A total of 44 patients with long-standing ulcerative colitis were studied to elucidate changes over time in colonoscopic and histological inflammatory activity. More than two years of symptomatic remission without melena or bloody diarrhea was achieved in 63.6% (28/44). All patients underwent total colonoscopic examinations. Compared with findings of the previously involved area, 70.5% (31/44) showed a reduction or disappearance of the inflammatory area on endoscopic and histological examinations; however, the rectal inflammation disappeared in 31.8% (14/44) of patients. Moreover, it became apparent that the remaining active inflammatory area tended to show discontinuous spread with patchy inflammatory foci. Thus, the mucosal inflammation in long-standing ulcerative colitis may be characterized by a reduction in both extent and degree.

We developed a new fabrication method for multilayer optical discs for the high-throughput production of such discs. We used web coating and lamination to prepare a stacked unit. The stacked unit was a layered structure consisting of a recording layer, a UV resin layer, a recording layer, and a pressure-sensitive adhesive layer. We obtained a 20-layer disc simply by laminating the stacked units 10 times. The transmittance of the 20 recording layers was 87% owing to the high transparency of the two-photon recording material. A scanning electron microscopy (SEM) image of the disc showed a clear multilayer structure. The recording layers of the disc were recorded using a pulse laser without interlayer cross write. The thickness variation of the transparent part of the disc was within ±2 µm, and the tilt angles of the disc satisfied the Blu-ray disc (BD) specifications.

We developed a novel heat-mode bump formation method using a two-photon material, and its feasibility for high-capacity recording was experimentally demonstrated. This unique recording method exhibits a very high recording resolution and uses a material with excellent optical transparency. These characteristics are very appropriate for realizing high-capacity multilayer optical discs. We also examined the high-density recording feasibility of a Blu-ray-equivalent format and we obtained a jitter value of 22%. We also fabricated quad-layer media and their recording performance was examined. All the layers exhibited almost identical performance characteristics (2T random pattern; jitter, 14.5 to 16.5%) under the same recording and reading conditions.

潰瘍性大腸炎の病変局所における液性免疫の病態をみる目的で,免疫グロブリン陽性細胞(IgA,IgG,IgM)について検討した.潰瘍性大腸炎27例の直腸粘膜より内視鏡下に採取した生検組織45病変,および活動期の症例で明らかに炎症部より離れた正常外観粘膜部よりの生検組織6試料を対象とし,酵素抗体直接法を用いて陽性細胞を同定した.その結果,いずれの陽性細胞も,潰瘍性大腸炎の活動期に,緩解期およびコントロール群に比べ,有意に増加した.特に,IgGおよびIgM陽性細胞は,コントロール群に比べ,おのおの4.3倍および4.5倍と著明に増加した,IgGおよびIgM陽性細胞は,活動期より緩解期になると,有意に減少した.炎症部より離れた正常外観粘膜部では,IgA陽性細胞の減少傾向,IgG陽性細胞の増加傾向が認められた.以上より,潰瘍性大腸炎の炎症粘膜のみならず,正常外観粘膜部でも液性免疫系の異常が示唆された.