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20 results on '"Kelsey, Morris I."'

2. Erratum: Clinical Evaluation of Safety and Immunogenicity of PADRE-Cytomegalovirus (CMV) and Tetanus-CMV Fusion Peptide Vaccines With or Without PF03512676 Adjuvant

Author

La Rosa, Corinna, Longmate, Jeff, Lacey, Simon F., Kaltcheva, Teodora, Sharan, Rahul, Marsano, Denise, Kwon, Peter, Drake, Jennifer, Williams, Brenda, Denison, Sharon, Broyer, Suenell, Couture, Larry, Nakamura, Ryotaro, Dadwal, Sanjeet, Kelsey, Morris I., Krieg, Arthur M., Diamond, Don J., and Zaia, John A.

Published
2013
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3. Clinical Evaluation of Safety and Immunogenicity of PADRE-Cytomegalovirus (CMV) and Tetanus-CMV Fusion Peptide Vaccines With or Without PF03512676 Adjuvant

Author

La Rosa, Corinna, Longmate, Jeff, Lacey, Simon F., Kaltcheva, Teodora, Sharan, Rahul, Marsano, Denise, Kwon, Peter, Drake, Jennifer, Williams, Brenda, Denison, Sharon, Broyer, Suenell, Couture, Larry, Nakamura, Ryotaro, Kelsey, Morris I., Krieg, Arthur M., Diamond, Don J., and Zaia, John A.

Published
2012
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4. Immunization With Mutant p53- and K-ras–Derived Peptides in Cancer Patients: Immune Response and Clinical Outcome

Author

Carbone, David P., Ciernik, I Frank, Kelley, Michael J., Smith, M Charles, Nadaf, Sorena, Kavanaugh, Denise, Maher, V Ellen, Stipanov, Michael, Contois, David, Johnson, Bruce E., Pendleton, C David, Seifert, Burkhardt, Carter, Charley, Read, Elizabeth J., Greenblatt, Jay, Top, Lois E., Kelsey, Morris I., Minna, John D., and Berzofsky, Jay A.

Published
2005
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7. Clinical Evaluation of Safety and Immunogenicity of PADRE-Cytomegalovirus (CMV) and Tetanus-CMV Fusion Peptide Vaccines With or Without PF03512676 Adjuvant.

Author

Rosa, Corinna La, Longmate, Jeff, Lacey, Simon F., Kaltcheva, Teodora, Sharan, Rahul, Marsano, Denise, Kwon, Peter, Drake, Jennifer, Williams, Brenda, Denison, Sharon, Broyer, Suenell, Couture, Larry, Nakamura, Ryotaro, Kelsey, Morris I., Krieg, Arthur M., Diamond, Don J., and Zaia, John A.

Subjects
IMMUNE response, CYTOMEGALOVIRUSES, TETANUS vaccines, T cells, EPITOPES, CYTOMETRY
Abstract

Background. It has been reported that cytomegalovirus (CMV) pp65-specific T cells can protect hematopoietic cell transplant (HCT) recipients from CMV complications. Two candidate CMV peptide vaccines composed of the HLA A*0201 pp65495-503 cytotoxic CD8+ T-cell epitope fused to 2 different universal T-helper epitopes (either the synthetic Pan DR epitope [PADRE] or a natural Tetanus sequence) were clinically evaluated for safety and ability to elicit pp65 T cells in HLA A*0201 healthy volunteers. Methods. Escalating doses (0.5, 2.5, 10 mg) of PADRE or Tetanus pp65495-503 vaccines with (30 adults) or without (28 adults) PF03512676 adjuvant were administered by subcutaneous injection every 3 weeks for a total of 4 injections. Results. No serious adverse events were reported, although vaccines used in combination with PF03512676 had enhanced reactogenicity. Ex vivo responses were detected by flow cytometry exclusively in volunteers who received the vaccine coadministered with PF03512676. In addition, using a sensitive in vitro stimulation system, vaccine-elicited pp65495-503 T cells were expanded in 30% of volunteers injected solely with the CMV peptides and in all tested subjects receiving the vaccines coinjected with PF03512676. Conclusions. Acceptable safety profiles and vaccine-driven expansion of pp65495-503 T cells in healthy adults support further evaluation of CMV peptide vaccines combined with PF03512676 in the HCT setting. [ABSTRACT FROM AUTHOR]

Published
2012
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20. La Rosa C et al (J Infect Dis 2012; 205:1294–304).

Author

Rosa, Corinna La, Longmate, Jeff, Lacey, Simon F., Kaltcheva, Teodora, Sharan, Rahul, Marsano, Denise, Kwon, Peter, Drake, Jennifer, Williams, Brenda, Denison, Sharon, Broyer, Suenell, Couture, Larry, Nakamura, Ryotaro, Dadwal, Sanjeet, Kelsey, Morris I., Krieg, Arthur M., Diamond, Don J., and Zaia, John A.

Subjects
CYTOMEGALOVIRUSES, TETANUS
Abstract

A correction to the article "Clinical Evaluation of Safety and Immunogenicity of PADRE-Cytomegalovirus (CMV) and Tetanus-CMV Fusion Peptide Vaccines With or Without PF03512676 Adjuvant" that was published in the 2012 issue is presented.

Published
2013
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