5 results on '"Kelsey Lamb"'
Search Results
2. Regional Asthma Management and Prevention in California
- Author
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Anne Kelsey Lamb, Jessica K. Peters, and Joel Ervice
- Subjects
Pulmonary and Respiratory Medicine ,Child care ,business.industry ,Psychological intervention ,Clinical settings ,Asthma management ,medicine.disease ,respiratory tract diseases ,Work (electrical) ,Environmental health ,Pediatrics, Perinatology and Child Health ,Immunology and Allergy ,Medicine ,Policy advocacy ,business ,Environmental planning ,Asthma - Abstract
In this article, authors describe the work of Regional Asthma Management and Prevention (RAMP) in developing a comprehensive model for reducing the burden of asthma through the integration of clinical management and environmental protection. Over the past 15 years, RAMP grew a small legal settlement involving air pollution into a nationally recognized asthma program. RAMP collaborates, coordinates, shares resources, advocates, and promotes policy change to reduce inequities, strengthen asthma prevention efforts, and improve management for all communities. RAMP's 4 functions-provide technical assistance, serve as a clearinghouse, serve as a convener, and lead policy advocacy efforts-have provided an important structure for implementing a broad and comprehensive program aimed at reducing the burden of asthma. RAMP has demonstrated that asthma interventions must take place in numerous settings including clinical settings, homes, schools, child care, and outdoor environments and that, to reduce asthma disparities, organizations need to understand and address the environmental and social inequities that contribute to those disparities. RAMP has also seen firsthand the importance of community asthma coalitions in addressing the problem of asthma and the way that these coalitions benefit from the support of an organization like RAMP. RAMP has created a framework for reducing the burden of asthma that ties together the knowledge gained over 15 years and provides a model for other organizations.
- Published
- 2022
3. Reducing Asthma Disparities by Addressing Environmental Inequities
- Author
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Anne Kelsey Lamb, Kathryn Lorenzen, Shannon White, Bob Prentice, and Joel Ervice
- Subjects
Health Knowledge, Attitudes, Practice ,Conservation of Energy Resources ,Health Promotion ,Asthma management ,Community Networks ,Interpersonal relationship ,Organizational Case Studies ,Environmental health ,Humans ,Medicine ,Interpersonal Relations ,Healthcare Disparities ,Policy outcomes ,Asthma ,African american ,Asthma therapy ,business.industry ,Public Health, Environmental and Occupational Health ,Health Care Coalitions ,Hispanic or Latino ,medicine.disease ,Community-Institutional Relations ,respiratory tract diseases ,Black or African American ,Work (electrical) ,Environmental Pollution ,business ,Gasoline - Abstract
Regional Asthma Management and Prevention describes its collaborative approach to address a social determinant of health--air quality--and the associated inequities that have led to asthma disparities impacting African American and Latino communities in the San Francisco Bay Area. The strategies, aimed at decreasing diesel pollution in disproportionately impacted communities, span the levels of the socioecological model, with an emphasis on policy outcomes. Regional Asthma Management and Prevention describes how this work fits within a larger comprehensive approach to address asthma disparities encompassing several components, ranging from clinical management to environmental protection.
- Published
- 2011
- Full Text
- View/download PDF
4. Swimming upstream: the challenges and rewards of evaluating efforts to address inequities and reduce health disparities
- Author
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Dana Hughes, Jessica K. Peters, Lindsay Docto, Claire D. Brindis, and Anne Kelsey Lamb
- Subjects
Research design ,Economic growth ,medicine.medical_specialty ,Social Psychology ,Strategy and Management ,Geography, Planning and Development ,Psychological intervention ,Ethnic group ,Environment ,Political science ,medicine ,Humans ,Business and International Management ,Health policy ,Data collection ,Equity (economics) ,Public economics ,Public health ,Data Collection ,Health Policy ,Racial Groups ,Public Health, Environmental and Occupational Health ,Health Status Disparities ,Health equity ,Asthma ,United States ,Socioeconomic Factors ,Research Design ,Data Interpretation, Statistical ,Program Evaluation - Abstract
Racial and ethnic disparities in the health of Americans are widespread and persistent in the United States despite improvements in the health of Americans overall. Increasingly, strategies for reducing disparities have focused on addressing the factors that contribute to - if not fundamentally underlie - health disparities: social, economic, and environmental inequities, which limit access to resources and cause unhealthy exposures. As public health shifts to interventions that seek to improve the circumstances of disproportionately affected populations and achieve equity through policy change, alternative methods to evaluate these efforts are also required. This paper presents an example of such approaches to addressing asthma disparities through Regional Asthma Management and Prevention's (RAMP) programmatic efforts and an evaluation of these activities. The paper describes RAMP's targets and strategies, as well as the specific evaluation methods applied to each, including activity tracking, observations, surveys, key informant interviews, and case studies. Preliminary evaluation findings are presented, as are lessons learned about the efficacy of the evaluation design features - both its strengths and shortcomings. Findings discussed are intended to contribute to the growing literature that provides evidence for the application of emerging approaches to evaluation that reflect non-traditional public health and support others interested in expanding or replicating this work.
- Published
- 2011
5. Cisplatin induces mitochondrial deficits in Drosophila larval segmental nerve
- Author
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Jewel L. Podratz, Han Lee, Patrizia Knorr, Stephanie Koehler, Steven Forsythe, Kelsey Lambrecht, Suzette Arias, Kiley Schmidt, Gabrielle Steinhoff, Georgiy Yudintsev, Amy Yang, Eugenia Trushina, and Anthony Windebank
- Subjects
Mitochondria ,Cisplatin ,Motor neuron ,Drosophila ,Axonal trafficking ,Membrane potential ,Neurosciences. Biological psychiatry. Neuropsychiatry ,RC321-571 - Abstract
Cisplatin is an effective chemotherapy drug that induces peripheral neuropathy in cancer patients. In rodent dorsal root ganglion neurons, cisplatin binds nuclear and mitochondrial DNA (mtDNA) inducing DNA damage and apoptosis. Platinum-mtDNA adducts inhibit mtDNA replication and transcription leading to mitochondrial degradation. Cisplatin also induces climbing deficiencies associated with neuronal apoptosis in adult Drosophila melanogaster. Here we used Drosophila larvae that express green fluorescent protein in the mitochondria of motor neurons to observe the effects of cisplatin on mitochondrial dynamics and function. Larvae treated with 10 μg/ml cisplatin had normal survival with deficiencies in righting and heat sensing behavior. Behavior was abrogated by, the pan caspase inhibitor, p35. However, active caspase 3 was not detected by immunostaining. There was a 27% decrease in mitochondrial membrane potential and a 42% increase in reactive oxygen species (ROS) in mitochondria along the axon. Examination of mitochondrial axonal trafficking showed no changes in velocity, flux or mitochondrial length. However, cisplatin treatment resulted in a greater number of stationary organelles caused by extended pausing during axonal motility. These results demonstrate that cisplatin induces behavior deficiencies in Drosophila larvae, decreased mitochondrial activity, increased ROS production and mitochondrial pausing without killing the larvae. Thus, we identified particular aspects of mitochondrial dynamics and function that are affected in cisplatin-induced peripheral neuropathy and may represent key therapeutic targets.
- Published
- 2017
- Full Text
- View/download PDF
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