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627 results on '"Kelly, J. D."'

1. Plasma-based antigen persistence in the post-acute phase of SARS-CoV-2 infection

Author

Peluso, Michael J., primary, Swank, Zoe N., additional, Goldberg, Sarah A., additional, Lu, Scott, additional, Dalhuisen, Thomas, additional, Borberg, Ella, additional, Senussi, Yasmeen, additional, Luna, Michael A., additional, Chang Song, Celina, additional, Viswanathan, Badri, additional, Huang, Beatrice, additional, Anglin, Khamal, additional, Hoh, Rebecca, additional, Hsue, Priscilla Y., additional, Durstenfeld, Matthew S., additional, Spinelli, Matthew A., additional, Glidden, David V., additional, Henrich, Timothy J., additional, Kelly, J. D., additional, Deeks, Steven G., additional, Walt, David R., additional, and Martin, Jeffrey N., additional

Published
2023
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6. Identifying Paucisymptomatic or Asymptomatic and Unrecognized Ebola Virus Disease Among Close Contacts Based on Exposure Risk Assessments and Screening Algorithms

Author

Gayedyu-Dennis, Dehkontee, primary, Fallah, Mosoka P, additional, Drew, Clara, additional, Badio, Moses, additional, Moses, J S, additional, Fayiah, Tamba, additional, Johnson, Kumblytee, additional, Richardson, Eugene T, additional, Weiser, Sheri D, additional, Porco, Travis C, additional, Martin, Jeffrey N, additional, Sneller, Michael C, additional, Rutherford, George W, additional, Reilly, Cavan, additional, Lindan, Christina P, additional, and Kelly, J D, additional

Published
2022
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7. Identifying Paucisymptomatic or Asymptomatic and Unrecognized Ebola Virus Disease Among Close Contacts Based on Exposure Risk Assessments and Screening Algorithms.

Author

Gayedyu-Dennis, Dehkontee, Fallah, Mosoka P, Drew, Clara, Badio, Moses, Moses, J S, Fayiah, Tamba, Johnson, Kumblytee, Richardson, Eugene T, Weiser, Sheri D, Porco, Travis C, Martin, Jeffrey N, Sneller, Michael C, Rutherford, George W, Reilly, Cavan, Lindan, Christina P, and Kelly, J D

Subjects
EBOLA virus disease, MEDICAL screening, RISK exposure, RAPID diagnostic tests, RISK assessment
Abstract

Background There is limited evidence to evaluate screening algorithms with rapid antigen testing and exposure assessments as identification strategies for paucisymptomatic or asymptomatic Ebola virus (EBOV) infection and unrecognized EBOV disease (EVD). Methods We used serostatus and self-reported postexposure symptoms from a cohort study to classify contact-participants as having no infection, paucisymptomatic or asymptomatic infection, or unrecognized EVD. Exposure risk was categorized as low, intermediate, or high. We created hypothetical scenarios to evaluate the World Health Organization (WHO) case definition with or without rapid diagnostic testing (RDT) or exposure assessments. Results This analysis included 990 EVD survivors and 1909 contacts, of whom 115 (6%) had paucisymptomatic or asymptomatic EBOV infection, 107 (6%) had unrecognized EVD, and 1687 (88%) were uninfected. High-risk exposures were drivers of unrecognized EVD (adjusted odds ratio, 3.5 [95% confidence interval, 2.4–4.9]). To identify contacts with unrecognized EVD who test negative by the WHO case definition, the sensitivity was 96% with RDT (95% confidence interval, 91%–99%), 87% with high-risk exposure (82%–92%), and 97% with intermediate- to high-risk exposures (93%–99%). The proportion of false-positives was 2% with RDT and 53%–93% with intermediate- and/or high-risk exposures. Conclusion We demonstrated the utility and trade-offs of sequential screening algorithms with RDT or exposure risk assessments as identification strategies for contacts with unrecognized EVD. [ABSTRACT FROM AUTHOR]

Published
2023
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8. 1998-1999 Biennium Officers

Author

Edwards, Ruth, Savage, Louise, Kelly, J. D., Tuley, Patricia Dyer, and Reed, Paul

Published
1998

16. Sylvester o’halloran surgical scientific meeting: Proceedings of meeting held 6th & 7th March 1998 in the Foundation Building, University of Limerick

Author

Relihan, N., McGreal, G., Murray, M., McDermott, E. W., O’Higgins, N. J., Duffy, M. J., McNamara, D. A., Harmey, J., Wang, J. H., Donovan, D., Walsh, T. N., Bouchier-Hayes, D. J., Kay, E., Kelly, J. D., Weir, H. P., Keane, P. F., Johnston, S. R., Williamson, K. E., Hamilton, P. W., McManus, D., Morrin, M., Delaney, P. V., Winter, D. C., Harvey, B. J., Geibel, J. P., O’Sullivan, G. C., Delaney, C. P., Coffey, R., Gorey, T. F., Fitzpatrick, J. M., Fanning, N. F., Kirwan, W., Cotter, T., Bouchier-Hayes, D., Redmond, H. P., McNamara, D. A., Pidgeon, G., Harmey, J., Walsh, T. N., Bouchier-Hayes, D. J., Redmond, H. P., Fennessy, F., Wang, J. H., Kelly, C., Bouchier-Hayes, D., Delaney, C. P., Flavin, R., Coffey, R., Gorey, T. F., Fitzpatrick, J. M., Rasheed, A. M., Wang, J. H., Kelly, C., Bouchier-Hayes, D. J., Leahy, A., Lang, E. E., Caldwell, M. T. P., Tanner, W. A., Kiely, P. D., O’Reilly, M., Tierney, S., Barry, M., Delaney, P. V., Drumm, J., Grace, P. A., Gallagher, C. M., Grant, D. C., Connell, P., Barry, M. K., Traynor, O., Hyland, J. M. P., O’Sullivan, M. J., Evoy, D., Redmond, H. P., Kirwan, W. O., Cannon, B., Kenny-Walshe, L., Whelton, M. J., O’Grady, H., O’Neill, S., Grant, D. C., Barry, M. K., Traynor, O., Hyland, J. M., Teh, S. H., O’Ceallaigh, S., O’Donohoe, M. K., Tanner, W. A., Keane, F. B., O’Toole, G. C., Grant, D. C., Barry, M. K., Hyland, J. M. P., Calleary, J., Basso, L., Amjad, S. B., Khan, Z., McMullin, L., Joyce, W. P., Balfe, P. J., Caldwell, M. T., Keane, F. B., Tanner, W. A., Teahan, S., Al-Brekeit, K., Tierney, S., Rasheed, A., Bouchier-Hayes, D., Leahy, A., O’Neill, S., Delaney, C. P., Gorey, T. F., Fitzpatrick, J. M., Cullen, A., O’Keane, C., Fennessy, F., Kelly, C., Bouchier-Hayes, D., Fennessy, F., Wang, J. H., Kelly, C., Bouchier-Hayes, D. J., Winter, D. C., MacFarlane, J., Harvey, B. J., O’Sullivan, G. C., Walsh, M., McGloughlin, T., Grace, P., Colgan, D., Madhavan, P., Sultan, S., Colgan, M. P., Moore, D., Shanik, G., McEniff, N., Molloy, M., Eguare, E., Fiuza, C., Grace, P., Burke, P., Maher, R., Creamer, M., Cronin, C. J., Sigurdsso, H. H., Kim, W., Linklater, G., Cross, K. S., Simpson, W. G., Shaw, J. A. M., Pearson, D. W. M., Fitzgerald, P., Quinn, P., Tierney, S., Bouchier-Hayes, D., Brady, C. M., Shah, S. M. A., Ehtisham, M., Khan, M. S., Flood, H. D., Loubani, M., Sweeney, K., Lenehan, B., Lynch, V., Joy, A., McGreal, G., Reidy, D., Mahalingam, K., Cashman, W., Mulligan, E. D., Purcell, T., Dunne, B., Griffin, M., Noonan, N., Hollywood, D., Keeling, N., Reynolds, J. V., Hennessy, T. P. J., O’Halloran, D., McGreal, G., McDermott, E. W., O’Higgins, N. J., Neary, P., Hamilton, D., Haider, N., Aherne, N., Watson, R. G. K., Walsh, D., Murphy, M., Joyce, M., Johnston, S., Clinton, O., Given, H. F., Brannigan, A., O’Donohoe, M., Donohoe, J., Corrigan, T., Bresnihan, M., O’Donohoe, M. K., Feeley, T. M., Sultan, S., Madhavan, P., Colgan, M. P., Moore, D., Shanik, G., McMonagle, M. P., Quinlan, D., Kelly, D., Hegarty, P. K., Tan, B., Cronin, C., Brady, M. P., Zeeshan, M., McAvinchey, D. J., Aherne, N., Mooney, C., Coyle, D., Haider, N., Hamilton, D., Neary, P., Watson, R. G. K., Khayyat, G., Masterson, E., Thambi-Pillai, T., Farah, K., Delaney, C. P., Codd, M. B., Fitzpatrick, J. M., Gorey, T. F., Barry, M. K., Tsiotos, G. G., Johnson, C. D., Sarr, M. G., Kell, M. R., Lynch, M., Ryan, D., O’Donovan, A., Winter, D. C., Redmond, H. P., Delaney, C. P., Cassidy, M., Doyle, M., Fulton, G., O’Connell, P. R., Kingston, R., Dillon, M., Barry, M., Tierney, S., Grace, P. A., McGreal, G., Lenehan, B., Murray, M., McDermott, E., O’Higgins, N., Kell, M. R., O’Sullivan, R. G., Tan, B., and O’Donnell, J. A.

Published
1998
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26. Morbidity and mortality after robot-assisted radical cystectomy with intracorporeal urinary diversion in octogenarians: results from the European Association of Urology Robotic Urology Section Scientific Working Group

Author

Canda, Abdullah Erdem (ORCID 0000-0002-5196-653X & YÖK ID 116202), Mortezavi, A.; Crippa, A.; Edeling, S.; Pokupic, S.; Dell'Oglio, P.; Montorsi, F.; D'Hondt, F.; Mottrie, A; Decaestecker, K.; Wijburg, C. J.; Collins, J.; Kelly, J. D.; Tan, W. S.; Sridhar, A.; John, H.; Schwentner, C.; Rönmark, E. P.; Wiklund, P.; Hosseini, A., School of Medicine, Canda, Abdullah Erdem (ORCID 0000-0002-5196-653X & YÖK ID 116202), Mortezavi, A.; Crippa, A.; Edeling, S.; Pokupic, S.; Dell'Oglio, P.; Montorsi, F.; D'Hondt, F.; Mottrie, A; Decaestecker, K.; Wijburg, C. J.; Collins, J.; Kelly, J. D.; Tan, W. S.; Sridhar, A.; John, H.; Schwentner, C.; Rönmark, E. P.; Wiklund, P.; Hosseini, A., and School of Medicine

Abstract

Objectives: to evaluate the postoperative complication and mortality rate following laparoscopic radical cystectomy (RARC) with intracorporeal urinary diversion (ICUD) in octogenarians. Patients and methods: we conducted a retrospective analysis comparing postoperative complication and mortality rates depending on age in a consecutive series of 1890 patients who underwent RARC with ICUD for bladder cancer between 2004 and 2018 in 10 European centres. Outcomes of patients aged <80 years and those aged ≥80 years were compared with regard to postoperative complications (Clavien–Dindo grading) and mortality rate. Cancer-specific mortality (CSM) and other-cause mortality (OCM) after surgery were calculated using the non-parametric Aalen-Johansen estimator. Results: a total of 1726 patients aged <80 years and 164 aged ≥80 years were included in the analysis. The 30- and 90-day rate for high-grade (Clavien–Dindo grades III–V) complications were 15% and 21% for patients aged <80 years compared to 11% and 13% for patients aged ≥80 years (P = 0.2 and P = 0.03), respectively. In a multivariable logistic regression analysis adjusting for pre- and postoperative variables, age ≥80 years was not an independent predictor of high-grade complications (odds ratio 0.6, 95% confidence interval 0.3–1.1; P = 0.12). The non-cancer-related 90-day mortality was 2.3% for patients aged ≥80 years and 1.8% for those aged <80 years, respectively (P = 0.7). The estimated 12-month CSM and OCM rates for those aged <80 years were 8% and 3%, and for those aged ≥80 years, 15% and 8%, respectively (P = 0.009 and P < 0.001). Conclusions: the minimally invasive approach to RARC with ICUD for bladder cancer in well-selected elderly patients (aged ≥80 years) achieved a tolerable high-grade complication rate; the 90-day postoperative mortality rate was driven by cancer progression and the non-cancer-related rate was equivalent to that of patients aged <80 years. However, an increased OCM rate in this elderly, NA

Published
2020

50. Development and validation of a haematuria cancer risk score to identify patients at risk of harbouring cancer

Author

Tan, W S; https://orcid.org/0000-0002-6119-4043, Ahmad, A, Feber, A, Mostafid, H, Cresswell, J, Fankhauser, C D, Waisbrod, S, Hermanns, T, Sasieni, P, Kelly, J D, DETECT I trial collaborators, Tan, W S; https://orcid.org/0000-0002-6119-4043, Ahmad, A, Feber, A, Mostafid, H, Cresswell, J, Fankhauser, C D, Waisbrod, S, Hermanns, T, Sasieni, P, Kelly, J D, and DETECT I trial collaborators

Abstract

BACKGROUND A lack of consensus exists amongst national guidelines regarding who should be investigated for haematuria. Type of haematuria and age-specific thresholds are frequently used to guide referral for the investigation of haematuria. OBJECTIVES To develop and externally validate the haematuria cancer risk score (HCRS) to improve patient selection for the investigation of haematuria. METHODS Development cohort comprise of 3539 prospectively recruited patients recruited at 40 UK hospitals (DETECT 1; ClinicalTrials.gov: NCT02676180) and validation cohort comprise of 656 Swiss patients. All patients were aged >18 years and referred to hospital for the evaluation of visible and nonvisible haematuria. Sensitivity and specificity of the HCRS in the validation cohort were derived from a cut-off identified from the discovery cohort. RESULTS Patient age, gender, type of haematuria and smoking history were used to develop the HCRS. HCRS validation achieves good discrimination (AUC 0.835; 95% CI: 0.789-0.880) and calibration (calibration slope = 1.215) with no significant overfitting (P = 0.151). The HCRS detected 11.4% (n = 8) more cancers which would be missed by UK National Institute for Health and Clinical Excellence guidelines. The American Urological Association guidelines would identify all cancers with a specificity of 12.6% compared to 30.5% achieved by the HCRS. All patients with upper tract cancers would have been identified. CONCLUSION The HCRS offers good discriminatory accuracy which is superior to existing guidelines. The simplicity of the model would facilitate adoption and improve patient and physician decision-making.

Published
2019

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