1. Overview of COVID‐19 testing and implications for otolaryngologists
- Author
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Vinh, Daniel B, Zhao, Xiao, Kiong, Kimberley L, Guo, Theresa, Jozaghi, Yelda, Yao, Chris, Kelley, James M, and Hanna, Ehab Y
- Subjects
Biomedical and Clinical Sciences ,Clinical Sciences ,Prevention ,Vaccine Related ,Lung ,Emerging Infectious Diseases ,Biodefense ,Infectious Diseases ,4.1 Discovery and preclinical testing of markers and technologies ,4.2 Evaluation of markers and technologies ,Detection ,screening and diagnosis ,Good Health and Well Being ,Antibodies ,Betacoronavirus ,COVID-19 ,COVID-19 Testing ,Clinical Laboratory Techniques ,Coronavirus Infections ,Cough ,Diarrhea ,Dyspnea ,Fatigue ,Fever ,Headache ,Hemoptysis ,Humans ,Immunoglobulin G ,Immunoglobulin M ,Myalgia ,Nasopharynx ,Otorhinolaryngologic Surgical Procedures ,Pandemics ,Pneumonia ,Viral ,Preoperative Care ,Quarantine ,RNA ,Viral ,Reverse Transcriptase Polymerase Chain Reaction ,SARS-CoV-2 ,Sputum ,Tomography ,X-Ray Computed ,PCR ,sensitivity ,testing ,Dentistry ,Otorhinolaryngology ,Clinical sciences - Abstract
BackgroundTesting for SARS-CoV-2 is important for decision making prior to surgery in otolaryngology. An understanding of current and developing testing methods is important for interpreting test results.MethodsWe performed a literature review of current evidence surrounding SARS-CoV-2 diagnostic testing highlighting its utility, limitations, and implications for otolaryngologists.ResultsThe currently accepted RT-PCR test for SARS-CoV-2 has varying sensitivity according to which subsite of the aerodigestive tract is sampled. Nasal swab sensitivities appear to be about 70%. Chest CT imaging for screening purposes is not currently recommended.ConclusionDue to the current sensitivity of RT-PCR based testing for SARS-CoV-2, a negative test cannot rule out COVID-19. Full PPE should be worn during high-risk procedures such as aerosol generating procedures even if testing is negative. Patients who test positive during screening should have their surgeries postponed if possible until asymptomatic and have tested negative for SARS-CoV-2.
- Published
- 2020