1. Clinical course of Immunoglobulin A nephropathy with crescents in a multi‐ethnic Southeast Asian cohort
- Author
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Keng T. Woo, Puay Hoon Tan, Shashidhar Baikunje, Marjorie Foo, Cynthia C. Lim, and Jason C J Choo
- Subjects
Male ,Nephrology ,medicine.medical_specialty ,Biopsy ,Kidney Glomerulus ,030232 urology & nephrology ,030204 cardiovascular system & hematology ,urologic and male genital diseases ,Southeast asian ,Gastroenterology ,Cohort Studies ,03 medical and health sciences ,0302 clinical medicine ,Median follow-up ,Internal medicine ,Ethnicity ,medicine ,Humans ,Singapore ,Proteinuria ,business.industry ,Glomerulonephritis, IGA ,Retrospective cohort study ,General Medicine ,Middle Aged ,medicine.disease ,Cohort ,Disease Progression ,Prednisolone ,Kidney Failure, Chronic ,Female ,medicine.symptom ,business ,Immunosuppressive Agents ,Glomerular Filtration Rate ,Kidney disease ,medicine.drug - Abstract
AIM Clinical presentation and course of Immunoglobulin A nephropathy vary by ethnicity and geography and significance of extracapillary proliferation or crescents (IgAN-C) in Southeast Asia is not well described. We aimed to describe the clinical course of IgAN-C in Singapore. METHODS Retrospective cohort study of adult biopsy-proven IgAN diagnosed between February 2011 and October 2016 in 2 hospital-based nephrology units. Outcome was chronic kidney disease (CKD) progression, defined as reduction in eGFR ≥50% or end stage renal failure (ESRF). RESULTS One hundred and forty-five patients were studied. Among individuals with IgAN-C (n = 44, 30%), 38 patients had cellular or fibrocellular crescents in 1 to 25% of the glomeruli and 6 had crescents in >25%. Median eGFR was 54 (33, 83) mL/min/1.73 m2 . Compared to IgAN without crescents, IgAN-C had greater proteinuria (median 2.9 [1.4, 5.4] g/g vs 1.9 [1.1, 3.6] g/g, P = .03) and more had endocapillary hypercellularity (96% vs 39%, P
- Published
- 2020