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23 results on '"Kelsey, Tom W."'

5. Performance of plasma kisspeptin as a biomarker for miscarriage improves with gestational age during the first trimester

Author

Abbara, Ali, Al-Memar, Maya, Phylactou, Maria, Kyriacou, Christopher, Eng, Pei Chia, Nadir, Rans, Izzi-Engbeaya, Chioma, Clarke, Sophie A., Mills, Edouard G., Daniels, Elisabeth, Huo, Lechun, Pacuszka, Ewa, Yang, Lisa, Patel, Bijal, Tan, Tricia, Bech, Paul, Comninos, Alexander N., Fourie, Hanine, Kelsey, Tom W., Bourne, Tom, and Dhillo, Waljit S.

Published
2021
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10. Changes in Circulating Kisspeptin Levels During Each Trimester in Women With Antenatal Complications

Author

Abbara, Ali, primary, Al-Memar, Maya, additional, Phylactou, Maria, additional, Daniels, Elisabeth, additional, Patel, Bijal, additional, Eng, Pei C, additional, Nadir, Rans, additional, Izzi-Engbeaya, Chioma, additional, Clarke, Sophie A, additional, Mills, Edouard G, additional, Hunjan, Tia, additional, Pacuszka, Ewa, additional, Yang, Lisa, additional, Bech, Paul, additional, Tan, Tricia, additional, Comninos, Alexander N, additional, Kelsey, Tom W, additional, Kyriacou, Christopher, additional, Fourie, Hanine, additional, Bourne, Tom, additional, and Dhillo, Waljit S, additional

Published
2021
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14. Changes in Circulating Kisspeptin Levels During Each Trimester in Women With Antenatal Complications.

Author

Abbara, Ali, Al-Memar, Maya, Phylactou, Maria, Daniels, Elisabeth, Patel, Bijal, Eng, Pei C., Nadir, Rans, Izzi-Engbeaya, Chioma, Clarke, Sophie A., Mills, Edouard G., Hunjan, Tia, Pacuszka, Ewa, Yang, Lisa, Bech, Paul, Tan, Tricia, Comninos, Alexander N., Kelsey, Tom W., Kyriacou, Christopher, Fourie, Hanine, and Bourne, Tom

Subjects
KISSPEPTINS, GESTATIONAL diabetes, PREGNANCY, FETAL growth retardation, PREMATURE labor, MATERNAL age, MEDIAN (Mathematics)
Abstract

Context: Antenatal complications such as hypertensive disorders of pregnancy (HDP), fetal growth restriction (FGR), gestational diabetes (GDM), and preterm birth (PTB) are associated with placental dysfunction. Kisspeptin has emerged as a putative marker of placental function, but limited data exist describing circulating kisspeptin levels across all 3 trimesters in women with antenatal complications. Objective: We aimed to assess whether kisspeptin levels are altered in women with antenatal complications. Methods: Women with antenatal complications (n = 105) and those with uncomplicated pregnancies (n = 265) underwent serial ultrasound scans and blood sampling at the Early Pregnancy Assessment Unit at Hammersmith Hospital, UK, at least once during each trimester (March 2014 to March 2017). The women with antenatal complications (HDP [n = 32], FGR [n = 17], GDM [n = 35], PTB [n = 11], and multiple complications [n=10]) provided 373 blood samples and the controls provided 930 samples. Differences in circulating kisspeptin levels were assessed. Results: Third-trimester kisspeptin levels were higher than controls in HDP but lower in FGR. The odds of HDP adjusted for gestational age, maternal age, ethnicity, BMI, smoking, and parity were increased by 30% (95% CI, 16%-47%; P < 0.0001), and of FGR were reduced by 28% (95% CI, 4-46%; P = 0.025), for every 1 nmol/L increase in plasma kisspeptin. Multiple of gestation-specific median values of kisspeptin were higher in pregnancies affected by PTB (P = 0.014) and lower in those with GDM (P = 0.020), but not significantly on multivariable analysis. Conclusion: We delineate changes in circulating kisspeptin levels at different trimesters and evaluate the potential of kisspeptin as a biomarker for antenatal complications. [ABSTRACT FROM AUTHOR]

Published
2022
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15. Pharmacodynamic Response to Anti-thyroid Drugs in Graves' Hyperthyroidism

Author

Abbara, Ali, primary, Clarke, Sophie A., additional, Brewster, Rosalind, additional, Simonnard, Alexia, additional, Eng, Pei Chia, additional, Phylactou, Maria, additional, Papadopoulou, Deborah, additional, Izzi-Engbeaya, Chioma, additional, Sam, Amir H., additional, Wernig, Florian, additional, Jonauskyte, Eliza, additional, Comninos, Alexander N., additional, Meeran, Karim, additional, Kelsey, Tom W., additional, and Dhillo, Waljit S., additional

Published
2020
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16. Kisspeptin as a novel biomarker for pregnancy complications

Author

Phylactou, Maria, primary, Abbara, Ali, additional, Al-Memar, Maya, additional, Eng, Pei Chia, additional, Comninos, Alexander N, additional, Izzi-Engbeaya, Chioma, additional, Clarke, Sophie A, additional, Mills, Edouard, additional, Nadir, Rans, additional, Sykes, Mark, additional, Pacuszka, Ewa, additional, Yang, Lisa, additional, Fourie, Hanine, additional, Bech, Paul, additional, Kelsey, Tom W, additional, Bourne, Tom, additional, and Dhillo, Waljit S, additional

Published
2019
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18. FSH Requirements for Follicle Growth During Controlled Ovarian Stimulation

Author

Abbara, Ali, primary, Patel, Aaran, additional, Hunjan, Tia, additional, Clarke, Sophie A., additional, Chia, Germaine, additional, Eng, Pei Chia, additional, Phylactou, Maria, additional, Comninos, Alexander N., additional, Lavery, Stuart, additional, Trew, Geoffrey H., additional, Salim, Rehan, additional, Rai, Raj S., additional, Kelsey, Tom W., additional, and Dhillo, Waljit S., additional

Published
2019
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21. Follicle Size on Day of Trigger Most Likely to Yield a Mature Oocyte

Author

Abbara, Ali, primary, Vuong, Lan N., additional, Ho, Vu N. A., additional, Clarke, Sophie A., additional, Jeffers, Lisa, additional, Comninos, Alexander N., additional, Salim, Rehan, additional, Ho, Tuong M., additional, Kelsey, Tom W., additional, Trew, Geoffrey H., additional, Humaidan, Peter, additional, and Dhillo, Waljit S., additional

Published
2018
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22. Corrigendum to The physiology and clinical utility of anti-Müllerian hormone in women [Hum Reprod Update, 20 (2014) 370-385]

Author

Dewailly, Didier, Andersen, Claus Yding, Balen, Adam, Broekmans, Frank, Dilaver, Nafi, Fanchin, Renato, Griesinger, Georg, Kelsey, Tom W., La Marca, Antonio, Lambalk, Cornelius, Mason, Helen, Nelson, Scott M., Visser, Jenny A., Hamish Wallace, W., Anderson, Richard A., Obstetrics and gynaecology, ICaR - Ischemia and repair, and NCA - Brain mechanisms in health and disease

Subjects
Reproductive Medicine, Obstetrics and Gynecology
Published
2014

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