11 results on '"Kelly Barnett"'
Search Results
2. Epigenetic activation of the FLT3 gene by ZNF384 fusion confers a therapeutic susceptibility in acute lymphoblastic leukemia
- Author
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Xujie Zhao, Ping Wang, Jonathan D. Diedrich, Brandon Smart, Noemi Reyes, Satoshi Yoshimura, Jingliao Zhang, Wentao Yang, Kelly Barnett, Beisi Xu, Zhenhua Li, Xin Huang, Jiyang Yu, Kristine Crews, Allen Eng Juh Yeoh, Marina Konopleva, Chia-Lin Wei, Ching-Hon Pui, Daniel Savic, and Jun J. Yang
- Subjects
Science - Abstract
Different molecular subtypes defined by specific gene rearrangements have been described for acute lymphoblastic leukaemia (ALL). Here, the authors show that ZNF384 fusion activates FLT3 expression conferring a therapeutic vulnerability for ZNF384- rearranged ALL subtype.
- Published
- 2022
- Full Text
- View/download PDF
3. EFFECT OF A NOVEL ENGAGEMENT STRATEGY USING TWITTER ON TEST PERFORMANCE
- Author
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Amanda L. Webb, Adam Dugan, Woodrow Burchett, Kelly Barnett, Nishi Patel, Scott Morehead, Mark Silverberg, Christopher Doty, Brian Adkins, and Lauren Falvo
- Subjects
Social Media ,Medical Education ,Twitter ,Medicine ,Medical emergencies. Critical care. Intensive care. First aid ,RC86-88.9 - Abstract
Introduction: Medical educators in recent years have been using social media for more penetrance to technologically-savvy learners. The utility of using Twitter for curriculum content delivery has not been studied. We sought to determine if participation in a social media-based educational supplement would improve student performance on a test of clinical images at the end of the semester. Methods: 116 second-year medical students were enrolled in a lecture-based clinical medicine course, in which images of common clinical exam findings were presented. An additional, optional assessment was performed on Twitter. Each week, a clinical presentation and physical exam image (not covered in course lectures) were distributed via Twitter, and students were invited to guess the exam finding or diagnosis. After the completion of the course, students were asked to participate in a slideshow “quiz” with 24 clinical images, half from lecture and half from Twitter. Results: We conducted a one-way analysis of variance to determine the effect Twitter participation had on total, Twitter-only, and lecture-only scores. Twitter participation data was collected from the end-of-course survey and was defined as submitting answers to the Twitter-only questions “all or most of the time”, “about half of the time”, and “little or none of the time.” We found a significant difference in overall scores (p
- Published
- 2015
- Full Text
- View/download PDF
4. Sustained Minimal Residual Disease Negativity in Multiple Myeloma is Associated with Stool Butyrate and Healthier Plant-Based Diets
- Author
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Urvi A. Shah, Kylee H. Maclachlan, Andriy Derkach, Meghan Salcedo, Kelly Barnett, Julia Caple, Jenna Blaslov, Linh Tran, Amanda Ciardiello, Miranda Burge, Tala Shekarkhand, Peter Adintori, Justin Cross, Matthew J. Pianko, Kinga Hosszu, Devin McAvoy, Sham Mailankody, Neha Korde, Malin Hultcrantz, Hani Hassoun, Carlyn R. Tan, Sydney X. Lu, Dhwani Patel, Benjamin Diamond, Gunjan Shah, Michael Scordo, Oscar Lahoud, David J. Chung, Heather Landau, Saad Z. Usmani, Sergio Giralt, Ying Taur, C. Ola Landgren, Gladys Block, Torin Block, Jonathan U. Peled, Marcel R.M. van den Brink, and Alexander M. Lesokhin
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Healthy ,Cancer Research ,Neoplasm, Residual ,Diet, Vegetarian ,Oncology and Carcinogenesis ,Hematology ,Oral and gastrointestinal ,Article ,Diet ,Butyrates ,Rare Diseases ,Good Health and Well Being ,Vegetarian ,Oncology ,Clinical Research ,Residual ,Complementary and Integrative Health ,Neoplasm ,Humans ,Oncology & Carcinogenesis ,Diet, Healthy ,Multiple Myeloma ,Nutrition ,Cancer - Abstract
Purpose: Sustained minimal residual disease (MRD) negativity is associated with long-term survival in multiple myeloma. The gut microbiome is affected by diet, and in turn can modulate host immunity, for example through production of short-chain fatty acids including butyrate. We hypothesized that dietary factors affect the microbiome (abundance of butyrate-producing bacteria or stool butyrate concentration) and may be associated with multiple myeloma outcomes. Experimental Design: We examined the relationship of dietary factors (via a food frequency questionnaire), stool metabolites (via gas chromatography–mass spectrometry), and the stool microbiome (via 16S sequencing - α-diversity and relative abundance of butyrate-producing bacteria) with sustained MRD negativity (via flow cytometry at two timepoints 1 year apart) in myeloma patients on lenalidomide maintenance. The Healthy Eating Index 2015 score and flavonoid nutrient values were calculated from the food frequency questionnaire. The Wilcoxon rank sum test was used to evaluate associations with two-sided P < 0.05 considered significant. Results: At 3 months, higher stool butyrate concentration (P = 0.037), butyrate producers (P = 0.025), and α-diversity (P = 0.0035) were associated with sustained MRD negativity. Healthier dietary proteins, (from seafood and plants), correlated with butyrate at 3 months (P = 0.009) and sustained MRD negativity (P = 0.05). Consumption of dietary flavonoids, plant nutrients with antioxidant effects, correlated with stool butyrate concentration (anthocyanidins P = 0.01, flavones P = 0.01, and flavanols P = 0.02). Conclusions: This is the first study to demonstrate an association between a plant-based dietary pattern, stool butyrate production, and sustained MRD negativity in multiple myeloma, providing rationale to evaluate a prospective dietary intervention.
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- 2022
5. A Phase 2 Trial of Colesevelam for Lenalidomide-Associated Diarrhea
- Author
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Malin Hultcrantz, Hani Hassoun, Neha Korde, Sham Mailankody, Tala Shekarkhand, Miranda Burge, Kylee H Maclachlan, Dhwani Patel, Urvi A Shah, David J. Chung, Michael Scordo, Kelly Barnett, Jenna Blaslov, Meghan Salcedo, Julia Caple, Linh Tran, Selena Hamid, Oscar B Lahoud, Heather Landau, Gunjan L. Shah, Sergio A Giralt, Andriy Derkach, Carlyn Tan, Cody Peer, William D. Figg, Saad Usmani, Ola Landgren, and Alexander M Lesokhin
- Subjects
Immunology ,Cell Biology ,Hematology ,Biochemistry - Published
- 2022
6. Supplementary fig 1 from Sustained Minimal Residual Disease Negativity in Multiple Myeloma is Associated with Stool Butyrate and Healthier Plant-Based Diets
- Author
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Alexander M. Lesokhin, Marcel R.M. van den Brink, Jonathan U. Peled, Torin Block, Gladys Block, C. Ola Landgren, Ying Taur, Sergio Giralt, Saad Z. Usmani, Heather Landau, David J. Chung, Oscar Lahoud, Michael Scordo, Gunjan Shah, Benjamin Diamond, Dhwani Patel, Sydney X. Lu, Carlyn R. Tan, Hani Hassoun, Malin Hultcrantz, Neha Korde, Sham Mailankody, Devin McAvoy, Kinga Hosszu, Matthew J. Pianko, Justin Cross, Peter Adintori, Tala Shekarkhand, Miranda Burge, Amanda Ciardiello, Linh Tran, Jenna Blaslov, Julia Caple, Kelly Barnett, Meghan Salcedo, Andriy Derkach, Kylee H. Maclachlan, and Urvi A. Shah
- Abstract
Supplementary Figure S1. Volcano plot showing the difference in the relative abundance of butyrate producers between sustained MRD negative and MRD positive/non-sustained MRD negative.
- Published
- 2023
7. Data from Sustained Minimal Residual Disease Negativity in Multiple Myeloma is Associated with Stool Butyrate and Healthier Plant-Based Diets
- Author
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Alexander M. Lesokhin, Marcel R.M. van den Brink, Jonathan U. Peled, Torin Block, Gladys Block, C. Ola Landgren, Ying Taur, Sergio Giralt, Saad Z. Usmani, Heather Landau, David J. Chung, Oscar Lahoud, Michael Scordo, Gunjan Shah, Benjamin Diamond, Dhwani Patel, Sydney X. Lu, Carlyn R. Tan, Hani Hassoun, Malin Hultcrantz, Neha Korde, Sham Mailankody, Devin McAvoy, Kinga Hosszu, Matthew J. Pianko, Justin Cross, Peter Adintori, Tala Shekarkhand, Miranda Burge, Amanda Ciardiello, Linh Tran, Jenna Blaslov, Julia Caple, Kelly Barnett, Meghan Salcedo, Andriy Derkach, Kylee H. Maclachlan, and Urvi A. Shah
- Abstract
Purpose:Sustained minimal residual disease (MRD) negativity is associated with long-term survival in multiple myeloma. The gut microbiome is affected by diet, and in turn can modulate host immunity, for example through production of short-chain fatty acids including butyrate. We hypothesized that dietary factors affect the microbiome (abundance of butyrate-producing bacteria or stool butyrate concentration) and may be associated with multiple myeloma outcomes.Experimental Design:We examined the relationship of dietary factors (via a food frequency questionnaire), stool metabolites (via gas chromatography–mass spectrometry), and the stool microbiome (via 16S sequencing - α-diversity and relative abundance of butyrate-producing bacteria) with sustained MRD negativity (via flow cytometry at two timepoints 1 year apart) in myeloma patients on lenalidomide maintenance. The Healthy Eating Index 2015 score and flavonoid nutrient values were calculated from the food frequency questionnaire. The Wilcoxon rank sum test was used to evaluate associations with two-sided P < 0.05 considered significant.Results:At 3 months, higher stool butyrate concentration (P = 0.037), butyrate producers (P = 0.025), and α-diversity (P = 0.0035) were associated with sustained MRD negativity. Healthier dietary proteins, (from seafood and plants), correlated with butyrate at 3 months (P = 0.009) and sustained MRD negativity (P = 0.05). Consumption of dietary flavonoids, plant nutrients with antioxidant effects, correlated with stool butyrate concentration (anthocyanidins P = 0.01, flavones P = 0.01, and flavanols P = 0.02).Conclusions:This is the first study to demonstrate an association between a plant-based dietary pattern, stool butyrate production, and sustained MRD negativity in multiple myeloma, providing rationale to evaluate a prospective dietary intervention.
- Published
- 2023
8. Epigenomic profiling of glucocorticoid responses identifies cis-regulatory disruptions impacting steroid resistance in childhood acute lymphoblastic leukemia
- Author
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Brennan Bergeron, Jonathan Diedrich, Yang Zhang, Kelly Barnett, Qian Dong, Daniel Ferguson, Robert Autry, Wenjian Yang, Baranda Hansen, Colton Smith, Kristine Crews, Yiping Fan, Ching-Hon Pui, Shondra Pruett-Miller, Mary Relling, Jun Yang, CHUNLIANG LI, William Evans, and Daniel Savic
- Abstract
Glucocorticoids (GCs) are a mainstay of contemporary, multi-drug chemotherapy in the treatment of childhood acute lymphoblastic leukemia (ALL), and resistance to GCs remains a major clinical concern. Resistance to GCs is predictive of ALL relapse and poor clinical outcome, and therefore represents a major hurdle limiting further improvements in survival rates. While advances have been made in identifying genes implicated in GC resistance, there remains an insufficient understanding of the impact of cis-regulatory disruptions in resistance. To address this, we mapped the gene regulatory response to GCs in two ALL cells using functional genomics and high-throughput reporter assays and identified thousands of GC-responsive changes to chromatin state, including the formation of over 250 GC-responsive super-enhancers and a depletion of AP-1 bound cis-regulatory elements implicated in cell proliferation and anti-apoptotic processes. By integrating our GC response maps with genetic and epigenetic datasets in primary ALL cells from patients, we further uncovered cis-regulatory disruptions at GC-responsive genes that impact GC resistance in childhood ALL. Overall, these data indicate that GCs initiate pervasive effects on the leukemia epigenome, and that alterations to the GC gene regulatory network contribute to GC resistance.
- Published
- 2022
9. Epigenetic activation of the FLT3 gene by ZNF384 fusion confers a therapeutic susceptibility in acute lymphoblastic leukemia
- Author
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Xujie Zhao, Ping Wang, Jonathan D. Diedrich, Brandon Smart, Noemi Reyes, Satoshi Yoshimura, Jingliao Zhang, Wentao Yang, Kelly Barnett, Beisi Xu, Zhenhua Li, Xin Huang, Jiyang Yu, Kristine Crews, Allen Eng Juh Yeoh, Marina Konopleva, Chia-Lin Wei, Ching-Hon Pui, Daniel Savic, and Jun J. Yang
- Subjects
Multidisciplinary ,Aniline Compounds ,fms-Like Tyrosine Kinase 3 ,Pyrazines ,Trans-Activators ,General Physics and Astronomy ,Humans ,General Chemistry ,Gene Fusion ,Precursor Cell Lymphoblastic Leukemia-Lymphoma ,General Biochemistry, Genetics and Molecular Biology ,Epigenesis, Genetic ,Transcription Factors - Abstract
FLT3 is an attractive therapeutic target in acute lymphoblastic leukemia (ALL) but the mechanism for its activation in this cancer is incompletely understood. Profiling global gene expression in large ALL cohorts, we identify over-expression of FLT3 in ZNF384-rearranged ALL, consistently across cases harboring different fusion partners with ZNF384. Mechanistically, we discover an intergenic enhancer element at the FLT3 locus that is exclusively activated in ZNF384-rearranged ALL, with the enhancer-promoter looping directly mediated by the fusion protein. There is also a global enrichment of active enhancers within ZNF384 binding sites across the genome in ZNF384-rearranged ALL cells. Downregulation of ZNF384 blunts FLT3 activation and decreases ALL cell sensitivity to FLT3 inhibitor gilteritinib in vitro. In patient-derived xenograft models of ZNF384-rearranged ALL, gilteritinib exhibits significant anti-leukemia efficacy as a monotherapy in vivo. Collectively, our results provide insights into FLT3 regulation in ALL and point to potential genomics-guided targeted therapy for this patient population.
- Published
- 2021
10. Forgiveness as a Ritual in Couples Therapy
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J. Kelly Barnett and Chris Youngberg
- Subjects
050103 clinical psychology ,Forgiveness ,Psychotherapist ,Social Psychology ,Process (engineering) ,media_common.quotation_subject ,05 social sciences ,050106 general psychology & cognitive sciences ,Intervention (counseling) ,0501 psychology and cognitive sciences ,Psychology ,Construct (philosophy) ,Social psychology ,Social Sciences (miscellaneous) ,media_common - Abstract
A violation of trust in intimate relationships is one of the most difficult presenting problems for partners to overcome. It is also difficult for clinicians to assist in the process of restoring the relationship. This article offers a technique for couples therapy that applies the construct of forgiveness through the metaphorical enactment of a ritual. Forgiveness is defined as the giving up of one’s right to hurt another in return for being hurt. Using a case study, the authors present a technique that uses the common items of a flowerpot, potting soil, and bulbs to implement an intervention that facilitates forgiveness and growth.
- Published
- 2004
11. The New Theological Frontier for Southern Baptists
- Author
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Das Kelly Barnett
- Subjects
Frontier ,History ,General Medicine ,Religious studies ,Theology - Published
- 1941
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