Search

Your search keyword '"Kelly, Patrick D."' showing total 198 results
Start Over Author "Kelly, Patrick D."
198 results on '"Kelly, Patrick D."'

1. A brave new framework for glioma drug development

Author

Hotchkiss, Kelly M, Karschnia, Philipp, Schreck, Karisa C, Geurts, Marjolein, Cloughesy, Timothy F, Huse, Jason, Duke, Elizabeth S, Lathia, Justin, Ashley, David M, Nduom, Edjah K, Long, Georgina, Singh, Kirit, Chalmers, Anthony, Ahluwalia, Manmeet S, Heimberger, Amy, Bagley, Stephen, Todo, Tomoki, Verhaak, Roel, Kelly, Patrick D, Hervey-Jumper, Shawn, de Groot, John, Patel, Anoop, Fecci, Peter, Parney, Ian, Wykes, Victoria, Watts, Colin, Burns, Terry C, Sanai, Nader, Preusser, Matthias, Tonn, Joerg Christian, Drummond, Katharine J, Platten, Michael, Das, Sunit, Tanner, Kirk, Vogelbaum, Michael A, Weller, Michael, Whittle, James R, Berger, Mitchel S, and Khasraw, Mustafa

Published
2024
Full Text
View/download PDF

7. Advocacy to Government and Stakeholders

Author

Lefever, Devon, Kelly, Patrick D., Zuckerman, Scott L., Agarwal, Nitin, Guthikonda, Bharat, Kimmell, Kristopher T., Schirmer, Clemens, Rosenow, Joshua M., Cozzens, Jeffrey, Orrico, Katie O., and Menger, Richard

Published
2021
Full Text
View/download PDF

20. Vestibular Schwannoma Management: Comparing Trajectories of Health-Related Quality of Life and Patient-Reported Outcomes.

Author

Gauhar, Fatima, IV, Robert J. Dambrino, Thompson, Reid C., Chambless, Lola B., Morone, Peter J., and Kelly, Patrick D.

Subjects
ACOUSTIC neuroma, QUALITY of life, PATIENT reported outcome measures
Abstract

This article examines the impact of different management strategies on the quality of life (QOL) of patients with vestibular schwannoma (VS). The study analyzed patient-reported outcome measures (PROMs) collected from a retrospective cohort of 347 patients with VS. The results showed that patients who underwent retrosigmoid (RS) surgery had the lowest QOL scores initially but experienced the most significant improvement in QOL at their last follow-up. However, patients who were under observation experienced a decline in QOL. The study highlights the importance of understanding the trajectory of PROMs in patient counseling. [Extracted from the article]

Published
2024
Full Text
View/download PDF

33. Child participation in collision sports and football: what influences parental decisions?

Author

Hibshman, Natalie, Yengo-Kahn, Aaron, Wiseman, Alyssa, Kelly, Patrick D., Wu, Jeffanie, Monk, Steve, Harris, Glenn, Gannon, Stephen, Shannon, Chevis, and Bonfield, Christopher M.

Abstract

Sport participation promotes health benefits for children. Current media and scientific coverage of sport-related head injury may influence a parent's decision on sports participation. Physicians must understand what influences these decisions to effectively counsel patients and families. This study sought to better understand and quantify the parental decisions to allow/disallow collision sports, including football participation. A 31-question survey related to child/parent demographics, sports history, and influences to allow/disallow sport participation was available to parents in the United States through a national volunteer registry, between November 2016 and September 2019. Pearson's chi-squared and Wilcoxon's signed-rank test were used to analyze categorical and continuous variables, respectively. Multivariate logistic regression was performed to identify the most powerful factors associated with the decision. Of the 884 responses, 430 (49%) parents would disallow collision sport participation and 334 (38%) would disallow football. Parents who would allow collision sports more commonly cited child desire, while those parents who would disallow cited safety concern as the greatest influence to generally disallow a sport. Those who would disallow reported doctors (35.1% vs 25.3%; P = 0.002), media (12.8% vs 7.3%; P = 0.006) and other parents (11.2% vs 7.3%; P = 0.045) as influences. A child's age (OR 1.039, 95%CI 1.007–1.073; P = 0.018) was independently associated with their parent responding that they would allow collision sports. Parent educational status showed that those with higher than a bachelor's degree would be less likely to allow football participation (OR 0.635, 95%CI 0.443–0.910; P = 0.013). Parents incorporate many sources of information into the decision to allow or disallow their child to participate in collision sports. A child's desire to play a sport and child safety are driving factors for parents faced with the decision of whether to allow participation in collision sports. Physician input is more frequently influential to parents than the media, underscoring the responsibility of physicians to engage families on the risks, benefits, and resources available for sport participation. [ABSTRACT FROM AUTHOR]

Published
2022
Full Text
View/download PDF

34. Beyond the Acute-Phase

Author

Yengo-Kahn, Aaron M, primary, Kelly, Patrick D, additional, Patel, Pious, additional, Wolfson, Daniel, additional, Ahluwalia, Ranbir, additional, Dawoud, Fakhry, additional, Bonfield, Christopher, additional, and Guillamondegui, Oscar, additional

Published
2020
Full Text
View/download PDF

40. Enhanced sensitivity using maldi imaging coupled with laser postionization (maldi-2) for pharmaceutical research

Author

Barré, Florian P.Y., Paine, Martin R.L., Flinders, Bryn, Trevitt, Adam J., Kelly, Patrick D., Ait-Belkacem, Rima, Garcia, João P., Creemers, Laura B., Stauber, Jonathan, Vreeken, Rob J., Cillero-Pastor, Berta, Ellis, Shane R., Heeren, Ron M.A., Barré, Florian P.Y., Paine, Martin R.L., Flinders, Bryn, Trevitt, Adam J., Kelly, Patrick D., Ait-Belkacem, Rima, Garcia, João P., Creemers, Laura B., Stauber, Jonathan, Vreeken, Rob J., Cillero-Pastor, Berta, Ellis, Shane R., and Heeren, Ron M.A.

Published
2019

41. Molecular Weight Growth in the Gas-Phase Reactions of Dehydroanilinium Radical Cations with Propene

Author

Kelly, Patrick D., Bright, Cameron C., Blanksby, Stephen J., Da Silva, Gabriel, Trevitt, Adam J., Kelly, Patrick D., Bright, Cameron C., Blanksby, Stephen J., Da Silva, Gabriel, and Trevitt, Adam J.

Abstract

Protonated aniline - one of the simplest nitrogen-bearing aromatic molecules - is speculated to be present within Titan's atmosphere, where it could play a role in molecular weight growth chemistry. To investigate this possibility, this paper examines the reactions of propene with distonic radical cations derived from protonated aniline. The reaction kinetics, products, and branching ratios of these distonic radical cations (i.e., 2-, 3-, and 4-dehydroanilinium radical cations) are measured in the gas phase using ion-trap mass spectrometry, and calculations (M06-2X/6-31G(2df,p) and G3X-K) are used to rationalize the results. The reaction efficiencies for the 2-, 3-, and 4-dehydroanilinium radical cations are reported as 30.7 (±3.1)%, 2.4 (±0.5)%, and 2.1 (±0.4)%, respectively (with ±50% absolute accuracy). The 4- and 3-dehydroanilinium radical cations undergo addition of propene followed by either (i) methyl radical loss forming ammonio styrene cations (m/z 120) or (ii) ethylene loss pathways forming the ammonio benzyl radical cation (m/z 107). The 4-dehydroanilinium reaction favors methyl loss over ethylene loss, whereas the reverse is true for 3-dehydroanilinium. In contrast, the 2-dehydroanilinium radical cation reacts with propene to purportedly form amino tropylium cation (m/z 106) with ethyl radical loss and methyl amino tropylium cation (m/z 120) with methyl radical loss. The energies of all minima and transition states leading to predicted dissociation products are below the energy of the initial reactants providing plausible pathways at the low temperatures of Titan's atmosphere.

Published
2019

42. Enhanced sensitivity using maldi imaging coupled with laser postionization (maldi-2) for pharmaceutical research

Author

UMC Utrecht, Orthopaedie Onderzoek, Regenerative Medicine and Stem Cells, Barré, Florian P.Y., Paine, Martin R.L., Flinders, Bryn, Trevitt, Adam J., Kelly, Patrick D., Ait-Belkacem, Rima, Garcia, João P., Creemers, Laura B., Stauber, Jonathan, Vreeken, Rob J., Cillero-Pastor, Berta, Ellis, Shane R., Heeren, Ron M.A., UMC Utrecht, Orthopaedie Onderzoek, Regenerative Medicine and Stem Cells, Barré, Florian P.Y., Paine, Martin R.L., Flinders, Bryn, Trevitt, Adam J., Kelly, Patrick D., Ait-Belkacem, Rima, Garcia, João P., Creemers, Laura B., Stauber, Jonathan, Vreeken, Rob J., Cillero-Pastor, Berta, Ellis, Shane R., and Heeren, Ron M.A.

Published
2019

47. Enhanced Sensitivity Using MALDI Imaging Coupled with Laser Postionization (MALDI-2) for Pharmaceutical Research

Author

Barré, Florian P. Y., primary, Paine, Martin R. L., additional, Flinders, Bryn, additional, Trevitt, Adam J., additional, Kelly, Patrick D., additional, Ait-Belkacem, Rima, additional, Garcia, João P., additional, Creemers, Laura B., additional, Stauber, Jonathan, additional, Vreeken, Rob J., additional, Cillero-Pastor, Berta, additional, Ellis, Shane R., additional, and Heeren, Ron M. A., additional

Published
2019
Full Text
View/download PDF

48. Image guidance in spine tumor surgery

Author

Kelly, Patrick D., primary, Zuckerman, Scott L., additional, Yamada, Yoshiya, additional, Lis, Eric, additional, Bilsky, Mark H., additional, Laufer, Ilya, additional, and Barzilai, Ori, additional

Published
2019
Full Text
View/download PDF

50. The Effect of Timing of Surgery in Pituitary Apoplexy on Continuously Valued Visual Acuity.

Author

Kelly, Patrick D., Fernando, Shanik J., Malenke, Jordan A., Chandra, Rakesh K., Turner, Justin H., and Chambless, Lola B.

Subjects
*VISUAL acuity, *CEREBROVASCULAR disease, *POSTOPERATIVE period, *SURGERY, *CONFIDENCE intervals
Abstract

Background  Pituitary apoplexy is often treated urgently, but this is based on studies which assess vision categorically and dichotomizes the time interval between symptom onset and surgery which may introduce bias in measuring an association between the two. Objective  This study was aimed to assess for a relationship between continuously valued surgery delay and visual acuity recovery after pituitary apoplexy. Methods  In this retrospective study, all patients presenting with symptomatic pituitary apoplexy between 2004 and 2016 were identified from an institutional database. The primary endpoint was visual acuity improvement, measured as the difference in acuity from the pre- to postoperative period, and measured in Logarithm of the Minimal Angle of Resolution (LogMAR) units. Analysis was performed using continuous values of time delay and visual acuity to assess for an underlying association. Results  Thirty-two pituitary apoplexy patients were identified. Visual acuity deficits were reported in 81%. The median visual acuity was 0.35 LogMAR (Snellen's fraction 20/40) preoperatively, and 0.1 (20/25) postoperatively (p  < 0.01). The time between symptom onset and surgery was not associated with improvement in visual acuity (p  = 0.46). When the time delay and visual outcome were intentionally dichotomized, patients undergoing surgery within 2 days of symptom onset had 0.21 times the odds of a good visual outcome (95% confidence interval [CI]: 0.04–1.05). Conclusion  When assessed as continuously valued measures, the time from symptom onset to surgical intervention and the improvement in visual acuity are not associated, although intentional dichotomization of data produced conflicting results. [ABSTRACT FROM AUTHOR]

Published
2021
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results