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The presence of green spaces within city centres has been recognized as a valuable component of the city landscape. Vegetation provides a variety of benefits including energy saving, improved air quality, reduced noise pollution, decreased ambient temperature and psychological restoration. Evidence also shows that the amount of vegetation, known as ‘greenness’, in densely populated areas, can also be an indicator of the relative wealth of a neighbourhood. The ‘grey-green divide’, the contrast between built-up areas with a dominant grey colour and green spaces, is taken as a proxy indicator of sustainable management of cities and planning of urban growth. Consistent and continuous assessment of greenness in cities is therefore essential for monitoring progress towards the United Nations Sustainable Development Goal 11. The availability of multi-temporal greenness information from Landsat data archives together with data derived from the city centres database of the Global Human Settlement Layer (GHSL) initiative, offers a unique perspective to quantify and analyse changes in greenness across 10,323 urban centres all around the globe. In this research, we assess differences between greenness within and outside the built-up area for all the urban centres described by the city centres database of the GHSL. We also analyse changes in the amount of green space over time considering changes in the built-up areas in the periods 1990, 2000 and 2014. The results show an overall trend of increased greenness between 1990 and 2014 in most cities. The effect of greening is observed also for most of the 32 world megacities. We conclude that using simple yet effective approaches exploiting open and free global data it is possible to provide quantitative information on the greenness of cities and its changes over time. This information is of direct interest for urban planners and decision-makers to mitigate urban related environmental and social impacts.

BackgroundAlzheimer's disease (AD) and its transitional state mild cognitive impairment (MCI) are characterized by amyloid plaque and tau neurofibrillary tangle (NFT) deposition within the cerebral neocortex and neuronal loss within the hippocampal formation. However, the precise relationship between pathologic changes in neocortical regions and hippocampal atrophy is largely unknown.Methodology/principal findingsIn this study, combining structural MRI scans and automated image analysis tools with reduced cerebrospinal fluid (CSF) Aβ levels, a surrogate for intra-cranial amyloid plaques and elevated CSF phosphorylated tau (p-tau) levels, a surrogate for neocortical NFTs, we examined the relationship between the presence of Alzheimer's pathology, gray matter thickness of select neocortical regions, and hippocampal volume in cognitively normal older participants and individuals with MCI and AD (n = 724). Amongst all 3 groups, only select heteromodal cortical regions significantly correlated with hippocampal volume. Amongst MCI and AD individuals, gray matter thickness of the entorhinal cortex and inferior temporal gyrus significantly predicted longitudinal hippocampal volume loss in both amyloid positive and p-tau positive individuals. Amongst cognitively normal older adults, thinning only within the medial portion of the orbital frontal cortex significantly differentiated amyloid positive from amyloid negative individuals whereas thinning only within the entorhinal cortex significantly discriminated p-tau positive from p-tau negative individuals.Conclusions/significanceCortical Aβ and tau pathology affects gray matter thinning within select neocortical regions and potentially contributes to downstream hippocampal degeneration. Neocortical Alzheimer's pathology is evident even amongst older asymptomatic individuals suggesting the existence of a preclinical phase of dementia.