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6. Dose finding study for on-demand HIV pre-exposure prophylaxis for insertive sex in sub-Saharan Africa: results from the CHAPS open label randomised controlled trial

Author

Ahmed, Nadia, Alinde, Berenice, Alieu, Amara, Atujuna, Millicent, Awino, Esther, Bekker, Linda-Gail, Callebaut, Christian, Chiodi, Francesca, Chirenje, Mike, Dietrich, Janan, Dorfman, Jeffrey, Else, Laura, Fox, Julie, Gray, Clive, Hansen, Christian Holm, Herrera, Carolina, Hornschuh, Stefanie, Kakande, Ayoub, Kaleebu, Pontiano, Kelly, Charles, Khoo, Saye, Khunwane, Mamkiri, Lebina, Limaktso, Makhura, Joseph, Mangxilana, Nomvuyo, Martinson, Neil, Mugaba, Susan, Muhumuza, Richard, Kibengo, Freddie Mukasa, Mutonyi, Gertrude, Mungate, Lucia, Nabukeera, Winnie, Nagawa, Rehema, Nalubega, Phiona, Namubiru, Patricia, Nash, Stephen, Ndekezi, Denis, Nematadzira, Teacler, Nobula, Lumka, O'Hagan, Kyle, Odoch, Geoffrey, Opoka, Daniel, Penchala, Sujan Dilly, Petkov, Stefan, Pillay, Azure-Dee, Rooney, Jim, Rousseau, Elzette, Ruzagira, Eugene, Sango, Alison, Seatlholo, Ntombexolo, Seeley, Janet, Seiphetlo, Thabiso, Serwanga, Jennifer, Shattock, Robin, Ssemata, Andrew S., Stranix-Chibanda, Lynda, Tshabalala, Gugulethu, Webb, Emily, Weiss, Helen, Limakatso, Lebina, Seiphetlo, Thabiso B., Seatlholo, Portia, Gray, Clive M., and Webb, Emily L.

Published
2023
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10. Process analytical technology for the manufacture of biotherapeutic protein products

Author

Moore-Kelly, Charles

Subjects
660, TP Chemical technology
Abstract

The emergence of new bioprocessing technologies for integrated, continuous biotherapeutics manufacturing has instigated a need to establish new process analytical technologies (PAT) that are able to monitor product attributes that ultimately define the safety and efficacy of the drug. The aim of this Engineering Doctorate has been to develop new analytical technologies that address a problematic facet of biologics manufacturing: the propensity for proteins to unfold and aggregate. A high-throughput system for circular dichroism (CD) and fluorescence spectroscopy has been developed for automated capillary-based structural analysis of biotherapeutics loaded in 96-well plate format. The system was used to examine the conformational stability of monoclonal antibody (mAb) using chemical denaturation (urea) and low pH elution buffers. Subsequently, an in-line methodology was developed for monitoring structural changes of mAb immediately following affinity chromatography (Protein A/Protein G/Byzen Pro) through measured changes in CD\(_{240 nm}\) g-factor and fluorescence \(\lambda_{max}\), establishing a new technique for real time release testing in bioprocessing. Finally, a fused silica microcapillary (220 μm i.d.) flow cell was developed for high-throughput/in-line CD analysis of concentrated protein solutions and further demonstrated as being suitable for the alignment of macromolecules for rapid linear dichroism (LD) detection.

Published
2019

13. Q1 Hamlet

Author

Kelly, Charles Adams, primary and Plehn-Peavyhouse, Dayna Leigh, additional

Published
2022
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17. Helicobacter pylori Adapts to Chronic Infection and Gastric Disease via pH-Responsive BabA-Mediated Adherence

Author

Bugaytsova, Jeanna A, Björnham, Oscar, Chernov, Yevgen A, Gideonsson, Pär, Henriksson, Sara, Mendez, Melissa, Sjöström, Rolf, Mahdavi, Jafar, Shevtsova, Anna, Ilver, Dag, Moonens, Kristof, Quintana-Hayashi, Macarena P, Moskalenko, Roman, Aisenbrey, Christopher, Bylund, Göran, Schmidt, Alexej, Åberg, Anna, Brännström, Kristoffer, Königer, Verena, Vikström, Susanne, Rakhimova, Lena, Hofer, Anders, Ögren, Johan, Liu, Hui, Goldman, Matthew D, Whitmire, Jeannette M, Ådén, Jörgen, Younson, Justine, Kelly, Charles G, Gilman, Robert H, Chowdhury, Abhijit, Mukhopadhyay, Asish K, Nair, G Balakrish, Papadakos, Konstantinos S, Martinez-Gonzalez, Beatriz, Sgouras, Dionyssios N, Engstrand, Lars, Unemo, Magnus, Danielsson, Dan, Suerbaum, Sebastian, Oscarson, Stefan, Morozova-Roche, Ludmilla A, Olofsson, Anders, Gröbner, Gerhard, Holgersson, Jan, Esberg, Anders, Strömberg, Nicklas, Landström, Maréne, Eldridge, Angela M, Chromy, Brett A, Hansen, Lori M, Solnick, Jay V, Lindén, Sara K, Haas, Rainer, Dubois, Andre, Merrell, D Scott, Schedin, Staffan, Remaut, Han, Arnqvist, Anna, Berg, Douglas E, and Borén, Thomas

Subjects
Medical Microbiology, Biomedical and Clinical Sciences, Biological Sciences, Emerging Infectious Diseases, Infectious Diseases, Prevention, Digestive Diseases, Digestive Diseases - (Peptic Ulcer), Biodefense, Vaccine Related, Adhesins, Bacterial, Bacterial Adhesion, Gastric Mucosa, Helicobacter Infections, Helicobacter pylori, Hydrogen-Ion Concentration, acid responsiveness, adaptation, blood group antigen-binding adhesion, diversity, gastric acidity, gastric cancer, multimerization, polymorphism, subpopulations, Microbiology, Immunology, Biochemistry and cell biology, Medical microbiology
Abstract

The BabA adhesin mediates high-affinity binding of Helicobacter pylori to the ABO blood group antigen-glycosylated gastric mucosa. Here we show that BabA is acid responsive-binding is reduced at low pH and restored by acid neutralization. Acid responsiveness differs among strains; often correlates with different intragastric regions and evolves during chronic infection and disease progression; and depends on pH sensor sequences in BabA and on pH reversible formation of high-affinity binding BabA multimers. We propose that BabA's extraordinary reversible acid responsiveness enables tight mucosal bacterial adherence while also allowing an effective escape from epithelial cells and mucus that are shed into the acidic bactericidal lumen and that bio-selection and changes in BabA binding properties through mutation and recombination with babA-related genes are selected by differences among individuals and by changes in gastric acidity over time. These processes generate diverse H. pylori subpopulations, in which BabA's adaptive evolution contributes to H. pylori persistence and overt gastric disease.

Published
2017

24. Accelerated Allograft Vasculopathy With Rituximab After Cardiac Transplantation

Author

Gus, Barbara, Keslar, Karen, Magyar, Bill, Petrich, John, Starling, Randall C., Tang, W. H. Wilson, Brooks, Kimberly, Givertz, Michael, Kelly, Charles, Klein, Katie, Crisalli, Kerry, DeBronkart, Sandra, Madsen, Joren, Semigran, Marc, Vetrano, John, DeMarco, Teresa, Fields, Scott, Maguire, Carol, Gordon, Robert, Anderson, Allen, Regalado, Jane, Warzecha, Anna, Goldberg, Lee, Olt, Caroline, Rockwell, Kenneth, Harris, Ashley, Johnson, Maryl, Johnston, Susan, Roginski, Chris, Ahmed, Rashid, Cohen, Ivy, Peace, Denise, Pinney, Sean, Yao, Tina, Araujo, Gloria, Bhimaraj, Arvind, Karanga, Eunice, Patel, Varsha, Chait, Julie, Deng, Mario, Fonarow, Gregg, Shin, Christina, Gibbs, Charles, Hunt, Judson, Johnson, Melissa, Worley, Tina, Gibbs, Jeff, Kirk, John, Redd, Winter, Stehlik, Josef, Bryan, Julia, French, Anna, Kfoury, A.G., Konery, Kristin, Feller, Erika, Lee, Myounghee, Pierson, Richard, Young, Cindi, Hollifield, Theodora, Porter, Kimberley, Schulz, Mariann, VanBakel, Adrian, Khush, Kiran, Luikart, Helen, Nguyen, Son, Pham, Michael, DeNofrio, David, O’Kelly, Ryan, Garcia, Lucilla, Kobashigawa, Jon, Sana, Sean, Starks, Brandy, Thottam, Maria, Yi, Annie, Cabuay, Barry, Olson, Rachel, Tucker, Larry, Uppgaard, Laura, Eisen, Howard, Lai, Denise, Poisker, Colleen, Dragicevic, Klaudija, Kelner, Harrison, Luke, Darlette, Nelson, Jennifer, Raveendran, Ganesh, Kleissas, Nick, Murali, Srinivas, Rayl, Kenneth, Sherry, Sarah, Cosgrove, Michele, Armstrong, Brian, Bridges, Nancy D., Givertz, Michael M., Kfoury, Abdallah G., Ikle, David, Morrison, Yvonne, Tripathi, Sudipta, Sayegh, Mohamed H., and Chandraker, Anil

Published
2019
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25. Digitizing images of electrical-circuit schematics.

Author

Kelly, Charles R. and Cole, Jacqueline M.

Subjects
ELECTRIC circuits, DIGITIZATION, OPTICAL character recognition, DATA analytics, MACHINE learning, AUTOMATION
Abstract

Electrical-circuit schematics are a foundational tool in electrical engineering. A method that can automatically digitalize them is desirable since a knowledge base of such schematics could preserve their functional information as well as provide a database that one can mine to predict more operationally efficient electrical circuits using data analytics and machine learning. We present a workflow that contains a novel pattern-recognition methodology and a custom-trained Optical Character Recognition (OCR) model that can digitalize images of electrical-circuit schematics with minimal configuration. The pattern-recognition and OCR stages of the workflow yield 86.4% and 99.6% success rates, respectively. We also present an extendable option toward predictive circuit-design efficiencies, subject to a large database of images being available. Thereby, data gathered from our pattern-recognition workflow are used to draw network graphs, which are in turn employed to form matrix equations that contain the voltages and currents for all nodes in the circuit in terms of component values. These equations could be applied to a database of electrical-circuit schematics to predict new circuit designs or circuit modifications that offer greater operational efficiency. Alternatively, these network graphs could be converted into simulation programs with integrated circuit emphasis netlists to afford more accurate and computationally automated simulations. [ABSTRACT FROM AUTHOR]

Published
2024
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26. English-speaking war correspondents of the Spanish Civil War : why was objectivity impossible?

Author

Kelly, Charles John

Subjects
070.4
Abstract

Clear Blue Waters of the Danube was planned and drafted from October 2007 to December 2012. It is written from the perspective of Daniel Rourke, a young man whose life is changed forever by the arrival into the family home of Marija Kovač, a Croatian refugee. The wars leading to the break-up of Yugoslavia, notably the Croatian War of Independence from 1990-5 and the Bosnian Civil War from 1992-5, provide the novel's historical background. Preparation included interviews with conflict survivors, witnesses, soldiers who fought in the war, and those who were children during the fighting. Research visits to Serbia, Croatia and Bosnia and Herzegovina took place during the summers of 2008 and 2009. I also drew upon conversations with former Yugoslav refugees from my time working in London during the 1990s and early 2000s. Other information was selected from biographies, historical records, documentary films, diaries and reports by the International Criminal Tribunal for the Former Yugoslavia. Although the novel notes the key moments of Yugoslavia's violent break-up, Clear Blue Waters of the Danube is not a political thriller. It follows a young man on a journey of self-discovery that takes him away from the family home, first to London, then across the Balkans. By establishing the truth about terrible incidents from the past, he comes to a greater understanding about himself and his previous behaviour. More importantly he is able to re-evaluate the relationship with his father that lies at the heart of everything he does, and in whose shadow he has always lived. The question of whether a writer is truly able to separate himself from his/her subject matter is investigated in greater depth throughout my critical project. Planned between October 2007 and June 2008 then written over the following two years, the perspectives of English-speaking war correspondents during the Spanish Civil War from 1936-1939 are examined. Newspaper articles, memoirs, biographies and films are scrutinised. Although the allegiances of British newspapers were split more or less evenly, the majority of writers and reporters supported the Republican effort and invested huge amounts of personal feeling into their work. For a war fought over such contrasting values, a degree of bias was perhaps inevitable. As I began my research, my aim was to investigate to what extent objectivity in such circumstances was even possible. If news reports bore the hallmarks of fiction, what then of the Spanish Civil War novel? The final part of the project deals with Ernest Hemingway and For Whom the Bell Tolls. As a journalist, Hemingway had engaged in propaganda on behalf of the Republic and readily accepted the weak evidence behind the denunciation of Republican dissidents. Following the war‟s conclusion, he returned to Cuba to write his novel of the Spanish Civil War, For Whom the Bell Tolls. Ironically having written newspaper reports to spread misinformation, he elected to use the form of a novel to reveal his version of what had actually happened. Can fiction reveal the 'truth' about events when supposedly non-fiction texts cannot? My thesis asks fundamental questions about why we write and what we choose to write about. Can any writer truly separate him/herself from the subject matter? Can our understanding ever be full and free from bias and prejudice? Or do a writer's values permeate the work to the extent that, whether a newspaper article or a novel is written, genuine objectivity becomes impossible? Is the quest for objectivity a desirable or realistic aspiration?

Published
2013

28. Information on the Twenty-First Century Battlefield: Proposing the Army's Seventh Warfighting Function

Author

Kelly, Charles M.

Subjects
United States. Army, Military personnel -- Military aspects, Smart phones -- Military aspects, Soldiers, Malware, Smart phone, General interest, Military and naval science
Abstract

In May 2013, Ukrainian artillery officer Yaroslav Sherstuk designed a smartphone application to decrease the artillery targeting process from minutes to less than fifteen seconds. (1) The application experienced initial [...]

Published
2020

33. Dose finding study for on-demand HIV pre-exposure prophylaxis for insertive sex in sub-Saharan Africa: results from the CHAPS open label randomised controlled trial

Author

Herrera, Carolina, primary, Serwanga, Jennifer, additional, Else, Laura, additional, Limakatso, Lebina, additional, Opoka, Daniel, additional, Ssemata, Andrew S., additional, Pillay, Azure-Dee, additional, Namubiru, Patricia, additional, Seiphetlo, Thabiso B., additional, Odoch, Geoffrey, additional, Mugaba, Susan, additional, Seatlholo, Portia, additional, Alieu, Amara, additional, Penchala, Sujan Dilly, additional, Muhumuza, Richard, additional, Alinde, Berenice, additional, Petkov, Stefan, additional, O'Hagan, Kyle, additional, Callebaut, Christian, additional, Seeley, Janet, additional, Weiss, Helen, additional, Khoo, Saye, additional, Chiodi, Francesca, additional, Gray, Clive M., additional, Kaleebu, Pontiano, additional, Webb, Emily L., additional, Martinson, Neil, additional, Fox, Julie, additional, Ahmed, Nadia, additional, Atujuna, Millicent, additional, Awino, Esther, additional, Bekker, Linda-Gail, additional, Chirenje, Mike, additional, Dietrich, Janan, additional, Dorfman, Jeffrey, additional, Gray, Clive, additional, Hansen, Christian Holm, additional, Herrera, Carolina, additional, Hornschuh, Stefanie, additional, Kakande, Ayoub, additional, Kelly, Charles, additional, Khunwane, Mamkiri, additional, Lebina, Limaktso, additional, Makhura, Joseph, additional, Mangxilana, Nomvuyo, additional, Kibengo, Freddie Mukasa, additional, Mutonyi, Gertrude, additional, Mungate, Lucia, additional, Nabukeera, Winnie, additional, Nagawa, Rehema, additional, Nalubega, Phiona, additional, Nash, Stephen, additional, Ndekezi, Denis, additional, Nematadzira, Teacler, additional, Nobula, Lumka, additional, Rooney, Jim, additional, Rousseau, Elzette, additional, Ruzagira, Eugene, additional, Sango, Alison, additional, Seatlholo, Ntombexolo, additional, Seiphetlo, Thabiso, additional, Shattock, Robin, additional, Stranix-Chibanda, Lynda, additional, Tshabalala, Gugulethu, additional, and Webb, Emily, additional

Published
2023
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41. Comprehensive Study of Antiretroviral Drug Permeability at the Cervicovaginal Mucosa via an In Vitro Model

Author

Carserides, Constandinos, primary, Smith, Kieron, additional, Zinicola, Marta, additional, Kumar, Abhinav, additional, Swedrowska, Magda, additional, Scala, Carlo, additional, Cameron, Gary, additional, Riches, Zoe, additional, Iannelli, Francesco, additional, Pozzi, Gianni, additional, Hold, Georgina L., additional, Forbes, Ben, additional, Kelly, Charles, additional, and Hijazi, Karolin, additional

Published
2022
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42. Adjuvant bevacizumab in patients with melanoma at high risk of recurrence (AVAST-M): preplanned interim results from a multicentre, open-label, randomised controlled phase 3 study

Author

Corrie, Pippa G, Marshall, Andrea, Dunn, Janet A, Middleton, Mark R, Nathan, Paul D, Gore, Martin, Davidson, Neville, Nicholson, Steve, Kelly, Charles G, Marples, Maria, Danson, Sarah J, Marshall, Ernest, Houston, Stephen J, Board, Ruth E, Waterston, Ashita M, Nobes, Jenny P, Harries, Mark, Kumar, Satish, Young, Gemma, and Lorigan, Paul

Published
2014
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43. List of Contributors

Author

Abdel-Galil, Khalild, primary, Ahmed, Abdul, additional, Ahmed, Nabeela, additional, Aldridge, Thomas, additional, Andi, Kavin, additional, Al-Nawas, Bilal, additional, Arnaud, Eric, additional, Avery, Christopher M.E., additional, Bainbridge, Mark, additional, Beale, Victoria, additional, Bell, William H., additional, Berridge, Natasha Louise, additional, Blancher, Adam, additional, Block, Michael S., additional, Blythe, John N St. J, additional, Bodem, Jens, additional, Boffano, Paolo, additional, Borumandi, Farzad, additional, Bos, Rudolf Robert Maria, additional, Breeze, Major John, additional, Brennan, Peter A., additional, Brown, James, additional, Buntic, Rudolf F., additional, Bürger, Heinz, additional, Burton, Brady, additional, Carlson, Eric R., additional, Cascarini, Luke, additional, Cassidy, Siwan, additional, Chalmers, Alison, additional, Chapireau, David, additional, Cobb, Alistair R.M., additional, Colbert, Serryth, additional, Coyle, Margaret Jean, additional, Cuzalina, Angelo, additional, Dashow, Jason E., additional, Dhanda, Jag, additional, Drake, David, additional, Ehrlich, Alex D., additional, Ellis, Simon, additional, Evans, T. William, additional, Extence, Helen, additional, Farook, Shahme Ahamed, additional, Farrier, Jerry N., additional, Fasanmade, Adekunmi, additional, Fernandes, Rui P., additional, Forouzanfar, Tim, additional, Fretwurst, Tobias, additional, Frost, David E., additional, Johann Gaggl Sr., Alexander, additional, Gandhi, Rishi Kumar, additional, Gellrich, Nils-Claudius Bernhard, additional, George, Katherine, additional, Ghali, G.E., additional, Gilhooly, Michael, additional, Godden, Daryl R., additional, Gonzalez, Marianela, additional, Gottlieb, Jonathan B., additional, Alan Gremillion, Henry A., additional, Green, Ben C., additional, Gruber, Elizabeth Anne, additional, Guerrero, Cesar A., additional, Gupta, Rishi Jay, additional, Harrington, Kevin J., additional, Harris, Christopher, additional, Hebert, Andrea M., additional, Helman, Joseph, additional, Hoffmann, Jürgen, additional, Hoffmeister, Bodo, additional, Holmes, Simon, additional, Horn, Dominik, additional, Jaspers, Birgit, additional, Jundt, Gernot, additional, Kabala, Julian Eamon, additional, Kaban, Leonard B., additional, Kaleem, Arshad, additional, Kanatas, Anastasios, additional, Kelly, Charles Gerald, additional, Klasser, Gary D., additional, Kim, Beomjune B., additional, Koppel, David A., additional, Kübler, Norbert R., additional, Likhterov, Ilya, additional, Lloyd, Timothy William, additional, Loukota, Richard A., additional, Lubek, Joshua E., additional, Lyons, Andrew, additional, Mackenzie, Col. Neil, additional, Madani, Gitta, additional, Markiewicz, Michael R., additional, Matthews, Nigel Shaun, additional, McQuillan, Joe, additional, McGurk, Mark, additional, Mehrotra, Divya, additional, Mercer, Nigel Stuart George, additional, Mercuri, Louis Gerard, additional, Messiha, Ashraf, additional, Monje, Florencio, additional, Mujica, Elena V., additional, Mumford, Rachel Anne, additional, Murakami, Kenlchiro, additional, Nauck, Friedemann, additional, Naujokat, Hendrik, additional, Neukam, Friedrich-Wilhelm, additional, Obagi, Suzan, additional, Ord, Robert A., additional, Ort, Yirae, additional, Pabla, Ravinder, additional, Padwa, Bonnie L., additional, Patel, Stavan, additional, Penfold, Chris Neil, additional, Perenack, Jon D., additional, Powers, Michael P., additional, Puelacher, Wolfgang, additional, Quereshy, Faisal A., additional, Raguse, Jan D., additional, Rajapakse, Sujeev, additional, Ramchandani, Parkash L., additional, Resnick, Cory M., additional, Risk, Janet Mary, additional, Robinson, Stephen N., additional, Rodriguez, Eduardo D., additional, Rogers, Simon N., additional, Roodenburg, J.L.N., additional, Saeed, Nadeem, additional, Schache, Andrew Graeme, additional, Schendel, Stephen A., additional, Schliephake, Henning, additional, Schmelzeisen, Rainer, additional, Schmidt-Westhausen, Andrea Maria, additional, Seppänen-Kaijansinkko, Riitta, additional, Shaw, Richard J., additional, Sidebottom, Andrew J., additional, Singh, Mark K., additional, Singh, Rabindra P., additional, Sinn, Douglas P., additional, Smeele, Ludi E., additional, Smith, C. Blake, additional, Sommerlad, Brian, additional, Strietzel, Frank Peter, additional, Sugar, Adrian, additional, Takwale, Anita, additional, Taylor, Clark O., additional, Townley, William Arthur, additional, Turvey, Timothy A., additional, Urken, Mark L., additional, Van Eeden, Simon, additional, Wagner, Wilfried, additional, Whitfield, Peter C., additional, Will, Michael J., additional, Williams, Jonathan, additional, Wiltfang, Jörg, additional, Witherow, Helen, additional, Woerner, Jennifer E., additional, Wolf, Jeffrey S., additional, Wolford, Larry M., additional, Wong, Wai Lup, additional, Woods, Martin, additional, Yu, Peirong, additional, and Zimmerer, Rüdiger M., additional

Published
2017
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45. Hsp-Induced Stimulation of Immune Responses

Author

Lehner, Thomas, Wang, Yufei, Whittall, Trevor, Bergmeier, Lesley A., Babaahmady, Kaboutar, Kelly, Charles, Asea, A. A. A., editor, Calderwood, S. K., editor, Asea, Alexzander A. A., editor, and Maio, Antonio De, editor

Published
2007
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49. Survival outcomes for patients with nasopharyngeal carcinoma in non–endemic region in the UK treated with intensity modulated based radiotherapy 65 Gy in 30 fractions ± weekly cisplatin chemotherapy

Author

Iqbal, Muhammad Shahid, primary, Tin, Aung, additional, Mian, Abdul, additional, Ali, Akram, additional, O'Hara, James, additional, Kovarik, Josef, additional, Patil, Rahul, additional, Aynsley, Eleanor, additional, and Kelly, Charles, additional

Published
2022
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