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2. Single-cell transcriptomic atlas-guided development of CAR-T cells for the treatment of acute myeloid leukemia

Author

Gottschlich, Adrian, Thomas, Moritz, Grünmeier, Ruth, Lesch, Stefanie, Rohrbacher, Lisa, Igl, Veronika, Briukhovetska, Daria, Benmebarek, Mohamed-Reda, Vick, Binje, Dede, Sertac, Müller, Katharina, Xu, Tao, Dhoqina, Dario, Märkl, Florian, Robinson, Sophie, Sendelhofert, Andrea, Schulz, Heiko, Umut, Öykü, Kavaka, Vladyslav, Tsiverioti, Christina Angeliki, Carlini, Emanuele, Nandi, Sayantan, Strzalkowski, Thaddäus, Lorenzini, Theo, Stock, Sophia, Müller, Philipp Jie, Dörr, Janina, Seifert, Matthias, Cadilha, Bruno L., Brabenec, Ruben, Röder, Natalie, Rataj, Felicitas, Nüesch, Manuel, Modemann, Franziska, Wellbrock, Jasmin, Fiedler, Walter, Kellner, Christian, Beltrán, Eduardo, Herold, Tobias, Paquet, Dominik, Jeremias, Irmela, von Baumgarten, Louisa, Endres, Stefan, Subklewe, Marion, Marr, Carsten, and Kobold, Sebastian

Published
2023
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3. Vision Zero in Germany

Author

Hell, Wolfram, Bodewig, Kurt, Hammer, Ute, Kellner, Christian, Klinke, Clemens, Mück, Matthias, Schreiner, Martin, Walz, Felix, Zielke, Guido, Edvardsson Björnberg, Karin, editor, Hansson, Sven Ove, editor, Belin, Matts-Åke, editor, and Tingvall, Claes, editor

Published
2023
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5. Vision Zero in Germany

Author

Hell, Wolfram, primary, Bodewig, Kurt, additional, Hammer, Ute, additional, Kellner, Christian, additional, Klinke, Clemens, additional, Mück, Matthias, additional, Schreiner, Martin, additional, Walz, Felix, additional, and Zielke, Guido, additional

Published
2022
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6. Engineering an inducible leukemia-associated fusion protein enables large-scale ex vivo production of functional human phagocytes

Author

Windisch, Roland, primary, Soliman, Sarah, additional, Hoffmann, Adrian, additional, Chen-Wichmann, Linping, additional, Danese, Anna, additional, Vosberg, Sebastian, additional, Bravo, Jimena, additional, Lutz, Sebastian, additional, Kellner, Christian, additional, Fischer, Alexander, additional, Gebhard, Claudia, additional, Redondo Monte, Enric, additional, Hartmann, Luise, additional, Schneider, Stephanie, additional, Beier, Fabian, additional, Strobl, Carolin Dorothea, additional, Weigert, Oliver, additional, Peipp, Matthias, additional, Schündeln, Michael, additional, Stricker, Stefan H., additional, Rehli, Michael, additional, Bernhagen, Jürgen, additional, Humpe, Andreas, additional, Klump, Hannes, additional, Brendel, Christian, additional, Krause, Daniela S., additional, Greif, Philipp A., additional, and Wichmann, Christian, additional

Published
2024
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14. Venetoclax enhances the efficacy of therapeutic antibodies in B-cell malignancies by augmenting tumor cell phagocytosis

Author

Vogiatzi, Fotini, Heymann, Julia, Müller, Kristina, Winterberg, Dorothee, Drakul, Aneta, Rösner, Thies, Lenk, Lennart, Heib, Michelle, Gehlert, Carina Lynn, Cario, Gunnar, Schrappe, Martin, Claviez, Alexander, Bornhauser, Beat, Bourquin, Jean-Pierre, Bomken, Simon, Adam, Dieter, Frielitz, Fabian-Simon, Maecker-Kolhoff, Britta, Stanulla, Martin, Valerius, Thomas, Peipp, Matthias, Kellner, Christian, and Schewe, Denis M.

Published
2022
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15. Combining daratumumab with CD47 blockade prolongs survival in preclinical models of pediatric T-ALL

Author

Müller, Kristina, Vogiatzi, Fotini, Winterberg, Dorothee, Rösner, Thies, Lenk, Lennart, Bastian, Lorenz, Gehlert, Carina L., Autenrieb, Marie-Pauline, Brüggemann, Monika, Cario, Gunnar, Schrappe, Martin, Kulozik, Andreas E., Eckert, Cornelia, Bergmann, Anke K., Bornhauser, Beat, Bourquin, Jean-Pierre, Valerius, Thomas, Peipp, Matthias, Kellner, Christian, and Schewe, Denis M.

Published
2022
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17. Enhanced potency of immunotherapy against B‐cell precursor acute lymphoblastic leukemia by combination of an Fc‐engineered CD19 antibody and CD47 blockade

Author

Schewe, Denis M., primary, Vogiatzi, Fotini, additional, Münnich, Ira A., additional, Zeller, Tobias, additional, Windisch, Roland, additional, Wichmann, Christian, additional, Müller, Kristina, additional, Bhat, Hilal, additional, Felix, Elisa, additional, Mougiakakos, Dimitrios, additional, Bruns, Heiko, additional, Lenk, Lennart, additional, Valerius, Thomas, additional, Humpe, Andreas, additional, Peipp, Matthias, additional, and Kellner, Christian, additional

Published
2024
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19. Requirements for storing electrophysiology data

Author

Teeters, Jeff, Benda, Jan, Davison, Andrew, Eglen, Stephen, Gerkin, Richard C., Grethe, Jeffrey, Grewe, Jan, Harris, Kenneth, Kellner, Christian, Franc, Yann Le, Mouček, Roman, Prodanov, Dimiter, Pröpper, Robert, Sessions, Hyrum L., Smith, Leslie, Sobolev, Andrey, Sommer, Friedrich, Stoewer, Adrian, Wachtler, Thomas, and Wark, Barry

Subjects
Computer Science - Other Computer Science, E.1, E.2, E.5
Abstract

The purpose of this document is to specify the basic data types required for storing electrophysiology and optical imaging data to facilitate computer-based neuroscience studies and data sharing. These requirements are being developed within a working group of the Electrophysiology Task Force in the International Neuroinformatics Coordinating Facility (INCF) Program on Standards for Data Sharing. While this document describes the requirements of the standard independent of the actual storage technology, the Task Force has recommended basing a standard on HDF5. This is in line with a number of groups who are already using HDF5 to store electrophysiology data, although currently without being based on a standard., Comment: 5 pages, 1 table

Published
2016

21. Efficient Chimeric Antigen Receptor T-Cell Generation Starting with Leukoreduction System Chambers of Thrombocyte Apheresis Sets.

Author

Xhaxho, Stefani, Chen-Wichmann, Linping, Kreissig, Sophie, Windisch, Roland, Gottschlich, Adrian, Nandi, Sayantan, Schabernack, Sophie, Kohler, Irmgard, Kellner, Christian, Kobold, Sebastian, Humpe, Andreas, and Wichmann, Christian

Abstract

Introduction: Primary human blood cells represent an essential model system to study physiology and disease. However, human blood is a limited resource. During healthy donor plateletpheresis, the leukoreduction system chamber (LRSC) reduces the leukocyte amount within the subsequent platelet concentrate through saturated, fluidized, particle bed filtration technology. Normally, the LRSC is discarded after apheresis is completed. Compared to peripheral blood, LRSC yields 10-fold mononuclear cell concentration. Methods: To explore if those retained leukocytes are attractive for research purposes, we isolated CD3+ T cells from the usually discarded LRSCs via density gradient centrifugation in order to manufacture CD19-targeted chimeric antigen receptor (CAR) T cells. Results: Immunophenotypic characterization revealed viable and normal CD4+ and CD8+ T-cell populations within LRSC, with low CD19+ B cell counts. Magnetic-activated cell sorting (MACS) purified CD3+ T cells were transduced with CD19 CAR-encoding lentiviral self-inactivating vectors using concentrated viral supernatants. Robust CD19 CAR cell surface expression on transduced T cells was confirmed by flow cytometry. CD19 CAR T cells were further enriched through anti-CAR MACS, yielding 80% CAR+ T-cell populations. In vitro CAR T cell expansion to clinically relevant numbers was achieved. To prove functionality, CAR T cells were co-incubated with the human CD19+ B cell precursor leukemia cell line Nalm6. Compared to unmodified T cells, CD19 CAR T cells effectively eradicated Nalm6 cells. Conclusion: Taken together, we can show that lymphocytes isolated from LRSCs of plateletpheresis sets can be efficiently used for the generation of functional CAR T cells for experimental purposes. [ABSTRACT FROM AUTHOR]

Published
2024
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22. Novel NKG2D-directed bispecific antibodies enhance antibody-mediated killing of malignant B cells by NK cells and T cells

Author

Lutz, Sebastian, primary, Klausz, Katja, additional, Albici, Anca-Maria, additional, Ebinger, Lea, additional, Sellmer, Lea, additional, Teipel, Hannah, additional, Frenzel, André, additional, Langner, Anna, additional, Winterberg, Dorothee, additional, Krohn, Steffen, additional, Hust, Michael, additional, Schirrmann, Thomas, additional, Dübel, Stefan, additional, Scherließ, Regina, additional, Humpe, Andreas, additional, Gramatzki, Martin, additional, Kellner, Christian, additional, and Peipp, Matthias, additional

Published
2023
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24. Efficient Chimeric Antigen Receptor T-Cell Generation Starting with Leukoreduction System Chambers of Thrombocyte Apheresis Sets

Author

Xhaxho, Stefani, primary, Chen-Wichmann, Linping, additional, Kreissig, Sophie, additional, Windisch, Roland, additional, Gottschlich, Adrian, additional, Nandi, Sayantan, additional, Schabernack, Sophie, additional, Kohler, Irmgard, additional, Kellner, Christian, additional, Kobold, Sebastian, additional, Humpe, Andreas, additional, and Wichmann, Christian, additional

Published
2023
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30. Novel NKG2D-directed bispecific antibodies enhance antibodymediated killing of malignant B cells by NK cells and T cells.

Author

Lutz, Sebastian, Klausz, Katja, Albici, Anca-Maria, Ebinger, Lea, Sellmer, Lea, Teipel, Hannah, Frenzel, André, Langner, Anna, Winterberg, Dorothee, Krohn, Steffen, Hust, Michael, Schirrmann, Thomas, Dübel, Stefan, Scherließ, Regina, Humpe, Andreas, Gramatzki, Martin, Kellner, Christian, and Peipp, Matthias

Subjects
KILLER cells, BISPECIFIC antibodies, CANCER cells, T cells, B cells, INTERLEUKIN-21, GRANZYMES
Abstract

The activating receptor natural killer group 2, member D (NKG2D) represents an attractive target for immunotherapy as it exerts a crucial role in cancer immunosurveillance by regulating the activity of cytotoxic lymphocytes. In this study, a panel of novel NKG2D-specific single-chain fragments variable (scFv) were isolated from naïve human antibody gene libraries and fused to the fragment antigen binding (Fab) of rituximab to obtain [CD20×NKG2D] bibodies with the aim to recruit cytotoxic lymphocytes to lymphoma cells. All bispecific antibodies bound both antigens simultaneously. Two bibody constructs, [CD20×NKG2D#3] and [CD20×NKG2D#32], efficiently activated natural killer (NK) cells in co-cultures with CD20+ lymphoma cells. Both bibodies triggered NK cell-mediated lysis of lymphoma cells and especially enhanced antibodydependent cell-mediated cytotoxicity (ADCC) by CD38 or CD19 specific monoclonal antibodies suggesting a synergistic effect between NKG2D and FcgRIIIA signaling pathways in NK cell activation. The [CD20×NKG2D] bibodies were not effective in redirecting CD8+ T cells as single agents, but enhanced cytotoxicity when combined with a bispecific [CD19×CD3] T cell engager, indicating that NKG2D signaling also supports CD3-mediated T cell activation. In conclusion, engagement of NKG2D with bispecific antibodies is attractive to directly activate cytotoxic lymphocytes or to support their activation by monoclonal antibodies or bispecific T cell engagers. As a perspective, cotargeting of two tumor antigens may allow fine-tuning of antibody cancer therapies. Our proposed combinatorial approach is potentially applicable for many existing immunotherapies but further testing in different preclinical models is necessary to explore the full potential. [ABSTRACT FROM AUTHOR]

Published
2023
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34. Supplementary Figure Legends from Novel Bispecific Antibodies Increase γδ T-Cell Cytotoxicity against Pancreatic Cancer Cells

Author

Oberg, Hans-Heinrich, primary, Peipp, Matthias, primary, Kellner, Christian, primary, Sebens, Susanne, primary, Krause, Sarah, primary, Petrick, Domantas, primary, Adam-Klages, Sabine, primary, Röcken, Christoph, primary, Becker, Thomas, primary, Vogel, Ilka, primary, Weisner, Dietrich, primary, Freitag-Wolf, Sandra, primary, Gramatzki, Martin, primary, Kabelitz, Dieter, primary, and Wesch, Daniela, primary

Published
2023
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35. Data from An Anti-EGFR IgA That Displays Improved Pharmacokinetics and Myeloid Effector Cell Engagement In Vivo

Author

Lohse, Stefan, primary, Meyer, Saskia, primary, Meulenbroek, Laura A.P.M., primary, Jansen, J.H. Marco, primary, Nederend, Maaike, primary, Kretschmer, Anna, primary, Klausz, Katja, primary, Möginger, Uwe, primary, Derer, Stefanie, primary, Rösner, Thies, primary, Kellner, Christian, primary, Schewe, Denis, primary, Sondermann, Peter, primary, Tiwari, Sanjay, primary, Kolarich, Daniel, primary, Peipp, Matthias, primary, Leusen, Jeanette H.W., primary, and Valerius, Thomas, primary

Published
2023
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36. Data from Novel Bispecific Antibodies Increase γδ T-Cell Cytotoxicity against Pancreatic Cancer Cells

Author

Oberg, Hans-Heinrich, primary, Peipp, Matthias, primary, Kellner, Christian, primary, Sebens, Susanne, primary, Krause, Sarah, primary, Petrick, Domantas, primary, Adam-Klages, Sabine, primary, Röcken, Christoph, primary, Becker, Thomas, primary, Vogel, Ilka, primary, Weisner, Dietrich, primary, Freitag-Wolf, Sandra, primary, Gramatzki, Martin, primary, Kabelitz, Dieter, primary, and Wesch, Daniela, primary

Published
2023
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37. Supplementary Methods from Novel Bispecific Antibodies Increase γδ T-Cell Cytotoxicity against Pancreatic Cancer Cells

Author

Oberg, Hans-Heinrich, primary, Peipp, Matthias, primary, Kellner, Christian, primary, Sebens, Susanne, primary, Krause, Sarah, primary, Petrick, Domantas, primary, Adam-Klages, Sabine, primary, Röcken, Christoph, primary, Becker, Thomas, primary, Vogel, Ilka, primary, Weisner, Dietrich, primary, Freitag-Wolf, Sandra, primary, Gramatzki, Martin, primary, Kabelitz, Dieter, primary, and Wesch, Daniela, primary

Published
2023
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38. Supplementary Table 1 from An Anti-EGFR IgA That Displays Improved Pharmacokinetics and Myeloid Effector Cell Engagement In Vivo

Author

Lohse, Stefan, primary, Meyer, Saskia, primary, Meulenbroek, Laura A.P.M., primary, Jansen, J.H. Marco, primary, Nederend, Maaike, primary, Kretschmer, Anna, primary, Klausz, Katja, primary, Möginger, Uwe, primary, Derer, Stefanie, primary, Rösner, Thies, primary, Kellner, Christian, primary, Schewe, Denis, primary, Sondermann, Peter, primary, Tiwari, Sanjay, primary, Kolarich, Daniel, primary, Peipp, Matthias, primary, Leusen, Jeanette H.W., primary, and Valerius, Thomas, primary

Published
2023
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39. Supplementary Table 3 from An Anti-EGFR IgA That Displays Improved Pharmacokinetics and Myeloid Effector Cell Engagement In Vivo

Author

Lohse, Stefan, primary, Meyer, Saskia, primary, Meulenbroek, Laura A.P.M., primary, Jansen, J.H. Marco, primary, Nederend, Maaike, primary, Kretschmer, Anna, primary, Klausz, Katja, primary, Möginger, Uwe, primary, Derer, Stefanie, primary, Rösner, Thies, primary, Kellner, Christian, primary, Schewe, Denis, primary, Sondermann, Peter, primary, Tiwari, Sanjay, primary, Kolarich, Daniel, primary, Peipp, Matthias, primary, Leusen, Jeanette H.W., primary, and Valerius, Thomas, primary

Published
2023
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40. Supplementary Table 2 from An Anti-EGFR IgA That Displays Improved Pharmacokinetics and Myeloid Effector Cell Engagement In Vivo

Author

Lohse, Stefan, primary, Meyer, Saskia, primary, Meulenbroek, Laura A.P.M., primary, Jansen, J.H. Marco, primary, Nederend, Maaike, primary, Kretschmer, Anna, primary, Klausz, Katja, primary, Möginger, Uwe, primary, Derer, Stefanie, primary, Rösner, Thies, primary, Kellner, Christian, primary, Schewe, Denis, primary, Sondermann, Peter, primary, Tiwari, Sanjay, primary, Kolarich, Daniel, primary, Peipp, Matthias, primary, Leusen, Jeanette H.W., primary, and Valerius, Thomas, primary

Published
2023
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41. Supplementary Figures 1 - 7 from Novel Bispecific Antibodies Increase γδ T-Cell Cytotoxicity against Pancreatic Cancer Cells

Author

Oberg, Hans-Heinrich, primary, Peipp, Matthias, primary, Kellner, Christian, primary, Sebens, Susanne, primary, Krause, Sarah, primary, Petrick, Domantas, primary, Adam-Klages, Sabine, primary, Röcken, Christoph, primary, Becker, Thomas, primary, Vogel, Ilka, primary, Weisner, Dietrich, primary, Freitag-Wolf, Sandra, primary, Gramatzki, Martin, primary, Kabelitz, Dieter, primary, and Wesch, Daniela, primary

Published
2023
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42. Supplementary Figure 1 from An Anti-EGFR IgA That Displays Improved Pharmacokinetics and Myeloid Effector Cell Engagement In Vivo

Author

Lohse, Stefan, primary, Meyer, Saskia, primary, Meulenbroek, Laura A.P.M., primary, Jansen, J.H. Marco, primary, Nederend, Maaike, primary, Kretschmer, Anna, primary, Klausz, Katja, primary, Möginger, Uwe, primary, Derer, Stefanie, primary, Rösner, Thies, primary, Kellner, Christian, primary, Schewe, Denis, primary, Sondermann, Peter, primary, Tiwari, Sanjay, primary, Kolarich, Daniel, primary, Peipp, Matthias, primary, Leusen, Jeanette H.W., primary, and Valerius, Thomas, primary

Published
2023
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43. Supplementary Material from An Anti-EGFR IgA That Displays Improved Pharmacokinetics and Myeloid Effector Cell Engagement In Vivo

Author

Lohse, Stefan, primary, Meyer, Saskia, primary, Meulenbroek, Laura A.P.M., primary, Jansen, J.H. Marco, primary, Nederend, Maaike, primary, Kretschmer, Anna, primary, Klausz, Katja, primary, Möginger, Uwe, primary, Derer, Stefanie, primary, Rösner, Thies, primary, Kellner, Christian, primary, Schewe, Denis, primary, Sondermann, Peter, primary, Tiwari, Sanjay, primary, Kolarich, Daniel, primary, Peipp, Matthias, primary, Leusen, Jeanette H.W., primary, and Valerius, Thomas, primary

Published
2023
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44. Supplementary Figure 2 from An Anti-EGFR IgA That Displays Improved Pharmacokinetics and Myeloid Effector Cell Engagement In Vivo

Author

Lohse, Stefan, primary, Meyer, Saskia, primary, Meulenbroek, Laura A.P.M., primary, Jansen, J.H. Marco, primary, Nederend, Maaike, primary, Kretschmer, Anna, primary, Klausz, Katja, primary, Möginger, Uwe, primary, Derer, Stefanie, primary, Rösner, Thies, primary, Kellner, Christian, primary, Schewe, Denis, primary, Sondermann, Peter, primary, Tiwari, Sanjay, primary, Kolarich, Daniel, primary, Peipp, Matthias, primary, Leusen, Jeanette H.W., primary, and Valerius, Thomas, primary

Published
2023
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47. Blocking the CD47-Sirpa Axis Enhances Tafasitamab-Mediated Phagocytosis

Author

Biedermann, Alexander, primary, Mangelberger-Eberl, Doris, additional, Mougiakakos, Dimitrios, additional, Büttner-Herold, Maike, additional, Flamann, Cindy, additional, Kellner, Christian, additional, Altmeyer, Sarah, additional, Bittenbring, Jörg, additional, Augsberger, Christian, additional, Patra-Kneuer, Maria, additional, Landgraf, Karin, additional, Ilieva-Babinsky, Kristina, additional, Haskamp, Stefan, additional, Beier, Fabian, additional, Voelkl, Simon, additional, Pallasch, Christian, additional, Jacobs, Benedikt, additional, Steidl, Stefan, additional, Heitmüller, Christina, additional, Mackensen, Andreas, additional, and Bruns, Heiko, additional

Published
2022
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