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Objective: Methotrexate (MTX) is a highly effective chemotherapy for cancer. This drug has a gonadotoxic effect, mainly in the testes and ovaries. Our study used histopathological and immunohistochemical methods to assess the potential damage to testicular and ovarian tissue caused by MTX use. Methods: Twenty-four Wistar albino rats, both male and female, were used in our study. Four sets of rats; control male, MTX male, control female, and MTX female were created. The male and female MTX-treated groups received a single intraperitoneal dose of 20 mg/kg MTX. The testes and ovaries of rats sacrificed under general anesthesia were extracted and histopathologically analyzed. In addition, the immunoreactivity intensities of stem cell factor (SCF), mechanistic target of rapamycin (mTOR), and SIRT-1 in both tissues were measured by immunohistochemistry. Results: Johnsen's testicular biopsy score in the testicular seminiferous tubules was significantly lower in the MTX group than in the control group (p<0.001). The ovary showed substantial follicular degeneration (p<0.05), vascular congestion (p<0.01), and fibrosis (p<0.001). MTX reduced SCF immunoreactivity density in the testis and ovary (p<0.05). Furthermore, MTX reduced mTOR, a marker of autophagy, in the testis (p<0.05) and ovary (p<0.001) compared with the control. SIRT-1 intensity increased dramatically in the testis (p<0.001) and ovary (p<0.01) in the injured group, unlike the mTOR marker. Conclusions: Our investigation revealed that the gonads incurred significant damage as a result of MTX. One vital option for reducing or eliminating this damage to the ovaries and testicles is the use of antioxidant-rich substances. [ABSTRACT FROM AUTHOR]

Copyright of Journal of Ankara University Faculty of Medicine / Ankara Üniversitesi Tip Fakültesi Mecmuasi is the property of Galenos Yayinevi Tic. LTD. STI and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Namık Kemal Tıp Dergisi is the property of Galenos Yayinevi Tic. LTD. STI and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective: To investigate the relationship between self-efficacy, marital status, and quality of life among Banda Aceh Hospital chemotherapy patients in Indonesia.Methods: The descriptive design was correlational with a cross-sectional approach. Sampling type of the research method used purposive sampling. The sample size of 100 breast cancer patients undergoing chemotherapy met the inclusion criteria. Instruments for this research used the Questionnaire Quality of Life-Breast Cancer (QOL-BC) and the Symptom Management Breast Cancer Self-Efficacy Scale (SMSES-BC). Multiple linear regression and spearman rank correlation were used in this analysis.Results: Self-efficacy (P

Background: Breast cancer is one of the leading causes of morbidity and mortality among women worldwide. In Indonesia, the distribution of breast cancer subtypes and response to treatment varies. This study aims to evaluate the clinical response to various chemotherapy regimens in patients with advanced breast cancer at Prof. Dr. R. D. Kandou Manado Hospital in 2023. Purpose: This study aims to identify the clinical response to chemotherapy regimen in advanced breast cancer and to analyze the relationship between molecular subtypes and clinical response to chemotherapy. Methods: This study uses a retrospective observational study design with a crosssection approach. Data was collected from the medical records of advanced breast cancer patients undergoing chemotherapy at Prof. Dr. R. D. Kandou Hospital in 2023. Clinical response was evaluated using RECIST criteria, with the chemotherapy regimen as the independent variable and clinical response as the dependent variable. Results: Of the 190 patients, 45.3% showed Partial Response (PR), 30.5% had Stable Disease (SD), and 4.2% had Progressive Disease (PD). The Platinum + Taxane (TP) regimen is the most widely used regimen with a significant clinical response. The Triple Negative subtype has the highest prevalence among patients, with varying clinical responses. Conclusion: The results showed that the majority of advanced breast cancer patients at Prof. Dr. R. D. Kandou Hospital responded positively to chemotherapy, with Partial Response as the most common response. The TP regimen showed high effectiveness in improving clinical response in the Triple Negative breast cancer subtype [ABSTRACT FROM AUTHOR]

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Copyright of Journal of Nursology is the property of Ataturk University Coordinatorship of Scientific Journals and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Amaç: Bu araştırmanın amacı ayaktan kemoterapi tedavisi alan kanser hastalarının hemşirelik bakımı ile ilgili deneyim ve düşüncelerini belirlemektir.Yöntemler: Fenomenolojik tipte nitel araştırma yöntemi kullanılarak tamamlanan bu araştırmada ayaktan kemoterapi ünitesinde tedavi alan 13 hasta yer aldı. Veriler Eylül-Kasım 2023 tarihleri arasında yarı yapılandırılmış görüşme formu ve ses kaydı yapılarak toplandı. Verilerin değerlendirilmesinde betimsel analiz yöntemi kullanıldı. Araştırmada gönüllülük esas alınarak katılımcılardan yazılı onam alındı.Bulgular: Çalışmadaki hastaların %61.5’i kadın, ilkokul mezunu ve şehir merkezinde yaşamaktadır. %53.8’i üçüncü evre kanser hastası ve ortalama 36 aydır kemoterapi tedavisi almaktadır. Kemoterapi tedavisi alan hastalar; hemşirelerin kendilerine karşı ilgili olduklarını belirttiler. Hemşirelerin uyguladıkları bakımı iyi olarak değerlendirdiler. Hemşirelerden en büyük beklentilerinin sabır, anlayış ve güler yüz olduğunu ifade ettiler. Tedavi süresince hemşirelerle iletişimlerinde sorun yaşamadıklarını ancak fiziki şartların uygunsuzluğu, hasta yoğunluğu, hemşire sayısının yetersiz olması ve tedavide kullanılan cihazların seslerinden ötürü çoğu zaman iletişim problemleri yaşayabildiklerini dile getirdiler (P

Chemotherapy drugs are commonly used in cancer treatment, despite their numerous negative side effects. Today, there are studies to reduce the side effects of these drugs and to increase their benefits by combining them with natural substances. Our study investigated the antioxidant and antiradical activities of Ellagic acid (EA), a natural substance, DOC and MIX, commonly used chemotherapeutics, as well as their combinations (EA+DOC, EA+MIX). For this purpose, the methods of DPPH• and ABTS•+ scavenging activity, Fe3+ -Fe2+ and Cu2+-Cu1+ reduction capacity were used. After the study, the interactions were analysed with the combination index using Compusyn software. Concentrations with maximum synergy in combinations have been identified. For this purpose, firstly, the combination concentrations used in the antioxidant activity methods and the absorbance values were entered into the Compusyn programme. When DPPH• and ABTS•+ scavenging activity results were entered into the programme, more effective synergistic effect was observed for EA+DOC at lower concentrations (7:7µg/mL), (0.125:1µg/mL) respectively. For EA+MIX, no synergistic effect was observed with the application of DPPH scavenging activity results to the programme, while for ABTS•+ scavenging activity, more effective synergistic effect was observed at higher concentrations within the applied doses (0.750:6µg/ml). When Fe3+ -Fe2+ and Cu2+ -Cu1+ reduction results were applied to the programme; synergistic effect was observed at higher concentrations (17:17µg/mL) for both EA+DOC and EA+MIX and even strong synergistic effect was observed in many of them. The obtained results provide guidance for the use of these combinations in further studies, such as anticancer and enzyme studies. [ABSTRACT FROM AUTHOR]

Copyright of Pamukkale Medical Journal is the property of Pamukkale Journal of Medicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Ankara University Faculty of Medicine / Ankara Üniversitesi Tip Fakültesi Mecmuasi is the property of Galenos Yayinevi Tic. LTD. STI and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Nursology is the property of Ataturk University Coordinatorship of Scientific Journals and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Aim: This study aimed to systematically review postgraduate thesis studies in the field of nursing related to oral mucositis. Material and Methods: The data for this study were collected by searching the National Thesis Center database of the Higher Education Council. The search was conducted using the keyword "oral mucositis" and the subject "nursing." Six thesis studies conducted between 2003 and 2023, with the keywords "chemotherapy," "radiotherapy," "stem cell transplantation," and "oral mucositis" in their titles, accessible in full text, and employing a randomized controlled study design, were selected for review. Results: It was determined that the sample size of the six included theses was 412 individuals. Seven different measurement tools for assessing OM were identified in the theses. The "WHO Oral Toxicity Scale" and "Oral Assessment Guide" measurement tools were used in 50% of the theses. Black mulberry syrup (50.0%) and sodium bicarbonate (33.3%) were frequently used among the products and methods for the prevention and treatment of oral mucositis in the theses. According to the results of the theses, it can be said that the mentioned products reduce the frequency and severity of oral mucositis and positively impact patients' quality of life. Conclusion: In conclusion, it may be recommended to conduct postgraduate theses with a high level of evidence involving patients, patient relatives and health professionals related to oral mucositis. [ABSTRACT FROM AUTHOR]

Copyright of Gazi Journal of Health Sciences is the property of Gazi University Faculty of Health Sciences and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Pendahuluan: Kejadian kanker meningkat dari tahun ke tahun dan terjadi hampir di seluruh dunia. Kanker menduduki urutan ke dua penyakit terbesar di dunia. Data jumlah penderita kanker di seluruh dunia mencapai 14 juta kasus dengan angka kematian 8,2 juta setiap tahunnya (WHO, 2018). Hasil penelitian Anggarwati (2018) terkait kepatuhan pasien kanker terhadap kemoterapi di RS Lavalette Kota Malang didapatkan bahwa dari 78 responden sebanyak 25 responden dalam kategori kepatuhan sedang dan rendah. Dibutuhkan self-efficacy yang baik dalam berkomunikasi antara perawat dan pasien. Tujuan: Untuk mengetahui hubungan self-efficacy dalam komunikasi terapeutik dengan kepatuhan pasien kanker menjalani kemoterapi di RS Hermina kota Bekasi. Metode: jenis deskriptif korelasional dengan pendekatan cross sectional. Populasi penelitian ini adalah jumlah pasien kanker yang menjalani kemoterapi dalam waktu 3 bulan terahir dan sesuai dengan kriteri inklusi peneliti sebanyak 103 pasien. Peneliti melakukan pengambilan data pada responden sebanyak 103 responden dengan mengunakan kuesioner self-efficacy dan kepatuhan menjalani kemoterapi. Uji statistic yang digunakan yaitu menggunakan uji Korelasi Chi Square. Hasil: Berdasarkan analisa statistic dengan tingkat signifikasi 95% atau nilai ɑ 5% (0,05) hasil Uji Chi Square diperoleh p – value (0,571) > nilai ɑ (0,05) sehingga dapat di simpulkan dari hasil tersebut H0 diterima tidak ada hubungan Self-efficacy dalam Komunikasi Terapeutik Perawat dengan Kepatuhan Kemoterapi pada Pasien Kanker di RS Hermina Kota Bekasi. Kesimpulan: hasil penelitian disimpulkan tidak terdapat hubungan Self-efficacy dalam komunikasi terapeutik dengan dengan Kepatuhan Kemoterapi pada Pasien Kanker di RS Hermina Kota Bekasi dengan p – value (0,571) > nilai ɑ (0,05).

Aim: This study’s goal is to evaluate the safety and efficacy of bevacizumab (BEV )-based therapies in patients with metastatic cervical cancer (CC) using real-life data. Materials and Methods: This study constitutes a retrospective observational analysis. Patients diagnosed with metastatic CC who received BEV treatment in the Medical Oncology department between January 2012 and December 2022 were included in the study. Results: This study encompassed 40 patients, with a median age of 51 years (range: 21-78), and a median follow-up duration post-treatment of 16.6 months. Predominant metastatic sites included the lymph nodes 72.5% (n=29), peritoneum 55% ( n=22), lungs 35% (n=14), liver 22.5% (n=9) and bones 15%( n=6). Regarding treatment responses, 12.5% (n = 5) of patients achieved complete response, 45% (n = 18) achieved partial response, 17.5% (n = 7) had stable disaese, and 25% (n = 10) experienced disease progression. The median progression-free survival was found 8.5 months (95% CI: 6.838 – 10.295), and the median overall survival was 16.3 months (95% CI: 11.305 – 21.362). The presence of bone metastasis (p=0.024) and obesity (p=0.020) are statistically significant factors affecting survival outcomes. There were no statistically significant differences in survival outcomes due to several factors, including age, pathology classification, number of metastatic sites, tumor grade, initial staging, previous surgeries and radiotherapy before starting therapy, and the type of cytotoxic agents administered with BEV (p > 0.05). Conclusions: Metastatic CC has a challenging prognosis. Combinations of BEV with chemotherapy agents are effective and safe in the treatment of this patient group. [ABSTRACT FROM AUTHOR]

This document is a review of the advancements in the treatment of hepatocellular carcinoma (HCC), specifically focusing on the integration of new systemic treatment options and surgical therapy. The review discusses the development of minimal invasive techniques that have allowed for more aggressive treatment strategies and improved oncological outcomes. It also highlights the significant progress in immunotherapy research, which has led to the emergence of new treatment regimens that can significantly improve prognosis and provide durable responses in certain subsets of patients. The review explores how these advancements are changing the treatment paradigm for advanced stages of HCC and discusses the challenges that still need to be addressed. Overall, the document provides a comprehensive discussion of the current trends in HCC treatment and the evolving treatment plans. [Extracted from the article]

Copyright of Namık Kemal Tıp Dergisi is the property of Galenos Yayinevi Tic. LTD. STI and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Turkish Journal of Trauma & Emergency Surgery / Ulusal Travma ve Acil Cerrahi Dergisi is the property of KARE Publishing and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Kemoterapi pada pasien kanker menyebabkan efek samping mual dan muntah. Kondisi ini dapat menimbulkan ketidakseimbangan cairan, elektrolit, anoreksia, penurunan berat badan, sehingga menyebabkan memperburuk kondisi dan pasien meninggalkan pengobatan. Studi ini bertujuan untuk menerapkan terapi akupressure PC6 dan ST36 untuk menurunkan mual muntah sebagai efek kemoterapi. Studi kasus ini menggunakan case report dengan multicase study melalui pendekatan asuhan keperawatan yang melibatkan dua subjek Perempuan, pasien 1 berusia 45 tahun dan pasien 2 berusia 48 tahun yang mengalami mual muntah. Pemijatan dilakukan pada titik PC6 dan ST36 selama 5 detik secara berulang dalam waktu 3 menit selama dua hari, akupressure dilakukan 30 menit sebelum kemoterapi,4 jam dan 12 jam setelah kemoterapi. pengukuran mual muntah dilakukan setelah 48 jam, alat ukur yang digunakan adalah Index Nausea, Vomiting, and Retching (INVR). Hasil studi menunjukkan adanya penurunan skore INVR dengan masing-masing subjek mengalami penurunan sebesar 4 point. Pada pasien ke-1 terjadi penurunan dari skala 16 menjadi 14 dengan kategori (tetap sedang), pada pasien ke-2 terjadi penurunan skala 12 menjadi 8 (dari sedang menjadi ringan). Titik PC6 dan ST36 merangsang saraf parasimpatis untuk bekerja sehingga produksi HCL atau asam lamung menurun dan rangsangan mual berkurang. Pemberian terapi akupressure PC6 dan ST36 dapat menurunkan mual muntah.

Amaç: Bu araştırma, Türkiye’de kemoterapi ilişkili oral mukozit yönetimine yönelik girişimsel tipte ve hemşirelik alanında yürütülen lisansüstü tezlerinin incelenmesi amacıyla yapılmıştır. Yöntem: Araştırmada doküman analizi yöntemi kullanılmıştır. Veriler, Eylül-Aralık 2022 tarihleri arasında “Yükseköğretim Kurulu Ulusal Tez Merkezi” veri tabanında “kemoterapi”, “oral mukozit”, “hemşirelik” anahtar kelimeleri kullanılarak toplanmıştır. 2007-2022 yılları arasında tamamlanan yirmi altı teze ulaşılmış ve araştırma kriterlerini karşılayan dokuz tez araştırmaya dâhil edilmiştir. Bulgular: İncelenen tezlerin %55,5’i yüksek lisans, %44,4’ü doktora tezidir. Tezlerin çoğunluğu (%44,4) Hemşirelik Anabilim Dalı’nda yürütülmüş olup, tez danışmanlarının uzmanlık alanı (%77,7) İç Hastalıkları Hemşireliği Anabilim Dalı’dır. Yapılan tezlerin çoğunluğu (%44,4) randomize kontrollü deneysel tiptedir. Oral mukozitin değerlendirilmesinde en sık Dünya Sağlık Örgütü Mukozit Değerlendirme Ölçeği’nin (%88,8) kullanıldığı belirlenmiştir. Kemoterapi ilişkili oral mukoziti önlemeye yönelik en sık uygulanan yöntemler karadut şurubu (%33,3) ve kriyoterapi (%33,3)’dir. Sonuç: Yapılan doküman analizi sonucunda, hemşirelik alanındaki lisansüstü tezlerinde karadut şurubu, kriyoterapi, propolisli gargara, klorheksidin, hyalüronik asit ve ankaferd hemostatın kanser bakımında oral mukozitin yönetiminde kullanılabilecek hemşirelik müdahalesi olarak bildirildiği belirlenmiştir.

Latar belakang. Leukemia merupakan keganasan yang sering terjadi pada anak dan kemoterapi merupakan terapi kuratif penting pada pasien leukemia limfablastik akut. Penggunaan kemoterapi pada awal diagnosis dapat memicu terbentuknya radikal bebas yang mengganggu homeostasis sel. Malondialdehid merupakan produk sekunder dari peroksida lipid yang dihasilkan oleh reaksi radikal bebas lemak tak jenuh dalam membran sel dan dapat digunakan sebagai penanda stress oksidatif. Protokol kemoterapi sebelumnya tidak konsisten. Protokol kemoterapi di Indonesia saat ini menggunakan protokol LLA 2018 yang berbeda dari protokol sebelumnya. Tujuan. Penelitian ini bertujuan mengetahui perbedaan kadar malondialdehid sebelum dan sesudah kemoterapi fase induksi pada anak dengan limfoblastik leukemia akut. Metode. Penelitian ini merupakan penelitian kohort prospektif dengan subjek penelitian anak berusia >1 bulan hingga 18 tahun dengan LLA yang mendapat pengobatan di Rumah Sakit Umum Pusat Prof. dr. IGN Gde Ngoerah dari bulan Juli 2021 hingga September 2022. Uji Wilcoxon digunakan untuk menilai perbedaan kadar malondialdehid sebelum dan sesudah kemoterapi fase induksi. Tingkat signifikansi ditentukan dengan nilai p

Aim: The study aims to identify the effect of symptoms experienced by patients undergoing chemotherapy treatment on their self-care behaviors. Material and Methods: The population of the descriptive study consists of 182 patients receiving treatment in the chemotherapy unit of a provincial center in eastern Turkey; the sample consisted of 125 patients. Research data were collected by the researchers through face-to-face interviews using the Descriptive Information Form, Memorial Symptom Assessment Scale, and Self-Care Behaviors Scale. Number, percentage, average, minimummaximum scores, standard deviation, skewness, kurtosis values, Pearson correlation, and regression analysis were used to evaluate the data. Results: The mean total score of the Self-Care Behaviors Scale was 63.67±15.33, and the mean total score of the Memorial Symptom Assessment Scale was 0.89±0.49 in patients receiving chemotherapy. The three most common symptoms were fatigue (81.6%), dry mouth (63.2%), and numbness/tingling in the hands and feet (58.4%). There was a moderate, negative, and statistically significant correlation between the patients' Memorial Symptom Assessment Scale and the Self-Care Behavior Scale total scores (p<0.05). Conclusions: It was found that symptoms experienced by the patients affected their self-care behaviors, and these behaviors were found to decrease as symptoms experienced increased. [ABSTRACT FROM AUTHOR]

Copyright of Journal of Health & Life Sciences / Sağlık ve Yaşam Bilimleri Dergisi is the property of Istanbul Kultur University and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Current Retina Journal / Güncel Retina Dergisi is the property of Anadolu Kitabevi Basim Yayim Medikal Turizm Kirtasiye Tic. Ltd. Sti. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective: Potentially inappropriate medications (PIM) is a crucial problem in the geriatric population. The amount of prescription and unadherence increase because of the different problems encountered in cancer patients. Our aim was to evaluate the effects of PIM in patients with gastrointestinal system cancer and to investigate its relationship with chemotherapy side effects, mortality, and progression. Methods: This retrospective cohort study assessed 154 patients with gastrointestinal system cancer. Demographics and disease features, the presence of PIM according to the “TIME-to-STOP” criteria and baseline laboratory parameters were recorded. The effects of PIM on survival and adverse treatment events were evaluated. Results: 66.9% of the cases were male and 33.1% were female. The mean age was 71.9±6.4 years. The most common side effects of chemotherapy are nausea, vomiting, kidney injury, and pain. The most frequently used prescriptions among the 98 PIMs were gliclazide, hyoscine N-butylbromide, simethicone, diphenoxylate atropine, and thiocolchicoside. PIM was detected in 68.1% of the participants. Chemotherapy side effects were more common in PIM group (p<0.001, odds ratio =5.6). PIM had no effect on mortality. Factors associated with mortality were age, stage, albumin, creatinine, operation history, and progression. A significant relationship was found between age, cancer stage, albumin, creatinine, operation history, and PIM in the regression model. There was no relationship between PIM and progression-free survival. Conclusion: Chemotherapy toxicity may increase with PIM detected on diagnosis. We suggest that PIM is an important factor in predicting the side effects of chemotherapy and minimizing the adverse effects. [ABSTRACT FROM AUTHOR]

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Introduction: Chemotherapeutic agents used in the treatment of leukemia patients may cause toxic effects in the liver where they are metabolized. Ursodeoxycholic acid (UDCA) is used because of its hepatoprotective effect in the treatment of drug-induced liver toxicity. This study investigated the efficacy of UDCA use, despite the effect of UDCA on tumor cells being unknown, in the treatment of liver toxicity in pediatric patients on chemotherapy for leukemia.Methods: Data from pediatric leukemia patients, who were on maintenance therapy and developed liver toxicity, were retrospectively analyzed. Patients were divided into three groups and the results were compared regarding development of liver toxicity. Patients who were not given UDCA and whose chemotherapy (CT) treatment was interrupted were defined as Group 1, patients who were given UDCA and whose CT was interrupted were defined as Group 2, and patients who were given UDCA and continued CT were defined as Group 3. Results: The study cohort numbered 119 patients, of whom 64 were included in Group 1, 26 patients were in Group 2 and 29 patients were included in Group 3. The mean age of the patients was 6.29±3.03 years and 57.1% of them were male. In Group 1, alanine aminotransferase (ALT) decreased to lt;100 IU/L so UDCA was interrupted, and CT could be rechallenged in 85.9%, in Group 2 this proportion was 100%, and in 69.2% of patients in Group 3, respectively. While there was no significant difference between Group 1 versus Group 2 and Group 1 versus Group 3, a significant difference was found between Group 2 and Group 3 (p=0.005). There were no patients in any group with a bilirubin level of gt;3 mg/dL. Duration for normalization of ALT and aspartate aminotransferase levels were similar. Conclusions: The most effective treatment for chemotherapy-induced liver toxicity in pediatric patients with leukemia seems to be to interrupt CT. It was noteworthy that UDCA administration without interruption of CT treatment, the source of the liver toxicity, was effective in 69.2% of patients. Further and comprehensive studies are needed to evaluate the role of UDCA in hepatoprotection in these patients.Keywords: Ursodeoxycholic acid; leukemia; chemotherapy; hepatotoxicity

Copyright of Journal of Ege University School of Dentistry / Ege Üniversitesi Dis Hekimligi Fakültesi Dergisi is the property of Ege University Faculty of Dentistry and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Jurnal Veteriner is the property of Fakultas Kedokteran Hewan, Universitas Udayana and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Mual dan muntah merupakan efek samping kemoterapi yang paling umum. Upaya untuk mengatasinya menggunakan terapi farmakologi dan non farmakologi. Mual dan muntah akibat kemoterapi dapat beribeikan aromaterapi peppermint. Studi ini bertujuan untuk mengetahui pengaruh pemberian aromaterapi Peppermint terhadap frekuensi mual dan muntah. Studi ini menggunakan deskriptif dengan pendekatan asuhan keperawatan yang melibatkan 3 subjek. Pengambilan data dilakukan secara accidental sampling. Kriteria inklusi meliputi pasien yang menerima kemoterapi regimen FOLFOX dan mendapatkan antiemetik yang sama yaitu Ondansetron 8mg/8jam. Aromaterapi di berikan dengan cara meneteskan 1 tetes minyak aromaterapi peppermint dan dioleskan diantara hidung dan bibir, aromaterapi peppermint diberikan 3x sehari setelah selesainya efek antiemetik. Studi kasus berlangsung dari tanggal 25 – 28 Desember 2023. Instrumen pengukuran menggunakan The Index of Nausea, Vomiting, and Retching (INRV) untuk mengobservasi frekuensi mual muntah pasca kemoterapi. Hasil evaluasi didapatkan adanya penurunan frekuensi mual dan muntah pada ketiga subjek studi kasus setelah pemberian aromaterapi peppermint. Hasil menunjukkan rerata skor INVR subjek 1 sebesar 14, subjek 2 sebesar 10,75 dan subjek 3 sebesar 10. Rata-rata penurunan skor INVR ketiga subjek sebesar 3 skor. Masalah keperawatan nausea berhubungan dengan efek agen farmakologis (tindakan pengobatan kemoterapi) teratasi sebagian ditandai dengan penurunan skor mual dan muntah. Molekul essensial oil dari aromaterapi Peppermint akan memberikan efek relaks dan tenang, efek lain juga dapat menghambat produksi serotonin sehingga dapat mengurangi kontraksi otot perut dan gejala mual muntah akan berkurang. Aromaterapi pappermint mampu mengurangi mual dan muntah paska kemoterapi.

Copyright of Turkiye Klinikleri Journal of Nursing Sciences is the property of Turkiye Klinikleri and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Ege Journal of Medicine is the property of Ege University, Faculty of Medicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Izmir Katip Celebi University Faculty of Health Sciences Journal / İzmir Katip Çelebi Üniversitesi Sağlık Bilimleri Fakültesi Dergisi is the property of Izmir Katip Celebi University, Faculty of Health Sciene Journal and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Ege University Nursing Faculty (JEUNF) is the property of Journal of Ege University Nursing Faculty (JEUNF) and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Docetaxel is a chemotherapy drug for breast cancer. Chemotherapy can cause various side effects. This study aims to provide an overview of the side effects of non-hematological and hematological drugs from the use of docetaxel chemotherapy. The non-hematological side effects observed included dermatological disorders, endocrine and metabolic disturbances, and gastrointestinal-related disorders. While the observed hematological side effects included anemia, thrombocytopenia, leukopenia, and neutropenia. The study used a cross-sectional design with prospective data collection on 45 patients undergoing a docetaxel chemotherapy regimen with a dose of 100 mg/m2 at Bhayangkara Hospital, Kediri from January 2022 - March 2023. Data collection was carried out through medical records and then identification of drug side effects was carried out through pharmacist discussion with a consultant clinician in oncology. Data evaluation was carried out descriptively in the form of percentages. The most common non-hematological side effects were hair loss, which reached 80%, followed by skin hypersensitivity reactions, which reached 73.3%, and nail changes, which reached 48.9%. At the mild severity level (grade 1), skin hypersensitivity reactions were the highest at 73.3%, followed by hair loss at 64.4%. The most significant hematological side effect is anemia. Patients experienced anemia with grade 1 as much as 37.3% and 2.2% occurred in grade 2. The side effects of docetaxel that occurred in this study were overall in the mild (grade 1) and moderate (grade 2) categories. Most patients can still tolerate the symptoms of side effects that arise. Monitoring of drug side effects and prompt management of symptoms is necessary to reduce the severity and improve patient quality of life.

Latar Belakang: Kemoterapi pada pasien keganasan payudara dapat menyebabkan gangguan kognitif. Sebuah studi menjelaskan bahwa terdapat 65% pasien dengan keganasan payudara mengalami gangguan kognitif akut dan 60% dari mereka mengalami penurunan kognitif terlambat Objektif: Mengetahui gambaran fungsi kognitif pada penderita keganasan payudara yang menjalani kemoterapi di RSUP Dr. M. Djamil Padang. Metode: Penelitian ini adalah penelitian deskriptif dengan desain cross-sectional. Pengambilan sampel dilakukan dengan teknik simple random sampling sebanyak 44 orang. Penelitian ini berlangsung dari Maret 2020-Januari 2021. Hasil: Sebanyak 75% subjek penelitian mengalami gangguan kognitif. Gangguan kognitif paling banyak ditemukan pada kelompok usia pertengahan dan pada tingkat pendidikan rendah, yaitu 100%. Gangguan kognitif mulai ditemukan pada kemoterapi kedua, paling banyak ditemukan pada kemoterapi ketiga dan keempat (18,2 %). Gangguan kognitif terjadi pada semua obat kemoterapi dan paling banyak ditemukan pada penggunaan obat kombinasi CAF. Kesimpulan: Gangguan kognitif terbanyak ditemukan pada usia pertengahan dengan tingkat pendidikan yang rendah, pada subjek yang menjalani kemoterapi yang ketiga dan keempat, serta pada pemberian terapi kombinasi 5-Flourouracil-Doxorubicin-Cyclophosphamide

Introduction: Organ toxicity is common in childhood cancers and can cause delays in chemotherapy and worsening of prognosis. In this study, we aimed to evaluate organ toxicities, biochemical and metabolic abnormalities associated with the tumor and/or chemotherapy in the acute phase of treatment in children with cancer. Materials and Methods: The data of 305 patients with lymphoma and solid tumors who received chemotherapy between 01.01.2010 and 31.12.2015 in a tertiary healthcare facility were retrospectively evaluated. The effects of age, gender, cancer stage, chemotherapy group, surgery and radiotherapy on organ toxicity in the first 30 days of treatment were analyzed. Results: The mean age of the patients at admission was 97 months, and the male/ female ratio was 1.5. The most common diagnoses were lymphomas (27.6%), CNS and spinal canal tumors (12.5%) and neuroblastoma (11.8%). Chemotherapy was applied to all the patients, surgery to 61.3% (n=187), and radiotherapy to 13.1% (n=40). Organ toxicity was detected in 59% (n=180) of the patients. The use of alkylating agents, antimetabolites, plant products, and no surgery were risk factors for hepatotoxicity (p<0.05). The only risk factor for nephrotoxicity was antimetabolite drug use (p<0.05). The most common electrolyte disorder was hyponatremia, observed in 56.7% (n=173) of the patients. Two patients died during the study period, which were not due to organ toxicity, metabolic disease, or electrolyte disturbance. Conclusion: The rate of organ toxicity as well as biochemical, electrolyte, and metabolic abnormalities were found to be high. These high rates were thought to be related to the excessive tumor burden and organ involvement and the intensity of the combined chemotherapies applied. No associated mortality was observed despite these high rates. Early detection of these pathologies, close follow-up and immediate treatment with the multidisciplinary approach to treatment were described as the reason for the absence of mortality. [ABSTRACT FROM AUTHOR]

Introduction: Acute leukemias are the most common malignancy of childhood, and acute lymphoblastic leukemia (ALL) is the most common subtype. In this study; we aimed to asses to acute endocrine and metabolic complications which occurs during treatment. Newly diagnosed ALL patients were included in the study. Materials and Methods: The endocrine and metabolic complication of 293 patients aged 1-18 years old who were newly diagnosed ALL between January 2007 and December 2017 in Uludağ University Faculty, Department of Pediatric Hematology were analyzed. Patients' age, gender, risk groups, leukemia subtypes, and chemotherapy phases at the time of endocrine complications were noted. Results: In total, 250 patients were follow-up with B-ALL and 43 patients with T-ALL. 64% (n=188) of patients were male and 36% (n=105) were female. In our study, 36.4% of patients were in the high risk group but ten of the patients died before the risk group could be determined. During the two-year treatment, We found that 83% of the patients developed at least one endocrine complication. Hyperglycemia, osteoporosis and avascular necrosis were observed more frequently in patients older than 10 years at the time of diagnosis. The difference between the sexes was found only in vitamin D and was lower in girls. In regression analysis, only to be high risk group were found to be effective for the development of endocrine complications. Conclusion: Although the chemotherapeutics used today have prolonged the survival time, they have caused an increase in the incidence of complications. We think that these complications can be reduced by determining the risk factors in advance. [ABSTRACT FROM AUTHOR]

Chemotherapy induced peripheral neuropathy is a syndrome with distal symmetrical sensorial-dominant pain, tingling and numbness caused by neurotoxic chemotherapeutic agents. The severity increases with cumulative doses of chemotherapy, besides decrease in quality of life, may lead to cessation of treatment which may effect survival. Neurotoxicity causes large fiber and small fiber neuropathy through many pathologic mechanisms including mitochondrial dysfunction and oxidative stress. Dose related neuropathic pain is most commonly seen with taxanes, platins, vinca alkaloids, bortezomib and brentuximab. There is a limited effect of anticonvulsant and antidepressant medication for treatment. In this review awareness about chemotherapy induced peripheral neuropathy, prevention and treatment are discussed. [ABSTRACT FROM AUTHOR]

Copyright of Turkiye Klinikleri Journal of Nursing Sciences is the property of Turkiye Klinikleri and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Turkiye Klinikleri Journal of Nursing Sciences is the property of Turkiye Klinikleri and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Kemoterapi merupakan salah satu penatalaksanaan medis untuk mengendalikan proliferasi sel kanker. Kemoterapi dilakukan dengan memberikan bahan kimia melalui oral atau intravena. Agen kemoterapi bersifat sitotoksik dan menghasilkan efek samping berupa mual dan muntah. Penanganan mual dan muntah akibat kemoterapi dengan memberikan terapi non farmakologi berupa pemberian aromaterapi jahe. Tujuan studi kasus untuk mengetahui pengaruh pemberian aromaterapi jahe terhadap skor mual dan muntah. Metode studi kasus yang digunakan adalah deskriptif dengan pendekatan asuhan keperawatan yang melibatkan 2 subjek yaitu klien yang menjalani kemoterapi dengan gejala mual dan muntah. Terapi ini dilakukan sebanyak 3 kali dalam 3 hari dengan lama pemberian 10 menit. Hasil evaluasi didapatkan adanya penurunan skor mual dan muntah kedua subjek studi kasus setelah pemberian aromaterapi jahe. Rerata penurunan skor mual subjek 1 sebesar 1 skor dan subjek 2 sebesar 1,3 skor. Terjadi rerata penurunan skor muntah subjek 1 sebesar 0,6 skor dan subjek 2 sebesar 1,6 skor. Masalah keperawatan nausea berhubungan dengan efek agen farmakologis (tindakan pengobatan kemoterapi) teratasi sebagian ditandai dengan penurunan skor mual dan muntah serta keluhan ketidaknyamanan pasien. Molekul essensial oil dari aromaterapi jahe akan menghambat produksi serotonin yang akan menurunkan kontraksi otot perut sehingga keluhan mual dan muntah dapat berkurang. Berdasarkan kesimpulan tersebut saran yang dapat diberikan yaitu mengajarkan dan meningkatkan partisipasi keluarga dalam menurunkan keluhan mual dan muntah pada klien yang menjalani kemoterapi.

Purpose: The goal of this study is to explain the characteristics of COVID-19 in this demographic, as well as the impact it had on pediatric cancer care during the pandemic. Materials and Methods: Fifteen COVID-19 patients diagnosed were studied retrospectively. Clinical, laboratory and radiological data were collected in relation to 15 patients under the age of 18 who tested positive for Sars-CoV-2. Results: Of the 12117 pediatric hemato-oncological patients tested for COVID-19, 1125 patients showed symptoms, and 14 tested positive. The majority of cases suffered minor illnesses. A total of ten children required inpatient care, five needed oxygen support, and four required mechanical ventilation and later died. It was noted that the duration of real-time polymerase chain reaction (RT-PCR) positivity was prolonged in patients receiving intensive chemotherapy and/or immunosuppressive therapy. Patients’ chemotherapy was delayed in all 15 (100%) Sars-CoV-2-positive patients. Although changes visible on chest computed tomography (CT) imaging of children were mainly milder than in adults, radiological findings were more severe in patients who received relatively intensive cancer treatment. Conclusion: Children who have been treated for cancer or who have undergone a hematopoietic stem cell transplantation (HSCT) may be at greater risk of severe COVID-19 and should be under constant observation.

ABSTRAK Pendahuluan: Mukositis oral merupakan efek samping perawatan kemoterapi dan/atau radioterapi untuk perawatan kanker kepala dan leher yang mengganggu asupan gizi sehingga menurunkan kualitas hidup pasien. Laporan kasus ini bertujuan untuk mengevaluasi faktor risiko yang memengaruhi keparahan dan perawatan mukositis oral dua pasien anak dan dewasa kanker kepala dan leher yang menjalani radioterapi dan kemoterapi. Laporan kasus: Kasus pertama, perempuan usia 15 tahun dengan kanker nasofaring stadium II (KNF) yang menjalani kemoterapi siklus ke-3. Pemeriksaan intraoral didapatkan lesi ulserasi dan eritema pada mukosa labial atas dan bawah dan oral hygiene (OH) baik. Kasus kedua, perempuan usia 42 tahun dengan kanker sinonasal stadium III post hemimaksilektomi yang menjalani radioterapi siklus ke-17. Pemeriksaan ekstraoral didapatkan fisur eritema pada sudut mulut. Pemeriksaan intraoral ditemukan ulser multipel dan erosi pada mukosa labial, palatum dan dorsum lidah serta OH yang buruk. Diagnosis lesi oral kasus pertama yaitu mukositis oral tingkat II dan kasus kedua yaitu mukositis oral tingkat III. Pasien pertama diberikan larutan NaCl 0,9% dan hidrokortison salep. Pasien kedua diberikan diphenhydramine, nystatin, klorheksidin diglukonat, dan parasetamol. Kedua pasien menunjukkan penyembuhan yang baik setelah terapi awal. Faktor risiko keparahan mukositis oral kedua kasus ialah usia, jenis kelamin, kebersihan mulut, tipe dan stadium kanker, agen kemoterapi, daerah radiasi, fraksionasi, frekuensi, dosis kumulatif dan volume mukosa teradiasi. Simpulan: Perbedaan tingkat mukositis oral yang terjadi pada dua kasus pada laporan ini dapat dikarenakan perbedaan usia, tingkat oral hygiene, dosis kemoterapi maupun radioterapi, dan stadium kanker pada pasien. Evaluasi faktor risiko dan tindakan preventif diperlukan pada pasien yang menjalani kemoterapi ataupun radioterapi guna terhindar dari mukositis oral yang parah dan dapat menurunkan kualitas hidup. Kata kunci: faktor risiko; kemoterapi; mucositis; radioterapi; kanker ABSTRACT Introduction: Oral mucositis is a side effect of chemotherapy and radiotherapy for treating head and neck cancer that interferes with nutritional intake, thereby reducing the patient's quality of life. This case report evaluates the risk factors influencing the severity and treatment of oral mucositis in two pediatric and adult head and neck cancer patients undergoing radiotherapy and chemotherapy. Case report: The first case was a 15-year-old woman with stage II nasopharyngeal cancer (NPC) who underwent third cycle chemotherapy. Intraoral examination revealed ulcerated and erythematous lesions on the upper and lower labial mucosa and good oral hygiene (OH). The second case was a 42-year-old woman with stage III sinonasal cancer after hemimaxillectomy who underwent radiotherapy in the 17th cycle. Extraoral examination revealed an erythematous fissure at the corners of the mouth. Intraoral examination revealed multiple ulcers and erosions on the tongue's labial, palate, and dorsum and poor OH. In the first case, the diagnosis of oral lesions was grade II oral mucositis and in the second case was grade III oral mucositis. The first patient was given 0.9% NaCl solution and hydrocortisone ointment. The second patient was given diphenhydramine, nystatin, chlorhexidine digluconate, and paracetamol. Both patients showed good recovery after initial therapy. The risk factors for the severity of oral mucositis in both cases were age, sex, oral hygiene, type and stage of cancer, chemotherapeutic agents, radiation area, fractionation, frequency, cumulative dose and volume of irradiated mucosa. Conclusions: The difference in the level of oral mucositis that occurred in the two cases in this report could be due to differences in age, level of oral hygiene, doses of chemotherapy and radiotherapy, and stage of cancer in patients. Evaluation of risk factors and preventive measures are needed in patients undergoing chemotherapy or radiotherapy to avoid severe oral mucositis and reduce the quality of life. Keywords: risk factors; chemotherapy; mucositis; radiotherapy; cancer

Copyright of Türk Radyoloji Seminerleri is the property of Galenos Yayinevi Tic. LTD. STI and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Ege University Nursing Faculty (JEUNF) is the property of Journal of Ege University Nursing Faculty (JEUNF) and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)