1. Pericardial Fat and the Risk of Heart Failure
- Author
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Kenchaiah, Satish, Ding, Jingzhong, Carr, J Jeffrey, Allison, Matthew A, Budoff, Matthew J, Tracy, Russell P, Burke, Gregory L, McClelland, Robyn L, Arai, Andrew E, and Bluemke, David A
- Subjects
Biomedical and Clinical Sciences ,Cardiovascular Medicine and Haematology ,Heart Disease ,Prevention ,Clinical Research ,Cardiovascular ,Aging ,Adiposity ,Aged ,Aged ,80 and over ,Cardiac Imaging Techniques ,Cohort Studies ,Female ,Heart Failure ,Humans ,Male ,Middle Aged ,Pericardium ,Risk ,Tomography ,X-Ray Computed ,adipose tissue ,adiposity ,heart failure ,obesity ,pericardial fat ,Cardiorespiratory Medicine and Haematology ,Public Health and Health Services ,Cardiovascular System & Hematology ,Cardiovascular medicine and haematology - Abstract
BackgroundObesity is a well-established risk factor for heart failure (HF). However, implications of pericardial fat on incident HF is unclear.ObjectivesThis study sought to examine the association between pericardial fat volume (PFV) and newly diagnosed HF.MethodsThis study ascertained PFV using cardiac computed tomography in 6,785 participants (3,584 women and 3,201 men) without pre-existing cardiovascular disease from the MESA (Multi-Ethnic Study of Atherosclerosis). Cox proportional hazards regression was used to evaluate PFV as continuous and dichotomous variable, maximizing the J-statistic: (Sensitivity + Specificity - 1).ResultsIn 90,686 person-years (median: 15.7 years; interquartile range: 11.7 to 16.5 years), 385 participants (5.7%; 164 women and 221 men) developed newly diagnosed HF. PFV was lower in women than in men (69 ± 33 cm3 vs. 92 ± 47 cm3; p
- Published
- 2021