Search

Your search keyword '"Kelley B"' showing total 865 results
Start Over Author "Kelley B"
865 results on '"Kelley B"'

1. Intrahepatic Cholestasis of Pregnancy and Transaminitis in Women with COVID-19: A Case Series

Author

Anne R. Waldrop, Andrea Henkel, Kelley B. Lee, Maurice L. Druzin, Natali Aziz, Yasser El-Sayed, and Deirdre J. Lyell

Subjects
COVID-19, IHCP, intrahepatic cholestasis of pregnancy, maternal, novel coronavirus, SARS-CoV-2, transaminitis, Gynecology and obstetrics, RG1-991
Abstract

Objective The four initial severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-infected pregnant women presenting at term gestation to our institution presented with transaminitis. Three of the four were diagnosed with intrahepatic cholestasis of pregnancy (IHCP). Growing evidence exists of an associated transaminitis in nonpregnant SARS-CoV-2 patients. However, there are limited data of hepatic involvement of SARS-CoV-2 in pregnancy, and no previous studies have assessed the association with IHCP in patients with coronavirus disease 2019 (COVID-19).

Published
2024
Full Text
View/download PDF

2. Evaluation of whole and core genome multilocus sequence typing allele schemes for Salmonella enterica outbreak detection in a national surveillance network, PulseNet USA

Author

Molly M. Leeper, Beth M. Tolar, Taylor Griswold, Eshaw Vidyaprakash, Kelley B. Hise, Grant M. Williams, Sung B. Im, Jessica C. Chen, Hannes Pouseele, and Heather A. Carleton

Subjects
Salmonella, cgMLST, wgMLST, hqSNP, surveillance, epidemiology, Microbiology, QR1-502
Abstract

Salmonella enterica is a leading cause of bacterial foodborne and zoonotic illnesses in the United States. For this study, we applied four different whole genome sequencing (WGS)-based subtyping methods: high quality single-nucleotide polymorphism (hqSNP) analysis, whole genome multilocus sequence typing using either all loci [wgMLST (all loci)] and only chromosome-associated loci [wgMLST (chrom)], and core genome multilocus sequence typing (cgMLST) to a dataset of isolate sequences from 9 well-characterized Salmonella outbreaks. For each outbreak, we evaluated the genomic and epidemiologic concordance between hqSNP and allele-based methods. We first compared pairwise genomic differences using all four methods. We observed discrepancies in allele difference ranges when using wgMLST (all loci), likely caused by inflated genetic variation due to loci found on plasmids and/or other mobile genetic elements in the accessory genome. Therefore, we excluded wgMLST (all loci) results from any further comparisons in the study. Then, we created linear regression models and phylogenetic tanglegrams using the remaining three methods. K-means analysis using the silhouette method was applied to compare the ability of the three methods to partition outbreak and sporadic isolate sequences. Our results showed that pairwise hqSNP differences had high concordance with cgMLST and wgMLST (chrom) allele differences. The slopes of the regressions for hqSNP vs. allele pairwise differences were 0.58 (cgMLST) and 0.74 [wgMLST (chrom)], and the slope of the regression was 0.77 for cgMLST vs. wgMLST (chrom) pairwise differences. Tanglegrams showed high clustering concordance between methods using two statistical measures, the Baker’s gamma index (BGI) and cophenetic correlation coefficient (CCC), where 9/9 (100%) of outbreaks yielded BGI values ≥ 0.60 and CCCs were ≥ 0.97 across all nine outbreaks and all three methods. K-means analysis showed separation of outbreak and sporadic isolate groups with average silhouette widths ≥ 0.87 for outbreak groups and ≥ 0.16 for sporadic groups. This study demonstrates that Salmonella isolates clustered in concordance with epidemiologic data using three WGS-based subtyping methods and supports using cgMLST as the primary method for national surveillance of Salmonella outbreak clusters.

Published
2023
Full Text
View/download PDF

4. Urbanized White Ibises (Eudocimus albus) as Carriers of Salmonella enterica of Significance to Public Health and Wildlife.

Author

Sonia M Hernandez, Catharine N Welch, Valerie E Peters, Erin K Lipp, Shannon Curry, Michael J Yabsley, Susan Sanchez, Andrea Presotto, Peter Gerner-Smidt, Kelley B Hise, Elizabeth Hammond, Whitney M Kistler, Marguerite Madden, April L Conway, Tiffany Kwan, and John J Maurer

Subjects
Medicine, Science
Abstract

Worldwide, Salmonella spp. is a significant cause of disease for both humans and wildlife, with wild birds adapted to urban environments having different opportunities for pathogen exposure, infection, and transmission compared to their natural conspecifics. Food provisioning by people may influence these factors, especially when high-density mixed species flocks aggregate. White Ibises (Eudocimus albus), an iconic Everglades species in decline in Florida, are becoming increasingly common in urbanized areas of south Florida where most are hand-fed. We examined the prevalence of Salmonella shedding by ibises to determine the role of landscape characteristics where ibis forage and their behavior, on shedding rates. We also compared Salmonella isolated from ibises to human isolates to better understand non-foodborne human salmonellosis. From 2010-2013, 13% (n = 261) adult/subadult ibises and 35% (n = 72) nestlings sampled were shedding Salmonella. The prevalence of Salmonella shedding by ibises significantly decreased as the percent of Palustrine emergent wetlands and herbaceous grasslands increased, and increased as the proportion of open-developed land types (e.g. parks, lawns, golf courses) increased, suggesting that natural ecosystem land cover types supported birds with a lower prevalence of infection. A high diversity of Salmonella serotypes (n = 24) and strain types (43 PFGE types) were shed by ibises, of which 33% of the serotypes ranked in the top 20 of high significance for people in the years of the study. Importantly, 44% of the Salmonella Pulsed-Field Gel Electrophoresis patterns for ibis isolates (n = 43) matched profiles in the CDC PulseNet USA database. Of these, 20% came from Florida in the same three years we sampled ibis. Importantly, there was a negative relationship between the amount of Palustrine emergent wetland and the number of Salmonella isolates from ibises that matched human cases in the PulseNet database (p = 0.056). Together, our results indicate that ibises are good indicators of salmonellae strains circulating in their environment and they have both the potential and opportunity to transmit salmonellae to people. Finally, they may act as salmonellae carriers to natural environments where other more highly-susceptible groups (nestlings) may be detrimentally affected.

Published
2016
Full Text
View/download PDF

5. Diversity and Persistence of Salmonella enterica Strains in Rural Landscapes in the Southeastern United States.

Author

John J Maurer, Gordon Martin, Sonia Hernandez, Ying Cheng, Peter Gerner-Smidt, Kelley B Hise, Melissa Tobin D'Angelo, Dana Cole, Susan Sanchez, Marguerite Madden, Steven Valeika, Andrea Presotto, and Erin K Lipp

Subjects
Medicine, Science
Abstract

Salmonellosis cases in the in the United States show distinct geographical trends, with the southeast reporting among the highest rates of illness. In the state of Georgia, USA, non-outbreak associated salmonellosis is especially high in the southern low-lying coastal plain. Here we examined the distribution of Salmonella enterica in environmental waters and associated wildlife in two distinct watersheds, one in the Atlantic Coastal Plain (a high case rate rural area) physiographic province and one in the Piedmont (a lower case rate rural area). Salmonella were isolated from the two regions and compared for serovar and strain diversity, as well as distribution, between the two study areas, using both a retrospective and prospective design. Thirty-seven unique serovars and 204 unique strain types were identified by pulsed-field gel electrophoresis (PFGE). Salmonella serovars Braenderup, Give, Hartford, and Muenchen were dominant in both watersheds. Two serovars, specifically S. Muenchen and S. Rubislaw, were consistently isolated from both systems, including water and small mammals. Conversely, 24 serovars tended to be site-specific (64.8%, n = 37). Compared to the other Salmonella serovars isolated from these sites, S. Muenchen and S. Rubislaw exhibited significant genetic diversity. Among a subset of PFGE patterns, approximately half of the environmental strain types matched entries in the USA PulseNet database of human cases. Ninety percent of S. Muenchen strains from the Little River basin (the high case rate area) matched PFGE entries in PulseNet compared to 33.33% of S. Muenchen strains from the North Oconee River region (the lower case rate area). Underlying the diversity and turnover of Salmonella strains observed for these two watersheds is the persistence of specific Salmonella serovars and strain types that may be adapted to these watersheds and landscapes.

Published
2015
Full Text
View/download PDF

6. Controls on spatial variation in porewater methane concentrations across United States tidal wetlands

Author

Koontz, Erika L., Parker, Sarah M., Stearns, Alice E., Roberts, Brian J., Young, Caitlin M., Windham-Myers, Lisamarie, Oikawa, Patricia Y., Megonigal, J. Patrick, Noyce, Genevieve L., Buskey, Edward J., Derby, R. Kyle, Dunn, Robert P., Ferner, Matthew C., Krask, Julie L., Marconi, Christina M., Savage, Kelley B., Shahan, Julie, Spivak, Amanda C., St. Laurent, Kari A., Argueta, Jacob M., Baird, Steven J., Beheshti, Kathryn M., Crane, Laura C., Cressman, Kimberly A., Crooks, Jeffrey A., Fernald, Sarah H., Garwood, Jason A., Goldstein, Jason S., Grothues, Thomas M., Habeck, Andrea, Lerberg, Scott B., Lucas, Samantha B., Marcum, Pamela, Peter, Christopher R., Phipps, Scott W., Raposa, Kenneth B., Rovai, Andre S., Schooler, Shon S., Twilley, Robert R., Tyrrell, Megan C., Uyeda, Kellie A., Wulfing, Sophie H., Aman, Jacob T., Giacchetti, Amanda, Cross-Johnson, Shelby N., and Holmquist, James R.

Published
2024
Full Text
View/download PDF

7. Meta-analysis of pulsed-field gel electrophoresis fingerprints based on a constructed Salmonella database.

Author

Wen Zou, Hung-Chia Chen, Kelley B Hise, Hailin Tang, Steven L Foley, Joe Meehan, Wei-Jiun Lin, Rajesh Nayak, Joshua Xu, Hong Fang, and James J Chen

Subjects
Medicine, Science
Abstract

A database was constructed consisting of 45,923 Salmonella pulsed-field gel electrophoresis (PFGE) patterns. The patterns, randomly selected from all submissions to CDC PulseNet during 2005 to 2010, included the 20 most frequent serotypes and 12 less frequent serotypes. Meta-analysis was applied to all of the PFGE patterns in the database. In the range of 20 to 1100 kb, serotype Enteritidis averaged the fewest bands at 12 bands and Paratyphi A the most with 19, with most serotypes in the 13-15 range among the 32 serptypes. The 10 most frequent bands for each of the 32 serotypes were sorted and distinguished, and the results were in concordance with those from distance matrix and two-way hierarchical cluster analyses of the patterns in the database. The hierarchical cluster analysis divided the 32 serotypes into three major groups according to dissimilarity measures, and revealed for the first time the similarities among the PFGE patterns of serotype Saintpaul to serotypes Typhimurium, Typhimurium var. 5-, and I 4,[5],12:i:-; of serotype Hadar to serotype Infantis; and of serotype Muenchen to serotype Newport. The results of the meta-analysis indicated that the pattern similarities/dissimilarities determined the serotype discrimination of PFGE method, and that the possible PFGE markers may have utility for serotype identification. The presence of distinct, serotype specific patterns may provide useful information to aid in the distribution of serotypes in the population and potentially reduce the need for laborious analyses, such as traditional serotyping.

Published
2013
Full Text
View/download PDF

9. Worldwide Variation in the Use of Nuclear Cardiology Camera Technology, Reconstruction Software, and Imaging Protocols

Author

Einstein, A.J., Pascual, T.N.B., Paez, D., Dondi, M., Better, N., Bouyoucef, S.E., Karthikeyan, G., Kashyap, R., Lele, V., Magboo, V.P.C., Mahmarian, J.J., Meeks, J.B., Mercuri, M., Mut, F., Rehani, M.M., Vitola, J.V., Alexanderson, E., Allam, A., Al-Mallah, M.H., Bom, H., Flotats, A., Jerome, S., Kaufmann, P.A., Luxenburg, O., Mahmarian, J., Shaw, L.J., Underwood, S.R., Vitola, J., Amouri, W., Essabbah, H., Gassama, S.S., Makhdomi, K.B., El Mustapha, G.I.E., El Ouchdi, N., Qaïs, N., Soni, N., Vangu, W., Abazid, R.M., Adams, B., Agarwal, V., Alfeeli, M.A., Alnafisi, N., Bernabe, L., Bural, G.G., Chaiwatanarat, T., Chandraguptha, J.M., Cheon, G.J., Cho, I., Dogan, A.S., Eftekhari, M., Frenkel, A., Garty, I., George, S., Geramifar, P., Golan, H., Habib, S., Hussain, R., Im, H., Jeon, H.-J., Kalawat, T., Kang, W.J., Keng, F., Klaipetch, A., Kumar, P.G., Lee, J., Lee, W.W., Lim, I., Macaisa, C.M.M., Malhotra, G., Mittal, B.R., Mohammad, M.H., Mohan, P., Mulyanto, I.D., Nariman, D., Nayak, U.N., Niaz, K., Nikolov, G., Obaldo, J.M., Ozturk, E., Park, J.M., Park, S., Patel, C.D., Phuong, H.K., Quinon, A.P., Rajini, T.R., Saengsuda, Y., Santiago, J., Sayman, H.B., Shinto, A.S., Sivasubramaniyan, V., Son, M.H., Sudhakar, P., Syed, G.M.S., Tamaki, N., Thamnirat, K., Thientunyakit, T., Thongmak, S., Velasco, D.N., Verma, A., Vutrapongwatana, U., Wang, Y., Won, K.S., Yao, Z., Yingsa-nga, T., Yudistiro, R., Yue, K.T., Zafrir, N., Adrian, S.C., Agostini, D., Aguadé, S., Armitage, G., Backlund, M., Backman, M., Baker, M., Balducci, M.T., Bavelaar, C., Berovic, M., Bertagna, F., Beuchel, R., Biggi, A., Bisi, G., Bonini, R., Bradley, A., Brudin, L., Bruno, I., Busnardo, E., Casoni, R., Choudhri, A., Cittanti, C., Clauss, R., Costa, D.C., Costa, M., Dixon, K., Dziuk, M., Egelic, N., Eriksson, I., Fagioli, G., de Faria, D.B., Florimonte, L., Francini, A., French, M., Gallagher, E., Garai, I., Geatti, O., Genovesi, D., Gianolli, L., Gimelli, A., Giudice, E. del, Halliwell, S., Hansson, M.J., Harrison, C., Homans, F., Horton, F., Jędrzejuk, D., Jogi, J., Johansen, A., Johansson, H., Kalnina, M., Kaminek, M., Kiss, A., Kobylecka, M., Kostkiewicz, M., Kropp, J., Kullenberg, R., Lahoutte, T., Lang, O., Larsson, Y.H., Lázár, M., Leccisotti, L., Leners, N., Lindner, O., Lipp, R.W., Maenhout, A., Maffioli, L., Marcassa, C., Martins, B., Marzullo, P., Medolago, G., Mendiguchía, C.G., Mirzaei, S., Mori, M., Nardi, B., Nazarenko, S., Nikoletic, K., Oleksa, R., Parviainen, T., Patrina, J., Peace, R., Pirich, C., Piwowarska-Bilska, H., Popa, S., Prakash, V., Pubul, V., Puklavec, L., Rac, S., Ratniece, M., Rogan, S.A., Romeo, A., Rossi, M., Ruiz, D., Sabharwal, N., Salobir, B.G., Santos, A.I., Saranovic, S., Sarkozi, A., Schneider, R.P., Sciagra, R., Scotti, S., Servini, Z., Setti, L.R., Starck, S.-Å., Vajauskas, D., Veselý, J., Vieni, A., Vignati, A., Vito, I.M., Weiss, K., Wild, D., Zdraveska-Kochovska, M., Agüro, R.N., Alvarado, N., Barral, C.M., Beretta, M., Berrocal, I., Cuellar, J.F. Batista, Cabral Chang, T.-M., Cabrera Rodríguez, L.O., Canessa, J., Castro Mora, G., Claudia, A.C., Clavelo, G.F., Júnior, A.F. Cruz, Faccio, F.F., Fernández, K.M., Garibo, J.R. Gomez, Gonzalez, U., González E, P., Guzzo, M.A., Jofre, J., Kapitán, M., Kempfer, G., Lopez, J.L., Massardo V, T., Medeiros Colaco, I., Mesquita, C.T., Montecinos, M., Neubauer, S., Pabon, L.M., Puente, A., Rochela Vazquez, L.M., Serna Macias, J.A., Silva Pino, A.G., Huber, F.Z. Tártari, Tovar, A.P., Vargas, L., Wiefels, C., Aljizeeri, A., Alvarez, R.J., Barger, D., Beardwood, W., Behrens, J., Brann, L., Brown, D., Carr, H., Churchwell, K., Comingore, G.A., Corbett, J., Costello, M., Cruz, F., Depinet, T., Dorbala, S., Earles, M., Esteves, F.P., Etherton, E., Fanning, R.J., Jr., Fornace, J., Franks, L., Gewirtz, H., Gulanchyn, K., Hannah, C.-L., Hays, J., Hendrickson, J., Hester, J., Holmes, K., Johnson, A., Jopek, C., Lewin, H., Lyons, J., Manley, C., Meden, J., Moore, S., Moore, W.H., Murthy, V., Nace, R., Neely, D., Nelson, L., Niedermaier, O., Rice, D., Rigs, R., Schiffer, K., Schockling, E., Schultz, T., Schumacker, T., Sheesley, B., Sheikh, A., Siegel, B., Slim, A.M., Smith, J., Szulc, M., Tanskersley, N., Tilkemeier, P., Valdez, G.D., Vrooman, R., Wawrowicz, D., Winchester, D.E., Alcheikh, A., Allen, B., Atkins, E., Bevan, J., Bonomini, C., Christiansen, J., Clack, L., Craig, E., Dixson, H., Duncan, I., Fredericks, S., Gales, S., Hampson, R., Hanley, T., Hartcher, K., Hassall, J., Kelley, B., Kelly, S., Kidd, T., de Kort, T., Larcos, G., Macdonald, W., McGrath, C., Murdoch, E., O'Malley, S., O'Rourke, M., Pack, M., Pearce, R., Praehofer, R., Ramsay, S., Scarlett, L., Smidt, K., Souvannavong, F., Taubman, K., Taylor, G., Tse, K., Unger, S., Weale, J., Hirschfeld, Cole B., Mercuri, Mathew, Pascual, Thomas N.B., Karthikeyan, Ganesan, Vitola, João V., Mahmarian, John J., Better, Nathan, Bouyoucef, Salah E., Hee-Seung Bom, Henry, Lele, Vikram, Magboo, V. Peter C., Alexánderson, Erick, Allam, Adel H., Al-Mallah, Mouaz H., Dorbala, Sharmila, Flotats, Albert, Jerome, Scott, Kaufmann, Philipp A., Luxenburg, Osnat, Shaw, Leslee J., Underwood, S. Richard, Rehani, Madan M., Paez, Diana, Dondi, Maurizio, and Einstein, Andrew J.

Published
2021
Full Text
View/download PDF

10. Worldwide Diagnostic Reference Levels for Single-Photon Emission Computed Tomography Myocardial Perfusion Imaging: Findings From INCAPS

Author

Einstein, A.J., Pascual, T.N.B., Paez, D., Dondi, M., Better, N., Bouyoucef, S.E., Karthikeyan, G., Kashyap, R., Lele, V., Magboo, V.P.C., Mahmarian, J.J., Meeks, J.B., Mercuri, M., Mut, F., Rehani, M.M., Vitola, J.V., Alexanderson, E., Allam, A., Al-Mallah, M.H., Bom, H., Flotats, A., Jerome, S., Kaufmann, P.A., Luxenburg, O., Mahmarian, J., Shaw, L.J., Underwood, S.R., Vitola, J., Amouri, W., Essabbah, H., Gassama, S.S., Makhdomi, K.B., El Mustapha, G.I.E., El Ouchdi, N., Qaïs, N., Soni, N., Vangu, W., Abazid, R.M., Adams, B., Agarwal, V., Alfeeli, M.A., Alnafisi, N., Bernabe, L., Bural, G.G., Chaiwatanarat, T., Chandraguptha, J.M., Cheon, G.J., Cho, I., Dogan, A.S., Eftekhari, M., Frenkel, A., Garty, I., George, S., Geramifar, P., Golan, H., Habib, S., Hussain, R., Im, H., Jeon, H.-J., Kalawat, T., Kang, W.J., Keng, F., Klaipetch, A., Kumar, P.G., Lee, J., Lee, W.W., Lim, I., Macaisa, C.M.M., Malhotra, G., Mittal, B.R., Mohammad, M.H., Mohan, P., Mulyanto, I.D., Nariman, D., Nayak, U.N., Niaz, K., Nikolov, G., Obaldo, J.M., Ozturk, E., Park, J.M., Park, S., Patel, C.D., Phuong, H.K., Quinon, A.P., Rajini, T.R., Saengsuda, Y., Santiago, J., Sayman, H.B., Shinto, A.S., Sivasubramaniyan, V., Son, M.H., Sudhakar, P., Syed, G.M.S., Tamaki, N., Thamnirat, K., Thientunyakit, T., Thongmak, S., Velasco, D.N., Verma, A., Vutrapongwatana, U., Wang, Y., Won, K.S., Yao, Z., Yingsa-nga, T., Yudistiro, R., Yue, K.T., Zafrir, N., Adrian, S.C., Agostini, D., Aguadé, S., Armitage, G., Backlund, M., Backman, M., Baker, M., Balducci, M.T., Bavelaar, C., Berovic, M., Bertagna, F., Beuchel, R., Biggi, A., Bisi, G., Bonini, R., Bradley, A., Brudin, L., Bruno, I., Busnardo, E., Casoni, R., Choudhri, A., Cittanti, C., Clauss, R., Costa, D.C., Costa, M., Dixon, K., Dziuk, M., Egelic, N., Eriksson, I., Fagioli, G., de Faria, D.B., Florimonte, L., Francini, A., French, M., Gallagher, E., Garai, I., Geatti, O., Genovesi, D., Gianolli, L., Gimelli, A., del Giudice, E., Halliwell, S., Hansson, M.J., Harrison, C., Homans, F., Horton, F., Jędrzejuk, D., Jogi, J., Johansen, A., Johansson, H., Kalnina, M., Kaminek, M., Kiss, A., Kobylecka, M., Kostkiewicz, M., Kropp, J., Kullenberg, R., Lahoutte, T., Lang, O., Larsson, Y.H., Lázár, M., Leccisotti, L., Leners, N., Lindner, O., Lipp, R.W., Maenhout, A., Maffioli, L., Marcassa, C., Martins, B., Marzullo, P., Medolago, G., Mendiguchía, C.G., Mirzaei, S., Mori, M., Nardi, B., Nazarenko, S., Nikoletic, K., Oleksa, R., Parviainen, T., Patrina, J., Peace, R., Pirich, C., Piwowarska-Bilska, H., Popa, S., Prakash, V., Pubul, V., Puklavec, L., Rac, S., Ratniece, M., Rogan, S.A., Romeo, A., Rossi, M., Ruiz, D., Sabharwal, N., Salobir, B.G., Santos, A.I., Saranovic, S., Sarkozi, A., Schneider, R.P., Sciagra, R., Scotti, S., Servini, Z., Setti, L.R., Starck, S.-Å., Vajauskas, D., Veselý, J., Vieni, A., Vignati, A., Vito, I.M., Weiss, K., Wild, D., Zdraveska-Kochovska, M., Agüro, R.N., Alvarado, N., Barral, C.M., Beretta, M., Berrocal, I., Cuellar, J.F. Batista, Chang, T-M. Cabral, Rodríguez, L.O. Cabrera, Canessa, J., Mora, G. Castro, Claudia, A.C., Clavelo, G.F., Júnior, A.F. Cruz, Faccio, F.F., Fernández, K.M., Garibo, J.R. Gomez, Gonzalez, U., González E, P., Guzzo, M.A., Jofre, J., Kapitán, M., Kempfer, G., Lopez, J.L., Massardo V, T., Colaco, I. Medeiros, Mesquita, C.T., Montecinos, M., Neubauer, S., Pabon, L.M., Puente, A., Vazquez, L.M. Rochela, Macias, J.A. Serna, Pino, A.G. Silva, Huber, F.Z. Tártari, Tovar, A.P., Vargas, L., Wiefels, C., Aljizeeri, A., Alvarez, R.J., Barger, D., Beardwood, W., Behrens, J., Brann, L., Brown, D., Carr, H., Churchwell, K., Comingore, G.A., Corbett, J., Costello, M., Cruz, F., Depinet, T., Dorbala, S., Earles, M., Esteves, F.P., Etherton, E., Fanning, R.J., Jr., Fornace, J., Franks, L., Gewirtz, H., Gulanchyn, K., Hannah, C.-L., Hays, J., Hendrickson, J., Hester, J., Holmes, K., Johnson, A., Jopek, C., Lewin, H., Lyons, J., Manley, C., Meden, J., Moore, S., Moore, W.H., Murthy, V., Nace, R., Neely, D., Nelson, L., Niedermaier, O., Rice, D., Rigs, R., Schiffer, K., Schockling, E., Schultz, T., Schumacker, T., Sheesley, B., Sheikh, A., Siegel, B., Slim, A.M., Smith, J., Szulc, M., Tanskersley, N., Tilkemeier, P., Valdez, G.D., Vrooman, R., Wawrowicz, D., Winchester, D.E., Alcheikh, A., Allen, B., Atkins, E., Bevan, J., Bonomini, C., Christiansen, J., Clack, L., Craig, E., Dixson, H., Duncan, I., Fredericks, S., Gales, S., Hampson, R., Hanley, T., Hartcher, K., Hassall, J., Kelley, B., Kelly, S., Kidd, T., de Kort, T., Larcos, G., Macdonald, W., McGrath, C., Murdoch, E., O'Malley, S., O'Rourke, M., Pack, M., Pearce, R., Praehofer, R., Ramsay, S., Scarlett, L., Smidt, K., Souvannavong, F., Taubman, K., Taylor, G., Tse, K., Unger, S., Weale, J., Hirschfeld, Cole B., Dondi, Maurizio, Pascual, Thomas N.B., Mercuri, Mathew, Vitola, Joao, Karthikeyan, Ganesan, Better, Nathan, Mahmarian, John J., Bouyoucef, Salah E., Hee-Seung Bom, Henry, Lele, Vikram, Magboo, Vincent Peter C., Alexánderson, Erick, Allam, Adel H., Al-Mallah, Mouaz H., Flotats, Albert, Jerome, Scott, Kaufmann, Philipp A., Luxenburg, Osnat, Underwood, S. Richard, Rehani, Madan M., Vassileva, Jenia, Paez, Diana, and Einstein, Andrew J.

Published
2021
Full Text
View/download PDF

11. B‐flow/spatiotemporal image correlation M‐mode ultrasound provides novel method to quantify spiral artery remodeling during normal human pregnancy.

Author

Turan, O. M., Liang, Y., Kelley, B., Turan, S., Pepe, G. J., and Albrecht, E. D.

Subjects
VASCULAR smooth muscle, PLACENTAL growth factor, UTERINE artery, SECOND trimester of pregnancy, THIRD trimester of pregnancy
Abstract

Objectives: During human pregnancy, placental extravillous trophoblasts replace vascular smooth muscle and elastic tissue within the walls of the uterine spiral arteries, thereby remodeling them into distensible low‐resistance vessels to promote placental perfusion. The present study determined whether B‐flow/spatiotemporal image correlation (STIC) M‐mode ultrasonography provides an in‐vivo imaging method able to digitally quantify spiral artery luminal distensibility as a physiological index of spiral artery remodeling during the advancing stages of normal human pregnancy. Methods: A prospective, longitudinal, observational study was conducted to quantify spiral artery distensibility (i.e. vessel luminal diameter at systole minus diameter at diastole) by B‐flow/STIC M‐mode ultrasonography during the first, second and third trimesters in 290 women exhibiting a normal pregnancy. Maternal serum levels of placental growth factor (PlGF) and soluble fms‐like tyrosine kinase‐1 (sFlt‐1), growth factors that modulate important events in spiral artery remodeling, were quantified in a subset of the women in the first, second and third trimesters of pregnancy. Results: Median (interquartile range (IQR)) spiral artery distensibility increased progressively between the first (0.17 (0.14–0.21) cm), second (0.23 (0.18–0.28) cm) and third (0.26 (0.21–0.35) cm) trimesters of pregnancy (P < 0.0001 for all). Median (IQR) spiral artery volume flow increased progressively between the first (2.49 (1.38–4.99) mL/cardiac cycle), second (3.86 (2.06–6.91) mL/cardiac cycle) and third (7.79 (3.83–14.98) mL/cardiac cycle) trimesters (P < 0.001 for all). In accordance with the elevation in spiral artery distensibility, the median (IQR) ratio of serum PlGF/sFlt‐1 × 103 levels increased between the first (7.2 (4.5–10.0)), second (22.7 (18.6–42.2)) and third (56.2 (41.9–92.5)) trimesters (P < 0.001 for all). Conclusions: The present study shows that B‐flow/STIC M‐mode ultrasonography provides an in‐vivo imaging technology to quantify digitally the structural and physiological expansion of the walls of the spiral arteries during the cardiac cycle as a consequence of their transformation into compliant vessels during advancing stages of normal human pregnancy. © 2024 International Society of Ultrasound in Obstetrics and Gynecology. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

15. Multistate Outbreak of Salmonella Thompson Infections Linked to Seafood Exposure--United States, 2021

Author

Shen, Ann Q., Dalen, Alyssa, Bankers, Laura, Matzinger, Shannon R., Schwensohn, Colin, Patel, Kane, Hise, Kelley B., Pereira, Evelyn, Cripe, Jennifer, and Jervis, Rachel H.

Subjects
Colorado. Department of Public Health and Environment, United States. Food and Drug Administration, United States. Department of Health and Human Services, Genomics -- Health aspects, Salmon -- Health aspects -- Contamination, Salmonella food poisoning -- Health aspects, Seafood industry -- Health aspects, Salmonella -- Health aspects, Health
Abstract

In July 2021, the Colorado Department of Public Health and Environment (CDPHE) laboratory identified a cluster of five Salmonella enterica serotype Thompson isolates related to one another within one allele [...]

Published
2023

16. Prognostic relevance of gait-related cognitive functions for dementia conversion in amnestic mild cognitive impairment

Author

Tuena, C, Maestri, S, Serino, S, Pedroli, E, Stramba-Badiale, M, Riva, G, Silbert, L, Lind, B, Crissey, R, Kaye, J, Carter, R, Dolen, S, Quinn, J, Schneider, L, Pawluczyk, S, Becerra, M, Teodoro, L, Dagerman, K, Spann, B, Brewer, J, Fleisher, A, Vanderswag, H, Ziolkowski, J, Heidebrink, J, Zbizek-Nulph, L, Lord, J, Albers, C, Petersen, R, Mason, S, Knopman, D, Johnson, K, Villanueva-Meyer, J, Pavlik, V, Pacini, N, Lamb, A, Kass, J, Doody, R, Shibley, V, Chowdhury, M, Rountree, S, Dang, M, Stern, Y, Honig, L, Mintz, A, Ances, B, Morris, J, Winkfield, D, Carroll, M, Stobbs-Cucchi, G, Oliver, A, Creech, M, Mintun, M, Schneider, S, Geldmacher, D, Love, M, Griffith, R, Clark, D, Brockington, J, Marson, D, Grossman, H, Goldstein, M, Greenberg, J, Mitsis, E, Shah, R, Lamar, M, Samuels, P, Duara, R, Greig-Custo, M, Rodriguez, R, Albert, M, Onyike, C, Farrington, L, Rudow, S, Brichko, R, Kielb, S, Smith, A, Raj, B, Fargher, K, Sadowski, M, Wisniewski, T, Shulman, M, Faustin, A, Rao, J, Castro, K, Ulysse, A, Chen, S, Doraiswamy, P, Petrella, J, James, O, Wong, T, Borges-Neto, S, Karlawish, J, Wolk, D, Vaishnavi, S, Clark, C, Arnold, S, Smith, C, Jicha, G, Khouli, R, Raslau, F, Lopez, O, Oakley, M, Simpson, D, Porsteinsson, A, Martin, K, Kowalski, N, Keltz, M, Goldstein, B, Makino, K, Ismail, M, Brand, C, Thai, G, Pierce, A, Yanez, B, Sosa, E, Witbracht, M, Kelley, B, Nguyen, T, Womack, K, Mathews, D, Quiceno, M, Levey, A, Lah, J, Hajjar, I, Burns, J, Swerdlow, R, Brooks, W, Silverman, D, Kremen, S, Apostolova, L, Tingus, K, Lu, P, Bartzokis, G, Woo, E, Teng, E, Graff-Radford, N, Parfitt, F, Poki-Walker, K, Farlow, M, Hake, A, Matthews, B, Brosch, J, Herring, S, van Dyck, C, Mecca, A, Good, S, Macavoy, M, Carson, R, Varma, P, Chertkow, H, Vaitekunas, S, Hosein, C, Black, S, Stefanovic, B, Heyn, C, Hsiung, G, Kim, E, Mudge, B, Sossi, V, Feldman, H, Assaly, M, Finger, E, Pasternak, S, Rachinsky, I, Kertesz, A, Drost, D, Rogers, J, Grant, I, Muse, B, Rogalski, E, Robson, J, Mesulam, M, Kerwin, D, Wu, C, Johnson, N, Lipowski, K, Weintraub, S, Bonakdarpour, B, Pomara, N, Hernando, R, Sarrael, A, Rosen, H, Miller, B, Weiner, M, Perry, D, Turner, R, Reynolds, B, Mccann, K, Poe, J, Marshall, G, Sperling, R, Yesavage, J, Taylor, J, Chao, S, Coleman, J, White, J, Lane, B, Rosen, A, Tinklenberg, J, Belden, C, Atri, A, Clark, K, Zamrini, E, Sabbagh, M, Killiany, R, Stern, R, Mez, J, Kowall, N, Budson, A, Obisesan, T, Ntekim, O, Wolday, S, Khan, J, Nwulia, E, Nadarajah, S, Lerner, A, Ogrocki, P, Tatsuoka, C, Fatica, P, Fletcher, E, Maillard, P, Olichney, J, Decarli, C, Carmichael, O, Bates, V, Capote, H, Rainka, M, Borrie, M, Lee, T, Bartha, R, Johnson, S, Asthana, S, Carlsson, C, Perrin, A, Burke, A, Scharre, D, Kataki, M, Tarawneh, R, Hart, D, Zimmerman, E, Celmins, D, Miller, D, Ponto, L, Smith, K, Koleva, H, Shim, H, Nam, K, Schultz, S, Williamson, J, Craft, S, Cleveland, J, Yang, M, Sink, K, Ott, B, Drake, J, Tremont, G, Daiello, L, Ritter, A, Bernick, C, Munic, D, O'Connelll, A, Mintzer, J, Wiliams, A, Masdeu, J, Shi, J, Garcia, A, Newhouse, P, Potkin, S, Salloway, S, Malloy, P, Correia, S, Kittur, S, Pearlson, G, Blank, K, Anderson, K, Flashman, L, Seltzer, M, Hynes, M, Santulli, R, Relkin, N, Chiang, G, Lee, A, Lin, M, Ravdin, L, Tuena C., Maestri S., Serino S., Pedroli E., Stramba-Badiale M., Riva G., Silbert L. C., Lind B., Crissey R., Kaye J. A., Carter R., Dolen S., Quinn J., Schneider L. S., Pawluczyk S., Becerra M., Teodoro L., Dagerman K., Spann B. M., Brewer J., Fleisher A., Vanderswag H., Ziolkowski J., Heidebrink J. L., Zbizek-Nulph L., Lord J. L., Albers C. S., Petersen R., Mason S. S., Knopman D., Johnson K., Villanueva-Meyer J., Pavlik V., Pacini N., Lamb A., Kass J. S., Doody R. S., Shibley V., Chowdhury M., Rountree S., Dang M., Stern Y., Honig L. S., Mintz A., Ances B., Morris J. C., Winkfield D., Carroll M., Stobbs-Cucchi G., Oliver A., Creech M. L., Mintun M. A., Schneider S., Geldmacher D., Love M. N., Griffith R., Clark D., Brockington J., Marson D., Grossman H., Goldstein M. A., Greenberg J., Mitsis E., Shah R. C., Lamar M., Samuels P., Duara R., Greig-Custo M. T., Rodriguez R., Albert M., Onyike C., Farrington L., Rudow S., Brichko R., Kielb S., Smith A., Raj B. A., Fargher K., Sadowski M., Wisniewski T., Shulman M., Faustin A., Rao J., Castro K. M., Ulysse A., Chen S., Doraiswamy P. M., Petrella J. R., James O., Wong T. Z., Borges-Neto S., Karlawish J. H., Wolk D. A., Vaishnavi S., Clark C. M., Arnold S. E., Smith C. D., Jicha G. A., Khouli R. E., Raslau F. D., Lopez O. L., Oakley M. A., Simpson D. M., Porsteinsson A. P., Martin K., Kowalski N., Keltz M., Goldstein B. S., Makino K. M., Ismail M. S., Brand C., Thai G., Pierce A., Yanez B., Sosa E., Witbracht M., Kelley B., Nguyen T., Womack K., Mathews D., Quiceno M., Levey A. I., Lah J. J., Hajjar I., Burns J. M., Swerdlow R. H., Brooks W. M., Silverman D. H. S., Kremen S., Apostolova L., Tingus K., Lu P. H., Bartzokis G., Woo E., Teng E., Graff-Radford N. R., Parfitt F., Poki-Walker K., Farlow M. R., Hake A. M., Matthews B. R., Brosch J. R., Herring S., van Dyck C. H., Mecca A. P., Good S. P., MacAvoy M. G., Carson R. E., Varma P., Chertkow H., Vaitekunas S., Hosein C., Black S., Stefanovic B., Heyn C., Hsiung G. -Y. R., Kim E., Mudge B., Sossi V., Feldman H., Assaly M., Finger E., Pasternak S., Rachinsky I., Kertesz A., Drost D., Rogers J., Grant I., Muse B., Rogalski E., Robson J., Mesulam M. -M., Kerwin D., Wu C. -K., Johnson N., Lipowski K., Weintraub S., Bonakdarpour B., Pomara N., Hernando R., Sarrael A., Rosen H. J., Miller B. L., Weiner M. W., Perry D., Turner R. S., Reynolds B., MCCann K., Poe J., Marshall G. A., Sperling R. A., Johnson K. A., Yesavage J., Taylor J. L., Chao S., Coleman J., White J. D., Lane B., Rosen A., Tinklenberg J., Belden C. M., Atri A., Clark K. A., Zamrini E., Sabbagh M., Killiany R., Stern R., Mez J., Kowall N., Budson A. E., Obisesan T. O., Ntekim O. E., Wolday S., Khan J. I., Nwulia E., Nadarajah S., Lerner A., Ogrocki P., Tatsuoka C., Fatica P., Fletcher E., Maillard P., Olichney J., DeCarli C., Carmichael O., Bates V., Capote H., Rainka M., Borrie M., Lee T. -Y., Bartha R., Johnson S., Asthana S., Carlsson C. M., Perrin A., Burke A., Scharre D. W., Kataki M., Tarawneh R., Hart D., Zimmerman E. A., Celmins D., Miller D. D., Ponto L. L. B., Smith K. E., Koleva H., Shim H., Nam K. W., Schultz S. K., Williamson J. D., Craft S., Cleveland J., Yang M., Sink K. M., Ott B. R., Drake J., Tremont G., Daiello L. A., Drake J. D., Ritter A., Bernick C., Munic D., O'Connelll A., Mintzer J., Wiliams A., Masdeu J., Shi J., Garcia A., Newhouse P., Potkin S., Salloway S., Malloy P., Correia S., Kittur S., Pearlson G. D., Blank K., Anderson K., Flashman L. A., Seltzer M., Hynes M. L., Santulli R. B., Relkin N., Chiang G., Lee A., Lin M., Ravdin L., Tuena, C, Maestri, S, Serino, S, Pedroli, E, Stramba-Badiale, M, Riva, G, Silbert, L, Lind, B, Crissey, R, Kaye, J, Carter, R, Dolen, S, Quinn, J, Schneider, L, Pawluczyk, S, Becerra, M, Teodoro, L, Dagerman, K, Spann, B, Brewer, J, Fleisher, A, Vanderswag, H, Ziolkowski, J, Heidebrink, J, Zbizek-Nulph, L, Lord, J, Albers, C, Petersen, R, Mason, S, Knopman, D, Johnson, K, Villanueva-Meyer, J, Pavlik, V, Pacini, N, Lamb, A, Kass, J, Doody, R, Shibley, V, Chowdhury, M, Rountree, S, Dang, M, Stern, Y, Honig, L, Mintz, A, Ances, B, Morris, J, Winkfield, D, Carroll, M, Stobbs-Cucchi, G, Oliver, A, Creech, M, Mintun, M, Schneider, S, Geldmacher, D, Love, M, Griffith, R, Clark, D, Brockington, J, Marson, D, Grossman, H, Goldstein, M, Greenberg, J, Mitsis, E, Shah, R, Lamar, M, Samuels, P, Duara, R, Greig-Custo, M, Rodriguez, R, Albert, M, Onyike, C, Farrington, L, Rudow, S, Brichko, R, Kielb, S, Smith, A, Raj, B, Fargher, K, Sadowski, M, Wisniewski, T, Shulman, M, Faustin, A, Rao, J, Castro, K, Ulysse, A, Chen, S, Doraiswamy, P, Petrella, J, James, O, Wong, T, Borges-Neto, S, Karlawish, J, Wolk, D, Vaishnavi, S, Clark, C, Arnold, S, Smith, C, Jicha, G, Khouli, R, Raslau, F, Lopez, O, Oakley, M, Simpson, D, Porsteinsson, A, Martin, K, Kowalski, N, Keltz, M, Goldstein, B, Makino, K, Ismail, M, Brand, C, Thai, G, Pierce, A, Yanez, B, Sosa, E, Witbracht, M, Kelley, B, Nguyen, T, Womack, K, Mathews, D, Quiceno, M, Levey, A, Lah, J, Hajjar, I, Burns, J, Swerdlow, R, Brooks, W, Silverman, D, Kremen, S, Apostolova, L, Tingus, K, Lu, P, Bartzokis, G, Woo, E, Teng, E, Graff-Radford, N, Parfitt, F, Poki-Walker, K, Farlow, M, Hake, A, Matthews, B, Brosch, J, Herring, S, van Dyck, C, Mecca, A, Good, S, Macavoy, M, Carson, R, Varma, P, Chertkow, H, Vaitekunas, S, Hosein, C, Black, S, Stefanovic, B, Heyn, C, Hsiung, G, Kim, E, Mudge, B, Sossi, V, Feldman, H, Assaly, M, Finger, E, Pasternak, S, Rachinsky, I, Kertesz, A, Drost, D, Rogers, J, Grant, I, Muse, B, Rogalski, E, Robson, J, Mesulam, M, Kerwin, D, Wu, C, Johnson, N, Lipowski, K, Weintraub, S, Bonakdarpour, B, Pomara, N, Hernando, R, Sarrael, A, Rosen, H, Miller, B, Weiner, M, Perry, D, Turner, R, Reynolds, B, Mccann, K, Poe, J, Marshall, G, Sperling, R, Yesavage, J, Taylor, J, Chao, S, Coleman, J, White, J, Lane, B, Rosen, A, Tinklenberg, J, Belden, C, Atri, A, Clark, K, Zamrini, E, Sabbagh, M, Killiany, R, Stern, R, Mez, J, Kowall, N, Budson, A, Obisesan, T, Ntekim, O, Wolday, S, Khan, J, Nwulia, E, Nadarajah, S, Lerner, A, Ogrocki, P, Tatsuoka, C, Fatica, P, Fletcher, E, Maillard, P, Olichney, J, Decarli, C, Carmichael, O, Bates, V, Capote, H, Rainka, M, Borrie, M, Lee, T, Bartha, R, Johnson, S, Asthana, S, Carlsson, C, Perrin, A, Burke, A, Scharre, D, Kataki, M, Tarawneh, R, Hart, D, Zimmerman, E, Celmins, D, Miller, D, Ponto, L, Smith, K, Koleva, H, Shim, H, Nam, K, Schultz, S, Williamson, J, Craft, S, Cleveland, J, Yang, M, Sink, K, Ott, B, Drake, J, Tremont, G, Daiello, L, Ritter, A, Bernick, C, Munic, D, O'Connelll, A, Mintzer, J, Wiliams, A, Masdeu, J, Shi, J, Garcia, A, Newhouse, P, Potkin, S, Salloway, S, Malloy, P, Correia, S, Kittur, S, Pearlson, G, Blank, K, Anderson, K, Flashman, L, Seltzer, M, Hynes, M, Santulli, R, Relkin, N, Chiang, G, Lee, A, Lin, M, Ravdin, L, Tuena C., Maestri S., Serino S., Pedroli E., Stramba-Badiale M., Riva G., Silbert L. C., Lind B., Crissey R., Kaye J. A., Carter R., Dolen S., Quinn J., Schneider L. S., Pawluczyk S., Becerra M., Teodoro L., Dagerman K., Spann B. M., Brewer J., Fleisher A., Vanderswag H., Ziolkowski J., Heidebrink J. L., Zbizek-Nulph L., Lord J. L., Albers C. S., Petersen R., Mason S. S., Knopman D., Johnson K., Villanueva-Meyer J., Pavlik V., Pacini N., Lamb A., Kass J. S., Doody R. S., Shibley V., Chowdhury M., Rountree S., Dang M., Stern Y., Honig L. S., Mintz A., Ances B., Morris J. C., Winkfield D., Carroll M., Stobbs-Cucchi G., Oliver A., Creech M. L., Mintun M. A., Schneider S., Geldmacher D., Love M. N., Griffith R., Clark D., Brockington J., Marson D., Grossman H., Goldstein M. A., Greenberg J., Mitsis E., Shah R. C., Lamar M., Samuels P., Duara R., Greig-Custo M. T., Rodriguez R., Albert M., Onyike C., Farrington L., Rudow S., Brichko R., Kielb S., Smith A., Raj B. A., Fargher K., Sadowski M., Wisniewski T., Shulman M., Faustin A., Rao J., Castro K. M., Ulysse A., Chen S., Doraiswamy P. M., Petrella J. R., James O., Wong T. Z., Borges-Neto S., Karlawish J. H., Wolk D. A., Vaishnavi S., Clark C. M., Arnold S. E., Smith C. D., Jicha G. A., Khouli R. E., Raslau F. D., Lopez O. L., Oakley M. A., Simpson D. M., Porsteinsson A. P., Martin K., Kowalski N., Keltz M., Goldstein B. S., Makino K. M., Ismail M. S., Brand C., Thai G., Pierce A., Yanez B., Sosa E., Witbracht M., Kelley B., Nguyen T., Womack K., Mathews D., Quiceno M., Levey A. I., Lah J. J., Hajjar I., Burns J. M., Swerdlow R. H., Brooks W. M., Silverman D. H. S., Kremen S., Apostolova L., Tingus K., Lu P. H., Bartzokis G., Woo E., Teng E., Graff-Radford N. R., Parfitt F., Poki-Walker K., Farlow M. R., Hake A. M., Matthews B. R., Brosch J. R., Herring S., van Dyck C. H., Mecca A. P., Good S. P., MacAvoy M. G., Carson R. E., Varma P., Chertkow H., Vaitekunas S., Hosein C., Black S., Stefanovic B., Heyn C., Hsiung G. -Y. R., Kim E., Mudge B., Sossi V., Feldman H., Assaly M., Finger E., Pasternak S., Rachinsky I., Kertesz A., Drost D., Rogers J., Grant I., Muse B., Rogalski E., Robson J., Mesulam M. -M., Kerwin D., Wu C. -K., Johnson N., Lipowski K., Weintraub S., Bonakdarpour B., Pomara N., Hernando R., Sarrael A., Rosen H. J., Miller B. L., Weiner M. W., Perry D., Turner R. S., Reynolds B., MCCann K., Poe J., Marshall G. A., Sperling R. A., Johnson K. A., Yesavage J., Taylor J. L., Chao S., Coleman J., White J. D., Lane B., Rosen A., Tinklenberg J., Belden C. M., Atri A., Clark K. A., Zamrini E., Sabbagh M., Killiany R., Stern R., Mez J., Kowall N., Budson A. E., Obisesan T. O., Ntekim O. E., Wolday S., Khan J. I., Nwulia E., Nadarajah S., Lerner A., Ogrocki P., Tatsuoka C., Fatica P., Fletcher E., Maillard P., Olichney J., DeCarli C., Carmichael O., Bates V., Capote H., Rainka M., Borrie M., Lee T. -Y., Bartha R., Johnson S., Asthana S., Carlsson C. M., Perrin A., Burke A., Scharre D. W., Kataki M., Tarawneh R., Hart D., Zimmerman E. A., Celmins D., Miller D. D., Ponto L. L. B., Smith K. E., Koleva H., Shim H., Nam K. W., Schultz S. K., Williamson J. D., Craft S., Cleveland J., Yang M., Sink K. M., Ott B. R., Drake J., Tremont G., Daiello L. A., Drake J. D., Ritter A., Bernick C., Munic D., O'Connelll A., Mintzer J., Wiliams A., Masdeu J., Shi J., Garcia A., Newhouse P., Potkin S., Salloway S., Malloy P., Correia S., Kittur S., Pearlson G. D., Blank K., Anderson K., Flashman L. A., Seltzer M., Hynes M. L., Santulli R. B., Relkin N., Chiang G., Lee A., Lin M., and Ravdin L.

Abstract

Background: Increasing research suggests that gait abnormalities can be a risk factor for Alzheimer’s Disease (AD). Notably, there is growing evidence highlighting this risk factor in individuals with amnestic Mild Cognitive Impairment (aMCI), however further studies are needed. The aim of this study is to analyze cognitive tests results and brain-related measures over time in aMCI and examine how the presence of gait abnormalities (neurological or orthopedic) or normal gait affects these trends. Additionally, we sought to assess the significance of gait and gait-related measures as prognostic indicators for the progression from aMCI to AD dementia, comparing those who converted to AD with those who remained with a stable aMCI diagnosis during the follow-up. Methods: Four hundred two individuals with aMCI from the Alzheimer’s Disease Neuroimaging Initiative (ADNI) database were included. Robust linear mixed-effects models were used to study the impact of gait abnormalities on a comprehensive neuropsychological battery over 36 months while controlling for relevant medical variables at baseline. The impact of gait on brain measures was also investigated. Lastly, the Cox proportional-hazards model was used to explore the prognostic relevance of abnormal gait and neuropsychological associated tests. Results: While controlling for relevant covariates, we found that gait abnormalities led to a greater decline over time in attention (DSST) and global cognition (MMSE). Intriguingly, psychomotor speed (TMT-A) and divided attention (TMT-B) declined uniquely in the abnormal gait group. Conversely, specific AD global cognition tests (ADAS-13) and auditory-verbal memory (RAVLT immediate recall) declined over time independently of gait profile. All the other cognitive tests were not significantly affected by time or by gait profile. In addition, we found that ventricles size increased faster in the abnormal gait group compared to the normal gait group. In terms of prognosis, abno

Published
2023

18. Environmental Investigation of a Multistate Salmonellosis Outbreak Linked to Live Backyard Poultry from a Mail-Order Hatchery — Michigan, 2018

Author

Hardy, Margaret C., Robertson, Scott A., Sidge, Jennifer, Signs, Kimberly, Stobierski, Mary Grace, Jones, Kelly, Soehnlen, Marty, Stefanovsky, Lisa, Hambley, Adeline, Brandenburg, Joshua M., Martin, Haley, Lauer, A.C., Fields, Patricia, Koski, Lia, Stevenson, Lauren M., Pabilonia, Kristy L., Nichols, Megin C., Basler, Colin A., Ribot, Efrain M., and Hise, Kelley B.

Published
2019

19. Child Trafficking: What School Nurses Need to Know.

Author

Peck, Jessica L., Rigby, Kelley B., Hettenhaus, Katherine P., and King, Kelcey Y.

Subjects
NURSING education, PREVENTION of child abuse, CHILD abuse & psychology, MEDICAL care use, RISK assessment, NURSES, OCCUPATIONAL roles, CHILD abuse, NURSING assessment, CHILDREN'S accident prevention, NURSING, SCHOOL nursing, NURSING practice, HUMAN trafficking, PROFESSIONAL competence, CHILDREN
Abstract

Human trafficking is a severe form of child abuse and maltreatment. Cases are pervasive and no demographic, socioeconomic status, community, or school is immune. The most effective response to human trafficking in school settings requires increased awareness and establishing policies, protocols, and procedures that support collaborative response to suspected human trafficking. School nurses are well equipped to lead these efforts. While the National Association of School Nurses acknowledges the importance of the role of the school nurse in child trafficking response in their Human Trafficking Position Statement, resources to aid school nurses in coordinated recognition and response efforts remain limited. This article reviews clinical guidance on human trafficking through a school-based lens, highlights indicators that should alert school nurses to the risk of trafficking, outlines best practices for response to abuse and exploitation, and provides additional tools and resources available to aid school nurses in their approach to caring for children experiencing trafficking. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

20. Antimicrobial resistance in multistate outbreaks of nontyphoidal Salmonella infections linked to animal contact—United States, 2015–2018

Author

Frey, Erin, primary, Stapleton, G. Sean, additional, Nichols, Megin C., additional, Gollarza, Lauren M., additional, Birhane, Meseret, additional, Chen, Jessica C., additional, McCullough, Andre, additional, Carleton, Heather A., additional, Trees, Eija, additional, Hise, Kelley B., additional, Tolar, Beth, additional, and Francois Watkins, Louise, additional

Published
2023
Full Text
View/download PDF

21. Protracted Outbreak of Salmonella Newport Infections Linked to Ground Beef : Possible Role of Dairy Cows — 21 States, 2016–2017

Author

Marshall, Katherine E. Heiman, Tewell, Mackenzie, Tecle, Selam, Leeper, Molly, Sinatra, Jennifer, Kissler, Bonnie, Fung, Adrienne, Brown, Kerri, Wagner, Darlene, Trees, Eija, Hise, Kelley B., Chaturvedi, Vishnu, Schlater, Linda K., Morningstar-Shaw, Brenda R., Whitlock, Laura, Holt, Kristin, Becker, Karen, Nichols, Megin, Williams, Ian T., Jhung, Michael, Wise, Matthew E., and Gieraltowski, Laura

Published
2018

28. Evaluation of whole and core genome multilocus sequence typing allele schemes for Salmonella enterica outbreak detection in a national surveillance network, PulseNet USA

Author

Leeper, Molly M., primary, Tolar, Beth M., additional, Griswold, Taylor, additional, Vidyaprakash, Eshaw, additional, Hise, Kelley B., additional, Williams, Grant M., additional, Im, Sung B., additional, Chen, Jessica C., additional, Pouseele, Hannes, additional, and Carleton, Heather A., additional

Published
2023
Full Text
View/download PDF

33. Gender Differences in Radiation Dose From Nuclear Cardiology Studies Across the World: Findings From the INCAPS Registry

Author

Einstein, A.J., Pascual, T.N.B., Paez, D., Dondi, M., Better, N., Bouyoucef, S.E., Karthikeyan, G., Kashyap, R., Lele, V., Magboo, V.P.C., Mahmarian, J.J., Meeks, J.B., Mercuri, M., Mut, F., Rehani, M.M., Vitola, J.V., Alexanderson, E., Allam, A., Al-Mallah, M.H., Bom, H., Flotats, A., Jerome, S., Kaufmann, P.A., Luxenburg, O., Mahmarian, J., Shaw, L.J., Underwood, S.R., Vitola, J., Amouri, W., Essabbah, H., Gassama, S.S., Makhdomi, K.B., El Mustapha, G.I.E., El Ouchdi, N., Qaïs, N., Soni, N., Vangu, W., Abazid, R.M., Adams, B., Agarwal, V., Alfeeli, M.A., Alnafisi, N., Bernabe, L., Bural, G.G., Chaiwatanarat, T., Chandraguptha, J.M., Cheon, G.J., Cho, I., Dogan, A.S., Eftekhari, M., Frenkel, A., Garty, I., George, S., Geramifar, P., Golan, H., Habib, S., Hussain, R., Im, H., Jeon, H.-J., Kalawat, T., Kang, W.J., Keng, F., Klaipetch, A., Kumar, P.G., Lee, J., Lee, W.W., Lim, I., Macaisa, C.M.M., Malhotra, G., Mittal, B.R., Mohammad, M.H., Mohan, P., Mulyanto, I.D., Nariman, D., Nayak, U.N., Niaz, K., Nikolov, G., Obaldo, J.M., Ozturk, E., Park, J.M., Park, S., Patel, C.D., Phuong, H.K., Quinon, A.P., Rajini, T.R., Saengsuda, Y., Santiago, J., Sayman, H.B., Shinto, A.S., Sivasubramaniyan, V., Son, M.H., Sudhakar, P., Syed, G.M.S., Tamaki, N., Thamnirat, K., Thientunyakit, T., Thongmak, S., Velasco, D.N., Verma, A., Vutrapongwatana, U., Wang, Y., Won, K.S., Yao, Z., Yingsa-nga, T., Yudistiro, R., Yue, K.T., Zafrir, N., Adrian, S.C., Agostini, D., Aguadé, S., Armitage, G., Backlund, M., Backman, M., Baker, M., Balducci, M.T., Bavelaar, C., Berovic, M., Bertagna, F., Beuchel, R., Biggi, A., Bisi, G., Bonini, R., Bradley, A., Brudin, L., Bruno, I., Busnardo, E., Casoni, R., Choudhri, A., Cittanti, C., Clauss, R., Costa, D.C., Costa, M., Dixon, K., Dziuk, M., Egelic, N., Eriksson, I., Fagioli, G., de Faria, D.B., Florimonte, L., Francini, A., French, M., Gallagher, E., Garai, I., Geatti, O., Genovesi, D., Gianolli, L., Gimelli, A., del Giudice, E., Halliwell, S., Hansson, M.J., Harrison, C., Homans, F., Horton, F., Jędrzejuk, D., Jogi, J., Johansen, A., Johansson, H., Kalnina, M., Kaminek, M., Kiss, A., Kobylecka, M., Kostkiewicz, M., Kropp, J., Kullenberg, R., Lahoutte, T., Lang, O., Larsson, Y.H., Lázár, M., Leccisotti, L., Leners, N., Lindner, O., Lipp, R.W., Maenhout, A., Maffioli, L., Marcassa, C., Martins, B., Marzullo, P., Medolago, G., Mendiguchía, C.G., Mirzaei, S., Mori, M., Nardi, B., Nazarenko, S., Nikoletic, K., Oleksa, R., Parviainen, T., Patrina, J., Peace, R., Pirich, C., Piwowarska-Bilska, H., Popa, S., Prakash, V., Pubul, V., Puklavec, L., Rac, S., Ratniece, M., Rogan, S.A., Romeo, A., Rossi, M., Ruiz, D., Sabharwal, N., Salobir, B.G., Santos, A.I., Saranovic, S., Sarkozi, A., Schneider, R.P., Sciagra, R., Scotti, S., Servini, Z., Setti, L.R., Starck, S.-Å., Vajauskas, D., Veselý, J., Vieni, A., Vignati, A., Vito, I.M., Weiss, K., Wild, D., Zdraveska-Kochovska, M., Agüro, R.N., Alvarado, N., Barral, C.M., Beretta, M., Berrocal, I., Batista Cuellar, J.F., Cabral Chang, T.-M., Cabrera Rodríguez, L.O., Canessa, J., Castro Mora, G., Claudia, A.C., Clavelo, G.F., Cruz Júnior, A.F., Faccio, F.F., Fernández, K.M., Gomez Garibo, J.R., Gonzalez, U., González E., P., Guzzo, M.A., Jofre, J., Kapitán, M., Kempfer, G., Lopez, J.L., Massardo V., T., Medeiros Colaco, I., Mesquita, C.T., Montecinos, M., Neubauer, S., Pabon, L.M., Puente, A., Rochela Vazquez, L.M., Serna Macias, J.A., Silva Pino, A.G., Tártari Huber, F.Z., Tovar, A.P., Vargas, L., Wiefels, C., Aljizeeri, A., Alvarez, R.J., Barger, D., Beardwood, W., Behrens, J., Brann, L., Brown, D., Carr, H., Churchwell, K., Comingore, G.A., Corbett, J., Costello, M., Cruz, F., Depinet, T., Dorbala, S., Earles, M., Esteves, F.P., Etherton, E., Fanning, R.J., Jr., Fornace, J., Franks, L., Gewirtz, H., Gulanchyn, K., Hannah, C.-L., Hays, J., Hendrickson, J., Hester, J., Holmes, K., Johnson, A., Jopek, C., Lewin, H., Lyons, J., Manley, C., Meden, J., Moore, S., Moore, W.H., Murthy, V., Nace, R., Neely, D., Nelson, L., Niedermaier, O., Rice, D., Rigs, R., Schiffer, K., Schockling, E., Schultz, T., Schumacker, T., Sheesley, B., Sheikh, A., Siegel, B., Slim, A.M., Smith, J., Szulc, M., Tanskersley, N., Tilkemeier, P., Valdez, G.D., Vrooman, R., Wawrowicz, D., Winchester, D.E., Alcheikh, A., Allen, B., Atkins, E., Bevan, J., Bonomini, C., Christiansen, J., Clack, L., Craig, E., Dixson, H., Duncan, I., Fredericks, S., Gales, S., Hampson, R., Hanley, T., Hartcher, K., Hassall, J., Kelley, B., Kelly, S., Kidd, T., de Kort, T., Larcos, G., Macdonald, W., McGrath, C., Murdoch, E., O'Malley, S., O'Rourke, M., Pack, M., Pearce, R., Praehofer, R., Ramsay, S., Scarlett, L., Smidt, K., Souvannavong, F., Taubman, K., Taylor, G., Tse, K., Unger, S., Weale, J., Shi, Lynn, Dorbala, Sharmila, Paez, Diana, Shaw, Leslee J., Zukotynski, Katherine A., Pascual, Thomas N.B., Karthikeyan, Ganesan, Vitola, João V., Better, Nathan, Bokhari, Nadia, Rehani, Madan M., Kashyap, Ravi, Dondi, Maurizio, Mercuri, Mathew, and Einstein, Andrew J.

Published
2016
Full Text
View/download PDF

34. Evaluation of core genome and whole genome multilocus sequence typing schemes for Campylobacter jejuni and Campylobacter coli outbreak detection in the USA

Author

Lavin A. Joseph, Taylor Griswold, Eshaw Vidyaprakash, Sung B. Im, Grant M. Williams, Hannes A. Pouseele, Kelley B. Hise, and Heather A. Carleton

Subjects
General Medicine
Abstract

Campylobacter is a leading causing of bacterial foodborne and zoonotic illnesses in the USA. Pulsed-field gene electrophoresis (PFGE) and 7-gene multilocus sequence typing (MLST) have been historically used to differentiate sporadic from outbreak Campylobacter isolates. Whole genome sequencing (WGS) has been shown to provide superior resolution and concordance with epidemiological data when compared with PFGE and 7-gene MLST during outbreak investigations. In this study, we evaluated epidemiological concordance for high-quality SNP (hqSNP), core genome (cg)MLST and whole genome (wg)MLST to cluster or differentiate outbreak-associated and sporadic Campylobacter jejuni and Campylobacter coli isolates. Phylogenetic hqSNP, cgMLST and wgMLST analyses were also compared using Baker’s gamma index (BGI) and cophenetic correlation coefficients. Pairwise distances comparing all three analysis methods were compared using linear regression models. Our results showed that 68/73 sporadic C. jejuni and C. coli isolates were differentiated from outbreak-associated isolates using all three methods. There was a high correlation between cgMLST and wgMLST analyses of the isolates; the BGI, cophenetic correlation coefficient, linear regression model R 2 and Pearson correlation coefficients were >0.90. The correlation was sometimes lower comparing hqSNP analysis to the MLST-based methods; the linear regression model R 2 and Pearson correlation coefficients were between 0.60 and 0.86, and the BGI and cophenetic correlation coefficient were between 0.63 and 0.86 for some outbreak isolates. We demonstrated that C. jejuni and C. coli isolates clustered in concordance with epidemiological data using WGS-based analysis methods. Discrepancies between allele and SNP-based approaches may reflect the differences between how genomic variation (SNPs and indels) are captured between the two methods. Since cgMLST examines allele differences in genes that are common in most isolates being compared, it is well suited to surveillance: searching large genomic databases for similar isolates is easily and efficiently done using allelic profiles. On the other hand, use of an hqSNP approach is much more computer intensive and not scalable to large sets of genomes. If further resolution between potential outbreak isolates is needed, wgMLST or hqSNP analysis can be used.

Published
2023
Full Text
View/download PDF

36. Oral histories document community mobilisation to participate in decision-making regarding a hazardous waste thermal treatment facility.

Author

Richmond-Bryant, Jennifer, Odera, M., Subra, W., Vallee, B., Rivers III, L., Kelley, B., Cramer, J. A., Wilson, A., Tran, J., Beckham, T., Irving, J., and Reams, M.

Subjects
WASTE treatment, HAZARDOUS wastes, ORAL history, ENVIRONMENTAL health, MASS mobilization, LOCAL history, ENVIRONMENTAL justice, VIRTUAL communities
Abstract

Colfax, Louisiana hosts a commercial hazardous waste thermal treatment (TT) facility, which treats fireworks, explosives, and military ordnances by open-burn/open-detonation one mile from the edge of the nearest community. Seventy-one percent of Colfax's residents are Black, and forty-six percent live below poverty, indicating the community's structural vulnerability. This community-based study originated at the behest of Colfax community members. We hypothesised that the close relationships among members of this enclave may have enhanced the community's ability to mobilise in opposition to the TT facility. We conducted semi-structured oral history interviews with nineteen community members and examined the social and interorganisational networks used by the Colfax community to claim its role in decision-making regarding the TT facility after years of exclusion from this process. Interview transcripts were analysed through the lens of community capacity theory to gain insight into how interactions among community members about the environmental hazards led to social mobilisation and improved participation in the decision-making process using codes for communication, organisation, and outcome. Additionally, we reviewed Louisiana Department of Environmental Quality records for complaints about the facility to gauge public participation. One notable theme across several interviews was exclusion from the initial decisionmaking process related to the facility. However, interviewees noted a sustained effort was made among community members to educate themselves about the facility, organise a response through neighbourto-neighbour contact, and take action by submitting formal complaints and participating in public hearings. Through the lens of environmental justice, this study illustrates an evolving condition of procedural justice. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

38. sj-docx-1-opp-10.1177_10781552231168951 - Supplemental material for New-onset persistent hyperglycemia with initiation of brentuximab treatment

Author

Quintas, Joseph, Mowatt, Kelley B, Mullally, Jamie A, and Steinberg, Amir

Subjects
FOS: Clinical medicine, 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified, 111299 Oncology and Carcinogenesis not elsewhere classified
Abstract

Supplemental material, sj-docx-1-opp-10.1177_10781552231168951 for New-onset persistent hyperglycemia with initiation of brentuximab treatment by Joseph Quintas, Kelley B Mowatt, Jamie A Mullally and Amir Steinberg in Journal of Oncology Pharmacy Practice

Published
2023
Full Text
View/download PDF

44. The Federal Workforce Development Program: An Analysis of Probationers and Characteristics Associated with and Predictive of Successful Reentry

Author

McNichols, Kelley B.

Abstract

With years of research focusing on soaring incarceration rates, the phenomena of prisoner reentry has been largely overlooked. The majority of incarcerated people will return to the community setting. In fact, millions of recently released offenders are on some form of community based supervision. Today, recidivism is a problem that plagues prisoner reentry. In order to address the challenge of prisoner reentry successfully, reentry initiatives have been established in an attempt to change the way corrections is conceptualized. The purpose of this study was to examine characteristics of probationers that are associated with and predictive of successful reentry. The data gathered for this study was existing data from the United States Probation and Pretrial Services office in the Western District of Pennsylvania. Existing data examined included a sample of probationers who were enrolled in the Federal Workforce Development Program (WFD) and a sample of probationers who were not enrolled in WFD. Chi-square and logistic regression tests were conducted to examine variables that may be associated with or predictive of successful reentry. The variables explored in this study included age, race, gender, type of offense, substance abuse, mental health, employment, education, WFD, and recidivism. Employment was the only variable found to be predictive and significant of successful reentry. Results may have been impacted by the type of sample, sample size, demographics, limited number of contextual variables, and ordinal nature of the data. Recommendations for future research and program implementation are included. [The dissertation citations contained here are published with the permission of ProQuest LLC. Further reproduction is prohibited without permission. Copies of dissertations may be obtained by Telephone (800) 1-800-521-0600. Web page: http://www.proquest.com/en-US/products/dissertations/individuals.shtml.]

Published
2012

46. Access to land and nature as health determinants: a qualitative analysis exploring meaningful human-nature relationships among Indigenous youth in central Canada

Author

Andrew R. Hatala, Darrien Morton, Cindy Deschenes, and Kelley Bird-Naytowhow

Subjects
Health Determinants, Indigenous Health, Youth, Land, Nature, Canada, Public aspects of medicine, RA1-1270
Abstract

Abstract Background Human relationships with and connections to nature and the “land” are a commonly accepted Social Determinant of Health. Greater knowledge about these relationships can inform public health policies and interventions focused on health equity among Indigenous populations. Two research questions were explored: (1) what are the experiences of meaningful human-nature relationships among Indigenous youth within central Canada; and (2) how do these relationships function as a determinant of health and wellness within their lives. Methods Drawing from three community-based participatory research (CBPR) projects within two urban centers in Saskatchewan and Manitoba, the integrated qualitative findings presented here involved 92 interviews with 52 Indigenous youth that occurred over a period of nine years (2014–2023). Informed by “two-eyed seeing,” this analysis combined Indigenous Methodologies and a Constructivist Grounded Theory approach. Results Our integrative analysis revealed three cross-cutting themes about meaningful human-nature relationships: (1) promoting cultural belonging and positive identity; (2) connecting to community and family; and (3) supporting spiritual health and relationships. The experiences of young people also emphasized barriers to land and nature access within their local environments. Discussion Policies, practices, and interventions aimed at strengthening urban Indigenous young peoples’ relationships to and connections with nature and the land can have a positive impact on their health and wellness. Public Health systems and healthcare providers can learn about leveraging the health benefits of human-nature relationships at individual and community levels, and this is particularly vital for those working to advance health equity among Indigenous populations.

Published
2024
Full Text
View/download PDF

47. Cognitive and Temperament Clusters in 3- to 5-Year-Old Children with Aggressive Behavior

Author

Sakimura, Jean N., Dang, Michelle T., and Ballard, Kelley B.

Abstract

Background: This study assessed the co-occurrence of cognitive problems and difficult temperament characteristics in children aged 3 to 5 years exhibiting aggressive behavior. Methods: Thirty-one children with high ratings on the Aggressive Behavior subscale of the Achenbach Child Behavior Checklist or Teacher Report Form were recruited from a school district-based clinic. Cognitive ability and temperament were assessed with the Differential Ability Scales and the Carey Temperament Scales Behavioral Styles Questionnaire, respectively. Cluster analysis was applied to these variables. Results: Three prominent groups of children sharing cognitive and temperament characteristics emerged. The first, comprising 41.9% of the sample, demonstrated low adaptability, low persistence, high activity, negative mood, and low rhythmicity, along with borderline-deficient cognitive scores. The second (38.7%) demonstrated low adaptability, low persistence, high activity, and negative mood, along with average cognitive scores. The third (19.4%) demonstrated essentially midrange temperament characteristics and average cognitive scores. All 3 groups shared temperamental tendencies toward a higher threshold of response. Most children in the sample also had significant sleep disturbances (54.5%), other health problems (63.6%), and/or suspected developmental problems (54.5%). Conclusions: The widespread presence of sleep, health, cognitive, temperament, and developmental problems in this sample supports the involvement of medical and developmental health experts in teams evaluating young children who present with high levels of aggressive behavior. The diverse nature of cognitive-temperament profiles in this sample also suggests a need to assess cognitive ability and temperament in young, aggressive children to provide individualized interventions. (Contains 6 tables.)

Published
2008

48. Analysis of Salmonella enterica Isolated from a Mixed-Use Watershed in Georgia, USA: Antimicrobial Resistance, Serotype Diversity, and Genetic Relatedness to Human Isolates

Author

Sohyun Cho, Lari M. Hiott, Sandra L. House, Tiffanie A. Woodley, Elizabeth A. McMillan, Poonam Sharma, John B. Barrett, Eric S. Adams, Joshua M. Brandenburg, Kelley B. Hise, Jacob M. Bateman McDonald, Elizabeth A. Ottesen, Erin K. Lipp, Charlene R. Jackson, and Jonathan G. Frye

Subjects
Georgia, Ecology, Salmonella enterica, Water, Microbial Sensitivity Tests, Serogroup, Applied Microbiology and Biotechnology, Anti-Bacterial Agents, Electrophoresis, Gel, Pulsed-Field, Salmonella, Drug Resistance, Multiple, Bacterial, Drug Resistance, Bacterial, Salmonella Infections, Environmental Microbiology, Animals, Humans, Serotyping, Food Science, Biotechnology
Abstract

As the cases of Salmonella enterica infections associated with contaminated water are increasing, this study was conducted to address the role of surface water as a reservoir of S. enterica serotypes. We sampled rivers and streams (n = 688) over a 3-year period (2015 to 2017) in a mixed-use watershed in Georgia, USA, and 70.2% of the total stream samples tested positive for Salmonella. A total of 1,190 isolates were recovered and characterized by serotyping, antimicrobial susceptibility testing, and pulsed-field gel electrophoresis (PFGE). A wide range of serotypes was identified, including those commonly associated with humans and animals, with S. enterica serotype Muenchen being predominant (22.7%) and each serotype exhibiting a high degree of strain diversity by PFGE. About half (46.1%) of the isolates had PFGE patterns indistinguishable from those of human clinical isolates in the CDC PulseNet database. A total of 52 isolates (4.4%) were resistant to antimicrobials, out of which 43 isolates were multidrug resistant (MDR; resistance to two or more classes of antimicrobials). These 52 resistant Salmonella isolates were screened for the presence of antimicrobial resistance genes, plasmid replicons, and class 1 integrons, out of which four representative MDR isolates were selected for whole-genome sequencing analysis. The results showed that 28 MDR isolates resistant to 10 antimicrobials had bla(cmy-2) on an A/C plasmid. Persistent contamination of surface water with a high diversity of Salmonella strains, some of which are drug resistant and genetically indistinguishable from human isolates, supports a role of environmental surface water as a reservoir for and transmission route of this pathogen. IMPORTANCE Salmonella has been traditionally considered a foodborne pathogen, as it is one of the most common etiologies of foodborne illnesses worldwide; however, recent Salmonella outbreaks attributed to fresh produce and water suggest a potential environmental source of Salmonella that causes some human illnesses. Here, we investigated the prevalence, diversity, and antimicrobial resistance of Salmonella isolated from a mixed-use watershed in Georgia, USA, in order to enhance the overall understanding of waterborne Salmonella. The persistence and widespread distribution of Salmonella in surface water confirm environmental sources of the pathogen. A high proportion of waterborne Salmonella with clinically significant serotypes and genetic similarity to strains of human origin supports the role of environmental water as a significant reservoir of Salmonella and indicates a potential waterborne transmission of Salmonella to humans. The presence of antimicrobial-resistant and MDR Salmonella demonstrates additional risks associated with exposure to contaminated environmental water.

Published
2022

49. Analysis of Salmonella enterica Isolated from a Mixed-Use Watershed in Georgia, USA: Antimicrobial Resistance, Serotype Diversity, and Genetic Relatedness to Human Isolates

Author

Cho, Sohyun, primary, Hiott, Lari M., additional, House, Sandra L., additional, Woodley, Tiffanie A., additional, McMillan, Elizabeth A., additional, Sharma, Poonam, additional, Barrett, John B., additional, Adams, Eric S., additional, Brandenburg, Joshua M., additional, Hise, Kelley B., additional, Bateman McDonald, Jacob M., additional, Ottesen, Elizabeth A., additional, Lipp, Erin K., additional, Jackson, Charlene R., additional, and Frye, Jonathan G., additional

Published
2022
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results